{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T07:00:33Z","timestamp":1782975633290,"version":"3.54.5"},"reference-count":82,"publisher":"Royal Society of Chemistry (RSC)","issue":"3","license":[{"start":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T00:00:00Z","timestamp":1614124800000},"content-version":"am","delay-in-days":420,"URL":"http:\/\/rsc.li\/journals-terms-of-use#chorus"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"crossref","award":["R01CA187678-01"],"award-info":[{"award-number":["R01CA187678-01"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Science Foundation","award":["DGE-1650504"],"award-info":[{"award-number":["DGE-1650504"]}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Med. Chem."],"abstract":"<p>Potent \u03b1-N-heterocyclic carboxaldehyde thiosemicarbazone (HCT) antiproliferatives were synthesized through iterative rounds of methylation and fluorination modifications, with anticancer activities being potentiated by physiological levels of copper.<\/p>","DOI":"10.1039\/c9md00594c","type":"journal-article","created":{"date-parts":[[2020,2,24]],"date-time":"2020-02-24T09:33:58Z","timestamp":1582536838000},"page":"392-410","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Isoquinoline thiosemicarbazone displays potent anticancer activity with\n                    <i>in vivo<\/i>\n                    efficacy against aggressive leukemias"],"prefix":"10.1039","volume":"11","author":[{"given":"Daniel L.","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Molecular and Medical Pharmacology"},{"name":"University of California, Los Angeles"},{"name":"USA"},{"name":"Ahmanson Translational Imaging Division"},{"name":"University of California, Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumya","family":"Poddar","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology"},{"name":"University of California, Los Angeles"},{"name":"USA"},{"name":"Ahmanson Translational Imaging Division"},{"name":"University of California, Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2840-283X","authenticated-orcid":false,"given":"Roy D.","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology"},{"name":"University of California, Los Angeles"},{"name":"USA"},{"name":"Ahmanson Translational Imaging Division"},{"name":"University of California, Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1060-7634","authenticated-orcid":false,"given":"Ethan W.","family":"Rosser","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology"},{"name":"University of California, Los Angeles"},{"name":"USA"},{"name":"Ahmanson Translational Imaging Division"},{"name":"University of California, Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan R.","family":"Abt","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology"},{"name":"University of California, Los Angeles"},{"name":"USA"},{"name":"Ahmanson Translational Imaging Division"},{"name":"University of California, Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juno","family":"Van Valkenburgh","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology"},{"name":"University of California, Los Angeles"},{"name":"USA"},{"name":"Ahmanson Translational Imaging Division"},{"name":"University of California, Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thuc M.","family":"Le","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology"},{"name":"University of California, Los Angeles"},{"name":"USA"},{"name":"Ahmanson Translational Imaging Division"},{"name":"University of California, Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Lok","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology"},{"name":"University of California, Los Angeles"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selena P.","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry"},{"name":"University of California, Los Angeles"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology"},{"name":"University of California, Los Angeles"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology"},{"name":"University of California, Los Angeles"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aneta","family":"Turlik","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry"},{"name":"University of California, Los Angeles"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry"},{"name":"University of California, Los Angeles"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6657-9137","authenticated-orcid":false,"given":"Chi-An","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry"},{"name":"University of California, Los Angeles"},{"name":"USA"},{"name":"Department of Bioengineering"},{"name":"University of California, Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry"},{"name":"University of California, Los Angeles"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine E.","family":"Mona","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology"},{"name":"University of California, Los Angeles"},{"name":"USA"},{"name":"Ahmanson Translational Imaging Division"},{"name":"University of California, Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreea D.","family":"Stuparu","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology"},{"name":"University of California, Los Angeles"},{"name":"USA"},{"name":"Ahmanson Translational Imaging Division"},{"name":"University of California, Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Vergnes","sequence":"additional","affiliation":[{"name":"Department of Human Genetics"},{"name":"David Geffen School of Medicine"},{"name":"University of California, Los Angeles"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Reue","sequence":"additional","affiliation":[{"name":"Department of Human Genetics"},{"name":"David Geffen School of Medicine"},{"name":"University of California, Los Angeles"},{"name":"USA"},{"name":"Molecular Biology Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Damoiseaux","sequence":"additional","affiliation":[{"name":"UCLA Metabolomic Center"},{"name":"University of California, Los Angeles"},{"name":"Los Angeles"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9792-4976","authenticated-orcid":false,"given":"Jeffrey I.","family":"Zink","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry"},{"name":"University of California, Los Angeles"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Czernin","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology"},{"name":"University of California, Los Angeles"},{"name":"USA"},{"name":"Ahmanson Translational Imaging Division"},{"name":"University of California, Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy R.","family":"Donahue","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology"},{"name":"University of California, Los Angeles"},{"name":"USA"},{"name":"Ahmanson Translational Imaging Division"},{"name":"University of California, Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8387-5261","authenticated-orcid":false,"given":"Kendall N.","family":"Houk","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry"},{"name":"University of California, Los Angeles"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry"},{"name":"University of California, Los Angeles"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9338-5397","authenticated-orcid":false,"given":"Caius G.","family":"Radu","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology"},{"name":"University of California, Los Angeles"},{"name":"USA"},{"name":"Ahmanson Translational Imaging Division"},{"name":"University of California, Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2020]]},"reference":[{"issue":"2","key":"C9MD00594C-(cit1)\/*[position()=1]","first-page":"167","volume":"16","author":"Brockman","year":"1956","journal-title":"Cancer Res."},{"issue":"1","key":"C9MD00594C-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"31","DOI":"10.2174\/1389557043487484","volume":"4","author":"Beraldo","year":"2004","journal-title":"Mini-Rev. Med. Chem."},{"issue":"1","key":"C9MD00594C-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S0006-291X(67)80034-2","volume":"27","author":"Sartorelli","year":"1967","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"20","key":"C9MD00594C-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3672","DOI":"10.1021\/jm00098a012","volume":"35","author":"Liu","year":"1992","journal-title":"J. Med. Chem."},{"issue":"7","key":"C9MD00594C-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1021\/jm00229a023","volume":"19","author":"Agrawal","year":"1976","journal-title":"J. Med. Chem."},{"issue":"6","key":"C9MD00594C-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1021\/jm00300a024","volume":"13","author":"French","year":"1970","journal-title":"J. Med. Chem."},{"issue":"9","key":"C9MD00594C-(cit7)\/*[position()=1]","first-page":"1454","volume":"29","author":"French","year":"1965","journal-title":"Cancer Res."},{"key":"C9MD00594C-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0065-2571(98)00017-X","volume":"39","author":"Finch","year":"1999","journal-title":"Adv. Enzyme Regul."},{"issue":"23","key":"C9MD00594C-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6876","DOI":"10.1158\/1078-0432.CCR-06-1954","volume":"12","author":"Yu","year":"2006","journal-title":"Clin. Cancer Res."},{"issue":"2","key":"C9MD00594C-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jsgi.2005.11.004","volume":"13","author":"Alvero","year":"2006","journal-title":"J. Soc. Gynecol. Invest."},{"issue":"17","key":"C9MD00594C-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.2174\/092986712800609706","volume":"19","author":"Yu","year":"2012","journal-title":"Curr. Med. Chem."},{"issue":"8","key":"C9MD00594C-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1089\/ars.2012.4540","volume":"18","author":"Merlot","year":"2013","journal-title":"Antioxid. Redox Signaling"},{"key":"C9MD00594C-(cit13)\/*[position()=1]","first-page":"402","volume":"9","author":"Chaston","year":"2003","journal-title":"Clin. Cancer Res."},{"issue":"2","key":"C9MD00594C-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0006-2952(94)90105-8","volume":"48","author":"Cory","year":"1994","journal-title":"Biochem. Pharmacol."},{"issue":"5","key":"C9MD00594C-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1021\/jm801585u","volume":"52","author":"Richardson","year":"2009","journal-title":"J. Med. Chem."},{"issue":"11","key":"C9MD00594C-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1016\/j.jinorgbio.2011.07.003","volume":"105","author":"Popovi\u0107-Bijeli\u0107","year":"2011","journal-title":"J. Inorg. Biochem."},{"issue":"3","key":"C9MD00594C-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.bcp.2014.08.006","volume":"91","author":"Ishiguro","year":"2014","journal-title":"Biochem. Pharmacol."},{"issue":"14","key":"C9MD00594C-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1002\/pros.23022","volume":"75","author":"Denoyer","year":"2015","journal-title":"Prostate"},{"issue":"1","key":"C9MD00594C-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1146\/annurev.neuro.30.051606.094232","volume":"30","author":"Madsen","year":"2007","journal-title":"Annu. Rev. Neurosci."},{"issue":"15","key":"C9MD00594C-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9588","DOI":"10.1074\/jbc.M114.631283","volume":"290","author":"Jansson","year":"2015","journal-title":"J. Biol. Chem."},{"issue":"40","key":"C9MD00594C-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"14901","DOI":"10.1073\/pnas.0604979103","volume":"103","author":"Whitnall","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"C9MD00594C-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.chembiol.2018.02.010","volume":"25","author":"Shimada","year":"2018","journal-title":"Cell Chem. Biol."},{"issue":"21","key":"C9MD00594C-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10425","DOI":"10.1158\/0008-5472.CAN-06-2126","volume":"66","author":"Chen","year":"2006","journal-title":"Cancer Res."},{"issue":"1","key":"C9MD00594C-(cit24)\/*[position()=1]","first-page":"1","volume":"6","author":"Brewer","year":"2000","journal-title":"Clin. Cancer Res."},{"issue":"3","key":"C9MD00594C-(cit25)\/*[position()=1]","first-page":"197","volume":"1","author":"Cen","year":"2002","journal-title":"Mol. Cancer Ther."},{"issue":"5846","key":"C9MD00594C-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1126\/science.1131943","volume":"317","author":"M\u00fcller","year":"2007","journal-title":"Science"},{"issue":"2","key":"C9MD00594C-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1039\/B610213C","volume":"37","author":"Purser","year":"2008","journal-title":"Chem. Soc. Rev."},{"issue":"21","key":"C9MD00594C-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8315","DOI":"10.1021\/acs.jmedchem.5b00258","volume":"58","author":"Gillis","year":"2015","journal-title":"J. Med. Chem."},{"issue":"3","key":"C9MD00594C-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1021\/ic010534g","volume":"41","author":"Belle","year":"2002","journal-title":"Inorg. Chem."},{"issue":"16","key":"C9MD00594C-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5032","DOI":"10.1021\/jm900528d","volume":"52","author":"Kowol","year":"2009","journal-title":"J. Med. Chem."},{"issue":"14","key":"C9MD00594C-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6739","DOI":"10.1021\/acs.jmedchem.6b00342","volume":"59","author":"Kowol","year":"2016","journal-title":"J. Med. Chem."},{"issue":"4","key":"C9MD00594C-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1021\/jm00310a014","volume":"11","author":"Agrawal","year":"1968","journal-title":"J. Med. Chem."},{"issue":"11","key":"C9MD00594C-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1021\/jm00257a004","volume":"17","author":"Mooney","year":"1974","journal-title":"J. Med. Chem."},{"issue":"6","key":"C9MD00594C-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3532","DOI":"10.1021\/acs.inorgchem.6b03178","volume":"56","author":"Zaltariov","year":"2017","journal-title":"Inorg. Chem."},{"issue":"25","key":"C9MD00594C-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"17689","DOI":"10.18632\/oncotarget.24844","volume":"9","author":"Malarz","year":"2018","journal-title":"Oncotarget"},{"issue":"9","key":"C9MD00594C-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1039\/C6MT00105J","volume":"8","author":"Park","year":"2016","journal-title":"Metallomics"},{"issue":"24","key":"C9MD00594C-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"37064","DOI":"10.18632\/oncotarget.9245","volume":"7","author":"Denoyer","year":"2016","journal-title":"Oncotarget"},{"issue":"7","key":"C9MD00594C-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1021\/cb400198p","volume":"8","author":"Cater","year":"2013","journal-title":"ACS Chem. Biol."},{"issue":"20","key":"C9MD00594C-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5819","DOI":"10.1158\/0008-5472.CAN-13-3527","volume":"74","author":"Safi","year":"2014","journal-title":"Cancer Res."},{"issue":"4","key":"C9MD00594C-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1097\/MPA.0b013e318288360a","volume":"42","author":"Kodydkova","year":"2013","journal-title":"Pancreas"},{"issue":"3","key":"C9MD00594C-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.4143\/crt.2015.282","volume":"48","author":"Lener","year":"2016","journal-title":"Cancer Res. Treat."},{"issue":"12","key":"C9MD00594C-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4863","DOI":"10.1177\/0300060518798507","volume":"46","author":"Zhang","year":"2018","journal-title":"J. Int. Med. Res."},{"issue":"8","key":"C9MD00594C-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/s12032-014-0136-z","volume":"31","author":"Wiernik","year":"2014","journal-title":"Med. Oncol."},{"issue":"9","key":"C9MD00594C-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"a012716","DOI":"10.1101\/cshperspect.a012716","volume":"5","author":"Mar\u00e9chal","year":"2013","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"C9MD00594C-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.pharmthera.2014.12.001","volume":"149","author":"Weber","year":"2015","journal-title":"Pharmacol. Ther."},{"issue":"10","key":"C9MD00594C-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1093\/carcin\/bgg137","volume":"24","author":"Yang","year":"2003","journal-title":"Carcinogenesis"},{"key":"C9MD00594C-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0076-6879(90)86093-B","volume":"186","author":"Halliwell","year":"1990","journal-title":"Methods Enzymol."},{"issue":"2","key":"C9MD00594C-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1039\/C2MT00174H","volume":"4","author":"Duncan","year":"2012","journal-title":"Metallomics"},{"issue":"26","key":"C9MD00594C-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10592","DOI":"10.1073\/pnas.1301445110","volume":"110","author":"Willis","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"C9MD00594C-(cit51)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-016-0009-6","volume":"8","author":"Le","year":"2017","journal-title":"Nat. Commun."},{"key":"C9MD00594C-(cit52)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s41021-017-0081-0","volume":"39","author":"Kino","year":"2017","journal-title":"Genes Environ."},{"issue":"2","key":"C9MD00594C-(cit53)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1089\/ars.2012.4886","volume":"20","author":"Dikalov","year":"2014","journal-title":"Antioxid. Redox Signaling"},{"issue":"1","key":"C9MD00594C-(cit54)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"C125","DOI":"10.1152\/ajpcell.00247.2006","volume":"292","author":"Wu","year":"2007","journal-title":"Am. J. Physiol."},{"issue":"11","key":"C9MD00594C-(cit55)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4440","DOI":"10.1210\/jc.2016-2670","volume":"101","author":"Vergnes","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"2","key":"C9MD00594C-(cit56)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1042\/BJ20110162","volume":"435","author":"Brand","year":"2011","journal-title":"Biochem. J."},{"issue":"12","key":"C9MD00594C-(cit57)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2916","DOI":"10.1016\/j.bbamcr.2016.09.011","volume":"1863","author":"Krishan","year":"2016","journal-title":"Biochim. Biophys. Acta, Mol. Cell Res."},{"issue":"1","key":"C9MD00594C-(cit58)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8760","DOI":"10.1038\/s41598-017-09206-0","volume":"7","author":"Dar","year":"2017","journal-title":"Sci. Rep."},{"issue":"13","key":"C9MD00594C-(cit59)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3585","DOI":"10.1182\/blood-2010-08-301267","volume":"117","author":"Boulos","year":"2011","journal-title":"Blood"},{"issue":"9","key":"C9MD00594C-(cit60)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1038\/leu.2015.168","volume":"29","author":"Hughes","year":"2015","journal-title":"Leukemia"},{"issue":"17","key":"C9MD00594C-(cit61)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6688","DOI":"10.1073\/pnas.0602030103","volume":"103","author":"Williams","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"11","key":"C9MD00594C-(cit62)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.1158\/0008-5472.CAN-17-3024","volume":"78","author":"Rahmani","year":"2018","journal-title":"Cancer Res."},{"issue":"4","key":"C9MD00594C-(cit63)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1182\/blood-2017-05-786657","volume":"131","author":"Yamaura","year":"2018","journal-title":"Blood"},{"issue":"15","key":"C9MD00594C-(cit64)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5759","DOI":"10.1021\/jm100561b","volume":"53","author":"Jansson","year":"2010","journal-title":"J. Med. Chem."},{"issue":"2","key":"C9MD00594C-(cit65)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1021\/acs.chemrev.8b00396","volume":"119","author":"Englinger","year":"2018","journal-title":"Chem. Rev."},{"issue":"1","key":"C9MD00594C-(cit66)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/1471-2407-14-76","volume":"14","author":"Goto","year":"2014","journal-title":"BMC Cancer"},{"issue":"6","key":"C9MD00594C-(cit67)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"241","DOI":"10.3109\/07357907.2014.907419","volume":"32","author":"Goto","year":"2014","journal-title":"Cancer Invest."},{"issue":"3","key":"C9MD00594C-(cit68)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.stem.2010.07.011","volume":"7","author":"Simsek","year":"2010","journal-title":"Cell Stem Cell"},{"issue":"5","key":"C9MD00594C-(cit69)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.ccr.2011.10.015","volume":"20","author":"\u0160krti\u0107","year":"2011","journal-title":"Cancer Cell"},{"issue":"13","key":"C9MD00594C-(cit70)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1182\/blood-2014-08-594408","volume":"125","author":"Sriskanthadevan","year":"2015","journal-title":"Blood"},{"issue":"3","key":"C9MD00594C-(cit71)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.stem.2012.12.013","volume":"12","author":"Lagadinou","year":"2013","journal-title":"Cell Stem Cell"},{"issue":"1","key":"C9MD00594C-(cit72)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1172\/JCI38942","volume":"120","author":"Samudio","year":"2010","journal-title":"J. Clin. Invest."},{"issue":"7","key":"C9MD00594C-(cit73)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1038\/s41591-018-0052-4","volume":"24","author":"Molina","year":"2018","journal-title":"Nat. Med."},{"issue":"18","key":"C9MD00594C-(cit74)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8762","DOI":"10.1158\/0008-5472.CAN-06-4807","volume":"67","author":"Rassool","year":"2007","journal-title":"Cancer Res."},{"issue":"1","key":"C9MD00594C-(cit75)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1034\/j.1600-065X.2003.00060.x","volume":"194","author":"Mills","year":"2003","journal-title":"Immunol. Rev."},{"issue":"24","key":"C9MD00594C-(cit76)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5298","DOI":"10.1182\/blood-2010-03-272591","volume":"116","author":"Fan","year":"2010","journal-title":"Blood"},{"issue":"22","key":"C9MD00594C-(cit77)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5816","DOI":"10.1182\/blood-2011-01-326025","volume":"117","author":"Hole","year":"2011","journal-title":"Blood"},{"issue":"7684","key":"C9MD00594C-(cit78)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/nature25016","volume":"552","author":"Skrott","year":"2017","journal-title":"Nature"},{"issue":"14","key":"C9MD00594C-(cit79)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1016\/j.yexcr.2008.06.008","volume":"314","author":"Lass","year":"2008","journal-title":"Exp. Cell Res."},{"issue":"1","key":"C9MD00594C-(cit80)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.pep.2011.04.022","volume":"79","author":"Vor\u00e1\u010dkov\u00e1","year":"2011","journal-title":"Protein Expression Purif."},{"issue":"1","key":"C9MD00594C-(cit81)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s40591-016-0048-8","volume":"4","author":"Larsen","year":"2016","journal-title":"Mol. Cell. Ther."},{"issue":"3","key":"C9MD00594C-(cit82)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1084\/jem.20131738","volume":"211","author":"Nathanson","year":"2014","journal-title":"J. Exp. Med."},{"issue":"11","key":"C9MD00594C-(cit83)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1182\/blood-2015-01-621870","volume":"126","author":"Jacque","year":"2015","journal-title":"Blood"}],"container-title":["RSC Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2020\/MD\/C9MD00594C","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2020\/MD\/C9MD00594C","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T05:27:17Z","timestamp":1782970037000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/md\/article\/11\/3\/392-410\/647953"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":82,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3,30]]}},"URL":"https:\/\/doi.org\/10.1039\/c9md00594c","relation":{},"ISSN":["2632-8682"],"issn-type":[{"value":"2632-8682","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C9MD00594C","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Roy D. Pan (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-2840-283X","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Ethan W. Rosser (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-1060-7634","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Chi-An Cheng (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-6657-9137","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Jeffrey I. Zink (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-9792-4976","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Kendall N. Houk (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-8387-5261","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Caius G. Radu (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-9338-5397","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 26 December 2019; Accepted 12 February 2020;  Advance Article published 24 February 2020;  Version of Record published 30 March 2020","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}