{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T04:49:25Z","timestamp":1782881365498,"version":"3.54.5"},"reference-count":40,"publisher":"Royal Society of Chemistry (RSC)","issue":"17","license":[{"start":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T00:00:00Z","timestamp":1596499200000},"content-version":"vor","delay-in-days":216,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100009531","name":"Istituto Italiano di Tecnologia","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009531","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005969","name":"Universit\u00e0 di Bologna","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005969","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Analyst"],"abstract":"<p>Development of an advanced analytical method coupling capillary dried blood spots and LC-MS\/MS for the TDM of patients undergoing treatment with CNS drugs.<\/p>","DOI":"10.1039\/d0an01039a","type":"journal-article","created":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T11:30:55Z","timestamp":1596540655000},"page":"5744-5753","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Assessment of capillary volumetric blood microsampling for the analysis of central nervous system drugs and metabolites"],"prefix":"10.1039","volume":"145","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9310-4957","authenticated-orcid":false,"given":"Michele","family":"Protti","sequence":"first","affiliation":[{"name":"Research Group of Pharmaco-Toxicological Analysis (PTA Lab)"},{"name":"Department of Pharmacy and Biotechnology (FaBiT)"},{"name":"Alma Mater Studiorum \u2013 University of Bologna"},{"name":"40126 Bologna"},{"name":"Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Marasca","sequence":"additional","affiliation":[{"name":"Research Group of Pharmaco-Toxicological Analysis (PTA Lab)"},{"name":"Department of Pharmacy and Biotechnology (FaBiT)"},{"name":"Alma Mater Studiorum \u2013 University of Bologna"},{"name":"40126 Bologna"},{"name":"Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Cirrincione","sequence":"additional","affiliation":[{"name":"Research Group of Pharmaco-Toxicological Analysis (PTA Lab)"},{"name":"Department of Pharmacy and Biotechnology (FaBiT)"},{"name":"Alma Mater Studiorum \u2013 University of Bologna"},{"name":"40126 Bologna"},{"name":"Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Cavalli","sequence":"additional","affiliation":[{"name":"Italian Institute of Technology (IIT)"},{"name":"16163 Genoa"},{"name":"Italy"},{"name":"Department of Pharmacy and Biotechnology (FaBiT)"},{"name":"Alma Mater Studiorum \u2013 University of Bologna"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9631-591X","authenticated-orcid":false,"given":"Roberto","family":"Mandrioli","sequence":"additional","affiliation":[{"name":"Department for Life Quality Studies"},{"name":"Alma Mater Studiorum \u2013 University of Bologna"},{"name":"47921 Rimini"},{"name":"Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Mercolini","sequence":"additional","affiliation":[{"name":"Research Group of Pharmaco-Toxicological Analysis (PTA Lab)"},{"name":"Department of Pharmacy and Biotechnology (FaBiT)"},{"name":"Alma Mater Studiorum \u2013 University of Bologna"},{"name":"40126 Bologna"},{"name":"Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2020]]},"reference":[{"key":"D0AN01039A-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.4155\/bio.15.123","volume":"7","author":"Mercolini","year":"2015","journal-title":"Bioanalysis"},{"key":"D0AN01039A-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.trac.2017.10.002","volume":"97","author":"Nys","year":"2017","journal-title":"Trends Anal. Chem."},{"key":"D0AN01039A-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.trac.2016.01.030","volume":"84","author":"Velghe","year":"2016","journal-title":"Trends Anal. Chem."},{"key":"D0AN01039A-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1002\/dta.2195","volume":"9","author":"Ferrone","year":"2017","journal-title":"Drug Test. Anal."},{"key":"D0AN01039A-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1007\/s00216-014-7619-9","volume":"406","author":"Berm","year":"2014","journal-title":"Anal. Bioanal. Chem."},{"key":"D0AN01039A-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.4155\/bio.15.99","volume":"7","author":"Linder","year":"2015","journal-title":"Bioanalysis"},{"key":"D0AN01039A-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.4155\/bio.14.3","volume":"6","author":"Mercolini","year":"2014","journal-title":"Bioanalysis"},{"key":"D0AN01039A-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1002\/jssc.201701315","volume":"41","author":"Protti","year":"2018","journal-title":"J. Sep. Sci."},{"key":"D0AN01039A-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1097\/FTD.0000000000000458","volume":"39","author":"Iboshi","year":"2017","journal-title":"Ther. Drug Monit."},{"key":"D0AN01039A-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"121741","DOI":"10.1016\/j.jchromb.2019.121741","volume":"1126\u20131127","author":"Bhatnagar","year":"2019","journal-title":"J. Chromatogr. B: Anal. Technol. Biomed. Life Sci."},{"key":"D0AN01039A-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1007\/s00216-017-0279-9","volume":"409","author":"Osteresch","year":"2017","journal-title":"Anal. Bioanal. Chem."},{"key":"D0AN01039A-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.3390\/molecules25051046","volume":"25","author":"Mandrioli","year":"2020","journal-title":"Molecules"},{"key":"D0AN01039A-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.aca.2018.09.004","volume":"1046","author":"Protti","year":"2019","journal-title":"Anal. Chim. Acta"},{"key":"D0AN01039A-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.jpba.2017.07.029","volume":"147","author":"Kok","year":"2018","journal-title":"J. Pharm. Biomed. Anal."},{"key":"D0AN01039A-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1021\/ac503931g","volume":"87","author":"Leuthold","year":"2015","journal-title":"Anal. Chem."},{"key":"D0AN01039A-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"12893","DOI":"10.1021\/acs.analchem.8b03512","volume":"90","author":"Velghe","year":"2018","journal-title":"Anal. Chem."},{"key":"D0AN01039A-(cit17)\/*[position()=1]","unstructured":"Trajan scientific and medical.  https:\/\/www.trajanscimed.com\/pages\/hemapen"},{"key":"D0AN01039A-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"14467","DOI":"10.1021\/acs.analchem.9b03179","volume":"91","author":"Deprez","year":"2019","journal-title":"Anal. Chem."},{"key":"D0AN01039A-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.jpha.2019.06.003","volume":"9","author":"Ion","year":"2019","journal-title":"J. Pharm. Anal."},{"key":"D0AN01039A-(cit20)\/*[position()=1]","volume-title":"Clinical Challenges in Therapeutic Drug Monitoring","author":"Capiau","year":"2016","unstructured":"S. Capiau  ,  J. W.Alffenaar  and  C. P.Stove , in  Clinical Challenges in Therapeutic Drug Monitoring , ed.  W. Clarke  and  A. Dasgupta ,  Elsevier ,  Amsterdam ,  2016 , Alternative sampling strategies for therapeutic drug monitoring, pp.  279\u2013336"},{"key":"D0AN01039A-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"141","DOI":"10.2174\/1389200216666150602145005","volume":"16","author":"Mandrioli","year":"2015","journal-title":"Curr. Drug Metab."},{"key":"D0AN01039A-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"772","DOI":"10.2174\/0929867324666170712165042","volume":"25","author":"Mandrioli","year":"2018","journal-title":"Curr. Med. Chem."},{"key":"D0AN01039A-(cit23)\/*[position()=1]","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/med.21671","author":"Protti","year":"2020","journal-title":"Med. Res. Rev."},{"key":"D0AN01039A-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/jssc.200900493","volume":"33","author":"Mercolini","year":"2010","journal-title":"J. Sep. Sci."},{"key":"D0AN01039A-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10408347.2014.964835","volume":"47","author":"Saka","year":"2017","journal-title":"Crit. Rev. Anal. Chem."},{"key":"D0AN01039A-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.jpba.2004.06.008","volume":"36","author":"Sabbioni","year":"2004","journal-title":"J. Pharm. Biomed. Anal."},{"key":"D0AN01039A-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1002\/elps.200600591","volume":"28","author":"Musenga","year":"2017","journal-title":"Electrophoresis"},{"key":"D0AN01039A-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.2174\/092986712800099749","volume":"19","author":"Mandrioli","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"D0AN01039A-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1055\/s-0043-116492","volume":"51","author":"Hiemke","year":"2018","journal-title":"Pharmacopsychiatry"},{"key":"D0AN01039A-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.clinbiochem.2017.10.002","volume":"52","author":"da Silva","year":"2018","journal-title":"Clin. Biochem."},{"key":"D0AN01039A-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1007\/s00216-009-3412-6","volume":"396","author":"D\u00e9glon","year":"2010","journal-title":"Anal. Bioanal. Chem."},{"key":"D0AN01039A-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.4155\/bio.15.126","volume":"7","author":"Luo","year":"2015","journal-title":"Bioanalysis"},{"key":"D0AN01039A-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8783","DOI":"10.1021\/ac301996n","volume":"84","author":"Eibak","year":"2012","journal-title":"Anal. Chem."},{"key":"D0AN01039A-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"E3636","DOI":"10.3390\/molecules24203636","volume":"24","author":"Moretti","year":"2019","journal-title":"Molecules"},{"key":"D0AN01039A-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0731-7085(98)00170-8","volume":"18","author":"Raggi","year":"1998","journal-title":"J. Pharm. Biomed. Anal."},{"key":"D0AN01039A-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jchromb.2006.03.026","volume":"836","author":"Mandrioli","year":"2006","journal-title":"J. Chromatogr. B: Anal. Technol. Biomed. Life Sci."},{"key":"D0AN01039A-(cit37)\/*[position()=1]","volume-title":"Guideline on Bioanalytical Method Validation","author":"European Medicines Agency","year":"2012","unstructured":"European Medicines Agency  ,  Guideline on Bioanalytical Method Validation ,  2012"},{"key":"D0AN01039A-(cit38)\/*[position()=1]","volume-title":"Bioanalytical Method Validation. Guidance for Industry","author":"U.S. Food and Drug Administration","year":"2018","unstructured":"U.S. Food and Drug Administration  ,  Bioanalytical Method Validation. Guidance for Industry ,  2018"},{"key":"D0AN01039A-(cit39)\/*[position()=1]","first-page":"134","volume":"35","author":"Amitai","year":"1993","journal-title":"Vet. Hum. Toxicol."},{"key":"D0AN01039A-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0009-9120(97)00101-X","volume":"30","author":"Vatassery","year":"1997","journal-title":"Clin. Biochem."}],"container-title":["The Analyst"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2020\/AN\/D0AN01039A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T03:47:43Z","timestamp":1782877663000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/an\/article\/145\/17\/5744-5753\/672321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":40,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2020,8,24]]}},"URL":"https:\/\/doi.org\/10.1039\/d0an01039a","relation":{},"ISSN":["0003-2654","1364-5528"],"issn-type":[{"value":"0003-2654","type":"print"},{"value":"1364-5528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/D0AN01039A","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Michele Protti (ORCID)","URL":"http:\/\/orcid.org\/0000-0001-9310-4957","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Roberto Mandrioli (ORCID)","URL":"http:\/\/orcid.org\/0000-0001-9631-591X","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Roberto Mandrioli (ResearcherID)","URL":"http:\/\/www.researcherid.com\/rid\/A-4535-2011","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Laura Mercolini (ResearcherID)","URL":"http:\/\/www.researcherid.com\/rid\/K-8991-2016","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 23 May 2020; Accepted 2 July 2020;  Advance Article published 4 August 2020;  Version of Record published 24 August 2020","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}