{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:06:18Z","timestamp":1787317578256,"version":"build-2736575974"},"reference-count":67,"publisher":"Royal Society of Chemistry (RSC)","issue":"1","license":[{"start":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T00:00:00Z","timestamp":1574640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Nanoscale Adv."],"abstract":"<p>Magnetic particle hyperthermia is a promising cancer therapy, but a typical constraint of its applicability is localizing heat solely to malignant regions sparing healthy surrounding tissues.<\/p>","DOI":"10.1039\/c9na00667b","type":"journal-article","created":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T03:43:46Z","timestamp":1574653426000},"page":"408-416","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Spatial focusing of magnetic particle hyperthermia"],"prefix":"10.1039","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0193-3470","authenticated-orcid":false,"given":"Eirini","family":"Myrovali","sequence":"first","affiliation":[{"name":"School of Physics"},{"name":"Aristotle University of Thessaloniki"},{"name":"Thessaloniki"},{"name":"Greece"},{"name":"Magnetic Nanostructure Characterization: Technology and Applications"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1825-9961","authenticated-orcid":false,"given":"Nikos","family":"Maniotis","sequence":"additional","affiliation":[{"name":"School of Physics"},{"name":"Aristotle University of Thessaloniki"},{"name":"Thessaloniki"},{"name":"Greece"},{"name":"Magnetic Nanostructure Characterization: Technology and Applications"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0170-4520","authenticated-orcid":false,"given":"Theodoros","family":"Samaras","sequence":"additional","affiliation":[{"name":"School of Physics"},{"name":"Aristotle University of Thessaloniki"},{"name":"Thessaloniki"},{"name":"Greece"},{"name":"Magnetic Nanostructure Characterization: Technology and Applications"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9109-0221","authenticated-orcid":false,"given":"Makis","family":"Angelakeris","sequence":"additional","affiliation":[{"name":"School of Physics"},{"name":"Aristotle University of Thessaloniki"},{"name":"Thessaloniki"},{"name":"Greece"},{"name":"Magnetic Nanostructure Characterization: Technology and Applications"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2020]]},"reference":[{"key":"C9NA00667B-(cit1)\/*[position()=1]","volume-title":"Magnetic Nanomaterials","author":"Konecny","year":"2017","unstructured":"A. Konecny  ,  J.Covarrubias  and  H.Wang ,  Magnetic Nanomaterials ,  2017 , pp.  25\u201358"},{"key":"C9NA00667B-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.7150\/thno.30238","volume":"9","author":"Curcio","year":"2019","journal-title":"Theranostics"},{"key":"C9NA00667B-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"20519","DOI":"10.1039\/C8NR05946B","volume":"10","author":"Moise","year":"2018","journal-title":"Nanoscale"},{"key":"C9NA00667B-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"041302","DOI":"10.1063\/1.4935688","volume":"2","author":"P\u00e9rigo","year":"2015","journal-title":"Appl. Phys. Rev."},{"key":"C9NA00667B-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.jmmm.2018.11.062","volume":"474","author":"Kaczmarek","year":"2019","journal-title":"J. Magn. Magn. Mater."},{"key":"C9NA00667B-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"587","DOI":"10.3109\/02656739709023559","volume":"13","author":"Jordan","year":"1997","journal-title":"Int. J. Hyperthermia"},{"key":"C9NA00667B-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"07B3061","DOI":"10.1063\/1.3671427","volume":"111","author":"Khandhar","year":"2012","journal-title":"J. Appl. Phys."},{"key":"C9NA00667B-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1016\/j.bbagen.2017.02.022","volume":"1861","author":"Angelakeris","year":"2017","journal-title":"Biochim. Biophys. Acta, Gen. Subj."},{"key":"C9NA00667B-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"19421","DOI":"10.1039\/C6NR07542H","volume":"8","author":"Wu","year":"2016","journal-title":"Nanoscale"},{"key":"C9NA00667B-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6383","DOI":"10.1021\/acsnano.8b06542","volume":"13","author":"Albarqi","year":"2019","journal-title":"ACS Nano"},{"key":"C9NA00667B-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s11060-006-9195-0","volume":"81","author":"Maier-Hauff","year":"2007","journal-title":"J. Neurooncol."},{"key":"C9NA00667B-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s11060-010-0389-0","volume":"103","author":"Maier-Hauff","year":"2011","journal-title":"J. Neurooncol."},{"key":"C9NA00667B-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1080\/02656730802104757","volume":"24","author":"Thiesen","year":"2008","journal-title":"Int. J. Hyperthermia"},{"key":"C9NA00667B-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s11060-018-03005-x","volume":"141","author":"Grauer","year":"2019","journal-title":"J. Neuro-Oncol."},{"key":"C9NA00667B-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1080\/02656730500158360","volume":"21","author":"Johannsen","year":"2005","journal-title":"Int. J. Hyperthermia"},{"key":"C9NA00667B-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1016\/j.eururo.2006.11.023","volume":"52","author":"Johannsen","year":"2007","journal-title":"Eur. Urol."},{"key":"C9NA00667B-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4040","DOI":"10.1039\/c3nr00544e","volume":"10","author":"Pablico-Lansigan","year":"2013","journal-title":"Nanoscale"},{"key":"C9NA00667B-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"206","DOI":"10.3174\/ajnr.A5896","volume":"40","author":"Wu","year":"2019","journal-title":"Am. J. Neuroradiol."},{"key":"C9NA00667B-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3883","DOI":"10.1039\/C8DT04685A","volume":"48","author":"S\u00e1nchez-Cabezas","year":"2019","journal-title":"Dalton Trans."},{"key":"C9NA00667B-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jmmm.2018.09.012","volume":"471","author":"W\u00f6ckel","year":"2019","journal-title":"J. Magn. Magn. Mater."},{"key":"C9NA00667B-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"L1","DOI":"10.1088\/0031-9155\/54\/5\/L01","volume":"54","author":"Weizenecker","year":"2009","journal-title":"Phys. Med. Biol."},{"key":"C9NA00667B-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"052403","DOI":"10.1063\/1.3681361","volume":"100","author":"Mehdaoui","year":"2012","journal-title":"Appl. Phys. Lett."},{"key":"C9NA00667B-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"12162","DOI":"10.1039\/C6NR01877G","volume":"8","author":"Bauer","year":"2016","journal-title":"Nanoscale"},{"key":"C9NA00667B-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/nmat3877","volume":"13","author":"Chun","year":"2014","journal-title":"Nat. Mater."},{"key":"C9NA00667B-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3483","DOI":"10.1088\/1361-6560\/aa5601","volume":"62","author":"Hensley","year":"2017","journal-title":"Phys. Med. Biol."},{"key":"C9NA00667B-(cit26)\/*[position()=1]","first-page":"1006603","volume":"10066","author":"Hensley","year":"2017","journal-title":"Int. Soc. Opt. Photon."},{"key":"C9NA00667B-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.ejmp.2012.08.005","volume":"29","author":"Murase","year":"2013","journal-title":"Phys. Med."},{"issue":"12","key":"C9NA00667B-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"839","DOI":"10.4236\/ojapps.2016.612073","volume":"6","author":"Murase","year":"2016","journal-title":"Open J. Appl. Sci."},{"key":"C9NA00667B-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.jmmm.2016.06.038","volume":"419","author":"Dhavalikar","year":"2016","journal-title":"J. Magn. Magn. Mater."},{"key":"C9NA00667B-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"052403","DOI":"10.1063\/1.3681361","volume":"100","author":"Mehdaoui","year":"2012","journal-title":"Appl. Phys. Lett."},{"key":"C9NA00667B-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1021\/ja067457e","volume":"129","author":"Fortin","year":"2007","journal-title":"J. Am. Chem. Soc."},{"key":"C9NA00667B-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"25602","DOI":"10.1021\/jp310771p","volume":"116","author":"De la Presa","year":"2012","journal-title":"J. Phys. Chem. C"},{"key":"C9NA00667B-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8235","DOI":"10.1039\/c2jm30472d","volume":"22","author":"Liu","year":"2012","journal-title":"J. Mater. Chem."},{"key":"C9NA00667B-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1023\/B:NANO.0000006155.67098.44","volume":"5","author":"Jordan","year":"2003","journal-title":"J. Nanopart. Res."},{"key":"C9NA00667B-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1021\/acs.jpcc.7b10528","volume":"122","author":"Nemati","year":"2018","journal-title":"J. Phys. Chem. C"},{"key":"C9NA00667B-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"76764","DOI":"10.1039\/C5RA12558H","volume":"5","author":"Lv","year":"2015","journal-title":"RSC Adv."},{"key":"C9NA00667B-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11553","DOI":"10.1039\/C4NR03482A","volume":"6","author":"Hervault","year":"2014","journal-title":"Nanoscale"},{"key":"C9NA00667B-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"083921","DOI":"10.1063\/1.3551582","volume":"109","author":"Carreya","year":"2011","journal-title":"J. Appl. Phys."},{"key":"C9NA00667B-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8209","DOI":"10.1039\/C5NR01538C","volume":"7","author":"Shi","year":"2015","journal-title":"Nanoscale"},{"key":"C9NA00667B-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"37934","DOI":"10.1038\/srep37934","volume":"6","author":"Myrovali","year":"2016","journal-title":"Sci. Rep."},{"key":"C9NA00667B-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"255001","DOI":"10.1088\/1361-6463\/ab140c","volume":"52","author":"Makridis","year":"2019","journal-title":"J. Phys. D: Appl. Phys."},{"key":"C9NA00667B-(cit42)\/*[position()=1]","unstructured":"https:\/\/www.supermagnete.gr"},{"key":"C9NA00667B-(cit43)\/*[position()=1]","volume-title":"AC\/DC Model","author":"Comsol Multiphysics Tutorial","unstructured":"Comsol Multiphysics Tutorial  ,  AC\/DC Model , version 3.5a"},{"key":"C9NA00667B-(cit44)\/*[position()=1]","volume-title":"The Principles of Electromagnetic Theory","author":"Kovetz","year":"1990","unstructured":"A. Kovetz  ,  The Principles of Electromagnetic Theory ,  Cambridge University Press ,  1990"},{"key":"C9NA00667B-(cit45)\/*[position()=1]","volume-title":"The Finite Element Method in Electromagnetics","author":"Jin","year":"2002","unstructured":"J. Jin  ,  The Finite Element Method in Electromagnetics , 2nd edn,  Wiley-IEEE Press , May  2002"},{"key":"C9NA00667B-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/S0304-8853(02)00334-7","volume":"248","author":"Brown","year":"2002","journal-title":"J. Magn. Magn. Mater."},{"key":"C9NA00667B-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"112001","DOI":"10.1088\/1361-6528\/aafbff","volume":"30","author":"Gutierrez","year":"2019","journal-title":"Nanotechnology"},{"key":"C9NA00667B-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3390\/nano6110221","volume":"6","author":"Phan","year":"2016","journal-title":"Nanomaterials"},{"key":"C9NA00667B-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1109\/TMAG.2011.2173474","volume":"48","author":"Bakoglidis","year":"2012","journal-title":"IEEE Trans. Magn."},{"key":"C9NA00667B-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"224002","DOI":"10.1088\/0022-3727\/42\/22\/224002","volume":"42","author":"Roca","year":"2009","journal-title":"J. Phys. D. Appl. Phys."},{"key":"C9NA00667B-(cit51)\/*[position()=1]","doi-asserted-by":"crossref","DOI":"10.1002\/0471220620","volume-title":"Nanoscale Material in Chemistry","author":"Klabunde","year":"2001","unstructured":"K. J. Klabunde  ,  Nanoscale Material in Chemistry ,  Wiley-Interscience ,  New York ,  2001"},{"key":"C9NA00667B-(cit52)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/S0304-8853(02)00706-0","volume":"252","author":"Rosensweig","year":"2002","journal-title":"J. Magn. Magn. Mater."},{"key":"C9NA00667B-(cit53)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6808","DOI":"10.1021\/acsnano.7b01762","volume":"11","author":"Tong","year":"2017","journal-title":"ACS Nano"},{"key":"C9NA00667B-(cit54)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3764","DOI":"10.1007\/s11664-017-5347-6","volume":"46","author":"Nemati","year":"2017","journal-title":"J. Electron. Mater."},{"key":"C9NA00667B-(cit55)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"083921","DOI":"10.1063\/1.3551582","volume":"109","author":"Carrey","year":"2011","journal-title":"J. Appl. Phys."},{"key":"C9NA00667B-(cit56)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"103903","DOI":"10.1063\/1.5082525","volume":"125","author":"Maniotis","year":"2019","journal-title":"J. Appl. Phys."},{"key":"C9NA00667B-(cit57)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1016\/j.bbagen.2017.02.022","volume":"1861","author":"Angelakeris","year":"2017","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"C9NA00667B-(cit58)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1109\/TMAG.2010.2046907","volume":"46","author":"Krishnan","year":"2010","journal-title":"IEEE Trans. Magn."},{"key":"C9NA00667B-(cit59)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"107298","DOI":"10.1039\/C6RA22382F","volume":"6","author":"Kwon","year":"2016","journal-title":"RSC Adv."},{"key":"C9NA00667B-(cit60)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.jmmm.2016.06.038","volume":"419","author":"Dhavalikar","year":"2016","journal-title":"J. Magn. Magn. Mater."},{"key":"C9NA00667B-(cit61)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"073914","DOI":"10.1063\/1.3359722","volume":"107","author":"D\u00e9jardin","year":"2010","journal-title":"J. Appl. Phys."},{"key":"C9NA00667B-(cit62)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"023901","DOI":"10.1063\/1.3605536","volume":"110","author":"Halim El Mrabti","year":"2011","journal-title":"J. Appl. Phys."},{"key":"C9NA00667B-(cit63)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.ejmp.2012.08.005","volume":"29","author":"Murase","year":"2013","journal-title":"Phys. Med."},{"key":"C9NA00667B-(cit64)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7771","DOI":"10.1039\/C9NR01395D","volume":"11","author":"Teeman","year":"2019","journal-title":"Nanoscale"},{"key":"C9NA00667B-(cit65)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jconrel.2010.01.036","volume":"145","author":"Sahay","year":"2010","journal-title":"J. Controlled Release"},{"key":"C9NA00667B-(cit66)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/s00249-001-0200-4","volume":"31","author":"Wilhelm","year":"2002","journal-title":"Eur. Biophys. J."},{"key":"C9NA00667B-(cit67)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1118\/1.3106343","volume":"36","author":"Tasci","year":"2009","journal-title":"Med. Phys."}],"container-title":["Nanoscale Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2020\/NA\/C9NA00667B","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T04:56:56Z","timestamp":1782881816000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/na\/article\/2\/1\/408-416\/649052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":67,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1,22]]}},"URL":"https:\/\/doi.org\/10.1039\/c9na00667b","relation":{},"ISSN":["2516-0230"],"issn-type":[{"value":"2516-0230","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Eirini Myrovali (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-0193-3470","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Nikos Maniotis (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-1825-9961","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Theodoros Samaras (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-0170-4520","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Makis Angelakeris (ORCID)","URL":"http:\/\/orcid.org\/0000-0001-9109-0221","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Makis Angelakeris (ResearcherID)","URL":"http:\/\/www.researcherid.com\/rid\/I-2419-2015","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 21 October 2019; Accepted 24 November 2019;  Accepted Manuscript published 25 November 2019;  Advance Article published 11 December 2019;  Version of Record published 22 January 2020","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}