{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T03:57:11Z","timestamp":1790222231447,"version":"4.1.0"},"reference-count":58,"publisher":"Royal Society of Chemistry (RSC)","issue":"23","license":[{"start":{"date-parts":[[2021,9,25]],"date-time":"2021-09-25T00:00:00Z","timestamp":1632528000000},"content-version":"am","delay-in-days":633,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81601513"],"award-info":[{"award-number":["81601513"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["31630026"],"award-info":[{"award-number":["31630026"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81630047"],"award-info":[{"award-number":["81630047"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81771845"],"award-info":[{"award-number":["81771845"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81873901"],"award-info":[{"award-number":["81873901"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012433","name":"Key Project of Application Development Plan of Chongqing City","doi-asserted-by":"crossref","award":["cstc2019jscx-dxwtBX0004"],"award-info":[{"award-number":["cstc2019jscx-dxwtBX0004"]}],"id":[{"id":"10.13039\/501100012433","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Biomater. Sci."],"abstract":"<p>\n                    A unique nanoreactor Fe-PDAP\/GOx\/ICG is engineered to realize starvation therapy and enhanced phototherapy\n                    <italic>via<\/italic>\n                    multilevel mechanisms for simultaneous glucose consumption, oxygen supply, glutathione (GSH) depletion, and heat-resistance relief.\n                  <\/p>","DOI":"10.1039\/d0bm01350a","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T21:03:33Z","timestamp":1600981413000},"page":"6561-6578","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["A multimodal imaging-guided nanoreactor for cooperative combination of tumor starvation and multiple mechanism-enhanced mild temperature phototherapy"],"prefix":"10.1039","volume":"8","author":[{"given":"Jin","family":"Cao","sequence":"first","affiliation":[{"name":"Institute of Ultrasound Imaging"},{"name":"the Second Affiliated Hospital of Chongqing Medical University"},{"name":"Chongqing"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Qiao","sequence":"additional","affiliation":[{"name":"Institute of Ultrasound Imaging"},{"name":"the Second Affiliated Hospital of Chongqing Medical University"},{"name":"Chongqing"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanli","family":"Luo","sequence":"additional","affiliation":[{"name":"Institute of Ultrasound Imaging"},{"name":"the Second Affiliated Hospital of Chongqing Medical University"},{"name":"Chongqing"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongqing","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Ultrasound"},{"name":"The First Affiliated Hospital of Chongqing Medical University"},{"name":"Chongqing 400042"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1251-7392","authenticated-orcid":false,"given":"Anyu","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Ultrasound Imaging"},{"name":"the Second Affiliated Hospital of Chongqing Medical University"},{"name":"Chongqing"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8151-194X","authenticated-orcid":false,"given":"Mengzhu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oncology"},{"name":"the Second Affiliated Hospital of Chongqing Medical University"},{"name":"Chongqing"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology"},{"name":"The Second Affiliated Hospital of Chongqing Medical University"},{"name":"Chongqing 400010"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kui","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Nephrology"},{"name":"The Second Affiliated Hospital of Chongqing Medical University"},{"name":"Chongqing 400010"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maoping","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ultrasound"},{"name":"The First Affiliated Hospital of Chongqing Medical University"},{"name":"Chongqing 400042"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4149-0862","authenticated-orcid":false,"given":"Zhigang","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Ultrasound Imaging"},{"name":"the Second Affiliated Hospital of Chongqing Medical University"},{"name":"Chongqing"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2020]]},"reference":[{"key":"D0BM01350A-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/nrc1071","volume":"3","author":"Dolmans","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"D0BM01350A-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"13566","DOI":"10.1021\/acs.chemrev.7b00258","volume":"117","author":"Fan","year":"2017","journal-title":"Chem. Rev."},{"key":"D0BM01350A-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1039\/C8CS00618K","volume":"48","author":"Liu","year":"2019","journal-title":"Chem. Soc. Rev."},{"key":"D0BM01350A-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3606","DOI":"10.1002\/anie.201510064","volume":"55","author":"Kolemen","year":"2016","journal-title":"Angew. Chem., Int. Ed."},{"key":"D0BM01350A-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S1470-2045(04)01529-3","volume":"5","author":"Brown","year":"2004","journal-title":"Lancet Oncol."},{"key":"D0BM01350A-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4881","DOI":"10.1021\/acs.chemrev.8b00626","volume":"119","author":"Yang","year":"2019","journal-title":"Chem. Rev."},{"key":"D0BM01350A-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1002\/adhm.201200423","volume":"2","author":"Lee","year":"2013","journal-title":"Adv. Healthcare Mater."},{"key":"D0BM01350A-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"12967","DOI":"10.1038\/ncomms12967","volume":"7","author":"Shao","year":"2016","journal-title":"Nat. Commun."},{"key":"D0BM01350A-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1605021","DOI":"10.1002\/adma.201605021","volume":"29","author":"Abbas","year":"2017","journal-title":"Adv. Mater."},{"key":"D0BM01350A-(cit10)\/*[position()=1]","first-page":"1","volume":"29","author":"Chen","year":"2017","journal-title":"Adv. Mater."},{"key":"D0BM01350A-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11376","DOI":"10.1021\/jacs.5b06025","volume":"137","author":"Wang","year":"2015","journal-title":"J. Am. Chem. Soc."},{"key":"D0BM01350A-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1704136","DOI":"10.1002\/adma.201704136","volume":"29","author":"Guo","year":"2017","journal-title":"Adv. Mater."},{"key":"D0BM01350A-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.addr.2015.10.019","volume":"98","author":"Kemp","year":"2016","journal-title":"Adv. Drug Delivery Rev."},{"key":"D0BM01350A-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1606857","DOI":"10.1002\/adma.201606857","volume":"29","author":"Li","year":"2017","journal-title":"Adv. Mater."},{"key":"D0BM01350A-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1900471","DOI":"10.1002\/advs.201900471","volume":"6","author":"Kim","year":"2019","journal-title":"Adv. Sci."},{"key":"D0BM01350A-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9855","DOI":"10.1158\/0008-5472.CAN-10-0250","volume":"70","author":"Fisher","year":"2010","journal-title":"Cancer Res."},{"key":"D0BM01350A-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.jconrel.2013.08.020","volume":"172","author":"Gaca","year":"2013","journal-title":"J. Controlled Release"},{"key":"D0BM01350A-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1021\/acsnano.6b06658","volume":"11","author":"Chen","year":"2017","journal-title":"ACS Nano"},{"key":"D0BM01350A-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6454","DOI":"10.1039\/C7CS00891K","volume":"47","author":"Fu","year":"2018","journal-title":"Chem. Soc. Rev."},{"key":"D0BM01350A-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8890","DOI":"10.1021\/acsnano.9b02466","volume":"13","author":"Ma","year":"2019","journal-title":"ACS Nano"},{"key":"D0BM01350A-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5044","DOI":"10.1038\/s41467-018-07197-8","volume":"9","author":"Yu","year":"2018","journal-title":"Nat. Commun."},{"key":"D0BM01350A-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10201","DOI":"10.1021\/acsnano.8b05200","volume":"12","author":"Zhang","year":"2018","journal-title":"ACS Nano"},{"key":"D0BM01350A-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e1805919","DOI":"10.1002\/adma.201805919","volume":"31","author":"Feng","year":"2019","journal-title":"Adv. Mater."},{"key":"D0BM01350A-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nrc3038","volume":"11","author":"Koppenol","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"D0BM01350A-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1126\/science.1160809","volume":"324","author":"Vander Heiden","year":"2009","journal-title":"Science"},{"key":"D0BM01350A-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/s41580-019-0123-5","volume":"20","author":"Zhu","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"D0BM01350A-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2858","DOI":"10.1021\/acsnano.8b00309","volume":"12","author":"Zhou","year":"2018","journal-title":"ACS Nano"},{"key":"D0BM01350A-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6867","DOI":"10.1021\/acs.nanolett.8b02732","volume":"18","author":"Yang","year":"2018","journal-title":"Nano Lett."},{"issue":"2","key":"D0BM01350A-(cit29)\/*[position()=1]","first-page":"1784","volume":"13","author":"Yu","year":"2019","journal-title":"ACS Nano"},{"key":"D0BM01350A-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9029","DOI":"10.1002\/anie.201703159","volume":"56","author":"Wang","year":"2017","journal-title":"Angew. Chem., Int. Ed."},{"key":"D0BM01350A-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e1808200","DOI":"10.1002\/adma.201808200","volume":"31","author":"Min","year":"2019","journal-title":"Adv. Mater."},{"key":"D0BM01350A-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1002\/adma.201204750","volume":"25","author":"Wang","year":"2013","journal-title":"Adv. Mater."},{"key":"D0BM01350A-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1021\/jacs.7b11114","volume":"140","author":"Bai","year":"2018","journal-title":"J. Am. Chem. Soc."},{"key":"D0BM01350A-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e2000005","DOI":"10.1002\/adhm.202000005","volume":"9","author":"Shi","year":"2020","journal-title":"Adv. Healthcare Mater."},{"key":"D0BM01350A-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/nrclinonc.2014.134","volume":"11","author":"Yankeelov","year":"2014","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"D0BM01350A-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4501","DOI":"10.1039\/C4CS00345D","volume":"44","author":"Shin","year":"2015","journal-title":"Chem. Soc. Rev."},{"key":"D0BM01350A-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1039\/C2CS15261D","volume":"41","author":"Lee","year":"2012","journal-title":"Chem. Soc. Rev."},{"key":"D0BM01350A-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.1021\/cr900266s","volume":"110","author":"Kim","year":"2010","journal-title":"Chem. Rev."},{"key":"D0BM01350A-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e1900378","DOI":"10.1002\/adhm.201900378","volume":"8","author":"Yu","year":"2019","journal-title":"Adv. Healthcare Mater."},{"key":"D0BM01350A-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1021\/ar200044b","volume":"44","author":"Xie","year":"2011","journal-title":"Acc. Chem. Res."},{"key":"D0BM01350A-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3546","DOI":"10.1021\/acsnano.9b09871","volume":"14","author":"Yuan","year":"2020","journal-title":"ACS Nano"},{"key":"D0BM01350A-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.actbio.2018.09.045","volume":"81","author":"Xue","year":"2018","journal-title":"Acta Biomater."},{"key":"D0BM01350A-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1021\/acsami.8b16801","volume":"11","author":"Yang","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D0BM01350A-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9701","DOI":"10.1021\/ja5042989","volume":"136","author":"Liu","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"D0BM01350A-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1089\/ars.2009.2695","volume":"11","author":"Mar\u00ed","year":"2009","journal-title":"Antioxid Redox Signal."},{"key":"D0BM01350A-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"12181","DOI":"10.1021\/acsnano.8b05860","volume":"12","author":"Liu","year":"2018","journal-title":"ACS Nano"},{"key":"D0BM01350A-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.apcatb.2016.01.015","volume":"187","author":"Bolobajev","year":"2016","journal-title":"Appl. Catal., B"},{"key":"D0BM01350A-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"27965","DOI":"10.1021\/acsami.8b08868","volume":"10","author":"He","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D0BM01350A-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10540","DOI":"10.1021\/acsami.8b22748","volume":"11","author":"Dai","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D0BM01350A-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8379","DOI":"10.1002\/adma.201602197","volume":"28","author":"Wang","year":"2016","journal-title":"Adv. Mater."},{"key":"D0BM01350A-(cit51)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1901616","DOI":"10.1002\/adhm.201901616","volume":"9","author":"Yang","year":"2020","journal-title":"Adv. Healthcare Mater."},{"key":"D0BM01350A-(cit52)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"342","DOI":"10.7150\/thno.11918","volume":"6","author":"Bai","year":"2016","journal-title":"Theranostics"},{"key":"D0BM01350A-(cit53)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biomaterials.2018.02.041","volume":"165","author":"Sheng","year":"2018","journal-title":"Biomaterials"},{"key":"D0BM01350A-(cit54)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/nmeth.3929","volume":"13","author":"Weber","year":"2016","journal-title":"Nat. Methods"},{"key":"D0BM01350A-(cit55)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3606","DOI":"10.1002\/adma.201670129","volume":"28","author":"Miao","year":"2016","journal-title":"Adv. Mater."},{"key":"D0BM01350A-(cit56)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s00261-008-9402-x","volume":"34","author":"Achiam","year":"2009","journal-title":"Abdom. Imaging"},{"key":"D0BM01350A-(cit57)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1002\/smll.201100442","volume":"7","author":"Wang","year":"2011","journal-title":"Small"},{"key":"D0BM01350A-(cit58)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0168-3659(01)00451-5","volume":"77","author":"Yamamoto","year":"2001","journal-title":"J. Controlled Release"}],"container-title":["Biomaterials Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2020\/BM\/D0BM01350A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T19:58:05Z","timestamp":1782849485000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/bm\/article\/8\/23\/6561-6578\/674008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":58,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2020,11,24]]}},"URL":"https:\/\/doi.org\/10.1039\/d0bm01350a","relation":{},"ISSN":["2047-4830","2047-4849"],"issn-type":[{"value":"2047-4830","type":"print"},{"value":"2047-4849","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/D0BM01350A","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Anyu Yang (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-1251-7392","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Mengzhu Wang (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-8151-194X","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Zhigang Wang (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-4149-0862","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 13 August 2020; Accepted 22 September 2020; Accepted Manuscript published 25 September 2020; Advance Article published 14 October 2020; Version of Record published 24 November 2020","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}