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Biol."],"abstract":"<jats:p>\n                    We report the rational design, novel syntheses and biophysical and\n                    <jats:italic>in silico<\/jats:italic>\n                    evaluation of tryptophan-inspired tool compounds to probe the illusive MOA of the clinically-relevant heme-dioxygenase protein, IDO1.\n                  <\/jats:p>","DOI":"10.1039\/d0cb00209g","type":"journal-article","created":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T04:55:35Z","timestamp":1631508935000},"page":"1651-1660","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Design, synthesis and evaluation of tryptophan analogues as tool compounds to study IDO1 activity"],"prefix":"10.1039","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6783-5422","authenticated-orcid":false,"given":"Nicholas J.","family":"Cundy","sequence":"first","affiliation":[{"name":"School of Chemistry, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roseanna K.","family":"Hare","sequence":"additional","affiliation":[{"name":"Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Tang","sequence":"additional","affiliation":[{"name":"Celentyx Ltd, Birmingham Research Park, 97 Vincent Drive, Birmingham, B15 2SQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1325-8273","authenticated-orcid":false,"given":"Andrew G.","family":"Leach","sequence":"additional","affiliation":[{"name":"Division of Pharmacy and Optometry, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Jowitt","sequence":"additional","affiliation":[{"name":"Wellcome Trust Centre for Cell Matrix Research, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Qureshi","sequence":"additional","affiliation":[{"name":"Celentyx Ltd, Birmingham Research Park, 97 Vincent Drive, Birmingham, B15 2SQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Gordon","sequence":"additional","affiliation":[{"name":"Celentyx Ltd, Birmingham Research Park, 97 Vincent Drive, Birmingham, B15 2SQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas M.","family":"Barnes","sequence":"additional","affiliation":[{"name":"Celentyx Ltd, Birmingham Research Park, 97 Vincent Drive, Birmingham, B15 2SQ, UK"},{"name":"Institute of Clinical Sciences, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine A.","family":"Brady","sequence":"additional","affiliation":[{"name":"Celentyx Ltd, Birmingham Research Park, 97 Vincent Drive, Birmingham, B15 2SQ, UK"},{"name":"Institute of Clinical Sciences, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma L.","family":"Raven","sequence":"additional","affiliation":[{"name":"School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0611-4386","authenticated-orcid":false,"given":"Richard S.","family":"Grainger","sequence":"additional","affiliation":[{"name":"School of Chemistry, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Butterworth","sequence":"additional","affiliation":[{"name":"Division of Pharmacy and Optometry, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2021]]},"reference":[{"key":"D0CB00209G\/cit1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1515\/bchm2.1936.243.6.237","volume":"243","author":"Kotake","year":"1936","journal-title":"Hoppe-Seyler's Z. 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