{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T10:32:41Z","timestamp":1769941961477,"version":"3.49.0"},"reference-count":80,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T00:00:00Z","timestamp":1566345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T00:00:00Z","timestamp":1597968000000},"content-version":"am","delay-in-days":366,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/100007359","name":"Fondazione Banco di Sardegna","doi-asserted-by":"publisher","award":["FDS15Garribba"],"award-info":[{"award-number":["FDS15Garribba"]}],"id":[{"id":"10.13039\/100007359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009873","name":"Regione Autonoma della Sardegna","doi-asserted-by":"publisher","award":["RASSR79857"],"award-info":[{"award-number":["RASSR79857"]}],"id":[{"id":"10.13039\/501100009873","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007359","name":"Fondazione Banco di Sardegna","doi-asserted-by":"crossref","award":["FDS15Garribba"],"award-info":[{"award-number":["FDS15Garribba"]}],"id":[{"id":"10.13039\/100007359","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100009873","name":"Regione Autonoma della Sardegna","doi-asserted-by":"crossref","award":["RASSR79857"],"award-info":[{"award-number":["RASSR79857"]}],"id":[{"id":"10.13039\/501100009873","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,10,16]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Malignant melanoma (MM) is the most fatal skin cancer, whose incidence has critically increased in the last decades. Recent molecular therapies are giving excellent results in the remission of melanoma but often they induce drug resistance in patients limiting their therapeutic efficacy. The search for new compounds able to overcome drug resistance is therefore essential. Vanadium has recently been cited for its anticancer properties against several tumors, but only a few data regard its effect against MM. In a previous work we demonstrated the anticancer activity of four different vanadium species towards MM cell lines. The inorganic anion vanadate(v) (VN) and the oxidovanadium(iv) complex [VO(dhp)2] (VS2), where dhp is 1,2-dimethyl-3-hydroxy-4(1H)-pyridinonate, showed IC50 values of 4.7 and 2.6 \u03bcM, respectively, against the A375 MM cell line, causing apoptosis and cell cycle arrest. Here we demonstrate the involvement of Reactive Oxygen Species (ROS) production in the pro-apoptotic effect of these two V species and evaluate the activation of different cell cycle regulators, to investigate the molecular mechanisms involved in their antitumor activity. We establish that VN and VS2 treatments reduce the phosphorylation of extracellular-signal regulated kinase (ERK) by about 80%, causing the deactivation of the mitogen activated protein kinase (MAPK) pathway in A375 cells. VN and VS2 also induce dephosphorylation of the retinoblastoma protein (Rb) (VN 100% and VS2 90%), together with a pronounced increase of cyclin-dependent kinase inhibitor 1 p21 (p21Cip1) protein expression up to 1800%. Taken together, our results confirm the antitumor properties of vanadium against melanoma cells, highlighting its ability to induce apoptosis through generation of ROS and cell cycle arrest by counteracting MAPK pathway activation and strongly inducing p21Cip1 expression and Rb hypo-phosphorylation.<\/jats:p>","DOI":"10.1039\/c9mt00174c","type":"journal-article","created":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T10:35:00Z","timestamp":1566383700000},"page":"1687-1699","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Antiproliferative activity of vanadium compounds: effects on the major malignant melanoma molecular pathways"],"prefix":"10.1093","volume":"11","author":[{"given":"Marina","family":"Pisano","sequence":"first","affiliation":[{"name":"Istituto di Chimica Biomolecolare (ICB), Consiglio Nazionale delle Ricerche (CNR), Traversa La Crucca 3, 07100 Sassari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Arru","sequence":"additional","affiliation":[{"name":"Istituto di Chimica Biomolecolare (ICB), Consiglio Nazionale delle Ricerche (CNR), Traversa La Crucca 3, 07100 Sassari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Serra","sequence":"additional","affiliation":[{"name":"Istituto di Chimica Biomolecolare (ICB), Consiglio Nazionale delle Ricerche (CNR), Traversa La Crucca 3, 07100 Sassari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grazia","family":"Galleri","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Mediche, Chirurgiche e Sperimentali, Universit\u00e0 di Sassari, V.le San Pietro 8, 07100 Sassari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9299-0141","authenticated-orcid":false,"given":"Daniele","family":"Sanna","sequence":"additional","affiliation":[{"name":"Istituto di Chimica Biomolecolare (ICB), Consiglio Nazionale delle Ricerche (CNR), Traversa La Crucca 3, 07100 Sassari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7229-5966","authenticated-orcid":false,"given":"Eugenio","family":"Garribba","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica e Farmacia, Universit\u00e0 di Sassari, Via Vienna 2, I-07100 Sassari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4350-2276","authenticated-orcid":false,"given":"Giuseppe","family":"Palmieri","sequence":"additional","affiliation":[{"name":"Istituto di Chimica Biomolecolare (ICB), Consiglio Nazionale delle Ricerche (CNR), Traversa La Crucca 3, 07100 Sassari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6581-2227","authenticated-orcid":false,"given":"Carla","family":"Rozzo","sequence":"additional","affiliation":[{"name":"Istituto di Chimica Biomolecolare (ICB), Consiglio Nazionale delle Ricerche (CNR), Traversa La Crucca 3, 07100 Sassari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,8,21]]},"reference":[{"key":"2021121514031873700_cit1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-2133.146.s61.2.x","article-title":"The epidemiology of skin cancer","volume":"146","author":"Diepgen","year":"2002","journal-title":"Br. J. Dermatol."},{"key":"2021121514031873700_cit2","first-page":"17","volume-title":"Melanoma Epidemiology and Prevention in Melanoma","author":"Berwick","year":"2016"},{"key":"2021121514031873700_cit3","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3389\/fonc.2015.00183","article-title":"Multiple Molecular Pathways in Melanomagenesis: Characterization of Therapeutic Targets","volume":"5","author":"Palmieri","year":"2015","journal-title":"Front. Oncol."},{"key":"2021121514031873700_cit4","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1684\/ejd.2016.2787","article-title":"Genetic epidemiology of melanoma","volume":"26","author":"Ribero","year":"2016","journal-title":"Eur. J. Dermatol."},{"key":"2021121514031873700_cit5"},{"key":"2021121514031873700_cit6","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1007\/s11912-018-0733-7","article-title":"for the Italian Melanoma Intergroup (IMI), Molecular Pathways in Melanomagenesis: What We Learned from Next-Generation Sequencing Approaches","volume":"20","author":"Palmieri","year":"2018","journal-title":"Curr. Oncol. Rep."},{"key":"2021121514031873700_cit7","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1479-5876-7-86","article-title":"Main roads to melanoma","volume":"7","author":"Palmieri","year":"2009","journal-title":"J. Transl. Med."},{"key":"2021121514031873700_cit8","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/978-3-319-22539-5_10","article-title":"Targeted Theraphy for Melanoma","volume-title":"Melanoma","author":"Wong","year":"2016"},{"key":"2021121514031873700_cit9","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1158\/1535-7163.MCT-11-0989","article-title":"Combinations of BRAF, MEK, and PI3K\/mTOR Inhibitors Overcome Acquired Resistance to the BRAF Inhibitor GSK2118436 Dabrafenib, Mediated by NRAS or MEK Mutations","volume":"11","author":"Greger","year":"2012","journal-title":"Mol. Cancer Ther."},{"key":"2021121514031873700_cit10","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.canlet.2015.01.016","article-title":"Targeting drivers of melanoma with synthetic small molecules and phytochemicals","volume":"359","author":"Strickland","year":"2015","journal-title":"Cancer Lett."},{"key":"2021121514031873700_cit11","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1200\/EDBK_199047","article-title":"Emerging Strategies in Systemic Therapy for the Treatment of Melanoma","author":"Ascierto","year":"2018","journal-title":"Am. Soc. Clin. Oncol. Educ. Book"},{"key":"2021121514031873700_cit12","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/bjc.2014.476","article-title":"Beyond BRAF: where next for melanoma therapy?","volume":"112","author":"Fedorenko","year":"2014","journal-title":"Br. J. Cancer"},{"key":"2021121514031873700_cit13","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/1479-5876-12-117","article-title":"Discrepant alterations in main candidate genes among multiple primary melanomas","volume":"12","author":"Colombino","year":"2014","journal-title":"J. Transl. Med."},{"key":"2021121514031873700_cit14","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1016\/j.ccr.2009.01.028","article-title":"Mechanistic insight into the cellular uptake and processing of cisplatin 30 years after its approval by FDA","volume":"253","author":"Arnesano","year":"2009","journal-title":"Coord. Chem. Rev."},{"key":"2021121514031873700_cit15","doi-asserted-by":"crossref","first-page":"5106","DOI":"10.1039\/c3cc41143e","article-title":"Exploration of the medical periodic table: towards new targets","volume":"49","author":"Barry","year":"2013","journal-title":"Chem. Commun."},{"key":"2021121514031873700_cit16","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1002\/(SICI)1521-3773(19990601)38:11<1512::AID-ANIE1512>3.0.CO;2-Y","article-title":"Metals in Medicine","volume":"38","author":"Guo","year":"1999","journal-title":"Angew. Chem., Int. Ed."},{"key":"2021121514031873700_cit17","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.ccr.2014.08.002","article-title":"Noble metals in medicine: Latest advances","volume":"284","author":"Medici","year":"2015","journal-title":"Coord. Chem. Rev."},{"key":"2021121514031873700_cit18","doi-asserted-by":"crossref","first-page":"4540","DOI":"10.1021\/cr400460s","article-title":"Metallodrugs in Medicinal Inorganic Chemistry","volume":"114","author":"Mjos","year":"2014","journal-title":"Chem. Rev."},{"key":"2021121514031873700_cit19","first-page":"1529","article-title":"Metals and Metal Compounds in Cancer Treatment","volume":"24","author":"Desoize","year":"2004","journal-title":"Anticancer Res."},{"key":"2021121514031873700_cit20","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ccr.2014.12.002","article-title":"Vanadium compounds in medicine","volume":"301\u2013302","author":"Costa Pessoa","year":"2015","journal-title":"Coord. Chem. Rev."},{"key":"2021121514031873700_cit21","doi-asserted-by":"crossref","first-page":"3701","DOI":"10.2174\/092986710793213742","article-title":"Transport of Therapeutic Vanadium and Ruthenium Complexes by Blood Plasma Components","volume":"17","author":"Costa Pessoa","year":"2010","journal-title":"Curr. Med. Chem."},{"key":"2021121514031873700_cit22","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.ccr.2017.01.002","article-title":"Speciation of metal drugs, supplements and toxins in media and bodily fluids controls in vitro activities","volume":"352","author":"Levina","year":"2017","journal-title":"Coord. Chem. Rev."},{"key":"2021121514031873700_cit23","doi-asserted-by":"crossref","first-page":"325","DOI":"10.4155\/fmc.15.187","article-title":"Perspectives for vanadium in health issues","volume":"8","author":"Rehder","year":"2016","journal-title":"Future Med. Chem."},{"key":"2021121514031873700_cit24","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.toxlet.2004.01.009","article-title":"Vanadium\u2014an element of atypical biological significance","volume":"150","author":"Mukherjee","year":"2004","journal-title":"Toxicol. Lett."},{"key":"2021121514031873700_cit25","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/978-94-007-7500-8_5","volume-title":"Interrelations between Essential Metal Ions and Human Diseases","author":"Rehder","year":"2013"},{"key":"2021121514031873700_cit26","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/s40828-018-0074-z","article-title":"Vanadium in health issues","volume":"4","author":"Rehder","year":"2018","journal-title":"ChemTexts"},{"issue":"Suppl. 343","key":"2021121514031873700_cit27","first-page":"154","article-title":"Studies on the antineoplastic effect of vanadium salts","author":"Kieler","year":"1965","journal-title":"Acta Chir. Scand."},{"key":"2021121514031873700_cit28","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1358\/dof.1986.011.04.237197","article-title":"Metallocene complexes: organometallic antitumor agents","volume":"11","author":"K\u00f6pf-Maier","year":"1986","journal-title":"Drugs Future"},{"key":"2021121514031873700_cit29","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1515\/9783110470734-009","volume-title":"Metallo-Drugs: Development and Action of Anticancer Agents","author":"Crans","year":"2018"},{"key":"2021121514031873700_cit30","first-page":"140284","article-title":"On the Discovery, Biological Effects, and Use of Cisplatin and Metallocenes in Anticancer Chemotherapy","author":"Gomez-Ruiz","year":"2012","journal-title":"Bioinorg. Chem. Appl."},{"key":"2021121514031873700_cit31","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.4155\/fmc.12.103","article-title":"The potentiality of vanadium in medicinal applications","volume":"4","author":"Rehder","year":"2012","journal-title":"Future Med. Chem."},{"key":"2021121514031873700_cit32","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0162-0134(00)00198-7","article-title":"Inhibition of human topoisomerase II by the antitumor metallocenes","volume":"83","author":"Mokdsi","year":"2001","journal-title":"J. Inorg. Biochem."},{"key":"2021121514031873700_cit33","doi-asserted-by":"crossref","first-page":"8950","DOI":"10.1039\/C7DT00943G","article-title":"Speciation in human blood of Metvan, a vanadium based potential anti-tumor drug","volume":"46","author":"Sanna","year":"2017","journal-title":"Dalton Trans."},{"key":"2021121514031873700_cit34","first-page":"1546","article-title":"Bis(4,7-dimethyl-1,10-phenanthroline) Sulfatooxovanadium(IV) as a Novel Apoptosis-inducing Anticancer Agent","volume":"6","author":"Narla","year":"2000","journal-title":"Clin. Cancer Res."},{"key":"2021121514031873700_cit35","first-page":"1094","article-title":"Bis(4,7-dimethyl-1,10-phenanthroline) Sulfatooxovanadium(IV) as a Novel Antileukemic Agent with Matrix Metalloproteinase Inhibitory Activity","volume":"7","author":"Narla","year":"2001","journal-title":"Clin. Cancer Res."},{"key":"2021121514031873700_cit36","doi-asserted-by":"crossref","first-page":"3632","DOI":"10.2174\/092986710793213805","article-title":"Potential Use of Vanadium Compounds in Therapeutics","volume":"17","author":"Barrio","year":"2010","journal-title":"Curr. Med. Chem."},{"key":"2021121514031873700_cit37","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1039\/C7MT00068E","article-title":"Decoding the anticancer activity of VO-clioquinol compound: the mechanism of action and cell death pathways in human osteosarcoma cells","volume":"9","author":"Le\u00f3n","year":"2017","journal-title":"Metallomics"},{"key":"2021121514031873700_cit38","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1039\/C6MT00045B","article-title":"Deciphering the effect of an oxovanadium(iv) complex with the flavonoid chrysin (VOChrys) on intracellular cell signalling pathways in an osteosarcoma cell line","volume":"8","author":"Le\u00f3n","year":"2016","journal-title":"Metallomics"},{"key":"2021121514031873700_cit39","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1007\/s00775-006-0122-9","article-title":"Synthesis, characterization, antitumoral and osteogenic activities of quercetin vanadyl(IV) complexes","volume":"11","author":"Ferrer","year":"2006","journal-title":"JBIC, J. Biol. Inorg. Chem."},{"key":"2021121514031873700_cit40","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1515\/9783110527872-008","volume-title":"Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic","author":"Crans","year":"2019"},{"key":"2021121514031873700_cit41","doi-asserted-by":"crossref","first-page":"112","DOI":"10.2174\/0929867323666160824162546","article-title":"Vanadium, Ruthenium and Copper Compounds: A New Class of Nonplatinum Metallodrugs with Anticancer Activity","volume":"24","author":"Leon","year":"2017","journal-title":"Curr. Med. Chem."},{"key":"2021121514031873700_cit42","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ccr.2015.03.010","article-title":"The chemistry and biology of vanadium compounds in cancer therapeutics","volume":"301-302","author":"Kioseoglou","year":"2015","journal-title":"Coord. Chem. Rev."},{"key":"2021121514031873700_cit43","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1007\/s00775-016-1389-0","article-title":"Bis(acetylacetonato)-oxidovanadium(IV) and sodium metavanadate inhibit cell proliferation via ROS-induced sustained MAPK\/ERK activation but with elevated AKT activity in human pancreatic cancer AsPC-1 cells","volume":"21","author":"Wu","year":"2016","journal-title":"J. Biol. Inorg. Chem."},{"key":"2021121514031873700_cit44","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1615\/JEnvironPatholToxicolOncol.v21.i3.30","article-title":"Vanadate Induces G2\/M Phase Arrest in p53-Deficient Mouse Embryo Fibroblasts","volume":"21","author":"Zhang","year":"2002","journal-title":"J. Environ. Pathol., Toxicol. Oncol."},{"key":"2021121514031873700_cit45","doi-asserted-by":"crossref","first-page":"3784","DOI":"10.1111\/j.1742-4658.2009.07093.x","article-title":"Vanadium-induced apoptosis of HaCaT cells is mediated by c-fos and involves nuclear accumulation of clusterin","volume":"276","author":"Markopoulou","year":"2009","journal-title":"FEBS J."},{"key":"2021121514031873700_cit46","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.lfs.2011.07.004","article-title":"Orthovanadate-induced cell death in RET\/PTC1-harboring cancer cells involves the activation of caspases and altered signaling through PI3K\/Akt\/mTOR","volume":"89","author":"Gon\u00e7alves","year":"2011","journal-title":"Life Sci."},{"key":"2021121514031873700_cit47","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jinorgbio.2017.05.010","article-title":"Antitumoral effect of vanadium compounds in malignant melanoma cell lines","volume":"174","author":"Rozzo","year":"2017","journal-title":"J. Inorg. Biochem."},{"key":"2021121514031873700_cit48","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1093\/jnci\/51.5.1417","article-title":"In Vitro Cultivation of Human Tumors: Establishment of Cell Lines Derived From a Series of Solid Tumors","volume":"51","author":"Giard","year":"1973","journal-title":"J. Natl. Cancer Inst."},{"key":"2021121514031873700_cit49","doi-asserted-by":"crossref","first-page":"8864","DOI":"10.1038\/s41598-017-08433-9","article-title":"Discovery of potential biomarkers in human melanoma cells with different metastatic potential by metabolic and lipidomic profiling","volume":"7","author":"Kim","year":"2017","journal-title":"Sci. Rep."},{"key":"2021121514031873700_cit50","first-page":"913","article-title":"A Human Melanoma Line Heterogeneous With Respect to Metastatic Capacity in Athymic Nude Mice234","volume":"72","author":"Kozlowski","year":"1984","journal-title":"J. Natl. Cancer Inst."},{"key":"2021121514031873700_cit51","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1001\/jamadermatol.2019.0440","article-title":"Risk of Melanoma Recurrence After Diagnosis of a High-Risk Primary Tumor","volume":"155","author":"von Schuckmann","year":"2019","journal-title":"JAMA Dermatol."},{"key":"2021121514031873700_cit52","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.3892\/or.2017.5963","article-title":"Phenotype characterization of human melanoma cells resistant to dabrafenib","volume":"38","author":"Cordaro","year":"2017","journal-title":"Oncol. Rep."},{"key":"2021121514031873700_cit53","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1039\/b200688j","article-title":"Interaction between the low molecular mass components of blood serum and the VO(IV)\u2013DHP system (DHP = 1,2-dimethyl-3-hydroxy-4(1H)-pyridinone","author":"Bugly\u00f3","year":"2002","journal-title":"J. Chem. Soc., Dalton Trans."},{"key":"2021121514031873700_cit54","doi-asserted-by":"crossref","first-page":"8086","DOI":"10.1021\/ic0605571","article-title":"Spectroscopic and Potentiometric Characterization of Oxovanadium(IV) Complexes Formed by 3-Hydroxy-4-Pyridinones. Rationalization of the Influence of Basicity and Electronic Structure of the Ligand on the Properties of VIVO Species in Aqueous Solution","volume":"45","author":"Rangel","year":"2006","journal-title":"Inorg. Chem."},{"key":"2021121514031873700_cit55","doi-asserted-by":"crossref","DOI":"10.1002\/9780470994429","volume-title":"Bioinorganic vanadium chemistry","author":"Rehder","year":"2008"},{"key":"2021121514031873700_cit56","first-page":"871","article-title":"In Vitro Activity of the \u03b1v\u03b23 Integrin Antagonist RGDechi-hCit on Malignant Melanoma Cells","volume":"33","author":"Pisano","year":"2013","journal-title":"Anticancer Res."},{"key":"2021121514031873700_cit57","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jinorgbio.2013.10.009","article-title":"Vanadium and cancer treatment: Antitumoral mechanisms of three oxidovanadium(IV) complexes on a human osteosarcoma cell line","volume":"134","author":"Le\u00f3n","year":"2014","journal-title":"J. Inorg. Biochem."},{"key":"2021121514031873700_cit58","doi-asserted-by":"crossref","first-page":"11868","DOI":"10.1039\/c3dt50524c","article-title":"Antitumor properties of a vanadyl(IV) complex with the flavonoid chrysin [VO(chrysin)2EtOH]2 in a human osteosarcoma model: the role of oxidative stress and apoptosis","volume":"42","author":"Leon","year":"2013","journal-title":"Dalton Trans."},{"key":"2021121514031873700_cit59","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1039\/C7MT00191F","article-title":"Vanadate oxidative and apoptotic effects are mediated by the MAPK-Nrf2 pathway in layer oviduct magnum epithelial cells","volume":"9","author":"Wang","year":"2017","journal-title":"Metallomics"},{"key":"2021121514031873700_cit60","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s000180300001","article-title":"Molecular mechanisms of N-acetylcysteine actions","volume":"60","author":"Zafarullah","year":"2003","journal-title":"Cell. Mol. Life Sci."},{"key":"2021121514031873700_cit61","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1021\/acs.jmedchem.8b01330","article-title":"Role of Ligands in the Uptake and Reduction of V(V) Complexes in Red Blood Cells","volume":"62","author":"Sanna","year":"2019","journal-title":"J. Med. Chem."},{"key":"2021121514031873700_cit62","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jinorgbio.2016.04.027","article-title":"Behavior of the potential antitumor VIVO complexes formed by flavonoid ligands. 3. Antioxidant properties and radical production capability","volume":"161","author":"Sanna","year":"2016","journal-title":"J. Inorg. Biochem."},{"key":"2021121514031873700_cit63","doi-asserted-by":"crossref","first-page":"2980","DOI":"10.1002\/anie.201803868","article-title":"Polyoxometalates as Potential Next-Generation Metallodrugs in the Combat Against Cancer","volume":"58","author":"Bijelic","year":"2019","journal-title":"Angew. Chem., Int. Ed."},{"key":"2021121514031873700_cit64","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.jinorgbio.2005.02.023","article-title":"Vanadate oligomers: In vivo effects in hepatic vanadium accumulation and stress markers","volume":"99","author":"G\u00e2ndara","year":"2005","journal-title":"J. Inorg. Biochem."},{"key":"2021121514031873700_cit65","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1002\/jcp.24385","article-title":"Therapeutic potential of a pyridoxal-based vanadium(IV) complex showing selective cytotoxicity for cancer versus healthy cells","volume":"228","author":"Strianese","year":"2013","journal-title":"J. Cell. Physiol."},{"key":"2021121514031873700_cit66","doi-asserted-by":"crossref","first-page":"3446","DOI":"10.1002\/cncr.28864","article-title":"The MAPK pathway across different malignancies: A new perspective","volume":"120","author":"Burotto","year":"2014","journal-title":"Cancer"},{"key":"2021121514031873700_cit67","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of Cancer: The Next Generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"2021121514031873700_cit68","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1007\/s00775-008-0387-2","article-title":"Vanadyl bisacetylacetonate induced G1\/S cell cycle arrest via high-intensity ERK phosphorylation in HepG2 cells","volume":"13","author":"Fu","year":"2008","journal-title":"J. Biol. Inorg. Chem."},{"key":"2021121514031873700_cit69","doi-asserted-by":"crossref","first-page":"9","DOI":"10.2174\/157340610791208754","article-title":"Cytotoxicity of a Vanadyl(IV) Complex with a Multidentate Oxygen Donor in Osteoblast Cell Lines in Culture","volume":"6","author":"Rivadeneira","year":"2010","journal-title":"Med. Chem."},{"key":"2021121514031873700_cit70","doi-asserted-by":"crossref","first-page":"5220","DOI":"10.1038\/sj.onc.1209615","article-title":"RB and cell cycle progression","volume":"25","author":"Giacinti","year":"2006","journal-title":"Oncogene"},{"key":"2021121514031873700_cit71","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/nrm1987","article-title":"Regulation of the INK4b\u2013ARF\u2013INK4a tumour suppressor locus: all for one or one for all","volume":"7","author":"Gil","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2021121514031873700_cit72","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.3390\/molecules22122269","article-title":"Vanadium Compounds as PTP Inhibitors","volume":"22","author":"Irving","year":"2017","journal-title":"Molecules"},{"key":"2021121514031873700_cit73","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jinorgbio.2015.04.005","article-title":"Evaluating transition state structures of vanadium\u2013phosphatase protein complexes using shape analysis","volume":"147","author":"S\u00e1nchez-Lombardo","year":"2015","journal-title":"J. Inorg. Biochem."},{"key":"2021121514031873700_cit74","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/366701a0","article-title":"p21 is a universal inhibitor of cyclin kinases","volume":"366","author":"Xiong","year":"1993","journal-title":"Nature"},{"key":"2021121514031873700_cit75","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.cell.2017.08.028","article-title":"Putting p53 in Context","volume":"170","author":"Kastenhuber","year":"2017","journal-title":"Cell"},{"key":"2021121514031873700_cit76","doi-asserted-by":"crossref","first-page":"3595","DOI":"10.1021\/bi700026j","article-title":"Cdc25 Phosphatases:\u2009 Structure, Specificity, and Mechanism","volume":"46","author":"Rudolph","year":"2007","journal-title":"Biochemistry"},{"key":"2021121514031873700_cit77","doi-asserted-by":"crossref","first-page":"7421","DOI":"10.1016\/S0021-9258(17)40978-1","article-title":"Vanadate is a potent (Na,K)-ATPase inhibitor found in ATP derived from muscle","volume":"252","author":"Cantley","year":"1977","journal-title":"J. Biol. Chem."},{"key":"2021121514031873700_cit78","doi-asserted-by":"crossref","first-page":"995","DOI":"10.2174\/138955705774575264","article-title":"Are Vanadium Compounds Drugable? Structures and Effects of Antidiabetic Vanadium Compounds: A Critical Review","volume":"5","author":"Scior","year":"2005","journal-title":"Mini-Rev. Med. Chem."},{"key":"2021121514031873700_cit79","doi-asserted-by":"crossref","first-page":"2874","DOI":"10.2174\/0929867323666160321121138","article-title":"Why Antidiabetic Vanadium Complexes are Not in the Pipeline of \u201cBig Pharma\u201d Drug Research? A Critical Review","volume":"23","author":"Scior","year":"2016","journal-title":"Curr. Med. Chem."},{"key":"2021121514031873700_cit80","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1476-4598-12-37","article-title":"Molecular changes induced by the curcumin analogue D6 in human melanoma cells","volume":"12","author":"Rozzo","year":"2013","journal-title":"Mol. Cancer"}],"container-title":["Metallomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/metallomics\/article-pdf\/11\/10\/1687\/41768055\/c9mt00174c.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/metallomics\/article-pdf\/11\/10\/1687\/41768055\/c9mt00174c.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T01:31:10Z","timestamp":1664155870000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/metallomics\/article\/11\/10\/1687\/5959834"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,21]]},"references-count":80,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10,16]]}},"URL":"https:\/\/doi.org\/10.1039\/c9mt00174c","relation":{},"ISSN":["1756-5901","1756-591X"],"issn-type":[{"value":"1756-5901","type":"print"},{"value":"1756-591X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,10]]},"published":{"date-parts":[[2019,8,21]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Daniele Sanna (ORCID)","URL":"http:\/\/orcid.org\/0000-0001-9299-0141","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Daniele Sanna (ResearcherID)","URL":"http:\/\/www.researcherid.com\/rid\/G-9021-2011","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Eugenio Garribba (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-7229-5966","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Giuseppe Palmieri (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-4350-2276","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Giuseppe Palmieri (ResearcherID)","URL":"http:\/\/www.researcherid.com\/rid\/K-6095-2016","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Carla Rozzo (ORCID)","URL":"http:\/\/orcid.org\/0000-0001-6581-2227","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 5 July 2019; Accepted 21 August 2019; Accepted Manuscript published 21 August 2019; Advance Article published 6 September 2019; Version of Record published 16 October 2019","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}