{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:09:35Z","timestamp":1790629775052,"version":"4.1.0"},"reference-count":24,"publisher":"Royal Society of Chemistry (RSC)","issue":"11","license":[{"start":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T00:00:00Z","timestamp":1571270400000},"content-version":"vor","delay-in-days":289,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"crossref","award":["2017-00695"],"award-info":[{"award-number":["2017-00695"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"crossref","award":["2017-02339"],"award-info":[{"award-number":["2017-02339"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"crossref","award":["2018-04589"],"award-info":[{"award-number":["2018-04589"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004063","name":"Knut and Alice Wallenberg Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007067","name":"Kempestiftelserna","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007067","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Stiftelsen f\u00f6r\u00a0Strategisk Forskning"},{"DOI":"10.13039\/501100003426","name":"G\u00f6ran Gustafssons Stiftelse f\u00f6r Naturvetenskaplig och Medicinsk Forskning","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003426","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Med. Chem. Commun."],"abstract":"<p>\n                    Methyl sulfonamide substituents effectively improve the pharmacokinetic properties of bicyclic 2-pyridones, a new class of\n                    <italic>Chlamydia trachomatis<\/italic>\n                    infectivity inhibitors.\n                  <\/p>","DOI":"10.1039\/c9md00405j","type":"journal-article","created":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T03:03:17Z","timestamp":1571281397000},"page":"1966-1987","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Methyl sulfonamide substituents improve the pharmacokinetic properties of bicyclic 2-pyridone based\n                    <i>Chlamydia trachomatis<\/i>\n                    inhibitors"],"prefix":"10.1039","volume":"10","author":[{"given":"Martina","family":"Kul\u00e9n","sequence":"first","affiliation":[{"name":"Department of Chemistry"},{"name":"Ume\u00e5 University"},{"name":"901 87 Ume\u00e5"},{"name":"Sweden"},{"name":"Ume\u00e5 Centre for Microbial Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7680-0918","authenticated-orcid":false,"given":"Carlos","family":"N\u00fa\u00f1ez-Otero","sequence":"additional","affiliation":[{"name":"Ume\u00e5 Centre for Microbial Research"},{"name":"Ume\u00e5 University"},{"name":"901 87 Ume\u00e5"},{"name":"Sweden"},{"name":"Laboratory for Molecular Infection Medicine Sweden (MIMS)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew G.","family":"Cairns","sequence":"additional","affiliation":[{"name":"Department of Chemistry"},{"name":"Ume\u00e5 University"},{"name":"901 87 Ume\u00e5"},{"name":"Sweden"},{"name":"Ume\u00e5 Centre for Microbial Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim","family":"Silver","sequence":"additional","affiliation":[{"name":"Ume\u00e5 Centre for Microbial Research"},{"name":"Ume\u00e5 University"},{"name":"901 87 Ume\u00e5"},{"name":"Sweden"},{"name":"Department of Molecular Biology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders E. G.","family":"Lindgren","sequence":"additional","affiliation":[{"name":"Department of Chemistry"},{"name":"Ume\u00e5 University"},{"name":"901 87 Ume\u00e5"},{"name":"Sweden"},{"name":"Ume\u00e5 Centre for Microbial Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Wede","sequence":"additional","affiliation":[{"name":"Ume\u00e5 Centre for Microbial Research"},{"name":"Ume\u00e5 University"},{"name":"901 87 Ume\u00e5"},{"name":"Sweden"},{"name":"Department of Molecular Biology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pardeep","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Chemistry"},{"name":"Ume\u00e5 University"},{"name":"901 87 Ume\u00e5"},{"name":"Sweden"},{"name":"Ume\u00e5 Centre for Microbial Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina","family":"Vielfort","sequence":"additional","affiliation":[{"name":"Ume\u00e5 Centre for Microbial Research"},{"name":"Ume\u00e5 University"},{"name":"901 87 Ume\u00e5"},{"name":"Sweden"},{"name":"Department of Molecular Biology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wael","family":"Bahnan","sequence":"additional","affiliation":[{"name":"Ume\u00e5 Centre for Microbial Research"},{"name":"Ume\u00e5 University"},{"name":"901 87 Ume\u00e5"},{"name":"Sweden"},{"name":"Department of Molecular Biology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A. D.","family":"Good","sequence":"additional","affiliation":[{"name":"Department of Chemistry"},{"name":"Ume\u00e5 University"},{"name":"901 87 Ume\u00e5"},{"name":"Sweden"},{"name":"Ume\u00e5 Centre for Microbial Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Svensson","sequence":"additional","affiliation":[{"name":"The Uppsala University Drug Optimization and Pharmaceutical Profiling Platform"},{"name":"Department of Pharmacy"},{"name":"Uppsala University"},{"name":"SE-751 23 Uppsala"},{"name":"Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Bergstr\u00f6m","sequence":"additional","affiliation":[{"name":"Ume\u00e5 Centre for Microbial Research"},{"name":"Ume\u00e5 University"},{"name":"901 87 Ume\u00e5"},{"name":"Sweden"},{"name":"Department of Molecular Biology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5sa","family":"Gylfe","sequence":"additional","affiliation":[{"name":"Ume\u00e5 Centre for Microbial Research"},{"name":"Ume\u00e5 University"},{"name":"901 87 Ume\u00e5"},{"name":"Sweden"},{"name":"Laboratory for Molecular Infection Medicine Sweden (MIMS)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrik","family":"Almqvist","sequence":"additional","affiliation":[{"name":"Department of Chemistry"},{"name":"Ume\u00e5 University"},{"name":"901 87 Ume\u00e5"},{"name":"Sweden"},{"name":"Ume\u00e5 Centre for Microbial Research"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2019]]},"reference":[{"key":"C9MD00405J-(cit1)\/*[position()=1]","author":"World Health Organization","year":"2012","unstructured":"World Health Organization , Global incidence and prevalence of selected curable sexually transmitted infections \u2013 2008, 978 92 4 150383 9, World Health Organization , Geneva, Switzerland , 2012"},{"key":"C9MD00405J-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1051\/nss:2005057","volume":"13","author":"Whittum-Hudson","year":"2005","journal-title":"Nat. Sci. Soc."},{"key":"C9MD00405J-(cit3)\/*[position()=1]","first-page":"1714","volume":"7","author":"Dautry-Varsat","year":"2005","journal-title":"Cell. Microbiol."},{"key":"C9MD00405J-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1111\/1574-6976.12059","volume":"38","author":"Omsland","year":"2014","journal-title":"FEMS Microbiol. Rev."},{"key":"C9MD00405J-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11430","DOI":"10.1073\/pnas.0703218104","volume":"104","author":"Hybiske","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C9MD00405J-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"S774","DOI":"10.1093\/cid\/civ694","volume":"61","author":"Geisler","year":"2015","journal-title":"Clin. Infect. Dis."},{"key":"C9MD00405J-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1517\/14656566.2012.658776","volume":"13","author":"Hammerschlag","year":"2012","journal-title":"Expert Opin. Pharmacother."},{"key":"C9MD00405J-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3216","DOI":"10.1099\/mic.0.040618-0","volume":"156","author":"Jernberg","year":"2010","journal-title":"Microbiology"},{"key":"C9MD00405J-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e02304","DOI":"10.1128\/mBio.02304-14","volume":"6","author":"Engstr\u00f6m","year":"2014","journal-title":"mBio"},{"key":"C9MD00405J-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1021\/acs.jmedchem.5b01759","volume":"59","author":"Good","year":"2016","journal-title":"J. Med. Chem."},{"key":"C9MD00405J-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9393","DOI":"10.1021\/acs.jmedchem.7b00716","volume":"60","author":"Good","year":"2017","journal-title":"J. Med. Chem."},{"key":"C9MD00405J-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0165-1161(75)90046-1","volume":"31","author":"Ames","year":"1975","journal-title":"Mutat. Res."},{"key":"C9MD00405J-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4165","DOI":"10.1021\/acs.jmedchem.8b00289","volume":"61","author":"Kul\u00e9n","year":"2018","journal-title":"J. Med. Chem."},{"key":"C9MD00405J-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5048","DOI":"10.1021\/ol201875q","volume":"13","author":"Dunetz","year":"2011","journal-title":"Org. Lett."},{"key":"C9MD00405J-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7563","DOI":"10.1016\/j.bmc.2006.07.017","volume":"14","author":"\u00c5berg","year":"2006","journal-title":"Bioorg. Med. Chem."},{"key":"C9MD00405J-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9337","DOI":"10.1016\/j.tetlet.2003.10.055","volume":"44","author":"Evans","year":"2003","journal-title":"Tetrahedron Lett."},{"key":"C9MD00405J-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1021\/jo1023393","volume":"76","author":"Castanedo","year":"2011","journal-title":"J. Org. Chem."},{"key":"C9MD00405J-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1124\/dmd.106.013359","volume":"35","author":"Yang","year":"2007","journal-title":"Drug Metab. Dispos."},{"key":"C9MD00405J-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1128\/IAI.31.3.1161-1176.1981","volume":"31","author":"Caldwell","year":"1981","journal-title":"Infect. Immun."},{"key":"C9MD00405J-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2968","DOI":"10.1128\/AAC.02015-13","volume":"58","author":"Marwaha","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"C9MD00405J-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1038\/nprot.2007.303","volume":"2","author":"Hubatsch","year":"2007","journal-title":"Nat. Protoc."},{"key":"C9MD00405J-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1002\/jps.24506","volume":"104","author":"Riccardi","year":"2015","journal-title":"J. Pharm. Sci."},{"key":"C9MD00405J-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6756","DOI":"10.1021\/jo015794u","volume":"66","author":"Emten\u00e4s","year":"2001","journal-title":"J. Org. Chem."},{"issue":"4","key":"C9MD00405J-(cit25)\/*[position()=1]","first-page":"453","volume":"58","author":"Baranczewski","year":"2006","journal-title":"Pharmacol. Rep."}],"container-title":["MedChemComm"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2019\/MD\/C9MD00405J","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T04:52:20Z","timestamp":1782967940000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/1m\/article\/10\/11\/1966-1987\/647903"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":24,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11,13]]}},"URL":"https:\/\/doi.org\/10.1039\/c9md00405j","relation":{},"ISSN":["2040-2503","2040-2511"],"issn-type":[{"value":"2040-2503","type":"print"},{"value":"2040-2511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Carlos N\u00fa\u00f1ez-Otero (ORCID)","URL":"http:\/\/orcid.org\/0000-0001-7680-0918","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 20 August 2019; Accepted 20 September 2019; Advance Article published 17 October 2019; Version of Record published 13 November 2019","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}