{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T21:06:02Z","timestamp":1782853562226,"version":"3.54.5"},"reference-count":50,"publisher":"Royal Society of Chemistry (RSC)","issue":"12","license":[{"start":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T00:00:00Z","timestamp":1645142400000},"content-version":"am","delay-in-days":413,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"crossref","award":["ZR2018PC008"],"award-info":[{"award-number":["ZR2018PC008"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["31800025"],"award-info":[{"award-number":["31800025"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Anal. Methods"],"abstract":"<p>\n                    Trimethylamine\n                    <italic>N<\/italic>\n                    -oxide (TMAO), a gut microbial metabolite involved in cardiovascular and kidney diseases, has great potential as a biomarker, thus making TMAO quantification of great significance.\n                  <\/p>","DOI":"10.1039\/d0ay02353a","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T03:58:52Z","timestamp":1613620732000},"page":"1527-1534","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Fluorescent assay for quantitative analysis of trimethylamine\n                    <i>N<\/i>\n                    -oxide"],"prefix":"10.1039","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0821-7143","authenticated-orcid":false,"given":"Wen","family":"Zhang","sequence":"first","affiliation":[{"name":"Institute of Medical Sciences"},{"name":"The Second Hospital"},{"name":"Cheeloo College of Medicine"},{"name":"Shandong University"},{"name":"Jinan 250033"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Sun","sequence":"additional","affiliation":[{"name":"Institute of Medical Sciences"},{"name":"The Second Hospital"},{"name":"Cheeloo College of Medicine"},{"name":"Shandong University"},{"name":"Jinan 250033"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Medical Sciences"},{"name":"The Second Hospital"},{"name":"Cheeloo College of Medicine"},{"name":"Shandong University"},{"name":"Jinan 250033"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Medical Sciences"},{"name":"The Second Hospital"},{"name":"Cheeloo College of Medicine"},{"name":"Shandong University"},{"name":"Jinan 250033"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Han","sequence":"additional","affiliation":[{"name":"Institute of Medical Sciences"},{"name":"The Second Hospital"},{"name":"Cheeloo College of Medicine"},{"name":"Shandong University"},{"name":"Jinan 250033"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Institute of Medical Sciences"},{"name":"The Second Hospital"},{"name":"Cheeloo College of Medicine"},{"name":"Shandong University"},{"name":"Jinan 250033"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1429-9467","authenticated-orcid":false,"given":"Dongqi","family":"Tang","sequence":"additional","affiliation":[{"name":"Institute of Medical Sciences"},{"name":"The Second Hospital"},{"name":"Cheeloo College of Medicine"},{"name":"Shandong University"},{"name":"Jinan 250033"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2021]]},"reference":[{"key":"D0AY02353A-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.2337\/dc19-0048","volume":"42","author":"Winther","year":"2019","journal-title":"Diabetes Care"},{"key":"D0AY02353A-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.kint.2017.03.053","volume":"92","author":"Tomlinson","year":"2017","journal-title":"Kidney Int."},{"key":"D0AY02353A-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1016\/j.cell.2015.11.055","volume":"163","author":"Wang","year":"2015","journal-title":"Cell"},{"key":"D0AY02353A-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1001\/jama.2018.5240","volume":"319","author":"Komaroff","year":"2018","journal-title":"JAMA, J. Am. Med. Assoc."},{"key":"D0AY02353A-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1146\/annurev-nutr-071816-064732","volume":"37","author":"Zeisel","year":"2017","journal-title":"Annu. Rev. Nutr."},{"key":"D0AY02353A-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1093\/cvr\/cvz135","volume":"115","author":"Katsimichas","year":"2019","journal-title":"Cardiovasc. Res."},{"key":"D0AY02353A-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1056\/NEJMoa1109400","volume":"368","author":"Tang","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"D0AY02353A-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature09922","volume":"472","author":"Wang","year":"2011","journal-title":"Nature"},{"key":"D0AY02353A-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.cmet.2014.10.006","volume":"20","author":"Koeth","year":"2014","journal-title":"Cell Metab."},{"key":"D0AY02353A-(cit10)\/*[position()=1]","first-page":"2494","volume":"374","author":"Tilg","year":"2016","journal-title":"J. Med."},{"key":"D0AY02353A-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e002767","DOI":"10.1161\/JAHA.115.002767","volume":"5","author":"Seldin","year":"2016","journal-title":"J. Am. Heart Assoc."},{"key":"D0AY02353A-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.cell.2016.02.011","volume":"165","author":"Zhu","year":"2016","journal-title":"Cell"},{"key":"D0AY02353A-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1038\/s41591-018-0128-1","volume":"24","author":"Roberts","year":"2018","journal-title":"Nat. Med."},{"key":"D0AY02353A-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1161\/CIRCRESAHA.116.305360","volume":"116","author":"Tang","year":"2015","journal-title":"Circ. Res."},{"key":"D0AY02353A-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1161\/CIRCRESAHA.114.305680","volume":"116","author":"Fogelman","year":"2015","journal-title":"Circ. Res."},{"key":"D0AY02353A-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.cmet.2019.08.021","volume":"30","author":"Chen","year":"2019","journal-title":"Cell Metab."},{"key":"D0AY02353A-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1182\/blood.2019003990","volume":"136","author":"Wu","year":"2020","journal-title":"Blood"},{"key":"D0AY02353A-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/jcmm.13307","volume":"22","author":"Qi","year":"2018","journal-title":"J. Cell. Mol. Med."},{"key":"D0AY02353A-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2948","DOI":"10.1093\/eurheartj\/ehx342","volume":"38","author":"Schiattarella","year":"2017","journal-title":"Eur. Heart J."},{"key":"D0AY02353A-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.atherosclerosis.2018.11.010","volume":"280","author":"Zheng","year":"2019","journal-title":"Atherosclerosis"},{"key":"D0AY02353A-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.jacc.2019.11.060","volume":"75","author":"Heianza","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"D0AY02353A-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1093\/advances\/nmz064","volume":"11","author":"Ge","year":"2020","journal-title":"Adv. Nutr."},{"key":"D0AY02353A-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1161\/STROKEAHA.118.021997","volume":"49","author":"Nie","year":"2018","journal-title":"Stroke"},{"key":"D0AY02353A-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.1016\/j.jacc.2016.03.546","volume":"67","author":"Senthong","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"D0AY02353A-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.amjcard.2018.12.018","volume":"123","author":"Sheng","year":"2019","journal-title":"Am. J. Cardiol."},{"key":"D0AY02353A-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1007\/s10571-019-00714-3","volume":"39","author":"Zhai","year":"2019","journal-title":"Cell. Mol. Neurobiol."},{"key":"D0AY02353A-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e002816","DOI":"10.1161\/JAHA.115.002816","volume":"5","author":"Senthong","year":"2016","journal-title":"J. Am. Heart Assoc."},{"key":"D0AY02353A-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e004237","DOI":"10.1161\/JAHA.116.004237","volume":"5","author":"Senthong","year":"2016","journal-title":"J. Am. Heart Assoc."},{"key":"D0AY02353A-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1016\/j.jacc.2014.02.617","volume":"64","author":"Tang","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"D0AY02353A-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1373\/clinchem.2016.263640","volume":"63","author":"Tang","year":"2017","journal-title":"Clin. Chem."},{"key":"D0AY02353A-(cit31)\/*[position()=1]","first-page":"814","volume":"38","author":"Li","year":"2017","journal-title":"Eur. Heart J."},{"key":"D0AY02353A-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/nrcardio.2017.10","volume":"14","author":"Fernandez-Ruiz","year":"2017","journal-title":"Nat. Rev. Cardiol."},{"key":"D0AY02353A-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11647","DOI":"10.1038\/s41598-019-48246-6","volume":"9","author":"Matsuzawa","year":"2019","journal-title":"Sci. Rep."},{"key":"D0AY02353A-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1373\/clinchem.2016.264853","volume":"63","author":"Suzuki","year":"2017","journal-title":"Clin. Chem."},{"key":"D0AY02353A-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1080\/0886022X.2020.1781170","volume":"42","author":"Zheng","year":"2020","journal-title":"Ren. Fail."},{"key":"D0AY02353A-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1080\/0886022X.2020.1822868","volume":"42","author":"Zhang","year":"2020","journal-title":"Ren. Fail."},{"key":"D0AY02353A-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"443","DOI":"10.2217\/bmm-2016-0262","volume":"11","author":"Liu","year":"2017","journal-title":"Biomark. Med."},{"key":"D0AY02353A-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/s41366-019-0430-0","volume":"44","author":"Aragones","year":"2020","journal-title":"Int. J. Obes."},{"key":"D0AY02353A-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s13195-018-0451-2","volume":"10","author":"Vogt","year":"2018","journal-title":"Alzheimers Res. Ther."},{"key":"D0AY02353A-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1007\/s00216-018-1522-8","volume":"411","author":"Le","year":"2019","journal-title":"Anal. Bioanal. Chem."},{"key":"D0AY02353A-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.talanta.2018.07.051","volume":"189","author":"Fiori","year":"2018","journal-title":"Talanta"},{"key":"D0AY02353A-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4624","DOI":"10.7150\/thno.33459","volume":"9","author":"Yu","year":"2019","journal-title":"Theranostics"},{"key":"D0AY02353A-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.ab.2012.03.011","volume":"425","author":"Takayama","year":"2012","journal-title":"Anal. Biochem."},{"key":"D0AY02353A-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1007\/s00401-012-1060-y","volume":"124","author":"Balss","year":"2012","journal-title":"Acta Neuropathol."},{"key":"D0AY02353A-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3318","DOI":"10.1111\/1462-2920.12585","volume":"16","author":"Zhu","year":"2014","journal-title":"Environ. Microbiol."},{"key":"D0AY02353A-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3979","DOI":"10.1111\/febs.13902","volume":"283","author":"Zhu","year":"2016","journal-title":"FEBS J."},{"key":"D0AY02353A-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.ab.2009.02.009","volume":"388","author":"Zhu","year":"2009","journal-title":"Anal. Biochem."},{"key":"D0AY02353A-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.aca.2011.02.030","volume":"690","author":"Wang","year":"2011","journal-title":"Anal. Chim. Acta"},{"key":"D0AY02353A-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/BF02163668","volume":"106","author":"Szarvas","year":"1986","journal-title":"J. Radioanal. Nucl. Chem."},{"key":"D0AY02353A-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15298668591394275","volume":"46","author":"Heck","year":"1985","journal-title":"Am. Ind. Hyg. Assoc. J."}],"container-title":["Analytical Methods"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2021\/AY\/D0AY02353A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T20:11:32Z","timestamp":1782850292000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ay\/article\/13\/12\/1527-1534\/673481"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":50,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,4,1]]}},"URL":"https:\/\/doi.org\/10.1039\/d0ay02353a","relation":{},"ISSN":["1759-9660","1759-9679"],"issn-type":[{"value":"1759-9660","type":"print"},{"value":"1759-9679","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/D0AY02353A","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Wen Zhang (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-0821-7143","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Dongqi Tang (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-1429-9467","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 29 December 2020; Accepted 15 February 2021; Accepted Manuscript published 18 February 2021; Advance Article published 12 March 2021; Version of Record published 1 April 2021","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}