{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:11:06Z","timestamp":1790417466390,"version":"4.1.0"},"reference-count":46,"publisher":"Royal Society of Chemistry (RSC)","issue":"19","license":[{"start":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T00:00:00Z","timestamp":1587081600000},"content-version":"am","delay-in-days":472,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["51803243"],"award-info":[{"award-number":["51803243"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["51820105004"],"award-info":[{"award-number":["51820105004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100012540","name":"Guangdong Province Introduction of Innovative R&D Team","doi-asserted-by":"crossref","award":["2013S086"],"award-info":[{"award-number":["2013S086"]}],"id":[{"id":"10.13039\/100012540","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"crossref","award":["2014A030312018"],"award-info":[{"award-number":["2014A030312018"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","award":["17lgpy06"],"award-info":[{"award-number":["17lgpy06"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Nanoscale"],"abstract":"<p>Scalable fabrication of highly uniform all-in-one theranostic nanoparticles through a coordination-driven flash nanocomplexation (cFNC) process in a kinetically controlled manner.<\/p>","DOI":"10.1039\/c9nr02185j","type":"journal-article","created":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T14:28:15Z","timestamp":1555511295000},"page":"9410-9421","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Scalable fabrication of metal\u2013phenolic nanoparticles by coordination-driven flash nanocomplexation for cancer theranostics"],"prefix":"10.1039","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8438-6961","authenticated-orcid":false,"given":"Zhijia","family":"Liu","sequence":"first","affiliation":[{"name":"School of Materials Science and Engineering"},{"name":"Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education"},{"name":"GD Research Center for Functional Biomaterials Engineering and Technology"},{"name":"Sun Yat-sen University"},{"name":"Guangzhou 510275"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhicheng","family":"Le","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering"},{"name":"Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education"},{"name":"GD Research Center for Functional Biomaterials Engineering and Technology"},{"name":"Sun Yat-sen University"},{"name":"Guangzhou 510275"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liejing","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Radiology"},{"name":"Sun Yat-sen Memorial Hospital"},{"name":"Sun Yat-sen University"},{"name":"Guangzhou 510120"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Radiology"},{"name":"The First Affiliated Hospital"},{"name":"Sun Yat-sen University"},{"name":"Guangzhou 510080"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengbiao","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering"},{"name":"Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education"},{"name":"GD Research Center for Functional Biomaterials Engineering and Technology"},{"name":"Sun Yat-sen University"},{"name":"Guangzhou 510275"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering"},{"name":"Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education"},{"name":"GD Research Center for Functional Biomaterials Engineering and Technology"},{"name":"Sun Yat-sen University"},{"name":"Guangzhou 510275"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0717-6549","authenticated-orcid":false,"given":"Zhiyong","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering"},{"name":"Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education"},{"name":"GD Research Center for Functional Biomaterials Engineering and Technology"},{"name":"Sun Yat-sen University"},{"name":"Guangzhou 510275"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7746-5285","authenticated-orcid":false,"given":"Jun","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Radiology"},{"name":"Sun Yat-sen Memorial Hospital"},{"name":"Sun Yat-sen University"},{"name":"Guangzhou 510120"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6133-4977","authenticated-orcid":false,"given":"Lixin","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering"},{"name":"Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education"},{"name":"GD Research Center for Functional Biomaterials Engineering and Technology"},{"name":"Sun Yat-sen University"},{"name":"Guangzhou 510275"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2843-5543","authenticated-orcid":false,"given":"Yongming","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering"},{"name":"Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education"},{"name":"GD Research Center for Functional Biomaterials Engineering and Technology"},{"name":"Sun Yat-sen University"},{"name":"Guangzhou 510275"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2019]]},"reference":[{"key":"C9NR02185J-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"17024","DOI":"10.1038\/natrevmats.2017.24","volume":"2","author":"Chen","year":"2017","journal-title":"Nat. Rev. Mater."},{"key":"C9NR02185J-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8003","DOI":"10.1038\/ncomms9003","volume":"6","author":"Liu","year":"2015","journal-title":"Nat. Commun."},{"key":"C9NR02185J-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2826","DOI":"10.1021\/acs.chemrev.5b00148","volume":"116","author":"Chen","year":"2016","journal-title":"Chem. Rev."},{"key":"C9NR02185J-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1021\/ar200105p","volume":"44","author":"Al-Jamal","year":"2011","journal-title":"Acc. Chem. Res."},{"key":"C9NR02185J-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"25090","DOI":"10.1021\/acsami.8b06598","volume":"10","author":"Sun","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"C9NR02185J-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"12533","DOI":"10.1039\/C7NR03611F","volume":"9","author":"Gao","year":"2017","journal-title":"Nanoscale"},{"key":"C9NR02185J-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7272","DOI":"10.1021\/acsnano.8b03476","volume":"12","author":"He","year":"2018","journal-title":"ACS Nano"},{"key":"C9NR02185J-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"15170","DOI":"10.1002\/anie.201709002","volume":"56","author":"Leroux","year":"2017","journal-title":"Angew. Chem., Int. Ed."},{"key":"C9NR02185J-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.progpolymsci.2011.01.001","volume":"36","author":"Rao","year":"2011","journal-title":"Prog. Polym. Sci."},{"key":"C9NR02185J-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.jconrel.2015.10.006","volume":"219","author":"Hickey","year":"2015","journal-title":"J. Controlled Release"},{"key":"C9NR02185J-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2906","DOI":"10.1021\/nl801736q","volume":"8","author":"Karnik","year":"2008","journal-title":"Nano Lett."},{"key":"C9NR02185J-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.addr.2017.08.003","volume":"128","author":"Liu","year":"2018","journal-title":"Adv. Drug Delivery Rev."},{"key":"C9NR02185J-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.nantod.2016.04.006","volume":"11","author":"Saad","year":"2016","journal-title":"Nano Today"},{"key":"C9NR02185J-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6056","DOI":"10.1021\/nn501371n","volume":"8","author":"Lim","year":"2014","journal-title":"ACS Nano"},{"key":"C9NR02185J-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.1039\/C7NR08047F","volume":"10","author":"He","year":"2018","journal-title":"Nanoscale"},{"key":"C9NR02185J-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1800285","DOI":"10.1002\/adhm.201800285","volume":"7","author":"Tian","year":"2018","journal-title":"Adv. Healthcare Mater."},{"key":"C9NR02185J-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1021\/acs.biomac.8b01530","volume":"20","author":"Sun","year":"2019","journal-title":"Biomacromolecules"},{"key":"C9NR02185J-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1126\/science.1147241","volume":"318","author":"Lee","year":"2007","journal-title":"Science"},{"key":"C9NR02185J-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1126\/science.1181044","volume":"328","author":"Harrington","year":"2010","journal-title":"Science"},{"key":"C9NR02185J-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"12850","DOI":"10.1073\/pnas.1007416107","volume":"107","author":"Zeng","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C9NR02185J-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1073\/pnas.1015862108","volume":"108","author":"Holten-Andersen","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C9NR02185J-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1002\/adma.201202343","volume":"25","author":"Sedo","year":"2013","journal-title":"Adv. Mater."},{"key":"C9NR02185J-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5057","DOI":"10.1021\/cr400407a","volume":"114","author":"Liu","year":"2014","journal-title":"Chem. Rev."},{"key":"C9NR02185J-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7157","DOI":"10.1016\/j.biomaterials.2014.04.106","volume":"35","author":"Qiao","year":"2014","journal-title":"Biomaterials"},{"key":"C9NR02185J-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"103292","DOI":"10.1039\/C5RA17246B","volume":"5","author":"Liu","year":"2015","journal-title":"RSC Adv."},{"key":"C9NR02185J-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1126\/science.1237265","volume":"341","author":"Ejima","year":"2013","journal-title":"Science"},{"key":"C9NR02185J-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5720","DOI":"10.1021\/acsnano.5b07276","volume":"10","author":"Shen","year":"2016","journal-title":"ACS Nano"},{"key":"C9NR02185J-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3917","DOI":"10.1021\/acsnano.8b01456","volume":"12","author":"Liu","year":"2018","journal-title":"ACS Nano"},{"key":"C9NR02185J-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"42186","DOI":"10.1021\/acsami.8b18979","volume":"10","author":"Le","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"C9NR02185J-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1021\/bc300632w","volume":"24","author":"Wei","year":"2013","journal-title":"Bioconjugate Chem."},{"key":"C9NR02185J-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jconrel.2015.01.012","volume":"205","author":"Zhong","year":"2015","journal-title":"J. Controlled Release"},{"key":"C9NR02185J-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1700821","DOI":"10.1002\/advs.201700821","volume":"5","author":"Zhang","year":"2018","journal-title":"Adv. Sci."},{"key":"C9NR02185J-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7450","DOI":"10.1021\/acs.macromol.6b01198","volume":"49","author":"Lee","year":"2016","journal-title":"Macromolecules"},{"key":"C9NR02185J-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1021\/acs.biomac.6b00537","volume":"17","author":"Ju","year":"2016","journal-title":"Biomacromolecules"},{"key":"C9NR02185J-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7318","DOI":"10.1002\/anie.201501748","volume":"54","author":"Kim","year":"2015","journal-title":"Angew. Chem., Int. Ed."},{"key":"C9NR02185J-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/nnano.2014.208","volume":"9","author":"Chung","year":"2014","journal-title":"Nat. Nanotechnol."},{"key":"C9NR02185J-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.biomaterials.2016.11.001","volume":"113","author":"He","year":"2017","journal-title":"Biomaterials"},{"key":"C9NR02185J-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1039\/C3PY01083J","volume":"5","author":"Liu","year":"2014","journal-title":"Polym. Chem."},{"key":"C9NR02185J-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.carbpol.2015.06.013","volume":"132","author":"Liu","year":"2015","journal-title":"Carbohydr. Polym."},{"key":"C9NR02185J-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ijpharm.2017.07.063","volume":"530","author":"Liu","year":"2017","journal-title":"Int. J. Pharm."},{"key":"C9NR02185J-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jconrel.2016.08.022","volume":"239","author":"Zou","year":"2016","journal-title":"J. Controlled Release"},{"key":"C9NR02185J-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11405","DOI":"10.1039\/C5CC04035C","volume":"51","author":"Hu","year":"2015","journal-title":"Chem. Commun."},{"key":"C9NR02185J-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"12495","DOI":"10.1021\/am502106e","volume":"6","author":"Sun","year":"2014","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"C9NR02185J-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7045","DOI":"10.1021\/acs.nanolett.8b03015","volume":"18","author":"Wang","year":"2018","journal-title":"Nano Lett."},{"key":"C9NR02185J-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1021\/bm200083n","volume":"12","author":"Van Vlierberghe","year":"2011","journal-title":"Biomacromolecules"},{"key":"C9NR02185J-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1021\/acs.molpharmaceut.7b00793","volume":"15","author":"Liu","year":"2018","journal-title":"Mol. Pharmaceutics"}],"container-title":["Nanoscale"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2019\/NR\/C9NR02185J","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:40:47Z","timestamp":1782927647000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/nr\/article\/11\/19\/9410-9421\/652205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":46,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2019,5,16]]}},"URL":"https:\/\/doi.org\/10.1039\/c9nr02185j","relation":{},"ISSN":["2040-3364","2040-3372"],"issn-type":[{"value":"2040-3364","type":"print"},{"value":"2040-3372","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C9NR02185J","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Zhijia Liu (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-8438-6961","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Zhiyong Wang (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-0717-6549","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Jun Shen (ORCID)","URL":"http:\/\/orcid.org\/0000-0001-7746-5285","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Lixin Liu (ORCID)","URL":"http:\/\/orcid.org\/0000-0001-6133-4977","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Yongming Chen (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-2843-5543","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Yongming Chen (ResearcherID)","URL":"http:\/\/www.researcherid.com\/rid\/E-3656-2015","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 13 March 2019; Accepted 12 April 2019;  Accepted Manuscript published 17 April 2019;  Advance Article published 30 April 2019;  Version of Record published 16 May 2019","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}