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During infection, various shifts in Cu homeostasis can ensue. In mice infected with Candida albicans, serum Cu progressively rises and at late stages of infection, liver Cu rises, while kidney Cu declines. The basis for these changes in Cu homeostasis was poorly understood. We report here that the progressive rise in serum Cu is attributable to liver production of the multicopper oxidase ceruloplasmin (Cp). Through studies using Cp\u2212\/\u2212 mice, we find this elevated Cp helps recover serum Fe levels at late stages of infection, consistent with a role for Cp in loading transferrin with Fe. Cp also accounts for the elevation in liver Cu seen during infection, but not for the fluctuations in kidney Cu. The Cu exporting ATPase ATP7B is one candidate for kidney Cu control, but we find no change in the pattern of kidney Cu loss during infection of Atp7b\u2212\/\u2212 mice, implying alternative mechanisms. To test whether fungal infiltration of kidney tissue was required for kidney Cu loss, we explored other paradigms of infection. Infection with the intravascular malaria parasite Plasmodium berghei caused a rise in serum Cu and decrease in kidney Cu similar to that seen with C. albicans. Thus, dynamics in kidney Cu homeostasis appear to be a common feature among vastly different infection paradigms. The implications for such Cu homeostasis control in immunity are discussed.<\/jats:p>","DOI":"10.1039\/c9mt00294d","type":"journal-article","created":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T13:03:33Z","timestamp":1579266213000},"page":"416-426","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Changes in mammalian copper homeostasis during microbial infection"],"prefix":"10.1093","volume":"12","author":[{"given":"Edward M","family":"Culbertson","sequence":"first","affiliation":[{"name":"The Department of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aslam A","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Missouri, Columbia, MO 65211, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigael","family":"Muchenditsi","sequence":"additional","affiliation":[{"name":"Department of Physiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Lutsenko","sequence":"additional","affiliation":[{"name":"Department of Physiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J","family":"Sullivan","sequence":"additional","affiliation":[{"name":"The W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J","family":"Petris","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Missouri, Columbia, MO 65211, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan P","family":"Cormack","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3213-1326","authenticated-orcid":false,"given":"Valeria C","family":"Culotta","sequence":"additional","affiliation":[{"name":"The Department of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,1,24]]},"reference":[{"key":"2021121004363538000_cit1","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1074\/jbc.R800055200","article-title":"New roles for copper metabolism in cell proliferation, signaling, and disease","volume":"284","author":"Turski","year":"2009","journal-title":"J. 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Microbiol."},{"key":"2021121004363538000_cit23","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.ijmm.2005.05.005","article-title":"Mutations in the cueA gene encoding a copper homeostasis P-type ATPase reduce the pathogenicity of Pseudomonas aeruginosa in mice","volume":"295","author":"Schwan","year":"2005","journal-title":"Int. J. Med. Microbiol."},{"key":"2021121004363538000_cit24","doi-asserted-by":"crossref","first-page":"18945","DOI":"10.1074\/jbc.R115.649129","article-title":"Copper at the fungal pathogen-host axis","volume":"290","author":"Garcia-Santamarina","year":"2015","journal-title":"J. Biol. 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Dis."},{"key":"2021121004363538000_cit33","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1439-0507.2005.01121.x","article-title":"Temporal events in the intravenous challenge model for experimental Candida albicans infections in female mice","volume":"48","author":"MacCallum","year":"2005","journal-title":"Mycoses"},{"issue":"38","key":"2021121004363538000_cit34","doi-asserted-by":"crossref","first-page":"E5336","DOI":"10.1073\/pnas.1513447112","article-title":"Candida albicans adapts to host copper during infection by swapping metal cofactors for superoxide dismutase","volume":"112","author":"Li","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. 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