{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T19:01:19Z","timestamp":1783537279185,"version":"3.55.0"},"reference-count":27,"publisher":"Royal Society of Chemistry (RSC)","issue":"27","license":[{"start":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T00:00:00Z","timestamp":1557878400000},"content-version":"vor","delay-in-days":134,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<p>Drug-induced liver injury is one of the main causes of drug non-approval and drug withdrawal by the Food and Drug Administration (FDA).<\/p>","DOI":"10.1039\/c9ra00483a","type":"journal-article","created":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T06:04:39Z","timestamp":1557900279000},"page":"15224-15228","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Design and synthesis of acetaminophen probe APAP-P1 for identification of the toxicity targets thioredoxin reductase-1 in HepaRG cells"],"prefix":"10.1039","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6912-1949","authenticated-orcid":false,"given":"Shan","family":"Wang","sequence":"first","affiliation":[{"name":"Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine"},{"name":"Institute of Medicinal Plant Development"},{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College"},{"name":"Beijing 100193"},{"name":"P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Tian","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine"},{"name":"Institute of Medicinal Plant Development"},{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College"},{"name":"Beijing 100193"},{"name":"P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Lu","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine"},{"name":"Institute of Medicinal Plant Development"},{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College"},{"name":"Beijing 100193"},{"name":"P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiying","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine"},{"name":"Institute of Medicinal Plant Development"},{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College"},{"name":"Beijing 100193"},{"name":"P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Shang","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine"},{"name":"Institute of Medicinal Plant Development"},{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College"},{"name":"Beijing 100193"},{"name":"P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuelian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine"},{"name":"Institute of Medicinal Plant Development"},{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College"},{"name":"Beijing 100193"},{"name":"P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine"},{"name":"Institute of Medicinal Plant Development"},{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College"},{"name":"Beijing 100193"},{"name":"P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guibo","family":"Sun","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine"},{"name":"Institute of Medicinal Plant Development"},{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College"},{"name":"Beijing 100193"},{"name":"P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Xu","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine"},{"name":"Institute of Medicinal Plant Development"},{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College"},{"name":"Beijing 100193"},{"name":"P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Sun","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine"},{"name":"Institute of Medicinal Plant Development"},{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College"},{"name":"Beijing 100193"},{"name":"P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2019]]},"reference":[{"key":"C9RA00483A-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1021\/acs.chemrestox.7b00025","volume":"30","author":"Chan","year":"2016","journal-title":"Chem. Res. Toxicol."},{"key":"C9RA00483A-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1136\/gutjnl-2016-313369","volume":"66","author":"Kullak-Ublick","year":"2017","journal-title":"Gut"},{"key":"C9RA00483A-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1053\/jhep.2001.23505","volume":"33","author":"Bissell","year":"2001","journal-title":"Hepatology"},{"key":"C9RA00483A-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.jhep.2017.07.005","volume":"67","author":"Lee","year":"2017","journal-title":"J. Hepatol."},{"key":"C9RA00483A-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.jen.2004.01.023","volume":"3","author":"Bartlett","year":"2004","journal-title":"J. Emerg. Nurs."},{"key":"C9RA00483A-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1007\/s11095-013-1007-6","volume":"30","author":"McGill","year":"2013","journal-title":"Pharm. Res."},{"key":"C9RA00483A-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1093\/toxsci\/kfh151","volume":"80","author":"Bajt","year":"2004","journal-title":"Toxicol. Sci."},{"key":"C9RA00483A-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1081\/DMR-200033494","volume":"36","author":"Hinson","year":"2004","journal-title":"Drug Metab. Rev."},{"key":"C9RA00483A-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1478-3231.2011.02501.x","volume":"32","author":"Jaeschke","year":"2012","journal-title":"Liver Int."},{"key":"C9RA00483A-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1517\/17425255.2015.1071353","volume":"11","author":"Du","year":"2015","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"C9RA00483A-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/978-3-642-00663-0_12","volume":"196","author":"Hinson","year":"2010","journal-title":"Handb. Exp. Pharmacol."},{"key":"C9RA00483A-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.freeradbiomed.2011.11.025","volume":"52","author":"Prigge","year":"2012","journal-title":"Free Radical Biol. Med."},{"key":"C9RA00483A-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.freeradbiomed.2013.05.028","volume":"63","author":"Iverson","year":"2013","journal-title":"Free Radical Biol. Med."},{"key":"C9RA00483A-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1021\/tx5000443","volume":"27","author":"Jan","year":"2014","journal-title":"Chem. Res. Toxicol."},{"key":"C9RA00483A-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1093\/emboj\/17.9.2596","volume":"17","author":"Saitoh","year":"1998","journal-title":"EMBO J."},{"key":"C9RA00483A-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"132","DOI":"10.4168\/aair.2012.4.3.132","volume":"4","author":"Kwon","year":"2012","journal-title":"Allergy, Asthma Immunol. Res."},{"key":"C9RA00483A-(cit17)\/*[position()=1]","first-page":"1","volume":"2017","author":"Fu","year":"2017","journal-title":"BioMed Res. Int."},{"key":"C9RA00483A-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.taap.2015.12.020","volume":"292","author":"Michaut","year":"2016","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"C9RA00483A-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1002\/hep.24132","volume":"53","author":"McGill","year":"2011","journal-title":"Hepatology"},{"key":"C9RA00483A-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"921","DOI":"10.3109\/00498254.2015.1026426","volume":"45","author":"Xie","year":"2015","journal-title":"Xenobiotica"},{"key":"C9RA00483A-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1039\/C6NP00001K","volume":"5","author":"Wright","year":"2016","journal-title":"Nat. Prod. Rep."},{"key":"C9RA00483A-(cit22)\/*[position()=1]","first-page":"43","author":"Krysiak","year":"2012","journal-title":"Top. Curr. Chem."},{"key":"C9RA00483A-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/9780470559277.ch090138","volume":"1","author":"Speers","year":"2009","journal-title":"Curr. Protoc. Chem. Biol."},{"key":"C9RA00483A-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"371","DOI":"10.2165\/00129785-200404060-00004","volume":"4","author":"Berger","year":"2004","journal-title":"Am. J. PharmacoGenomics"},{"key":"C9RA00483A-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1021\/tx4001013","volume":"26","author":"Patterson","year":"2013","journal-title":"Chem. Res. Toxicol."},{"key":"C9RA00483A-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1124\/dmd.110.036723","volume":"39","author":"Li","year":"2011","journal-title":"Drug Metab. Dispos."},{"key":"C9RA00483A-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"154","DOI":"10.3390\/toxins10040154","volume":"10","author":"Wang","year":"2018","journal-title":"Toxins"}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2019\/RA\/C9RA00483A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T17:41:32Z","timestamp":1783532492000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ra\/article\/9\/27\/15224-15228\/658296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":27,"journal-issue":{"issue":"27","published-print":{"date-parts":[[2019,5,15]]}},"URL":"https:\/\/doi.org\/10.1039\/c9ra00483a","relation":{},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C9RA00483A","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Shan Wang (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-6912-1949","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 20 January 2019; Accepted 21 April 2019; Version of Record published 15 May 2019","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}