{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T18:26:28Z","timestamp":1783016788206,"version":"3.54.6"},"reference-count":51,"publisher":"Royal Society of Chemistry (RSC)","issue":"26","license":[{"start":{"date-parts":[[2021,5,22]],"date-time":"2021-05-22T00:00:00Z","timestamp":1621641600000},"content-version":"am","delay-in-days":507,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001502","name":"Department of Atomic Energy, Government of India","doi-asserted-by":"crossref","award":["12-R&D-TFR-5.10-0100-RTI2001"],"award-info":[{"award-number":["12-R&D-TFR-5.10-0100-RTI2001"]}],"id":[{"id":"10.13039\/501100001502","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Phys. Chem. Chem. Phys."],"abstract":"<p>Single molecule imaging addresses the \u201cwhich oligomer\u201d question in membrane mediated toxicity of amyloid oligomers.<\/p>","DOI":"10.1039\/d0cp00450b","type":"journal-article","created":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T07:44:03Z","timestamp":1590133443000},"page":"14613-14620","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Membrane affinity of individual toxic protein oligomers determined at the single-molecule level"],"prefix":"10.1039","volume":"22","author":[{"given":"Simli","family":"Dey","sequence":"first","affiliation":[{"name":"Department of Chemical Sciences"},{"name":"Tata Institute of Fundamental Research"},{"name":"Mumbai 400005"},{"name":"India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anirban","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences"},{"name":"Tata Institute of Fundamental Research"},{"name":"Mumbai 400005"},{"name":"India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arpan","family":"Dey","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences"},{"name":"Tata Institute of Fundamental Research"},{"name":"Mumbai 400005"},{"name":"India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6540-7472","authenticated-orcid":false,"given":"Sudipta","family":"Maiti","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences"},{"name":"Tata Institute of Fundamental Research"},{"name":"Mumbai 400005"},{"name":"India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2020]]},"reference":[{"key":"D0CP00450B-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0166-2236(00)01749-5","volume":"24","author":"Klein","year":"2001","journal-title":"Trends Neurosci."},{"key":"D0CP00450B-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nrm2101","volume":"8","author":"Haass","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"D0CP00450B-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1111\/j.1742-4658.2010.07568.x","volume":"277","author":"Sakono","year":"2010","journal-title":"FEBS J."},{"key":"D0CP00450B-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/nm1782","volume":"14","author":"Shankar","year":"2008","journal-title":"Nat. Med."},{"key":"D0CP00450B-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4077","DOI":"10.1074\/jbc.271.8.4077","volume":"271","author":"Kuo","year":"1996","journal-title":"J. Biol. Chem."},{"key":"D0CP00450B-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1038\/nm0798-832","volume":"4","author":"Pitschke","year":"1998","journal-title":"Nat. Med."},{"key":"D0CP00450B-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1126\/science.1079469","volume":"300","author":"Kayed","year":"2003","journal-title":"Science"},{"key":"D0CP00450B-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/nature04533","volume":"440","author":"Lesn\u00e9","year":"2006","journal-title":"Nature"},{"key":"D0CP00450B-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nn.3028","volume":"15","author":"Benilova","year":"2012","journal-title":"Nat. Neurosci."},{"key":"D0CP00450B-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3518","DOI":"10.1021\/cr500638n","volume":"115","author":"Nasica-Labouze","year":"2015","journal-title":"Chem. Rev."},{"key":"D0CP00450B-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.bpj.2012.06.045","volume":"103","author":"Sciacca","year":"2012","journal-title":"Biophys. J."},{"key":"D0CP00450B-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/S0006-3495(01)76109-7","volume":"80","author":"Yip","year":"2001","journal-title":"Biophys. J."},{"key":"D0CP00450B-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/418291a","volume":"418","author":"Lashuel","year":"2002","journal-title":"Nature"},{"key":"D0CP00450B-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10427","DOI":"10.1073\/pnas.0502066102","volume":"102","author":"Quist","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D0CP00450B-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10573","DOI":"10.1073\/pnas.90.22.10573","volume":"90","author":"Arispe","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D0CP00450B-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3643","DOI":"10.1021\/acs.jpcb.9b01206","volume":"123","author":"Nguyen","year":"2019","journal-title":"J. Phys. Chem. B"},{"key":"D0CP00450B-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1038\/nature07761","volume":"457","author":"Laur\u00e9n","year":"2009","journal-title":"Nature"},{"key":"D0CP00450B-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.ceca.2009.12.010","volume":"47","author":"Alberdi","year":"2010","journal-title":"Cell Calcium"},{"key":"D0CP00450B-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11590","DOI":"10.1074\/jbc.M607483200","volume":"282","author":"De Felice","year":"2007","journal-title":"J. Biol. Chem."},{"key":"D0CP00450B-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/0092-8674(94)90131-7","volume":"77","author":"Behl","year":"1994","journal-title":"Cell"},{"key":"D0CP00450B-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10129","DOI":"10.1523\/JNEUROSCI.0535-12.2012","volume":"32","author":"Scott","year":"2012","journal-title":"J. Neurosci."},{"key":"D0CP00450B-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.nbd.2013.03.004","volume":"55","author":"Park","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"D0CP00450B-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.neuroscience.2007.03.047","volume":"147","author":"Kelly","year":"2007","journal-title":"Neuroscience"},{"key":"D0CP00450B-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1002\/ana.410300410","volume":"30","author":"Terry","year":"1991","journal-title":"Ann. Neurol."},{"key":"D0CP00450B-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1097\/00005072-199708000-00011","volume":"56","author":"Sze","year":"1997","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"D0CP00450B-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5901","DOI":"10.1073\/pnas.0900944106","volume":"106","author":"Moreno","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D0CP00450B-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6011","DOI":"10.1523\/JNEUROSCI.1189-06.2006","volume":"26","author":"Deshpande","year":"2006","journal-title":"J. Neurosci."},{"key":"D0CP00450B-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8559","DOI":"10.1039\/C9CP00040B","volume":"21","author":"Sahoo","year":"2019","journal-title":"Phys. Chem. Chem. Phys."},{"key":"D0CP00450B-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphys.2013.00084","volume":"4","author":"Sarkar","year":"2013","journal-title":"Front. Physiol."},{"key":"D0CP00450B-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1021\/ja3103567","volume":"135","author":"Narayan","year":"2013","journal-title":"J. Am. Chem. Soc."},{"key":"D0CP00450B-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1523\/JNEUROSCI.1698-16.2016","volume":"37","author":"Yang","year":"2017","journal-title":"J. Neurosci."},{"key":"D0CP00450B-(cit32)\/*[position()=1]","volume-title":"Amyloid Proteins: Methods and Protocols","author":"Rosensweig","year":"2012","unstructured":"C. Rosensweig  ,  K.Ono ,  K.Murakami ,  D. K.Lowenstein ,  G.Bitan  and  D. B.Teplow , in  Amyloid Proteins: Methods and Protocols , ed.  E. M. Sigurdsson ,  M. Calero  and  M. Gasset ,  Humana Press ,  Totowa, NJ ,  2012 ,  pp. 23\u201331"},{"key":"D0CP00450B-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/nchem.247","volume":"1","author":"Bernstein","year":"2009","journal-title":"Nat. Chem."},{"key":"D0CP00450B-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/S0006-3495(00)76359-4","volume":"79","author":"Nettleton","year":"2000","journal-title":"Biophys. J."},{"key":"D0CP00450B-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10440","DOI":"10.1021\/jacs.9b04596","volume":"141","author":"\u00d6sterlund","year":"2019","journal-title":"J. Am. Chem. Soc."},{"key":"D0CP00450B-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10399","DOI":"10.1021\/jp983227d","volume":"102","author":"Ying","year":"1998","journal-title":"J. Phys. Chem. B"},{"key":"D0CP00450B-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6462","DOI":"10.1073\/pnas.0401638101","volume":"101","author":"Gordon","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D0CP00450B-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"103001","DOI":"10.1103\/PhysRevLett.92.103001","volume":"92","author":"Lippitz","year":"2004","journal-title":"Phys. Rev. Lett."},{"key":"D0CP00450B-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1261\/rna.587607","volume":"13","author":"Zhang","year":"2007","journal-title":"RNA"},{"key":"D0CP00450B-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1016\/j.bbamem.2018.03.017","volume":"1860","author":"Chang","year":"2018","journal-title":"Biochim. Biophys. Acta, Biomembr."},{"key":"D0CP00450B-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e23970","DOI":"10.1371\/journal.pone.0023970","volume":"6","author":"Johnson","year":"2011","journal-title":"PLoS One"},{"key":"D0CP00450B-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1016\/j.bpj.2012.08.051","volume":"103","author":"Ding","year":"2012","journal-title":"Biophys. J."},{"key":"D0CP00450B-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.1021\/bi501369k","volume":"54","author":"Stefanovic","year":"2015","journal-title":"Biochemistry"},{"key":"D0CP00450B-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.bpj.2019.12.034","volume":"118","author":"Dey","year":"2020","journal-title":"Biophys. J."},{"key":"D0CP00450B-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1016\/j.bbamem.2018.03.027","volume":"1860","author":"Rawat","year":"2018","journal-title":"Biochim. Biophys. Acta, Biomembr."},{"key":"D0CP00450B-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9155","DOI":"10.1039\/c3cc44880k","volume":"49","author":"Bag","year":"2013","journal-title":"Chem. Commun."},{"key":"D0CP00450B-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s12038-018-9770-5","volume":"43","author":"Dey","year":"2018","journal-title":"J. Biosci."},{"key":"D0CP00450B-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ymeth.2016.09.016","volume":"115","author":"Tinevez","year":"2017","journal-title":"Methods"},{"key":"D0CP00450B-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5163","DOI":"10.1073\/pnas.1218765110","volume":"110","author":"Hastie","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D0CP00450B-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3098","DOI":"10.1529\/biophysj.106.099424","volume":"92","author":"Yeow","year":"2007","journal-title":"Biophys. J."},{"key":"D0CP00450B-(cit51)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"19129","DOI":"10.1039\/c3cp52732h","volume":"15","author":"Nag","year":"2013","journal-title":"Phys. Chem. Chem. Phys."}],"container-title":["Physical Chemistry Chemical Physics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2020\/CP\/D0CP00450B","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:28:50Z","timestamp":1783013330000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/cp\/article\/22\/26\/14613-14620\/679070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":51,"journal-issue":{"issue":"26","published-print":{"date-parts":[[2020,7,8]]}},"URL":"https:\/\/doi.org\/10.1039\/d0cp00450b","relation":{},"ISSN":["1463-9076","1463-9084"],"issn-type":[{"value":"1463-9076","type":"print"},{"value":"1463-9084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/D0CP00450B","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Sudipta Maiti (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-6540-7472","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 27 January 2020; Accepted 22 May 2020;  Accepted Manuscript published 22 May 2020;  Advance Article published 2 June 2020;  Version of Record published 8 July 2020","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}