{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T06:52:07Z","timestamp":1782975127670,"version":"3.54.5"},"reference-count":55,"publisher":"Royal Society of Chemistry (RSC)","issue":"32","license":[{"start":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T00:00:00Z","timestamp":1615334400000},"content-version":"am","delay-in-days":434,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Chem. Commun."],"abstract":"<p>An unprecedented carbonic anhydrase-mediated hydrolysis of selenolesters enables the release of selenolates, acting as potent CA inhibitors. A wide range of functionalised selenolesters, smoothly achieved from the corresponding selenols, are studied.<\/p>","DOI":"10.1039\/d0cc00995d","type":"journal-article","created":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T08:49:57Z","timestamp":1583830197000},"page":"4444-4447","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Selenolesterase enzyme activity of carbonic anhydrases"],"prefix":"10.1039","volume":"56","author":[{"given":"Andrea","family":"Angeli","sequence":"first","affiliation":[{"name":"University of Florence"},{"name":"NEUROFARBA Department"},{"name":"Sezione di Scienze Farmaceutiche"},{"name":"50019 Sesto Fiorentino (Florence)"},{"name":"Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1141-6146","authenticated-orcid":false,"given":"Fabrizio","family":"Carta","sequence":"additional","affiliation":[{"name":"University of Florence"},{"name":"NEUROFARBA Department"},{"name":"Sezione di Scienze Farmaceutiche"},{"name":"50019 Sesto Fiorentino (Florence)"},{"name":"Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selene","family":"Donnini","sequence":"additional","affiliation":[{"name":"University of Florence"},{"name":"Department of Chemistry \u201cUgo Schiff\u201d"},{"name":"I-50019 Sesto Fiorentino"},{"name":"Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1087-8143","authenticated-orcid":false,"given":"Antonella","family":"Capperucci","sequence":"additional","affiliation":[{"name":"University of Florence"},{"name":"Department of Chemistry \u201cUgo Schiff\u201d"},{"name":"I-50019 Sesto Fiorentino"},{"name":"Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Ferraroni","sequence":"additional","affiliation":[{"name":"University of Florence"},{"name":"Department of Chemistry \u201cUgo Schiff\u201d"},{"name":"I-50019 Sesto Fiorentino"},{"name":"Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8930-3566","authenticated-orcid":false,"given":"Damiano","family":"Tanini","sequence":"additional","affiliation":[{"name":"University of Florence"},{"name":"Department of Chemistry \u201cUgo Schiff\u201d"},{"name":"I-50019 Sesto Fiorentino"},{"name":"Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4262-0323","authenticated-orcid":false,"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[{"name":"University of Florence"},{"name":"NEUROFARBA Department"},{"name":"Sezione di Scienze Farmaceutiche"},{"name":"50019 Sesto Fiorentino (Florence)"},{"name":"Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2020]]},"reference":[{"key":"D0CC00995D-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nrd2467","volume":"7","author":"Supuran","year":"2008","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D0CC00995D-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1038\/s41396-019-0426-8","volume":"13","author":"Jensen","year":"2019","journal-title":"ISME J."},{"key":"D0CC00995D-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1042\/BCJ20160115","volume":"473","author":"Supuran","year":"2016","journal-title":"Biochem. J."},{"key":"D0CC00995D-(cit4a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1080\/13543784.2018.1548608","volume":"12","author":"Supuran","year":"2018","journal-title":"Expert Opin. Invest. Drugs"},{"key":"D0CC00995D-(cit4b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"603","DOI":"10.2174\/138161208783877884","volume":"14","author":"Supuran","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"D0CC00995D-(cit4c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1080\/13543776.2018.1523897","volume":"28","author":"Supuran","year":"2018","journal-title":"Expert Opin. Ther. Pat."},{"key":"D0CC00995D-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"E48","DOI":"10.3390\/metabo7030048","volume":"7","author":"Supuran","year":"2017","journal-title":"Metabolites"},{"key":"D0CC00995D-(cit6a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11353","DOI":"10.1039\/C6OB02299E","volume":"14","author":"Angeli","year":"2016","journal-title":"Org. Biomol. Chem."},{"key":"D0CC00995D-(cit6b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.bioorg.2019.03.062","volume":"87","author":"Tanini","year":"2019","journal-title":"Bioorg. Chem."},{"key":"D0CC00995D-(cit6c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1021\/acsmedchemlett.8b00362","volume":"9","author":"Angeli","year":"2018","journal-title":"ACS Med. Chem. Lett."},{"key":"D0CC00995D-(cit7a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1039\/C8CC08562E","volume":"55","author":"Angeli","year":"2019","journal-title":"Chem. Commun."},{"key":"D0CC00995D-(cit7b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"111811","DOI":"10.1016\/j.ejmech.2019.111811","volume":"185","author":"Tanini","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"D0CC00995D-(cit8a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5497","DOI":"10.1021\/ja00951a049","volume":"87","author":"Pocker","year":"1965","journal-title":"J. Am. Chem. Soc."},{"key":"D0CC00995D-(cit8b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"18452","DOI":"10.1021\/ja207855c","volume":"133","author":"Lopez","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"D0CC00995D-(cit8c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1021\/ml500470b","volume":"6","author":"Tanc","year":"2015","journal-title":"ACS Med. Chem. Lett."},{"key":"D0CC00995D-(cit8d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"148","DOI":"10.3109\/14756366.2011.629198","volume":"27","author":"\u00c7avdar","year":"2012","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"D0CC00995D-(cit8e)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6208","DOI":"10.1016\/j.bmcl.2010.08.110","volume":"20","author":"Innocenti","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D0CC00995D-(cit9a)\/*[position()=1]","volume-title":"Chalcogenocarboxylic Acid Derivatives","author":"Fujiwara","year":"2005","unstructured":"S. Fujiwara and N.Kambe , in Chalcogenocarboxylic Acid Derivatives , ed. S. Kato , Springer , Berlin\/Heidelberg, Germany , 2005 , pp. 87\u2013140"},{"key":"D0CC00995D-(cit9b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8359","DOI":"10.1021\/jo901986v","volume":"74","author":"Bennasar","year":"2009","journal-title":"J. Org. Chem."},{"key":"D0CC00995D-(cit9c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5805","DOI":"10.1021\/ol062350h","volume":"8","author":"Inoue","year":"2006","journal-title":"Org. Lett."},{"key":"D0CC00995D-(cit10a)\/*[position()=1]","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-319-92405-2","volume-title":"New Frontiers in Organoselenium Compounds","author":"Lenard\u00e3o","year":"2018","unstructured":"E. J. Lenard\u00e3o , C.Santi and L.Sancineto , New Frontiers in Organoselenium Compounds , Springer , New York , 2018"},{"key":"D0CC00995D-(cit10b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3201","DOI":"10.1002\/anie.201610657","volume":"56","author":"Liao","year":"2017","journal-title":"Angew. Chem., Int. Ed."},{"key":"D0CC00995D-(cit10c)\/*[position()=1]","first-page":"11","author":"Marini","year":"2013","journal-title":"Synlett"},{"key":"D0CC00995D-(cit10d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"12226","DOI":"10.1021\/ja106116v","volume":"132","author":"Sohn","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"D0CC00995D-(cit10e)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4357","DOI":"10.1021\/cr900352j","volume":"110","author":"Mukherjee","year":"2010","journal-title":"Chem. Rev."},{"key":"D0CC00995D-(cit11a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6637","DOI":"10.1039\/C8TB01794H","volume":"6","author":"Gao","year":"2018","journal-title":"J. Mater. Chem. B"},{"key":"D0CC00995D-(cit11b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9361","DOI":"10.1002\/anie.201503418","volume":"54","author":"Li","year":"2015","journal-title":"Angew. Chem., Int. Ed."},{"key":"D0CC00995D-(cit12a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7435","DOI":"10.1021\/acs.macromol.8b01597","volume":"51","author":"Xia","year":"2018","journal-title":"Macromolecules"},{"key":"D0CC00995D-(cit12b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1021\/ar4000339","volume":"46","author":"Xu","year":"2013","journal-title":"Acc. Chem. Res."},{"key":"D0CC00995D-(cit13a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1038\/s41598-018-19854-5","volume":"8","author":"Patra","year":"2018","journal-title":"Sci. Rep."},{"key":"D0CC00995D-(cit13b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.cbi.2018.09.016","volume":"296","author":"Adedara","year":"2018","journal-title":"Chem.-Biol. Interact."},{"key":"D0CC00995D-(cit13c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1002\/anie.201611700","volume":"56","author":"Nuthanakanti","year":"2017","journal-title":"Angew. Chem., Int. Ed."},{"key":"D0CC00995D-(cit13d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3729","DOI":"10.1002\/anie.201510947","volume":"55","author":"Kumar","year":"2016","journal-title":"Angew. Chem., Int. Ed."},{"issue":"26","key":"D0CC00995D-(cit13e)\/*[position()=1]","first-page":"1","volume":"1","author":"Arai","year":"2018","journal-title":"Commun. Chem."},{"key":"D0CC00995D-(cit14)\/*[position()=2]","doi-asserted-by":"crossref","first-page":"6255","DOI":"10.1021\/cr0406559","volume":"104","author":"Nogueira","year":"2004","journal-title":"Chem. Rev."},{"key":"D0CC00995D-(cit14a)\/*[position()=1]","volume-title":"Organoselenium Compounds in Biology and Medicine: Synthesis, Biological and Therapeutic Treatments","author":"Singh","year":"2018","unstructured":"F. V. Singh and T.Wirth , in Organoselenium Compounds in Biology and Medicine: Synthesis, Biological and Therapeutic Treatments , ed. V. K. Jain and K. I. Priyadarsini , Royal Society of Chemistry , London , 2018 , ch. 3 and references cited therein"},{"key":"D0CC00995D-(cit14b)\/*[position()=1]","volume-title":"Organoselenium Compounds in Biology and Medicine: Synthesis, Biological and Therapeutic Treatments","author":"Carrol","year":"2018","unstructured":"L. D. Carrol and M. J.Davies , in Organoselenium Compounds in Biology and Medicine: Synthesis, Biological and Therapeutic Treatments , ed. V. K. Jain , K. I. Priyadarsini , Royal Society of Chemistry , London , 2018 , ch. 9 and references cited therein. Inter alia : F. Kumakura, B. Mishra, K. I. Priyadarsini and M. Iwaoka, Eur. J. Org. Chem ., 2010, 440"},{"key":"D0CC00995D-(cit15a)\/*[position()=1]","volume-title":"Organoselenium Compounds in Biology and Medicine: Synthesis, Biological and Therapeutic Treatments","author":"Rocha","year":"2018","unstructured":"J. B. T. Rocha , C. S.Oliveir and P. A.Nogara , in Organoselenium Compounds in Biology and Medicine: Synthesis, Biological and Therapeutic Treatments , ed. V. K. Jain and K. I. Priyadarsini , Royal Society of Chemistry , London , 2018 , ch. 13"},{"key":"D0CC00995D-(cit15b)\/*[position()=1]","volume-title":"Organoselenium Compounds in Biology and Medicine: Synthesis, Biological and Therapeutic Treatments","author":"Diamond","year":"2018","unstructured":"A. M. Diamond , in Organoselenium Compounds in Biology and Medicine: Synthesis, Biological and Therapeutic Treatments , ed. V. K. Jain and K. I. Priyadarsini , Royal Society of Chemistry , London , 2018 , ch. 16"},{"key":"D0CC00995D-(cit16a)\/*[position()=1]","volume-title":"Organoselenium Compounds in Biology and Medicine: Synthesis, Biological and Therapeutic Treatments","author":"Singh","year":"2018","unstructured":"F. V. Singh and T.Wirth , in Organoselenium Compounds in Biology and Medicine: Synthesis, Biological and Therapeutic Treatments , ed. V. K. Jain and K. I. Priyadarsini , Royal Society of Chemistry , London , 2018 , ch. 3 and references cited therein"},{"key":"D0CC00995D-(cit16b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.lfs.2012.07.023","volume":"91","author":"Nedel","year":"2012","journal-title":"Life Sci."},{"key":"D0CC00995D-(cit17a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1002\/adsc.201900168","volume":"361","author":"Tanini","year":"2019","journal-title":"Adv. Synth. Catal."},{"key":"D0CC00995D-(cit17b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5705","DOI":"10.1039\/C9CC02427A","volume":"55","author":"Tanini","year":"2019","journal-title":"Chem. Commun."},{"key":"D0CC00995D-(cit17c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11451","DOI":"10.1039\/C9NJ02320H","volume":"43","author":"Tanini","year":"2019","journal-title":"New J. Chem."},{"key":"D0CC00995D-(cit17d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3390\/catal9040333","volume":"9","author":"Tanini","year":"2019","journal-title":"Catalysts"},{"key":"D0CC00995D-(cit17e)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6831","DOI":"10.1002\/ejoc.201701066","author":"Mlosto\u0144","year":"2017","journal-title":"Eur. J. Org. Chem."},{"key":"D0CC00995D-(cit18a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3046","DOI":"10.1016\/j.jorganchem.2004.06.054","volume":"689","author":"Kumar","year":"2004","journal-title":"J. Organomet. Chem."},{"key":"D0CC00995D-(cit18b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5183","DOI":"10.1021\/om990589e","volume":"18","author":"Silveira","year":"1999","journal-title":"Organometallics"},{"key":"D0CC00995D-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"953","DOI":"10.3390\/molecules22060953","volume":"22","author":"Sancineto","year":"2017","journal-title":"Molecules"},{"key":"D0CC00995D-(cit20a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1002\/chem.201904686","volume":"26","author":"Tanini","year":"2020","journal-title":"Chem. \u2013 Eur. J."},{"key":"D0CC00995D-(cit20b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3367","DOI":"10.1002\/adsc.201800602","volume":"360","author":"Tanini","year":"2018","journal-title":"Adv. Synth. Catal."},{"key":"D0CC00995D-(cit21a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1021\/ja809683v","volume":"131","author":"Maresca","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"D0CC00995D-(cit21b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.3109\/14756366.2015.1115401","volume":"31","author":"Nocentini","year":"2016","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"D0CC00995D-(cit22a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1016\/S0021-9258(18)62326-9","volume":"246","author":"Khalifah","year":"1971","journal-title":"J. Biol. Chem."},{"key":"D0CC00995D-(cit22b)\/*[position()=1]","first-page":"553","volume":"58","author":"Pinnell","year":"1985","journal-title":"Yale J. Biol. Med."}],"container-title":["Chemical Communications"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2020\/CC\/D0CC00995D","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T05:21:00Z","timestamp":1782969660000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/cc\/article\/56\/32\/4444-4447\/1247054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":55,"journal-issue":{"issue":"32","published-print":{"date-parts":[[2020,4,21]]}},"URL":"https:\/\/doi.org\/10.1039\/d0cc00995d","relation":{},"ISSN":["1359-7345","1364-548X"],"issn-type":[{"value":"1359-7345","type":"print"},{"value":"1364-548X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/D0CC00995D","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Fabrizio Carta (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-1141-6146","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Antonella Capperucci (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-1087-8143","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Damiano Tanini (ORCID)","URL":"http:\/\/orcid.org\/0000-0001-8930-3566","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Claudiu T. Supuran (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-4262-0323","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Authors can choose between single-blind and double-blind peer review","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 7 February 2020; Accepted 10 March 2020; Accepted Manuscript published 10 March 2020; Advance Article published 20 March 2020; Version of Record published 21 April 2020","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}