{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T19:23:53Z","timestamp":1783538633901,"version":"3.55.0"},"reference-count":24,"publisher":"Royal Society of Chemistry (RSC)","issue":"4","license":[{"start":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T00:00:00Z","timestamp":1639094400000},"content-version":"am","delay-in-days":343,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/100014717","name":"National Outstanding Youth Science Fund Project of National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81802222"],"award-info":[{"award-number":["81802222"]}],"id":[{"id":"10.13039\/100014717","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"crossref","award":["2018A030310694"],"award-info":[{"award-number":["2018A030310694"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100009330","name":"Medical Science and Technology Foundation of Guangdong Province","doi-asserted-by":"crossref","award":["2018114214430383"],"award-info":[{"award-number":["2018114214430383"]}],"id":[{"id":"10.13039\/501100009330","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"crossref","award":["201904010424"],"award-info":[{"award-number":["201904010424"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"crossref","award":["2018M640871"],"award-info":[{"award-number":["2018M640871"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Biomater. Sci."],"abstract":"<p>Our study demonstrated wear particles, which are generated by the abrasion of implanted prostheses, could induced STAT3 activation in osteoblasts. And further, inflammatory responses and RANKL expression would activate osteoclasts and cause osteolysis.<\/p>","DOI":"10.1039\/d0bm01256d","type":"journal-article","created":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T16:41:39Z","timestamp":1607618499000},"page":"1291-1300","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["STAT3\/IL-6 dependent induction of inflammatory response in osteoblast and osteoclast formation in nanoscale wear particle-induced aseptic prosthesis loosening"],"prefix":"10.1039","volume":"9","author":[{"given":"Zhantao","family":"Deng","sequence":"first","affiliation":[{"name":"Department of Orthopedics"},{"name":"Guangdong Provincial People's Hospital"},{"name":"Guangdong Academy of Medical Sciences"},{"name":"Guangzhou"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics"},{"name":"Guangdong Provincial People's Hospital"},{"name":"Guangdong Academy of Medical Sciences"},{"name":"Guangzhou"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedics"},{"name":"Guangdong Provincial People's Hospital"},{"name":"Guangdong Academy of Medical Sciences"},{"name":"Guangzhou"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics"},{"name":"Guangdong Provincial People's Hospital"},{"name":"Guangdong Academy of Medical Sciences"},{"name":"Guangzhou"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangtao","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics"},{"name":"Guangdong Provincial People's Hospital"},{"name":"Guangdong Academy of Medical Sciences"},{"name":"Guangzhou"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiewen","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Endocrinology"},{"name":"The First Affiliated Hospital"},{"name":"Sun Yat-Sen University"},{"name":"Guangzhou"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics"},{"name":"The First Affiliated Hospital of Soochow University"},{"name":"Soochow"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanchen","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Orthopedics"},{"name":"Guangdong Provincial People's Hospital"},{"name":"Guangdong Academy of Medical Sciences"},{"name":"Guangzhou"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3078-6601","authenticated-orcid":false,"given":"Qiujian","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Orthopedics"},{"name":"Guangdong Provincial People's Hospital"},{"name":"Guangdong Academy of Medical Sciences"},{"name":"Guangzhou"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2021]]},"reference":[{"key":"D0BM01256D-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1302\/0301-620X.99B6.38053","volume":"99-B","author":"Meermans","year":"2017","journal-title":"Bone Joint J."},{"key":"D0BM01256D-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1016\/j.arth.2019.03.061","volume":"34","author":"Hanly","year":"2019","journal-title":"J. Arthroplasty"},{"key":"D0BM01256D-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1016\/S0140-6736(17)30059-4","volume":"389","author":"Bayliss","year":"2017","journal-title":"Lancet"},{"key":"D0BM01256D-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.3389\/fimmu.2017.01026","volume":"8","author":"Dyskova","year":"2017","journal-title":"Front. Immunol."},{"key":"D0BM01256D-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s00441-015-2205-9","volume":"363","author":"Liu","year":"2016","journal-title":"Cell Tissue Res."},{"key":"D0BM01256D-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8046","DOI":"10.1016\/j.actbio.2013.05.005","volume":"9","author":"Gallo","year":"2013","journal-title":"Acta Biomater."},{"key":"D0BM01256D-(cit7)\/*[position()=1]","first-page":"e23930","volume":"2","author":"Li","year":"2013","journal-title":"JAKSTAT"},{"key":"D0BM01256D-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1136\/annrheumdis-2016-209757","volume":"76","author":"Latourte","year":"2017","journal-title":"Ann. Rheum. Dis."},{"key":"D0BM01256D-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.actbio.2016.11.020","volume":"48","author":"Wang","year":"2017","journal-title":"Acta Biomater."},{"key":"D0BM01256D-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.actbio.2016.11.051","volume":"49","author":"Deng","year":"2017","journal-title":"Acta Biomater."},{"key":"D0BM01256D-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.bone.2011.04.020","volume":"49","author":"Zhou","year":"2011","journal-title":"Bone"},{"key":"D0BM01256D-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1136\/annrheumdis-2014-207201","volume":"75","author":"Gao","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"D0BM01256D-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0140-6736(12)61424-X","volume":"381","author":"Burmester","year":"2013","journal-title":"Lancet"},{"key":"D0BM01256D-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1002\/art.41042","volume":"71","author":"Ward","year":"2019","journal-title":"Arthritis Rheumatol."},{"key":"D0BM01256D-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.actbio.2017.08.046","volume":"62","author":"Ping","year":"2017","journal-title":"Acta Biomater."},{"key":"D0BM01256D-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/jbm.a.35176","volume":"103","author":"Zhang","year":"2015","journal-title":"J. Biomed. Mater. Res., Part A"},{"key":"D0BM01256D-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"788","DOI":"10.3389\/fendo.2018.00788","volume":"9","author":"Harmer","year":"2019","journal-title":"Front. Endocrinol."},{"key":"D0BM01256D-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.4049\/jimmunol.145.10.3297","volume":"145","author":"Ishimi","year":"1990","journal-title":"J. Immunol."},{"key":"D0BM01256D-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/s41586-018-0482-7","volume":"561","author":"Ikebuchi","year":"2018","journal-title":"Nature"},{"key":"D0BM01256D-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1159\/000465455","volume":"41","author":"Wu","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"D0BM01256D-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"a028415","DOI":"10.1101\/cshperspect.a028415","volume":"10","author":"Rose-John","year":"2018","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"D0BM01256D-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"21182","DOI":"10.1002\/jcp.28721","volume":"234","author":"Zhu","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"D0BM01256D-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2013.09.034","volume":"10","author":"Lin","year":"2014","journal-title":"Acta Biomater."},{"key":"D0BM01256D-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1136\/annrheumdis-2016-210457","volume":"76","author":"Cohen","year":"2017","journal-title":"Ann. Rheum. Dis."}],"container-title":["Biomaterials Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2021\/BM\/D0BM01256D","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T17:56:29Z","timestamp":1783533389000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/bm\/article\/9\/4\/1291-1300\/673977"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,2,23]]}},"URL":"https:\/\/doi.org\/10.1039\/d0bm01256d","relation":{},"ISSN":["2047-4830","2047-4849"],"issn-type":[{"value":"2047-4830","type":"print"},{"value":"2047-4849","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/D0BM01256D","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Qiujian Zheng (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-3078-6601","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 29 July 2020; Accepted 21 November 2020; Accepted Manuscript published 10 December 2020; Advance Article published 18 December 2020; Version of Record published 23 February 2021","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}