{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T12:49:53Z","timestamp":1784033393553,"version":"3.55.0"},"reference-count":43,"publisher":"Royal Society of Chemistry (RSC)","issue":"7","license":[{"start":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T00:00:00Z","timestamp":1592524800000},"content-version":"am","delay-in-days":535,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<p>\n                    The search for new\n                    <italic>in vitro<\/italic>\n                    modular bioreactors to simulate flow-mediated transport and absorption of chemical substances is a very important issue in toxicology and in drug and bioactive delivery research.\n                  <\/p>","DOI":"10.1039\/c9fo00332k","type":"journal-article","created":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T11:34:42Z","timestamp":1560944082000},"page":"4330-4338","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["A new millifluidic-based gastrointestinal platform to evaluate the effect of simulated dietary methylglyoxal intakes"],"prefix":"10.1039","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9675-6598","authenticated-orcid":false,"given":"Raffaella","family":"Colombo","sequence":"first","affiliation":[{"name":"Department of Drug Sciences"},{"name":"University of Pavia"},{"name":"Pavia"},{"name":"Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7751-3336","authenticated-orcid":false,"given":"Mayra","family":"Paolillo","sequence":"additional","affiliation":[{"name":"Department of Drug Sciences"},{"name":"University of Pavia"},{"name":"Pavia"},{"name":"Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1523-7759","authenticated-orcid":false,"given":"Adele","family":"Papetti","sequence":"additional","affiliation":[{"name":"Department of Drug Sciences"},{"name":"University of Pavia"},{"name":"Pavia"},{"name":"Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2019]]},"reference":[{"key":"C9FO00332K-(cit1)\/*[position()=1]","volume-title":"The Principles of Humane Experimental Technique","author":"Russell","year":"1959","unstructured":"W. M. S. Russell   and  R. L.Burch ,  The Principles of Humane Experimental Technique ,  Methuen London ,  1959 , ISBN: 0900767782"},{"key":"C9FO00332K-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/S1359-6446(02)02273-0","volume":"7","author":"Bhadriraju","year":"2002","journal-title":"Drug Discovery Today"},{"key":"C9FO00332K-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.tibtech.2005.04.006","volume":"23","author":"Bhogal","year":"2005","journal-title":"Trends Biotechnol."},{"issue":"2","key":"C9FO00332K-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","DOI":"10.3390\/bioengineering6020047","volume":"4","author":"Lee","year":"2017","journal-title":"Bioengineering"},{"key":"C9FO00332K-(cit5)\/*[position()=1]","volume-title":"The Impact of Food Bio-Actives on Health","author":"Alegr\u00eda","year":"2015","unstructured":"A. Alegr\u00eda  ,  G.Garcia-Llatas  and  A.Cilla ,  Static digestion models: general introduction , in  The Impact of Food Bio-Actives on Health ,  Springer ,  2015 , pp.  3\u201312 , ISBN: 978-3-319-15791-7"},{"key":"C9FO00332K-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3326","DOI":"10.1021\/es010204v","volume":"36","author":"Oomen","year":"2002","journal-title":"Environ. Sci. Technol."},{"key":"C9FO00332K-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/bmc.2771","volume":"27","author":"Yao","year":"2013","journal-title":"Biomed. Chromatogr."},{"key":"C9FO00332K-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1039\/C3FO60702J","volume":"5","author":"Minekus","year":"2014","journal-title":"Food Funct."},{"key":"C9FO00332K-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1039\/C8FO00155C","volume":"9","author":"Blanco-Morales","year":"2018","journal-title":"Food Funct."},{"key":"C9FO00332K-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4992","DOI":"10.1039\/C6FO01293K","volume":"7","author":"Bobrowski Rodrigues","year":"2016","journal-title":"Food Funct."},{"key":"C9FO00332K-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1039\/c2fo10248j","volume":"3","author":"Vors","year":"2012","journal-title":"Food Funct."},{"key":"C9FO00332K-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7172","DOI":"10.1021\/jf030733d","volume":"52","author":"Boyer","year":"2004","journal-title":"J. Agric. Food Chem."},{"issue":"10\u201311","key":"C9FO00332K-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1080\/00498250701704819","volume":"37","author":"Lennernass","year":"2007","journal-title":"Xenobiotica"},{"key":"C9FO00332K-(cit14)\/*[position()=1]","volume-title":"Bioreactors: design, properties and applications","author":"Mazzei","year":"2011","unstructured":"D. Mazzei  ,  S.Giusti ,  T.Sbrana  and  A.Ahluwalia ,  Multicompartmental modular bioreactor as innovative system for dynamic cell cultures and co-cultures , in  Bioreactors: design, properties and applications ,  Nova Science Publisher, Inc. ,  2011 , pp.  159\u2013178 , ISBN: 978-1-62100-164-5"},{"key":"C9FO00332K-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1002\/biot.201400004","volume":"9","author":"Giusti","year":"2014","journal-title":"Biotechnol. J."},{"key":"C9FO00332K-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"697","DOI":"10.3109\/17435390.2013.831500","volume":"8","author":"Ucciferri","year":"2014","journal-title":"Nanotoxicology"},{"key":"C9FO00332K-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/biot.201100177","volume":"7","author":"Vinci","year":"2012","journal-title":"Biotechnol. J."},{"key":"C9FO00332K-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e34704","DOI":"10.1371\/journal.pone.0034704","volume":"7","author":"Iori","year":"2012","journal-title":"PLoS One"},{"key":"C9FO00332K-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1039\/c2lc40089h","volume":"12","author":"Huh","year":"2012","journal-title":"Lab Chip"},{"key":"C9FO00332K-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"20030","DOI":"10.1038\/srep20030","volume":"6","author":"Oleaga","year":"2016","journal-title":"Sci. Rep."},{"key":"C9FO00332K-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3185","DOI":"10.1039\/b915147h","volume":"9","author":"Zhang","year":"2009","journal-title":"Lab Chip"},{"key":"C9FO00332K-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3538","DOI":"10.1039\/c3lc50234a","volume":"13","author":"Wagner","year":"2013","journal-title":"Lab Chip"},{"issue":"9","key":"C9FO00332K-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3389\/fphar.2018.00006","volume":"23","author":"Langhans","year":"2018","journal-title":"Front. Pharmacol."},{"key":"C9FO00332K-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.foodchem.2014.05.022","volume":"164","author":"Papetti","year":"2014","journal-title":"Food Chem."},{"key":"C9FO00332K-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.semcancer.2017.11.014","volume":"49","author":"Hellwig","year":"2018","journal-title":"Semin. Cancer Biol."},{"key":"C9FO00332K-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s12640-015-9588-y","volume":"29","author":"Chun","year":"2016","journal-title":"Neurotoxic. Res."},{"key":"C9FO00332K-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1002\/mnfr.200600065","volume":"50","author":"Nemet","year":"2006","journal-title":"Mol. Nutr. Food Res."},{"key":"C9FO00332K-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.2337\/db16-1578","volume":"66","author":"Hanssen","year":"2017","journal-title":"Diabetes"},{"key":"C9FO00332K-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1111\/dme.13201","volume":"33","author":"Jensen","year":"2016","journal-title":"Diabetic Med."},{"key":"C9FO00332K-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7071","DOI":"10.1021\/jf301306g","volume":"60","author":"Degen","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"C9FO00332K-(cit31)\/*[position()=1]","first-page":"52","volume":"35","author":"Mirza","year":"2013","journal-title":"J. Chem. Soc. Pak."},{"key":"C9FO00332K-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1039\/C5FO01555C","volume":"7","author":"Hamzal\u0131o\u011flu","year":"2016","journal-title":"Food Funct."},{"key":"C9FO00332K-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1006\/abio.1996.0271","volume":"238","author":"Chaplen","year":"1996","journal-title":"Anal. Biochem."},{"key":"C9FO00332K-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.clinbiochem.2004.05.024","volume":"37","author":"Nemet","year":"2004","journal-title":"Clin. Biochem."},{"key":"C9FO00332K-(cit35)\/*[position()=1]","volume-title":"Validation of analytical procedures: text and methodology","author":"ICH guideline Q2(R1)","year":"2005","unstructured":"ICH guideline Q2(R1)  ,  Validation of analytical procedures: text and methodology ,  2005"},{"key":"C9FO00332K-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1039\/c3fo60032g","volume":"4","author":"Kokkinidou","year":"2013","journal-title":"Food Funct."},{"key":"C9FO00332K-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1007\/s00216-012-5817-x","volume":"403","author":"Gensberger","year":"2012","journal-title":"Anal. Bioanal. Chem."},{"key":"C9FO00332K-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1023\/A:1015827908309","volume":"7","author":"Dressman","year":"1996","journal-title":"Pharm. Res."},{"key":"C9FO00332K-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.redox.2013.12.024","volume":"2","author":"Lee","year":"2014","journal-title":"Redox Biol."},{"key":"C9FO00332K-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1042\/bst0311343","volume":"31","author":"Thornalley","year":"2003","journal-title":"Biochem. Soc. Trans."},{"key":"C9FO00332K-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1007\/s00726-010-0783-0","volume":"42","author":"Rabbani","year":"2012","journal-title":"Amino Acids"},{"key":"C9FO00332K-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3631","DOI":"10.1016\/j.bbadis.2018.08.036","volume":"1864","author":"Rowan","year":"2018","journal-title":"BBA, Mol. Basis Dis."},{"key":"C9FO00332K-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10253","DOI":"10.1021\/jf304946p","volume":"61","author":"Degen","year":"2013","journal-title":"J. Agric. Food Chem."}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2019\/FO\/C9FO00332K","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T04:10:59Z","timestamp":1782965459000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/10\/7\/4330-4338\/645482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":43,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7,17]]}},"URL":"https:\/\/doi.org\/10.1039\/c9fo00332k","relation":{},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C9FO00332K","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Raffaella Colombo (ORCID)","URL":"http:\/\/orcid.org\/0000-0001-9675-6598","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Mayra Paolillo (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-7751-3336","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Adele Papetti (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-1523-7759","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 18 February 2019; Accepted 19 June 2019;  Accepted Manuscript published 19 June 2019;  Advance Article published 5 July 2019;  Version of Record published 17 July 2019","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}