{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T18:36:47Z","timestamp":1783017407711,"version":"3.54.6"},"reference-count":44,"publisher":"Royal Society of Chemistry (RSC)","issue":"9","license":[{"start":{"date-parts":[[2020,7,4]],"date-time":"2020-07-04T00:00:00Z","timestamp":1593820800000},"content-version":"am","delay-in-days":550,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"crossref","award":["AGL2016-79813-C2-1-R"],"award-info":[{"award-number":["AGL2016-79813-C2-1-R"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"crossref","award":["AGL2016-79813-C2-1-R"],"award-info":[{"award-number":["AGL2016-79813-C2-1-R"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Med. Chem. Commun."],"abstract":"<p>4-Aryldihydropyrimidine-2-thiones are proposed as potential antitumour dual agents, both as Eg5 inhibitors and L-type calcium channel blockers.<\/p>","DOI":"10.1039\/c9md00108e","type":"journal-article","created":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T12:33:09Z","timestamp":1562243589000},"page":"1589-1598","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Dihydropyrimidine-2-thiones as Eg5 inhibitors and L-type calcium channel blockers: potential antitumour dual agents"],"prefix":"10.1039","volume":"10","author":[{"given":"Elena","family":"Gonz\u00e1lez-Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"Pharmaceutical Sciences Department"},{"name":"School of Pharmacy"},{"name":"University of Salamanca"},{"name":"37007 Salamanca"},{"name":"Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8589-088X","authenticated-orcid":false,"given":"Rub\u00e9n","family":"Aparicio","sequence":"additional","affiliation":[{"name":"Physiology and Pharmacology Department"},{"name":"School of Pharmacy"},{"name":"University of Salamanca"},{"name":"37007 Salamanca"},{"name":"Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2194-2841","authenticated-orcid":false,"given":"Mercedes","family":"Garayoa","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Research of Salamanca (IBSAL)"},{"name":"University Hospital of Salamanca"},{"name":"37007 Salamanca"},{"name":"Spain"},{"name":"Cancer Research Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2125-0378","authenticated-orcid":false,"given":"M. Jos\u00e9","family":"Montero","sequence":"additional","affiliation":[{"name":"Physiology and Pharmacology Department"},{"name":"School of Pharmacy"},{"name":"University of Salamanca"},{"name":"37007 Salamanca"},{"name":"Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2960-8514","authenticated-orcid":false,"given":"M. \u00c1ngeles","family":"Sevilla","sequence":"additional","affiliation":[{"name":"Physiology and Pharmacology Department"},{"name":"School of Pharmacy"},{"name":"University of Salamanca"},{"name":"37007 Salamanca"},{"name":"Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6791-7927","authenticated-orcid":false,"given":"Concepci\u00f3n","family":"P\u00e9rez-Melero","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Department"},{"name":"School of Pharmacy"},{"name":"University of Salamanca"},{"name":"37007 Salamanca"},{"name":"Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2019]]},"reference":[{"key":"C9MD00108E-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7874","DOI":"10.1021\/jm5006463","volume":"57","author":"Anighoro","year":"2014","journal-title":"J. Med. Chem."},{"key":"C9MD00108E-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8955","DOI":"10.1021\/jm400856t","volume":"56","author":"Peters","year":"2013","journal-title":"J. Med. Chem."},{"key":"C9MD00108E-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1111\/cns.12279","volume":"20","author":"Nikolic","year":"2014","journal-title":"CNS Neurosci. Ther."},{"key":"C9MD00108E-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1039\/C4MD00069B","volume":"5","author":"Prati","year":"2014","journal-title":"Med. Chem. Commun."},{"key":"C9MD00108E-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/med.20248","volume":"33","author":"Le\u00f3n","year":"2013","journal-title":"Med. Res. Rev."},{"key":"C9MD00108E-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2174\/1570159X1203140511153200","volume":"12","author":"Dias","year":"2014","journal-title":"Curr. Neuropharmacol."},{"key":"C9MD00108E-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.2174\/0929867311320130013","volume":"20","author":"Hwang","year":"2013","journal-title":"Curr. Med. Chem."},{"key":"C9MD00108E-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.2174\/0929867311320130011","volume":"20","author":"Zhan","year":"2013","journal-title":"Curr. Med. Chem."},{"key":"C9MD00108E-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.2174\/0929867311320130012","volume":"20","author":"Bisi","year":"2013","journal-title":"Curr. Med. Chem."},{"key":"C9MD00108E-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.2174\/0929867311320130010","volume":"20","author":"Njogu","year":"2013","journal-title":"Curr. Med. Chem."},{"key":"C9MD00108E-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1517\/17460441.2013.743991","volume":"8","author":"East","year":"2013","journal-title":"Expert Opin. Drug Discovery"},{"key":"C9MD00108E-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.coph.2013.06.012","volume":"13","author":"Melisi","year":"2013","journal-title":"Curr. Opin. Pharmacol."},{"key":"C9MD00108E-(cit13)\/*[position()=1]","volume-title":"Polypharmacology in drug discovery","author":"Petrelli","year":"2012","unstructured":"A. Petrelli , in Polypharmacology in drug discovery , ed. J. U. Peters , Wiley , Hoboken (NJ) , 2012 , pp. 149\u2013165"},{"key":"C9MD00108E-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/S1359-6446(04)03163-0","volume":"9","author":"Morphy","year":"2004","journal-title":"Drug Discovery Today"},{"key":"C9MD00108E-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(96)00423-1","volume":"23","author":"Lipinski","year":"1997","journal-title":"Adv. Drug Delivery Rev."},{"key":"C9MD00108E-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s007260070042","volume":"19","author":"Rogawski","year":"2000","journal-title":"Amino Acids"},{"key":"C9MD00108E-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.tips.2009.07.004","volume":"30","author":"Mestres","year":"2009","journal-title":"Trends Pharmacol. Sci."},{"key":"C9MD00108E-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1517\/17460441.2.6.799","volume":"2","author":"Korcsm\u00e1ros","year":"2007","journal-title":"Expert Opin. Drug Discovery"},{"key":"C9MD00108E-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/359540a0","volume":"359","author":"Sawin","year":"1992","journal-title":"Nature"},{"key":"C9MD00108E-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/0092-8674(95)90142-6","volume":"63","author":"Blangy","year":"1995","journal-title":"Cell"},{"key":"C9MD00108E-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1200\/JCO.2005.04.0543","volume":"24","author":"Lee","year":"2006","journal-title":"J. Clin. Oncol."},{"key":"C9MD00108E-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.critrevonc.2011.04.012","volume":"82","author":"Argyriou","year":"2012","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"C9MD00108E-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.2174\/1568026614666141130095532","volume":"14","author":"P\u00e9rez-Melero","year":"2014","journal-title":"Curr. Top. Med. Chem."},{"key":"C9MD00108E-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"15258","DOI":"10.1021\/bi048282t","volume":"43","author":"Luo","year":"2004","journal-title":"Biochemistry"},{"key":"C9MD00108E-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1021\/bi026716j","volume":"42","author":"DeBonis","year":"2003","journal-title":"Biochemistry"},{"key":"C9MD00108E-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"25496","DOI":"10.1074\/jbc.M100395200","volume":"276","author":"Turner","year":"2001","journal-title":"J. Biol. Chem."},{"key":"C9MD00108E-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1126\/science.286.5441.971","volume":"286","author":"Mayer","year":"1999","journal-title":"Science"},{"key":"C9MD00108E-(cit30)\/*[position()=1]","first-page":"156","volume":"3","author":"Li","year":"2011","journal-title":"Int. J. Physiol., Pathophysiol. Pharmacol."},{"key":"C9MD00108E-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.molmed.2010.01.005","volume":"16","author":"Prevarskaya","year":"2010","journal-title":"Trends Mol. Med."},{"key":"C9MD00108E-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/nrc3105","volume":"11","author":"Prevarskaya","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"C9MD00108E-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"C969","DOI":"10.1152\/ajpcell.00136.2011","volume":"301","author":"Lee","year":"2011","journal-title":"Am. J. Physiol."},{"key":"C9MD00108E-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/S0002-9440(10)64792-X","volume":"157","author":"Wang","year":"2000","journal-title":"Am. J. Pathol."},{"key":"C9MD00108E-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/S0025-6196(12)61144-6","volume":"67","author":"Oguro-Okano","year":"1992","journal-title":"Mayo Clin. Proc."},{"key":"C9MD00108E-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1021\/jm00001a017","volume":"38","author":"Rovnyak","year":"1995","journal-title":"J. Med. Chem."},{"key":"C9MD00108E-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3254","DOI":"10.1021\/jm00095a023","volume":"35","author":"Rovnyak","year":"1992","journal-title":"J. Med. Chem."},{"key":"C9MD00108E-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1111\/j.2042-7158.2012.01466.x","volume":"64","author":"Cernecka","year":"2012","journal-title":"J. Pharm. Pharmacol."},{"key":"C9MD00108E-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"99","DOI":"10.5012\/jkcs.2013.57.1.99","volume":"57","author":"Choudhari","year":"2013","journal-title":"J. Korean Chem. Soc."},{"key":"C9MD00108E-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6937","DOI":"10.1016\/S0040-4020(01)87971-0","volume":"49","author":"Kappe","year":"1993","journal-title":"Tetrahedron"},{"key":"C9MD00108E-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.bioorg.2006.04.003","volume":"34","author":"Russowsky","year":"2006","journal-title":"Bioorg. Chem."},{"key":"C9MD00108E-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.jmb.2003.10.074","volume":"335","author":"Yan","year":"2004","journal-title":"J. Mol. Biol."},{"key":"C9MD00108E-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1472-6769-6-2","volume":"6","author":"Maliga","year":"2006","journal-title":"BMC Chem. Biol."},{"key":"C9MD00108E-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5676","DOI":"10.1021\/jm100421n","volume":"53","author":"Kaan","year":"2010","journal-title":"J. Med. Chem."},{"key":"C9MD00108E-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9740","DOI":"10.1074\/jbc.M608883200","volume":"282","author":"Garcia-Saez","year":"2007","journal-title":"J. Biol. Chem."},{"key":"C9MD00108E-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."}],"container-title":["MedChemComm"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2019\/MD\/C9MD00108E","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:36:26Z","timestamp":1783013786000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/1m\/article\/10\/9\/1589-1598\/1246627"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":44,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9,18]]}},"URL":"https:\/\/doi.org\/10.1039\/c9md00108e","relation":{},"ISSN":["2040-2503","2040-2511"],"issn-type":[{"value":"2040-2503","type":"print"},{"value":"2040-2511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C9MD00108E","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Rub\u00e9n Aparicio (ORCID)","URL":"http:\/\/orcid.org\/0000-0001-8589-088X","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Mercedes Garayoa (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-2194-2841","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Mercedes Garayoa (ResearcherID)","URL":"http:\/\/www.researcherid.com\/rid\/O-6039-2017","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"M. Jos\u00e9 Montero (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-2125-0378","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"M. Jos\u00e9 Montero (ResearcherID)","URL":"http:\/\/www.researcherid.com\/rid\/C-3084-2018","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"M. \u00c1ngeles Sevilla (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-2960-8514","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"M. \u00c1ngeles Sevilla (ResearcherID)","URL":"http:\/\/www.researcherid.com\/rid\/J-8146-2017","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Concepci\u00f3n P\u00e9rez-Melero (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-6791-7927","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Concepci\u00f3n P\u00e9rez-Melero (ResearcherID)","URL":"http:\/\/www.researcherid.com\/rid\/B-5178-2017","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 22 February 2019; Accepted 29 June 2019; Accepted Manuscript published 4 July 2019; Advance Article published 12 July 2019; Version of Record published 18 September 2019","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}