{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:01:55Z","timestamp":1790787715688,"version":"4.1.0"},"reference-count":65,"publisher":"Royal Society of Chemistry (RSC)","issue":"9","license":[{"start":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T00:00:00Z","timestamp":1581033600000},"content-version":"am","delay-in-days":402,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Org. Biomol. Chem."],"abstract":"<p>\n                    A convenient and operationally simple protocol for the synthesis of quinazolin-4(1\n                    <italic>H<\/italic>\n                    )-one derivatives has been developed\n                    <italic>via<\/italic>\n                    amination and annulation of amidines and benzamides.\n                  <\/p>","DOI":"10.1039\/c9ob00020h","type":"journal-article","created":{"date-parts":[[2019,2,6]],"date-time":"2019-02-06T22:04:21Z","timestamp":1549490661000},"page":"2356-2360","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Synthesis of quinazolin-4(1\n                    <i>H<\/i>\n                    )-ones\n                    <i>via<\/i>\n                    amination and annulation of amidines and benzamides"],"prefix":"10.1039","volume":"17","author":[{"given":"Fangpeng","family":"Hu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Applied Organic Chemistry"},{"name":"Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province"},{"name":"Department of Chemistry"},{"name":"Lanzhou University"},{"name":"Lanzhou 730000"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinfeng","family":"Cui","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Applied Organic Chemistry"},{"name":"Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province"},{"name":"Department of Chemistry"},{"name":"Lanzhou University"},{"name":"Lanzhou 730000"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihui","family":"Ban","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Applied Organic Chemistry"},{"name":"Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province"},{"name":"Department of Chemistry"},{"name":"Lanzhou University"},{"name":"Lanzhou 730000"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqiang","family":"Lu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Applied Organic Chemistry"},{"name":"Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province"},{"name":"Department of Chemistry"},{"name":"Lanzhou University"},{"name":"Lanzhou 730000"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Luo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Applied Organic Chemistry"},{"name":"Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province"},{"name":"Department of Chemistry"},{"name":"Lanzhou University"},{"name":"Lanzhou 730000"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3866-6241","authenticated-orcid":false,"given":"Guosheng","family":"Huang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Applied Organic Chemistry"},{"name":"Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province"},{"name":"Department of Chemistry"},{"name":"Lanzhou University"},{"name":"Lanzhou 730000"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2019]]},"reference":[{"key":"C9OB00020H-(cit1a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1021\/cr500410y","volume":"115","author":"Guo","year":"2015","journal-title":"Chem. Rev."},{"key":"C9OB00020H-(cit1b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/nrd2445","volume":"6","author":"Leeson","year":"2007","journal-title":"Nat. Rev. Drug Discovery"},{"key":"C9OB00020H-(cit1c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1039\/B612168N","volume":"25","author":"Michael","year":"2008","journal-title":"Nat. Prod. Rep."},{"key":"C9OB00020H-(cit1d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1039\/b310691h","volume":"21","author":"Michael","year":"2004","journal-title":"Nat. Prod. Rep."},{"key":"C9OB00020H-(cit1e)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9336","DOI":"10.1039\/C5OB01379H","volume":"13","author":"Kshirsagar","year":"2015","journal-title":"Org. Biomol. Chem."},{"key":"C9OB00020H-(cit1f)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1039\/b706709g","volume":"37","author":"Murahashi","year":"2008","journal-title":"Chem. Soc. Rev."},{"key":"C9OB00020H-(cit2a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9787","DOI":"10.1016\/j.tet.2006.07.098","volume":"62","author":"Mhaske","year":"2006","journal-title":"Tetrahedron"},{"key":"C9OB00020H-(cit2b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1021\/jm00106a024","volume":"34","author":"Lowe 3rd","year":"1991","journal-title":"J. Med. Chem."},{"key":"C9OB00020H-(cit2c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/j.bmcl.2008.01.075","volume":"18","author":"Ott","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"C9OB00020H-(cit2d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1016\/j.bmcl.2005.01.083","volume":"15","author":"Cao","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"C9OB00020H-(cit2e)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.1016\/j.ejmech.2010.04.020","volume":"45","author":"Aly","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"C9OB00020H-(cit3a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10153","DOI":"10.1016\/j.tet.2005.07.010","volume":"61","author":"Connolly","year":"2005","journal-title":"Tetrahedron"},{"key":"C9OB00020H-(cit3b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2842","DOI":"10.1021\/ol4011745","volume":"15","author":"Wang","year":"2013","journal-title":"Org. Lett."},{"key":"C9OB00020H-(cit3c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.3762\/bjoc.9.135","volume":"9","author":"Richers","year":"2013","journal-title":"Beilstein J. Org. Chem."},{"key":"C9OB00020H-(cit3d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2682","DOI":"10.1002\/ejoc.201400108","author":"Wang","year":"2014","journal-title":"Eur. J. Org. Chem."},{"key":"C9OB00020H-(cit3e)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8966","DOI":"10.1021\/jo4010876","volume":"78","author":"Mertens","year":"2013","journal-title":"J. Org. Chem."},{"key":"C9OB00020H-(cit3f)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"12251","DOI":"10.1021\/jacs.7b05899","volume":"139","author":"Gutierrez-Bonet","year":"2017","journal-title":"J. Am. Chem. Soc."},{"key":"C9OB00020H-(cit3g)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"59289","DOI":"10.1039\/C4RA10799C","volume":"4","author":"Guo","year":"2014","journal-title":"RSC Adv."},{"key":"C9OB00020H-(cit3h)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1039\/C6OB02699K","volume":"15","author":"Guo","year":"2017","journal-title":"Org. Biomol. Chem."},{"key":"C9OB00020H-(cit3i)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.1039\/C7OB00256D","volume":"15","author":"Guo","year":"2017","journal-title":"Org. Biomol. Chem."},{"key":"C9OB00020H-(cit4a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1039\/c000047g","volume":"12","author":"Bahrami","year":"2010","journal-title":"Green Chem."},{"key":"C9OB00020H-(cit4b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1039\/C7OB03064A","volume":"16","author":"Sharma","year":"2018","journal-title":"Org. Biomol. Chem."},{"key":"C9OB00020H-(cit4c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1021\/ol900557u","volume":"11","author":"Blacker","year":"2009","journal-title":"Org. Lett."},{"key":"C9OB00020H-(cit4d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1039\/b212394k","volume":"5","author":"Dudd","year":"2003","journal-title":"Green Chem."},{"key":"C9OB00020H-(cit4e)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9392","DOI":"10.1021\/acs.joc.5b00937","volume":"80","author":"Li","year":"2015","journal-title":"J. Org. Chem."},{"key":"C9OB00020H-(cit4f)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6486","DOI":"10.1039\/c3ra46363j","volume":"4","author":"Zhao","year":"2014","journal-title":"RSC Adv."},{"key":"C9OB00020H-(cit4g)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7730","DOI":"10.1021\/jo201054k","volume":"76","author":"Zhou","year":"2011","journal-title":"J. Org. Chem."},{"key":"C9OB00020H-(cit5a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3512","DOI":"10.1039\/C7SC00283A","volume":"8","author":"Matsui","year":"2017","journal-title":"Chem. Sci."},{"key":"C9OB00020H-(cit5b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4802","DOI":"10.1002\/anie.201402023","volume":"53","author":"Dirocco","year":"2014","journal-title":"Angew. Chem., Int. Ed."},{"key":"C9OB00020H-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3846","DOI":"10.1021\/jo2002227","volume":"76","author":"Xu","year":"2011","journal-title":"J. Org. Chem."},{"key":"C9OB00020H-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9205","DOI":"10.1039\/C5CC02785C","volume":"51","author":"Zhang","year":"2015","journal-title":"Chem. Commun."},{"key":"C9OB00020H-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6471","DOI":"10.1039\/C4CC02648A","volume":"50","author":"Zhao","year":"2014","journal-title":"Chem. Commun."},{"key":"C9OB00020H-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1021\/ol7029454","volume":"10","author":"Zheng","year":"2008","journal-title":"Org. Lett."},{"key":"C9OB00020H-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1002\/adsc.201701286","volume":"360","author":"Liu","year":"2018","journal-title":"Adv. Synth. Catal."},{"key":"C9OB00020H-(cit11a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4950","DOI":"10.1021\/ol3023165","volume":"14","author":"Fan","year":"2012","journal-title":"Org. Lett."},{"key":"C9OB00020H-(cit11b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5400","DOI":"10.1002\/anie.200300594","volume":"42","author":"Ley","year":"2003","journal-title":"Angew. Chem., Int. Ed."},{"key":"C9OB00020H-(cit11c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1021\/ar8000298","volume":"41","author":"Ma","year":"2008","journal-title":"Acc. Chem. Res."},{"key":"C9OB00020H-(cit12a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6338","DOI":"10.1002\/anie.200800497","volume":"47","author":"Surry","year":"2008","journal-title":"Angew. Chem., Int. Ed."},{"key":"C9OB00020H-(cit12b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1021\/cr900184e","volume":"110","author":"Lyons","year":"2010","journal-title":"Chem. Rev."},{"key":"C9OB00020H-(cit13a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1002\/anie.200504450","volume":"45","author":"Ackermann","year":"2006","journal-title":"Angew. Chem., Int. Ed."},{"key":"C9OB00020H-(cit13b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7500","DOI":"10.1021\/ja072219k","volume":"129","author":"Stokes","year":"2007","journal-title":"J. Am. Chem. Soc."},{"key":"C9OB00020H-(cit13c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5013","DOI":"10.1021\/ol061742l","volume":"8","author":"Reddy","year":"2006","journal-title":"Org. Lett."},{"key":"C9OB00020H-(cit13d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"16107","DOI":"10.1002\/chem.201405221","volume":"20","author":"Chen","year":"2014","journal-title":"Chem. \u2013 Eur. J."},{"key":"C9OB00020H-(cit14a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5578","DOI":"10.1039\/C4OB00796D","volume":"12","author":"Chen","year":"2014","journal-title":"Org. Biomol. Chem."},{"key":"C9OB00020H-(cit14b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6362","DOI":"10.1021\/jo2007362","volume":"76","author":"Ma","year":"2011","journal-title":"J. Org. Chem."},{"key":"C9OB00020H-(cit15a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5609","DOI":"10.1021\/ol062339h","volume":"8","author":"Chen","year":"2006","journal-title":"Org. Lett."},{"key":"C9OB00020H-(cit15b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1021\/jo102235u","volume":"76","author":"Cortes-Salva","year":"2011","journal-title":"J. Org. Chem."},{"key":"C9OB00020H-(cit15c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6333","DOI":"10.1039\/b814011a","volume":"62","author":"Huang","year":"2008","journal-title":"Chem. Commun."},{"key":"C9OB00020H-(cit15d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3054","DOI":"10.1021\/cr8002505","volume":"108","author":"Evano","year":"2008","journal-title":"Chem. Rev."},{"key":"C9OB00020H-(cit15e)\/*[position()=1]","first-page":"4087","author":"Kulkarni","year":"2009","journal-title":"Synthesis"},{"key":"C9OB00020H-(cit15f)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1246\/cl.150354","volume":"44","author":"Hirano","year":"2015","journal-title":"Chem. Lett."},{"key":"C9OB00020H-(cit15g)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1002\/adsc.201600031","volume":"358","author":"Liu","year":"2016","journal-title":"Adv. Synth. Catal."},{"key":"C9OB00020H-(cit16a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1002\/anie.200705420","volume":"47","author":"Brasche","year":"2008","journal-title":"Angew. Chem., Int. Ed."},{"key":"C9OB00020H-(cit16b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"14560","DOI":"10.1021\/ja055353i","volume":"127","author":"Tsang","year":"2005","journal-title":"J. Am. Chem. Soc."},{"key":"C9OB00020H-(cit16c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3354","DOI":"10.1021\/ja412880r","volume":"136","author":"Shang","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"C9OB00020H-(cit16d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11590","DOI":"10.1021\/ja507704b","volume":"136","author":"Shang","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"C9OB00020H-(cit17a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4066","DOI":"10.1021\/acs.orglett.5b01986","volume":"17","author":"Takamatsu","year":"2015","journal-title":"Org. Lett."},{"key":"C9OB00020H-(cit17b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1246\/cl.150041","volume":"44","author":"Uemura","year":"2015","journal-title":"Chem. Lett."},{"key":"C9OB00020H-(cit17c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4308","DOI":"10.1002\/anie.201512018","volume":"55","author":"Gandeepan","year":"2016","journal-title":"Angew. Chem., Int. Ed."},{"key":"C9OB00020H-(cit17d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9112","DOI":"10.1021\/acs.joc.7b01667","volume":"82","author":"Yamamoto","year":"2017","journal-title":"J. Org. Chem."},{"key":"C9OB00020H-(cit17e)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11797","DOI":"10.1002\/anie.201807664","volume":"57","author":"Xu","year":"2018","journal-title":"Angew. Chem., Int. Ed."},{"key":"C9OB00020H-(cit18a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6418","DOI":"10.1039\/C5CC00202H","volume":"51","author":"Liu","year":"2015","journal-title":"Chem. Commun."},{"key":"C9OB00020H-(cit18b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2884","DOI":"10.1021\/ol501023n","volume":"16","author":"Dong","year":"2014","journal-title":"Org. Lett."},{"key":"C9OB00020H-(cit18c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5666","DOI":"10.1021\/ol5027377","volume":"16","author":"Shang","year":"2014","journal-title":"Org. Lett."},{"key":"C9OB00020H-(cit18d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5160","DOI":"10.1039\/C8SC01256C","volume":"9","author":"Xu","year":"2018","journal-title":"Chem. Sci."}],"container-title":["Organic &amp; Biomolecular Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2019\/OB\/C9OB00020H","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T03:39:05Z","timestamp":1782877145000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ob\/article\/17\/9\/2356-2360\/654374"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":65,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,2,27]]}},"URL":"https:\/\/doi.org\/10.1039\/c9ob00020h","relation":{},"ISSN":["1477-0520","1477-0539"],"issn-type":[{"value":"1477-0520","type":"print"},{"value":"1477-0539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C9OB00020H","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Crystal Structure Data","URL":"http:\/\/xlink.rsc.org?ccdc=true&msid=C9OB00020H","name":"related_data"},{"value":"Guosheng Huang (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-3866-6241","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 4 January 2019; Accepted 6 February 2019;  Accepted Manuscript published 7 February 2019;  Advance Article published 13 February 2019;  Version of Record published 27 February 2019","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}