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It was identified as Burkholderia cenocepacia based on genomic, physiological and biochemical analyses. The Cd removal rate by YG-3 could reach about 60.0% in Cd aqueous solution with high concentrations of both 100 and 500 mg L\u22121. Meanwhile, various absorption and adsorption strategies were found in the two different Cd concentrations. The global resistance mechanisms of YG-3 were investigated in several levels, i.e., physiological observation, such as scanning electron microscopy and transmission electron microscopy; biochemical detection for active compound production and infrared spectroscopy; label-free quantitative proteomic profile analysis. The results indicated that YG-3 possesses a complex mechanism to adapt to Cd stress: (1) binding of Cd to prevent it from entering the cell by the cell wall components, as well as secreted siderophores and exopolysaccharides; (2) intracellular sequestration of Cd by metalloproteins; (3) excretion of Cd from the cell by efflux pumps; (4) alleviation of Cd toxicity by antioxidants. Our results demonstrate that endophyte YG-3 is well adjusted to largely remove Cd and has potential to cooperate with its host to improve phytoremediation efficiency in heavy metal-contaminated sites.<\/jats:p>","DOI":"10.1039\/c9mt00054b","type":"journal-article","created":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T13:34:21Z","timestamp":1558704861000},"page":"1252-1264","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Physiological, biochemical and proteomic insight into integrated strategies of an endophytic bacterium <i>Burkholderia cenocepacia<\/i> strain YG-3 response to cadmium stress"],"prefix":"10.1093","volume":"11","author":[{"given":"Xiang","family":"Wang","sequence":"first","affiliation":[{"name":"Hunan Province Key Laboratory of Plant Functional Genomics and Developmental Regulation, College of Biology, Hunan University, Changsha 410082, Hunan, P. R. China. Tel: +08673188664048"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hunan Province Key Laboratory of Plant Functional Genomics and Developmental Regulation, College of Biology, Hunan University, Changsha 410082, Hunan, P. R. China. Tel: +08673188664048"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuanming","family":"Liu","sequence":"additional","affiliation":[{"name":"Hunan Province Key Laboratory of Plant Functional Genomics and Developmental Regulation, College of Biology, Hunan University, Changsha 410082, Hunan, P. R. China. Tel: +08673188664048"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongliang","family":"Huang","sequence":"additional","affiliation":[{"name":"Hunan Academy of Forestry, Changsha 410000, Hunan, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuqi","family":"Niu","sequence":"additional","affiliation":[{"name":"Hunan Province Key Laboratory of Plant Functional Genomics and Developmental Regulation, College of Biology, Hunan University, Changsha 410082, Hunan, P. R. China. Tel: +08673188664048"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Xu","sequence":"additional","affiliation":[{"name":"Hunan Province Key Laboratory of Plant Functional Genomics and Developmental Regulation, College of Biology, Hunan University, Changsha 410082, Hunan, P. R. China. Tel: +08673188664048"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiarui","family":"Zeng","sequence":"additional","affiliation":[{"name":"Hunan Province Key Laboratory of Plant Functional Genomics and Developmental Regulation, College of Biology, Hunan University, Changsha 410082, Hunan, P. R. China. Tel: +08673188664048"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[{"name":"Hunan Academy of Forestry, Changsha 410000, Hunan, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6448-0491","authenticated-orcid":false,"given":"Tengfei","family":"Wang","sequence":"additional","affiliation":[{"name":"Hunan Province Key Laboratory of Plant Functional Genomics and Developmental Regulation, College of Biology, Hunan University, Changsha 410082, Hunan, P. R. China. Tel: +08673188664048"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Gao","sequence":"additional","affiliation":[{"name":"Hunan Province Key Laboratory of Plant Functional Genomics and Developmental Regulation, College of Biology, Hunan University, Changsha 410082, Hunan, P. R. China. Tel: +08673188664048"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Huang","sequence":"additional","affiliation":[{"name":"Hunan Province Key Laboratory of Plant Functional Genomics and Developmental Regulation, College of Biology, Hunan University, Changsha 410082, Hunan, P. R. China. Tel: +08673188664048"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lidan","family":"Cao","sequence":"additional","affiliation":[{"name":"Hunan Province Key Laboratory of Plant Functional Genomics and Developmental Regulation, College of Biology, Hunan University, Changsha 410082, Hunan, P. R. China. 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