{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T03:26:32Z","timestamp":1784431592421,"version":"3.55.0"},"reference-count":35,"publisher":"Royal Society of Chemistry (RSC)","issue":"2","license":[{"start":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T00:00:00Z","timestamp":1609977600000},"content-version":"am","delay-in-days":372,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100004712","name":"Tianjin University of Science and Technology","doi-asserted-by":"crossref","award":["2019001"],"award-info":[{"award-number":["2019001"]}],"id":[{"id":"10.13039\/501100004712","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<p>\n                    Bilberry anthocyanins reversed Alzheimer's disease-induced cognitive disfunction, reduced neuroinflammatory response and induced phagocytosis to beta-amyloid protein plaques\n                    <italic>via<\/italic>\n                    activating microglia.\n                  <\/p>","DOI":"10.1039\/c9fo02103e","type":"journal-article","created":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T21:23:37Z","timestamp":1578345817000},"page":"1572-1584","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Bilberry anthocyanins improve neuroinflammation and cognitive dysfunction in APP\/PSEN1 mice\n                    <i>via<\/i>\n                    the CD33\/TREM2\/TYROBP signaling pathway in microglia"],"prefix":"10.1039","volume":"11","author":[{"given":"Jing","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Food Nutrition and Safety"},{"name":"Tianjin University of Science and Technology"},{"name":"Tianjin 300457"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runtian","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Nutrition and Safety"},{"name":"Tianjin University of Science and Technology"},{"name":"Tianjin 300457"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Jiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Nutrition and Safety"},{"name":"Tianjin University of Science and Technology"},{"name":"Tianjin 300457"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Nutrition and Safety"},{"name":"Tianjin University of Science and Technology"},{"name":"Tianjin 300457"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Nutrition and Safety"},{"name":"Tianjin University of Science and Technology"},{"name":"Tianjin 300457"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2727-0193","authenticated-orcid":false,"given":"Xiaoling","family":"Lyu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Nutrition and Safety"},{"name":"Tianjin University of Science and Technology"},{"name":"Tianjin 300457"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0629-8421","authenticated-orcid":false,"given":"Tao","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Nutrition and Safety"},{"name":"Tianjin University of Science and Technology"},{"name":"Tianjin 300457"},{"name":"China"},{"name":"Beijing Advanced Innovation Center for Food Nutrition and Human Health"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2020]]},"reference":[{"key":"C9FO02103E-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0140-6736(06)69113-7","volume":"368","author":"Blennow","year":"2006","journal-title":"Lancet"},{"key":"C9FO02103E-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.neuron.2019.06.010","volume":"103","author":"Griciuc","year":"2019","journal-title":"Neuron"},{"key":"C9FO02103E-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1172\/JCI122954","volume":"129","author":"Beckelman","year":"2019","journal-title":"J. Clin. Invest."},{"key":"C9FO02103E-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"318p","DOI":"10.1126\/scitranslmed.aal2074","volume":"8","author":"Katsnelson","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"C9FO02103E-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.cell.2017.05.018","volume":"169","author":"Keren-Shaul","year":"2017","journal-title":"Cell"},{"key":"C9FO02103E-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/s41586-019-1769-z","volume":"575","author":"Ising","year":"2019","journal-title":"Nature"},{"key":"C9FO02103E-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/nature25158","volume":"552","author":"Venegas","year":"2017","journal-title":"Nature"},{"key":"C9FO02103E-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"172500","DOI":"10.1016\/j.ejphar.2019.172500","volume":"858","author":"Zhang","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"C9FO02103E-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1002\/mnfr.200700002","volume":"51","author":"Zafra-Stone","year":"2007","journal-title":"Mol. Nutr. Food Res."},{"key":"C9FO02103E-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.foodchem.2018.01.055","volume":"250","author":"Ongkowijoyo","year":"2018","journal-title":"Food Chem."},{"key":"C9FO02103E-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6076","DOI":"10.1007\/s12035-017-0798-6","volume":"55","author":"Ali","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"C9FO02103E-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1039\/C8FO01962B","volume":"10","author":"Li","year":"2019","journal-title":"Food Funct."},{"key":"C9FO02103E-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1007\/s00401-018-1920-1","volume":"136","author":"Oveisgharan","year":"2018","journal-title":"Acta Neuropathol."},{"key":"C9FO02103E-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/752894","volume":"2012","author":"Funk","year":"2012","journal-title":"Int. J. Alzheimer's Dis."},{"key":"C9FO02103E-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7832","DOI":"10.1021\/acs.jafc.9b02567","volume":"67","author":"Li","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"C9FO02103E-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/nature25143","volume":"552","author":"Sorrentino","year":"2017","journal-title":"Nature"},{"key":"C9FO02103E-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.18632\/aging.101464","volume":"10","author":"Zhan","year":"2018","journal-title":"Aging"},{"key":"C9FO02103E-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1002\/jssc.201101121","volume":"35","author":"Garc\u00eda-Villalba","year":"2012","journal-title":"J. Sep. Sci."},{"key":"C9FO02103E-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3260","DOI":"10.3389\/fmicb.2018.03260","volume":"9","author":"Cao","year":"2018","journal-title":"Front. Microbiol."},{"key":"C9FO02103E-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/s41593-018-0332-9","volume":"22","author":"Fang","year":"2019","journal-title":"Nat. Neurosci."},{"key":"C9FO02103E-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.brainresbull.2019.08.007","volume":"153","author":"Giorgi","year":"2019","journal-title":"Brain Res. Bull."},{"key":"C9FO02103E-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5973","DOI":"10.1021\/acs.jafc.7b02136","volume":"65","author":"Wei","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"C9FO02103E-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1111\/1750-3841.14609","volume":"84","author":"Yu","year":"2019","journal-title":"J. Food Sci."},{"key":"C9FO02103E-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s00401-018-1928-6","volume":"137","author":"Broce","year":"2019","journal-title":"Acta Neuropathol."},{"key":"C9FO02103E-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.neuron.2019.06.010","volume":"103","author":"Griciuc","year":"2019","journal-title":"Neuron"},{"key":"C9FO02103E-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s40168-019-0713-7","volume":"7","author":"Li","year":"2019","journal-title":"Microbiome"},{"key":"C9FO02103E-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e00327-17","DOI":"10.1128\/mSphere.00327-17","volume":"2","author":"Bian","year":"2017","journal-title":"mSphere"},{"key":"C9FO02103E-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.cell.2019.02.014","volume":"177","author":"Martorell","year":"2019","journal-title":"Cell"},{"key":"C9FO02103E-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/nature20587","volume":"540","author":"Iaccarino","year":"2016","journal-title":"Nature"},{"key":"C9FO02103E-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1038\/nm1474","volume":"12","author":"Skokowa","year":"2006","journal-title":"Nat. Med."},{"key":"C9FO02103E-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/cdd.2008.172","volume":"16","author":"Rodr\u00edguez","year":"2009","journal-title":"Cell Death Differ."},{"key":"C9FO02103E-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1039\/C8FO01822G","volume":"10","author":"Wang","year":"2019","journal-title":"Food Funct."},{"key":"C9FO02103E-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.molmed.2017.03.008","volume":"23","author":"Yeh","year":"2017","journal-title":"Trends Mol. Med."},{"key":"C9FO02103E-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.2174\/1871527313666140806124850","volume":"13","author":"Gambuzza","year":"2014","journal-title":"CNS Neurol. Disord.: Drug Targets"},{"key":"C9FO02103E-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1007\/s12035-014-8811-9","volume":"51","author":"Ma","year":"2015","journal-title":"Mol. Neurobiol."}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2020\/FO\/C9FO02103E","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T19:52:04Z","timestamp":1782849124000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/11\/2\/1572-1584\/645932"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2,26]]}},"URL":"https:\/\/doi.org\/10.1039\/c9fo02103e","relation":{},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Xiaoling Lyu (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-2727-0193","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Tao Wu (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-0629-8421","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 10 September 2019; Accepted 6 January 2020;  Accepted Manuscript published 7 January 2020;  Advance Article published 31 January 2020;  Version of Record published 26 February 2020","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}