{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:57:10Z","timestamp":1792029430931,"version":"4.4.0"},"reference-count":44,"publisher":"Royal Society of Chemistry (RSC)","issue":"20","license":[{"start":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T00:00:00Z","timestamp":1599696000000},"content-version":"am","delay-in-days":618,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100007053","name":"Korea Institute of Energy Technology Evaluation and Planning","doi-asserted-by":"crossref","award":["20161110100230"],"award-info":[{"award-number":["20161110100230"]}],"id":[{"id":"10.13039\/501100007053","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["NRF-2017R1A3B1023598"],"award-info":[{"award-number":["NRF-2017R1A3B1023598"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Lab Chip"],"abstract":"<p>In this study, we present a new numbering-up metal microreactor by integrating a flow distributor and a copper catalytic module for high productivity of a commercial synthetic drug.<\/p>","DOI":"10.1039\/c9lc00764d","type":"journal-article","created":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T11:03:37Z","timestamp":1568113417000},"page":"3535-3542","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["A numbering-up metal microreactor for the high-throughput production of a commercial drug by copper catalysis"],"prefix":"10.1039","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1001-9958","authenticated-orcid":false,"given":"Gwang-Noh","family":"Ahn","sequence":"first","affiliation":[{"name":"Center of Intelligent Microprocess for Pharmaceutical Synthesis"},{"name":"Department of Chemical Engineering"},{"name":"Pohang University of Science and Technology"},{"name":"Pohang"},{"name":"South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taejong","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering"},{"name":"Pohang University of Science and Technology"},{"name":"Pohang"},{"name":"South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyune-Jea","family":"Lee","sequence":"additional","affiliation":[{"name":"Center of Intelligent Microprocess for Pharmaceutical Synthesis"},{"name":"Department of Chemical Engineering"},{"name":"Pohang University of Science and Technology"},{"name":"Pohang"},{"name":"South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki-Won","family":"Gyak","sequence":"additional","affiliation":[{"name":"Center of Intelligent Microprocess for Pharmaceutical Synthesis"},{"name":"Department of Chemical Engineering"},{"name":"Pohang University of Science and Technology"},{"name":"Pohang"},{"name":"South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Ho","family":"Kang","sequence":"additional","affiliation":[{"name":"Center of Intelligent Microprocess for Pharmaceutical Synthesis"},{"name":"Department of Chemical Engineering"},{"name":"Pohang University of Science and Technology"},{"name":"Pohang"},{"name":"South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghyun","family":"You","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering"},{"name":"Pohang University of Science and Technology"},{"name":"Pohang"},{"name":"South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6804-1955","authenticated-orcid":false,"given":"Dong-Pyo","family":"Kim","sequence":"additional","affiliation":[{"name":"Center of Intelligent Microprocess for Pharmaceutical Synthesis"},{"name":"Department of Chemical Engineering"},{"name":"Pohang University of Science and Technology"},{"name":"Pohang"},{"name":"South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2019]]},"reference":[{"key":"C9LC00764D-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11796","DOI":"10.1021\/acs.chemrev.7b00183","volume":"117","author":"Plutschack","year":"2017","journal-title":"Chem. Rev."},{"key":"C9LC00764D-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1002\/ejoc.201800149","volume":"2018","author":"G\u00e9rardy","year":"2018","journal-title":"Eur. J. Org. Chem."},{"key":"C9LC00764D-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1007\/s11814-016-0114-6","volume":"33","author":"Singh","year":"2016","journal-title":"Korean J. Chem. Eng."},{"key":"C9LC00764D-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1021\/acs.oprd.8b00008","volume":"23","author":"Sharma","year":"2019","journal-title":"Org. Process Res. Dev."},{"key":"C9LC00764D-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9896","DOI":"10.1039\/C3CC44709J","volume":"49","author":"Yoshida","year":"2013","journal-title":"Chem. Commun."},{"key":"C9LC00764D-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1556\/1846.2017.00017","volume":"7","author":"Yoshida","year":"2017","journal-title":"J. Flow Chem."},{"key":"C9LC00764D-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1126\/science.aaf1389","volume":"352","author":"Kim","year":"2016","journal-title":"Science"},{"key":"C9LC00764D-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1126\/science.aaf1337","volume":"352","author":"Behnam","year":"2016","journal-title":"Science"},{"key":"C9LC00764D-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6180","DOI":"10.1016\/j.bmc.2016.12.046","volume":"25","author":"Bana","year":"2017","journal-title":"Bioorg. Med. Chem."},{"key":"C9LC00764D-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1021\/acs.oprd.5b00325","volume":"20","author":"Porta","year":"2016","journal-title":"Org. Process Res. Dev."},{"key":"C9LC00764D-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.3762\/bjoc.11.134","volume":"11","author":"Baumann","year":"2015","journal-title":"Beilstein J. Org. Chem."},{"key":"C9LC00764D-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1039\/C8RE00224J","volume":"4","author":"Qiu","year":"2019","journal-title":"React. Chem. Eng."},{"key":"C9LC00764D-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1021\/acs.oprd.5b00414","volume":"20","author":"Nagaki","year":"2016","journal-title":"Org. Process Res. Dev."},{"key":"C9LC00764D-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1021\/op400138v","volume":"17","author":"Kulkarni","year":"2013","journal-title":"Org. Process Res. Dev."},{"key":"C9LC00764D-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/ceat.201000334","volume":"34","author":"Ufer","year":"2011","journal-title":"Chem. Eng. Technol."},{"key":"C9LC00764D-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1021\/acssuschemeng.7b02687","volume":"6","author":"Zhao","year":"2018","journal-title":"ACS Sustainable Chem. Eng."},{"key":"C9LC00764D-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1039\/C8LC00004B","volume":"18","author":"Park","year":"2018","journal-title":"Lab Chip"},{"key":"C9LC00764D-(cit18)\/*[position()=1]","author":"Braungardt","year":"2017","unstructured":"S. Braungardt  ,  B.Lange  and  T.Oltersdorf , 12th IEA Pump Conf.,  2017 , O.4.2.3"},{"key":"C9LC00764D-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1039\/C4LC00987H","volume":"15","author":"Su","year":"2015","journal-title":"Lab Chip"},{"key":"C9LC00764D-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"308","DOI":"10.3390\/catal9040308","volume":"9","author":"Tonomura","year":"2019","journal-title":"Catalysts"},{"key":"C9LC00764D-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.procs.2013.09.130","volume":"22","author":"Noda","year":"2013","journal-title":"Procedia Comput. Sci."},{"key":"C9LC00764D-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.ifacol.2018.09.304","volume":"51","author":"Wang","year":"2018","journal-title":"IFAC-PapersOnLine"},{"key":"C9LC00764D-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1016\/j.tet.2018.02.006","volume":"74","author":"Masuda","year":"2018","journal-title":"Tetrahedron"},{"key":"C9LC00764D-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nature14343","volume":"520","author":"Tsubogo","year":"2015","journal-title":"Nature"},{"key":"C9LC00764D-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"734","DOI":"10.3762\/bjoc.13.73","volume":"13","author":"Moreno-Marrodan","year":"2017","journal-title":"Beilstein J. Org. Chem."},{"key":"C9LC00764D-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.jcat.2009.11.015","volume":"269","author":"Ng","year":"2010","journal-title":"J. Catal."},{"key":"C9LC00764D-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1039\/C4CC09221J","volume":"51","author":"Bao","year":"2015","journal-title":"Chem. Commun."},{"key":"C9LC00764D-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1021\/ol1026848","author":"Zhang","year":"2011","journal-title":"Org. Lett."},{"key":"C9LC00764D-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1002\/adsc.200800758","volume":"351","author":"Bogdan","year":"2009","journal-title":"Adv. Synth. Catal."},{"key":"C9LC00764D-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"101515","DOI":"10.1063\/1.3006077","volume":"20","author":"You","year":"2008","journal-title":"Phys. Fluids"},{"key":"C9LC00764D-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.cej.2007.07.101","volume":"139","author":"Kumar","year":"2008","journal-title":"Chem. Eng. J."},{"key":"C9LC00764D-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7761","DOI":"10.1002\/chem.201700816","volume":"23","author":"Singh","year":"2017","journal-title":"Chem. \u2013 Eur. J."},{"key":"C9LC00764D-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"12353","DOI":"10.1021\/ja011195t","volume":"123","author":"Halter","year":"2001","journal-title":"J. Am. Chem. Soc."},{"key":"C9LC00764D-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1021\/op500166n","volume":"18","author":"Zhang","year":"2014","journal-title":"Org. Process Res. Dev."},{"key":"C9LC00764D-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.energy.2016.04.016","volume":"136","author":"Wei","year":"2017","journal-title":"Energy"},{"key":"C9LC00764D-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.cej.2003.10.017","volume":"101","author":"Engler","year":"2004","journal-title":"Chem. Eng. J."},{"key":"C9LC00764D-(cit37)\/*[position()=1]","first-page":"183","volume":"10","author":"Viktorov","year":"2016","journal-title":"Eng. Appl. Comput. Fluid Mech."},{"key":"C9LC00764D-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.ces.2009.06.010","volume":"65","author":"Saber","year":"2010","journal-title":"Chem. Eng. Sci."},{"key":"C9LC00764D-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1039\/C7RE00024C","volume":"2","author":"Kuijpers","year":"2017","journal-title":"React. Chem. Eng."},{"key":"C9LC00764D-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8997","DOI":"10.1021\/ie050472s","volume":"44","author":"De Mas","year":"2005","journal-title":"Ind. Eng. Chem. Res."},{"key":"C9LC00764D-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1039\/C5RE00021A","volume":"1","author":"Su","year":"2016","journal-title":"React. Chem. Eng."},{"key":"C9LC00764D-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0920-1211(00)00185-6","volume":"43","author":"P\u00e5lhagen","year":"2001","journal-title":"Epilepsy Res."},{"key":"C9LC00764D-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1021\/jm00161a022","volume":"29","author":"Buckle","year":"1986","journal-title":"J. Med. Chem."},{"key":"C9LC00764D-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1039\/C5CY01847A","volume":"6","author":"Chassaing","year":"2016","journal-title":"Catal. Sci. Technol."}],"container-title":["Lab on a Chip"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2019\/LC\/C9LC00764D","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T18:05:42Z","timestamp":1783533942000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/lc\/article\/19\/20\/3535-3542\/647493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":44,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2019,10,9]]}},"URL":"https:\/\/doi.org\/10.1039\/c9lc00764d","relation":{},"ISSN":["1473-0197","1473-0189"],"issn-type":[{"value":"1473-0197","type":"print"},{"value":"1473-0189","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C9LC00764D","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Gwang-Noh Ahn (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-1001-9958","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Dong-Pyo Kim (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-6804-1955","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 5 August 2019; Accepted 10 September 2019;  Accepted Manuscript published 10 September 2019;  Advance Article published 26 September 2019;  Version of Record published 9 October 2019","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}