{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T06:06:58Z","timestamp":1782886018574,"version":"3.54.5"},"reference-count":40,"publisher":"Royal Society of Chemistry (RSC)","issue":"5","license":[{"start":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T00:00:00Z","timestamp":1610064000000},"content-version":"am","delay-in-days":373,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["CA149387"],"award-info":[{"award-number":["CA149387"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["CA198999"],"award-info":[{"award-number":["CA198999"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["CA151652"],"award-info":[{"award-number":["CA151652"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Nanoscale"],"abstract":"<p>Combining vaccination immunotherapy with multi-targeting Sunitinib (SUN) nano-therapy to remodel fibrotic tumor microenvironment of desmoplastic melanoma and generate synergistic anti-cancer effect.<\/p>","DOI":"10.1039\/c9nr09610h","type":"journal-article","created":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T23:43:34Z","timestamp":1578440614000},"page":"3400-3410","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Remodeling the fibrotic tumor microenvironment of desmoplastic melanoma to facilitate vaccine immunotherapy"],"prefix":"10.1039","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3871-8857","authenticated-orcid":false,"given":"Hongda","family":"Zhu","sequence":"first","affiliation":[{"name":"Division of Pharmacoengineering and Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery"},{"name":"University of North Carolina at Chapel Hill"},{"name":"Chapel Hill"},{"name":"USA"},{"name":"School of Food and Biological Engineering"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Pharmacoengineering and Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery"},{"name":"University of North Carolina at Chapel Hill"},{"name":"Chapel Hill"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Miao","sequence":"additional","affiliation":[{"name":"Division of Pharmacoengineering and Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery"},{"name":"University of North Carolina at Chapel Hill"},{"name":"Chapel Hill"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Musetti","sequence":"additional","affiliation":[{"name":"Division of Pharmacoengineering and Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery"},{"name":"University of North Carolina at Chapel Hill"},{"name":"Chapel Hill"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meirong","family":"Huo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines"},{"name":"Department of Pharmaceutics"},{"name":"China Pharmaceutical University"},{"name":"Nanjing 210009"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9421-8283","authenticated-orcid":false,"given":"Leaf","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Pharmacoengineering and Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery"},{"name":"University of North Carolina at Chapel Hill"},{"name":"Chapel Hill"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2020]]},"reference":[{"key":"C9NR09610H-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1002\/jso.25317","volume":"119","author":"Nicolson","year":"2019","journal-title":"J. Surg. Oncol."},{"key":"C9NR09610H-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.addr.2017.09.016","volume":"127","author":"Liu","year":"2018","journal-title":"Adv. Drug Delivery Rev."},{"key":"C9NR09610H-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jaad.2018.08.055","volume":"80","author":"Swetter","year":"2019","journal-title":"J. Am. Acad. Dermatol."},{"key":"C9NR09610H-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1001\/jamadermatol.2013.2248","volume":"149","author":"Jaimes","year":"2013","journal-title":"JAMA Dermatol."},{"key":"C9NR09610H-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7812","DOI":"10.1021\/acsnano.8b01890","volume":"12","author":"Liu","year":"2018","journal-title":"ACS Nano"},{"key":"C9NR09610H-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"32258","DOI":"10.18632\/oncotarget.15632","volume":"8","author":"Liu","year":"2017","journal-title":"Oncotarget"},{"key":"C9NR09610H-(cit7)\/*[position()=1]","first-page":"182","volume":"1845","author":"Burkholder","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"C9NR09610H-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.7150\/thno.24821","volume":"8","author":"Hou","year":"2018","journal-title":"Theranostics"},{"key":"C9NR09610H-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/nature25187","volume":"553","author":"Eroglu","year":"2018","journal-title":"Nature"},{"key":"C9NR09610H-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1080\/14737140.2019.1574573","volume":"19","author":"Ochoa","year":"2019","journal-title":"Expert Rev. Anticancer Ther."},{"key":"C9NR09610H-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s00262-017-2079-7","volume":"67","author":"Liu","year":"2018","journal-title":"Cancer Immunol. Immunother."},{"key":"C9NR09610H-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1021\/acsnano.7b07384","volume":"12","author":"Liu","year":"2018","journal-title":"ACS Nano"},{"key":"C9NR09610H-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e989764","DOI":"10.4161\/2162402X.2014.989764","volume":"4","author":"Draghiciu","year":"2015","journal-title":"OncoImmunology"},{"key":"C9NR09610H-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e1372079","DOI":"10.1080\/2162402X.2017.1372079","volume":"7","author":"Liu","year":"2017","journal-title":"OncoImmunology"},{"key":"C9NR09610H-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jconrel.2016.11.013","volume":"245","author":"Huo","year":"2017","journal-title":"J. Controlled Release"},{"key":"C9NR09610H-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/nm.4123","volume":"22","author":"Jiang","year":"2016","journal-title":"Nat. Med."},{"key":"C9NR09610H-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4996","DOI":"10.1021\/nn5010815","volume":"8","author":"Guo","year":"2014","journal-title":"ACS Nano"},{"key":"C9NR09610H-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1159\/000342506","volume":"225","author":"Coupelon","year":"2012","journal-title":"Dermatology"},{"key":"C9NR09610H-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.jconrel.2009.11.008","volume":"142","author":"Li","year":"2010","journal-title":"J. Controlled Release"},{"key":"C9NR09610H-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ymthe.2017.10.020","volume":"26","author":"Liu","year":"2018","journal-title":"Mol. Ther."},{"key":"C9NR09610H-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11822","DOI":"10.1038\/ncomms11822","volume":"7","author":"Zhao","year":"2016","journal-title":"Nat. Commun."},{"key":"C9NR09610H-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.addr.2014.10.001","volume":"91","author":"Eetezadi","year":"2015","journal-title":"Adv. Drug Delivery Rev."},{"key":"C9NR09610H-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.biomaterials.2016.06.030","volume":"102","author":"Luo","year":"2016","journal-title":"Biomaterials"},{"key":"C9NR09610H-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1158\/0008-5472.CAN-16-0866","volume":"77","author":"Miao","year":"2017","journal-title":"Cancer Res."},{"key":"C9NR09610H-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/path.5213","volume":"247","author":"Rabbie","year":"2019","journal-title":"J. Pathol."},{"key":"C9NR09610H-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.tcb.2014.11.006","volume":"25","author":"Klemm","year":"2015","journal-title":"Trends Cell Biol."},{"key":"C9NR09610H-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jconrel.2016.11.015","volume":"244","author":"Danhier","year":"2016","journal-title":"J. Controlled Release"},{"key":"C9NR09610H-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"717","DOI":"10.7150\/jca.10865","volume":"6","author":"Zhou","year":"2015","journal-title":"J. Cancer"},{"key":"C9NR09610H-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.canlet.2019.01.032","volume":"448","author":"Liu","year":"2019","journal-title":"Cancer Lett."},{"key":"C9NR09610H-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.molimm.2011.09.006","volume":"49","author":"Rygiel","year":"2011","journal-title":"Mol. Immunol."},{"key":"C9NR09610H-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1126\/science.1068883","volume":"296","author":"Medzhitov","year":"2002","journal-title":"Science"},{"key":"C9NR09610H-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5162","DOI":"10.1021\/acs.molpharmaceut.8b00717","volume":"15","author":"Chen","year":"2018","journal-title":"Mol. Pharm."},{"key":"C9NR09610H-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.humimm.2014.09.021","volume":"76","author":"Zhang","year":"2015","journal-title":"Hum. Immunol."},{"key":"C9NR09610H-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/cdd.2013.67","volume":"21","author":"Bracci","year":"2014","journal-title":"Cell Death Differ."},{"key":"C9NR09610H-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1158\/1541-7786.MCR-09-0220","volume":"8","author":"Yang","year":"2010","journal-title":"Mol. Cancer Res."},{"key":"C9NR09610H-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7352","DOI":"10.1021\/acsnano.8b03831","volume":"12","author":"Esqueda","year":"2018","journal-title":"ACS Nano"},{"key":"C9NR09610H-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1158\/0008-5472.CAN-08-4323","volume":"69","author":"Xin","year":"2009","journal-title":"Cancer Res."},{"key":"C9NR09610H-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e1701","DOI":"10.1038\/cddis.2015.63","volume":"6","author":"Yang","year":"2015","journal-title":"Cell Death Dis."},{"key":"C9NR09610H-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nri1995","volume":"7","author":"Yu","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"C9NR09610H-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3835","DOI":"10.4049\/jimmunol.1401572","volume":"193","author":"Ostrand-Rosenberg","year":"2014","journal-title":"J. Immunol."}],"container-title":["Nanoscale"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2020\/NR\/C9NR09610H","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T04:47:23Z","timestamp":1782881243000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/nr\/article\/12\/5\/3400-3410\/653774"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,2,6]]}},"URL":"https:\/\/doi.org\/10.1039\/c9nr09610h","relation":{},"ISSN":["2040-3364","2040-3372"],"issn-type":[{"value":"2040-3364","type":"print"},{"value":"2040-3372","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C9NR09610H","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Hongda Zhu (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-3871-8857","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Lei Miao (ResearcherID)","URL":"http:\/\/www.researcherid.com\/rid\/L-3566-2016","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Leaf Huang (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-9421-8283","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 11 November 2019; Accepted 31 December 2019; Accepted Manuscript published 8 January 2020; Advance Article published 28 January 2020; Version of Record published 6 February 2020","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}