{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:50:13Z","timestamp":1790265013692,"version":"4.1.0"},"reference-count":137,"publisher":"Royal Society of Chemistry (RSC)","issue":"8","license":[{"start":{"date-parts":[[2020,6,20]],"date-time":"2020-06-20T00:00:00Z","timestamp":1592611200000},"content-version":"am","delay-in-days":536,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Med. Chem. Commun."],"abstract":"<p>Targeting the T3SS injectisome using the anti-virulence strategy offers an alternative to antibiotic therapeutic approaches when dealing with resistance.<\/p>","DOI":"10.1039\/c9md00146h","type":"journal-article","created":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T08:54:03Z","timestamp":1561020843000},"page":"1273-1289","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["On the road to structure-based development of anti-virulence therapeutics targeting the type III secretion system injectisome"],"prefix":"10.1039","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8029-404X","authenticated-orcid":false,"given":"Bronwyn J. E.","family":"Lyons","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology and Center for Blood Research"},{"name":"University of British Columbia"},{"name":"2350 Health Sciences Mall"},{"name":"Vancouver"},{"name":"Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie C. J.","family":"Strynadka","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology and Center for Blood Research"},{"name":"University of British Columbia"},{"name":"2350 Health Sciences Mall"},{"name":"Vancouver"},{"name":"Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2019]]},"reference":[{"key":"C9MD00146H-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1086\/320737","volume":"183","author":"Roy-Burman","year":"2001","journal-title":"J. Infect. Dis."},{"key":"C9MD00146H-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/S1473-3099(15)00003-1","volume":"15","author":"Agaisse","year":"2015","journal-title":"Lancet Infect. Dis."},{"key":"C9MD00146H-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1542\/pir.36-4-167","volume":"36","author":"Makvana","year":"2015","journal-title":"Pediatr. Rev."},{"key":"C9MD00146H-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.ijmm.2017.07.004","volume":"307","author":"Stefani","year":"2017","journal-title":"Int. J. Med. Microbiol."},{"key":"C9MD00146H-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.mib.2016.06.001","volume":"33","author":"Maura","year":"2016","journal-title":"Curr. Opin. Microbiol."},{"key":"C9MD00146H-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.tips.2017.01.004","volume":"38","author":"Johnson","year":"2017","journal-title":"Trends Pharmacol. Sci."},{"key":"C9MD00146H-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1128\/MMBR.05017-11","volume":"76","author":"B\u00fcttner","year":"2012","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"C9MD00146H-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nrmicro.2017.20","volume":"15","author":"Deng","year":"2017","journal-title":"Nat. Rev. Microbiol."},{"key":"C9MD00146H-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3517","DOI":"10.15252\/embj.201797515","volume":"36","author":"Portaliou","year":"2017","journal-title":"EMBO J."},{"key":"C9MD00146H-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1517\/14728222.2014.855199","volume":"18","author":"Marshall","year":"2014","journal-title":"Expert Opin. Ther. Targets"},{"key":"C9MD00146H-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.tibs.2015.09.005","volume":"41","author":"Portaliou","year":"2016","journal-title":"Trends Biochem. Sci."},{"key":"C9MD00146H-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms1488","volume":"2","author":"Minamino","year":"2011","journal-title":"Nat. Commun."},{"key":"C9MD00146H-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"E2027","DOI":"10.1073\/pnas.1402658111","volume":"111","author":"Lee","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C9MD00146H-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1038\/nature03992","volume":"437","author":"Akeda","year":"2005","journal-title":"Nature"},{"key":"C9MD00146H-(cit16)\/*[position()=1]","first-page":"1","volume":"9","author":"Yoshida","year":"2014","journal-title":"PLoS One"},{"key":"C9MD00146H-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1073\/pnas.1411610112","volume":"112","author":"Hu","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C9MD00146H-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-019-08477-7","volume":"10","author":"Majewski","year":"2019","journal-title":"Nat. Commun."},{"key":"C9MD00146H-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"25837","DOI":"10.1074\/jbc.M116.755256","volume":"291","author":"Burgess","year":"2016","journal-title":"J. Biol. Chem."},{"key":"C9MD00146H-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/nsmb1196","volume":"14","author":"Zarivach","year":"2007","journal-title":"Nat. Struct. Mol. Biol."},{"key":"C9MD00146H-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"23734","DOI":"10.1074\/jbc.M114.578476","volume":"289","author":"Allison","year":"2014","journal-title":"J. Biol. Chem."},{"key":"C9MD00146H-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2018.00001","volume":"9","author":"Gao","year":"2018","journal-title":"Front. Microbiol."},{"key":"C9MD00146H-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/nsmb.1977","volume":"18","author":"Ibuki","year":"2011","journal-title":"Nat. Struct. Mol. Biol."},{"key":"C9MD00146H-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41594-018-0086-9","volume":"25","author":"Kuhlen","year":"2018","journal-title":"Nat. Struct. Mol. Biol."},{"key":"C9MD00146H-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1074\/mcp.M115.056598","volume":"15","author":"Zilkenat","year":"2016","journal-title":"Mol. Cell. Proteomics"},{"key":"C9MD00146H-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1128\/JB.186.8.2495-2498.2004","volume":"186","author":"Van Arnam","year":"2004","journal-title":"J. Bacteriol."},{"key":"C9MD00146H-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nature20576","volume":"540","author":"Worrall","year":"2016","journal-title":"Nature"},{"key":"C9MD00146H-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-017-02088-w","volume":"9","author":"Hu","year":"2018","journal-title":"Nat. Commun."},{"key":"C9MD00146H-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.ppat.1006071","volume":"12","author":"Dietsche","year":"2016","journal-title":"PLoS Pathog."},{"key":"C9MD00146H-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/nature06832","volume":"453","author":"Zarivach","year":"2008","journal-title":"Nature"},{"key":"C9MD00146H-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1186\/1471-2180-11-205","volume":"11","author":"Thomassin","year":"2011","journal-title":"BMC Microbiol."},{"key":"C9MD00146H-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1038\/sj.emboj.7601731","volume":"26","author":"Sorg","year":"2007","journal-title":"EMBO J."},{"key":"C9MD00146H-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3391\/mbi.2015.6.1.01","volume":"6","author":"Feria","year":"2015","journal-title":"mBio"},{"key":"C9MD00146H-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1002\/pro.56","volume":"18","author":"Lountos","year":"2009","journal-title":"Protein Sci."},{"key":"C9MD00146H-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1365-2958.2008.06293.x","volume":"69","author":"Deane","year":"2008","journal-title":"Mol. Microbiol."},{"key":"C9MD00146H-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1074\/jbc.M115.684423","volume":"291","author":"Bergeron","year":"2016","journal-title":"J. Biol. Chem."},{"key":"C9MD00146H-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1107\/S0907444913002102","volume":"69","author":"Meshcheryakov","year":"2013","journal-title":"Acta Crystallogr., Sect. D: Biol. Crystallogr."},{"key":"C9MD00146H-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nsmb.2452","volume":"20","author":"Abrusci","year":"2013","journal-title":"Nat. Struct. Mol. Biol."},{"key":"C9MD00146H-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1002\/pro.382","volume":"19","author":"Worrall","year":"2010","journal-title":"Protein Sci."},{"key":"C9MD00146H-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-017-02088-w","volume":"9","author":"Xing","year":"2018","journal-title":"Nat. Commun."},{"key":"C9MD00146H-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1107\/S2053230X15016064","volume":"71","author":"Burkinshaw","year":"2015","journal-title":"Acta Crystallogr., Sect. F: Struct. Biol. Commun."},{"key":"C9MD00146H-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1128\/JB.02401-14","volume":"197","author":"Deng","year":"2015","journal-title":"J. Bacteriol."},{"key":"C9MD00146H-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.sbi.2018.02.008","volume":"51","author":"Majewski","year":"2018","journal-title":"Curr. Opin. Struct. Biol."},{"key":"C9MD00146H-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5421","DOI":"10.1128\/JB.00531-07","volume":"189","author":"Kohler","year":"2007","journal-title":"J. Bacteriol."},{"key":"C9MD00146H-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-22527-y","volume":"8","author":"Byun","year":"2018","journal-title":"Sci. Rep."},{"key":"C9MD00146H-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0149204","volume":"11","author":"Zaloba","year":"2016","journal-title":"PLoS One"},{"key":"C9MD00146H-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1099\/mic.0.045617-0","volume":"157","author":"Garc\u00eda-G\u00f3mez","year":"2011","journal-title":"Microbiology"},{"key":"C9MD00146H-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10406","DOI":"10.1074\/jbc.M115.639013","volume":"290","author":"Burkinshaw","year":"2015","journal-title":"J. Biol. Chem."},{"key":"C9MD00146H-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1128\/IAI.00048-15","volume":"83","author":"Perdu","year":"2015","journal-title":"Infect. Immun."},{"key":"C9MD00146H-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1046\/j.1365-2958.1998.01036.x","volume":"30","author":"Crago","year":"1998","journal-title":"Mol. Microbiol."},{"key":"C9MD00146H-(cit51)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1046\/j.1365-2958.1998.00908.x","volume":"28","author":"Daefler","year":"1998","journal-title":"Mol. Microbiol."},{"key":"C9MD00146H-(cit52)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1128\/IAI.67.4.1982-1991.1999","volume":"67","author":"Schuch","year":"1999","journal-title":"Infect. Immun."},{"key":"C9MD00146H-(cit53)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5366","DOI":"10.1128\/JB.186.16.5366-5375.2004","volume":"186","author":"Burghout","year":"2004","journal-title":"J. Bacteriol."},{"key":"C9MD00146H-(cit54)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.jmb.2011.07.043","volume":"413","author":"Izor\u00e9","year":"2011","journal-title":"J. Mol. Biol."},{"key":"C9MD00146H-(cit55)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1046\/j.1365-2958.1999.01627.x","volume":"34","author":"Raymond","year":"1999","journal-title":"Mol. Microbiol."},{"key":"C9MD00146H-(cit56)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1038\/sj.emboj.7600610","volume":"24","author":"Lario","year":"2005","journal-title":"EMBO J."},{"key":"C9MD00146H-(cit57)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1016\/j.str.2008.08.006","volume":"16","author":"Okon","year":"2008","journal-title":"Structure"},{"key":"C9MD00146H-(cit58)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1574-6968.2011.02464.x","volume":"328","author":"Koo","year":"2012","journal-title":"FEMS Microbiol. Lett."},{"key":"C9MD00146H-(cit59)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/nature11079","volume":"486","author":"Loquet","year":"2012","journal-title":"Nature"},{"key":"C9MD00146H-(cit60)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms5976","volume":"5","author":"Demers","year":"2014","journal-title":"Nat. Commun."},{"key":"C9MD00146H-(cit61)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"42929","DOI":"10.1074\/jbc.M508377200","volume":"280","author":"Kenjale","year":"2005","journal-title":"J. Biol. Chem."},{"key":"C9MD00146H-(cit62)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.jsb.2015.10.005","volume":"192","author":"Verasdonck","year":"2015","journal-title":"J. Struct. Biol."},{"key":"C9MD00146H-(cit63)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1111\/j.1365-2958.2005.04790.x","volume":"57","author":"Torruellas","year":"2005","journal-title":"Mol. Microbiol."},{"key":"C9MD00146H-(cit64)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.35886","volume":"7","author":"Kato","year":"2018","journal-title":"eLife"},{"key":"C9MD00146H-(cit65)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4055","DOI":"10.1128\/IAI.69.6.4055-4064.2001","volume":"69","author":"Daniell","year":"2001","journal-title":"Infect. Immun."},{"key":"C9MD00146H-(cit66)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"34062","DOI":"10.1074\/jbc.M803408200","volume":"283","author":"Gazi","year":"2008","journal-title":"J. Biol. Chem."},{"key":"C9MD00146H-(cit67)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/nsmb879","volume":"12","author":"Yip","year":"2005","journal-title":"Nat. Struct. Mol. Biol."},{"key":"C9MD00146H-(cit68)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ijmm.2012.12.001","volume":"303","author":"Larz\u00e1bal","year":"2013","journal-title":"Int. J. Med. Microbiol."},{"key":"C9MD00146H-(cit69)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/psc.3149","volume":"25","author":"Larz\u00e1bal","year":"2019","journal-title":"J. Pept. Sci."},{"key":"C9MD00146H-(cit70)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"25303","DOI":"10.1074\/jbc.M112.381574","volume":"287","author":"Zhong","year":"2012","journal-title":"J. Biol. Chem."},{"key":"C9MD00146H-(cit71)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1126\/science.1091422","volume":"302","author":"Journet","year":"2003","journal-title":"Science"},{"key":"C9MD00146H-(cit72)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.1074\/jbc.M116.770255","volume":"292","author":"Ho","year":"2017","journal-title":"J. Biol. Chem."},{"key":"C9MD00146H-(cit73)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jmb.2012.03.025","volume":"420","author":"Epler","year":"2012","journal-title":"J. Mol. Biol."},{"key":"C9MD00146H-(cit74)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1107\/S1744309113008579","volume":"69","author":"Chaudhury","year":"2013","journal-title":"Acta Crystallogr., Sect. F: Struct. Biol. Cryst. Commun."},{"key":"C9MD00146H-(cit75)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/pro.537","volume":"20","author":"Chatterjee","year":"2011","journal-title":"Protein Sci."},{"key":"C9MD00146H-(cit76)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4035","DOI":"10.1074\/jbc.M607945200","volume":"282","author":"Johnson","year":"2007","journal-title":"J. Biol. Chem."},{"key":"C9MD00146H-(cit77)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11638","DOI":"10.1073\/pnas.191378598","volume":"98","author":"Sekiya","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C9MD00146H-(cit78)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1046\/j.1365-2958.2003.03555.x","volume":"49","author":"Daniell","year":"2003","journal-title":"Mol. Microbiol."},{"key":"C9MD00146H-(cit79)\/*[position()=1]","first-page":"1","volume":"7","author":"Park","year":"2018","journal-title":"eLife"},{"key":"C9MD00146H-(cit80)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6304","DOI":"10.1074\/jbc.M115.681031","volume":"291","author":"Romano","year":"2016","journal-title":"J. Biol. Chem."},{"key":"C9MD00146H-(cit81)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2972","DOI":"10.1128\/JB.00153-11","volume":"193","author":"Luo","year":"2011","journal-title":"J. Bacteriol."},{"key":"C9MD00146H-(cit82)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.jmb.2012.01.026","volume":"417","author":"Barta","year":"2012","journal-title":"J. Mol. Biol."},{"key":"C9MD00146H-(cit83)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1016\/j.str.2015.08.014","volume":"23","author":"Nguyen","year":"2015","journal-title":"Structure"},{"key":"C9MD00146H-(cit84)\/*[position()=1]","first-page":"147","volume":"398","author":"Muhlen","year":"2015","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"C9MD00146H-(cit85)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1128\/AAC.01492-06","volume":"51","author":"Hudson","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"C9MD00146H-(cit86)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1128\/AAC.00223-07","volume":"51","author":"Negrea","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"C9MD00146H-(cit87)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3104","DOI":"10.1128\/IAI.73.5.3104-3114.2005","volume":"73","author":"Nordfelth","year":"2005","journal-title":"Infect. Immun."},{"key":"C9MD00146H-(cit88)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1128\/JB.01004-08","volume":"191","author":"Veenendaal","year":"2009","journal-title":"J. Bacteriol."},{"key":"C9MD00146H-(cit89)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S1074-5521(03)00046-2","volume":"10","author":"Kauppi","year":"2003","journal-title":"Chem. Biol."},{"key":"C9MD00146H-(cit90)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fcimb.2018.00404","volume":"8","author":"Morgan","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"C9MD00146H-(cit91)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1128\/AAC.02795-13","volume":"58","author":"Bowlin","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"C9MD00146H-(cit92)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1128\/IAI.54.2.428-434.1986","volume":"54","author":"Perry","year":"1986","journal-title":"Infect. Immun."},{"key":"C9MD00146H-(cit93)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1111\/j.1365-2958.2006.05347.x","volume":"61","author":"Wolf","year":"2006","journal-title":"Mol. Microbiol."},{"key":"C9MD00146H-(cit94)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4209","DOI":"10.1128\/IAI.00562-09","volume":"77","author":"Tree","year":"2009","journal-title":"Infect. Immun."},{"key":"C9MD00146H-(cit95)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"29922","DOI":"10.1074\/jbc.M111.233858","volume":"286","author":"Wang","year":"2011","journal-title":"J. Biol. Chem."},{"key":"C9MD00146H-(cit96)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1111\/mmi.13719","volume":"105","author":"Zambelloni","year":"2017","journal-title":"Mol. Microbiol."},{"key":"C9MD00146H-(cit97)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4220","DOI":"10.1128\/IAI.00919-13","volume":"81","author":"Koppolu","year":"2013","journal-title":"Infect. Immun."},{"key":"C9MD00146H-(cit98)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4683","DOI":"10.1128\/IAI.01305-09","volume":"78","author":"Garrity-Ryan","year":"2010","journal-title":"Infect. Immun."},{"key":"C9MD00146H-(cit99)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3380","DOI":"10.1016\/j.bmcl.2010.04.014","volume":"20","author":"Grier","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"C9MD00146H-(cit100)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1128\/JB.00686-15","volume":"198","author":"Schwiesow","year":"2016","journal-title":"J. Bacteriol."},{"key":"C9MD00146H-(cit101)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5626","DOI":"10.1021\/jm9006577","volume":"52","author":"Kim","year":"2009","journal-title":"J. Med. Chem."},{"key":"C9MD00146H-(cit102)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1128\/AAC.02242-15","volume":"60","author":"Marsden","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"C9MD00146H-(cit103)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/cbdd.13130","volume":"91","author":"Grishin","year":"2018","journal-title":"Chem. Biol. Drug Des."},{"key":"C9MD00146H-(cit104)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0019716","volume":"6","author":"Swietnicki","year":"2011","journal-title":"PLoS One"},{"key":"C9MD00146H-(cit105)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6906","DOI":"10.1021\/acs.biochem.8b01077","volume":"57","author":"Case","year":"2018","journal-title":"Biochemistry"},{"key":"C9MD00146H-(cit106)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1128\/AAC.01598-09","volume":"54","author":"Aiello","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"C9MD00146H-(cit107)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.bmc.2015.01.011","volume":"23","author":"Williams","year":"2015","journal-title":"Bioorg. Med. Chem."},{"key":"C9MD00146H-(cit108)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/AAC.01202-17","volume":"61","author":"Berube","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"C9MD00146H-(cit109)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1002\/cmdc.201700348","volume":"12","author":"Dey","year":"2017","journal-title":"ChemMedChem"},{"key":"C9MD00146H-(cit110)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.bbrc.2016.07.018","volume":"477","author":"Guo","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"C9MD00146H-(cit111)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.12688\/f1000research.8466.1","volume":"5","author":"Atkinson","year":"2016","journal-title":"F1000Research"},{"key":"C9MD00146H-(cit112)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0081969","volume":"8","author":"Zetterstr\u00f6m","year":"2013","journal-title":"PLoS One"},{"key":"C9MD00146H-(cit113)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/S1369-5274(02)00301-6","volume":"5","author":"Francis","year":"2002","journal-title":"Curr. Opin. Microbiol."},{"key":"C9MD00146H-(cit114)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1021\/jacs.5b11575","volume":"138","author":"Tsou","year":"2016","journal-title":"J. Am. Chem. Soc."},{"key":"C9MD00146H-(cit115)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/IAI.00595-18","volume":"87","author":"McHugh","year":"2019","journal-title":"Infect. Immun."},{"key":"C9MD00146H-(cit116)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/ja.2010.155","volume":"64","author":"Kimura","year":"2011","journal-title":"J. Antibiot."},{"key":"C9MD00146H-(cit117)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1056\/NEJMoa1106483","volume":"365","author":"Frank","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"C9MD00146H-(cit118)\/*[position()=1]","first-page":"1","volume":"2","author":"Zhou","year":"2007","journal-title":"PLoS One"},{"key":"C9MD00146H-(cit119)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-016-0001-8","volume":"6","author":"Wang","year":"2016","journal-title":"Sci. Rep."},{"key":"C9MD00146H-(cit120)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6755","DOI":"10.1039\/c1ob05581j","volume":"9","author":"Yin","year":"2011","journal-title":"Org. Biomol. Chem."},{"key":"C9MD00146H-(cit121)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.4161\/21645515.2014.971641","volume":"10","author":"Sawa","year":"2014","journal-title":"Hum. Vaccines Immunother."},{"key":"C9MD00146H-(cit122)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.cmi.2018.08.004","volume":"25","author":"Ali","year":"2019","journal-title":"Clin. Microbiol. Infect."},{"key":"C9MD00146H-(cit123)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/AAC.02565-17","volume":"62","author":"Le","year":"2018","journal-title":"Antimicrob. Agents Chemother."},{"key":"C9MD00146H-(cit124)\/*[position()=1]","first-page":"1983","volume":"218","author":"Tabor","year":"2018","journal-title":"J. Infect. Dis."},{"key":"C9MD00146H-(cit125)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.jcf.2017.12.006","volume":"17","author":"Jain","year":"2018","journal-title":"J. Cystic Fibrosis"},{"key":"C9MD00146H-(cit126)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4384","DOI":"10.1128\/AAC.02643-14","volume":"58","author":"Warrener","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"C9MD00146H-(cit127)\/*[position()=1]","first-page":"49","volume":"64","author":"Bzdzion","year":"2017","journal-title":"Acta Biochim. Pol."},{"key":"C9MD00146H-(cit128)\/*[position()=1]","first-page":"98","volume":"75","author":"Allen","year":"2011","journal-title":"Can. J. Vet. Res."},{"key":"C9MD00146H-(cit129)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1002\/jsfa.8125","volume":"97","author":"Wadamori","year":"2017","journal-title":"J. Sci. Food Agric."},{"key":"C9MD00146H-(cit130)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.vetimm.2012.09.028","volume":"152","author":"Vande Walle","year":"2013","journal-title":"Vet. Immunol. Immunopathol."},{"key":"C9MD00146H-(cit131)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pcbi.1004851","volume":"12","author":"Nariya","year":"2016","journal-title":"PLoS Comput. Biol."},{"key":"C9MD00146H-(cit132)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.chom.2008.08.001","volume":"4","author":"Felise","year":"2008","journal-title":"Cell Host Microbe"},{"key":"C9MD00146H-(cit133)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7065","DOI":"10.1021\/jm8004515","volume":"51","author":"Kline","year":"2008","journal-title":"J. Med. Chem."},{"key":"C9MD00146H-(cit134)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"30","DOI":"10.2174\/2210303106666160506120057","volume":"6","author":"Totsika","year":"2016","journal-title":"Drug Delivery Lett."},{"key":"C9MD00146H-(cit135)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3389\/fmicb.2018.00149","volume":"9","author":"Zhang","year":"2018","journal-title":"Front. Microbiol."},{"key":"C9MD00146H-(cit136)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1074\/jbc.M509644200","volume":"281","author":"Morita-Ishihara","year":"2006","journal-title":"J. Biol. Chem."},{"key":"C9MD00146H-(cit137)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/JB.00538-16","volume":"199","author":"Soto","year":"2017","journal-title":"J. Bacteriol."},{"key":"C9MD00146H-(cit138)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1128\/AAC.01170-13","volume":"58","author":"Jessen","year":"2014","journal-title":"Antimicrob. Agents Chemother."}],"container-title":["MedChemComm"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2019\/MD\/C9MD00146H","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:38:19Z","timestamp":1783449499000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/1m\/article\/10\/8\/1273-1289\/647816"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":137,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8,14]]}},"URL":"https:\/\/doi.org\/10.1039\/c9md00146h","relation":{},"ISSN":["2040-2503","2040-2511"],"issn-type":[{"value":"2040-2503","type":"print"},{"value":"2040-2511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Bronwyn J. E. Lyons (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-8029-404X","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 11 March 2019; Accepted 7 June 2019; Advance Article published 20 June 2019; Version of Record published 14 August 2019","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}