{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:01:43Z","timestamp":1790812903619,"version":"4.1.0"},"reference-count":58,"publisher":"Royal Society of Chemistry (RSC)","issue":"45","license":[{"start":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T00:00:00Z","timestamp":1620691200000},"content-version":"am","delay-in-days":496,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000704","name":"Royal Society of Chemistry","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000704","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100009573","name":"Universidad Nacional de Rosario","doi-asserted-by":"crossref","award":["CUA-DAHZ 007\/11"],"award-info":[{"award-number":["CUA-DAHZ 007\/11"]}],"id":[{"id":"10.13039\/100009573","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006668","name":"Fondo para la Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"crossref","award":["PICT 2014-3704"],"award-info":[{"award-number":["PICT 2014-3704"]}],"id":[{"id":"10.13039\/501100006668","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100005156","name":"Alexander von Humboldt-Stiftung","doi-asserted-by":"crossref","award":["P4507"],"award-info":[{"award-number":["P4507"]}],"id":[{"id":"10.13039\/100005156","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Max-Planck-Gesellschaft","award":["P10390"],"award-info":[{"award-number":["P10390"]}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["SFB1286"],"award-info":[{"award-number":["SFB1286"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Dalton Trans."],"abstract":"<p>\n                    By tuning the copper(\n                    <sc>i<\/sc>\n                    )\/copper(\n                    <sc>ii<\/sc>\n                    ) affinity of a novel\n                    <italic>N<\/italic>\n                    -acylhydrazone, a more soluble, hydrolysis resistant and less toxic improved Metal\u2013Protein Attenuating Compound for the bioinorganic management of metal-enhanced aggregopathies was obtained.\n                  <\/p>","DOI":"10.1039\/d0dt01138j","type":"journal-article","created":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T08:03:31Z","timestamp":1589184211000},"page":"16252-16267","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["X1INH, an improved next-generation affinity-optimized hydrazonic ligand, attenuates abnormal copper(\n                    <scp>i<\/scp>\n                    )\/copper(\n                    <scp>ii<\/scp>\n                    )-\u03b1-Syn interactions and affects protein aggregation in a cellular model of synucleinopathy"],"prefix":"10.1039","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8606-2194","authenticated-orcid":false,"given":"Daphne S.","family":"Cukierman","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica"},{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Rio de Janeiro"},{"name":"Rio de Janeiro"},{"name":"Brazil"},{"name":"Department of Experimental Neurodegeneration"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana F.","family":"L\u00e1zaro","sequence":"additional","affiliation":[{"name":"Department of Experimental Neurodegeneration"},{"name":"Center for Biostructural Imaging of Neurodegeneration"},{"name":"University Medical Center Goettingen"},{"name":"Goettingen"},{"name":"Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Sacco","sequence":"additional","affiliation":[{"name":"Max Planck Laboratory for Structural Biology"},{"name":"Chemistry and Molecular Biophysics of Rosario (MPLbioR"},{"name":"UNR-MPIbpC)"},{"name":"and Instituto de Investigaciones para el Descubrimiento de F\u00e1rmacos de Rosario (IIDEFAR"},{"name":"UNR-CONICET)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia R.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica"},{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Rio de Janeiro"},{"name":"Rio de Janeiro"},{"name":"Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9042-9094","authenticated-orcid":false,"given":"Renata","family":"Diniz","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica"},{"name":"Universidade Federal de Minas Gerais"},{"name":"Belo Horizonte"},{"name":"Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0454-7735","authenticated-orcid":false,"given":"Claudio O.","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Max Planck Laboratory for Structural Biology"},{"name":"Chemistry and Molecular Biophysics of Rosario (MPLbioR"},{"name":"UNR-MPIbpC)"},{"name":"and Instituto de Investigaciones para el Descubrimiento de F\u00e1rmacos de Rosario (IIDEFAR"},{"name":"UNR-CONICET)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago F.","family":"Outeiro","sequence":"additional","affiliation":[{"name":"Department of Experimental Neurodegeneration"},{"name":"Center for Biostructural Imaging of Neurodegeneration"},{"name":"University Medical Center Goettingen"},{"name":"Goettingen"},{"name":"Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0624-7560","authenticated-orcid":false,"given":"Nicol\u00e1s A.","family":"Rey","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica"},{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Rio de Janeiro"},{"name":"Rio de Janeiro"},{"name":"Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2020]]},"reference":[{"key":"D0DT01138J-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1152\/physrev.1950.30.3.393","volume":"30","author":"Lehninger","year":"1950","journal-title":"Physiol. Rev."},{"key":"D0DT01138J-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1039\/c1mt00008j","volume":"3","author":"Tamano","year":"2011","journal-title":"Metallomics"},{"key":"D0DT01138J-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s11243-012-9583-6","volume":"37","author":"Jomova","year":"2012","journal-title":"Transition Met. Chem."},{"key":"D0DT01138J-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1080\/15216540051081074","volume":"50","author":"Rotilio","year":"2000","journal-title":"IUBMB Life"},{"key":"D0DT01138J-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S1367-5931(99)80035-0","volume":"3","author":"Sayre","year":"1999","journal-title":"Curr. Opin. Chem. Biol."},{"key":"D0DT01138J-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/S1367-5931(99)00073-3","volume":"4","author":"Bush","year":"2000","journal-title":"Curr. Opin. Chem. Biol."},{"key":"D0DT01138J-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.cbi.2010.04.010","volume":"186","author":"Rivera-Manc\u00eda","year":"2010","journal-title":"Chem.\u2013Biol. Interact."},{"key":"D0DT01138J-(cit8)\/*[position()=1]","doi-asserted-by":"publisher","DOI":"10.15586\/codonpublications.parkinsonsdisease.2018","volume-title":"Parkinson's Disease: Pathogenesis and Clinical Aspects","author":"Stoker","year":"2018","unstructured":"T. B. Stoker   and  J. C.Greenland ,  Parkinson's Disease: Pathogenesis and Clinical Aspects ,  2018 ,  10.15586\/codonpublications.parkinsonsdisease.2018"},{"key":"D0DT01138J-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S0140-6736(87)90827-0","volume":"2","author":"Pall","year":"1987","journal-title":"Lancet"},{"key":"D0DT01138J-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.neurobiolaging.2013.09.034","volume":"35","author":"Davies","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"D0DT01138J-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9843","DOI":"10.1073\/pnas.0403495101","volume":"101","author":"Zecca","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D0DT01138J-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4294","DOI":"10.1073\/pnas.0407881102","volume":"102","author":"Rasia","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"Pt 3","key":"D0DT01138J-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1042\/bj3400821","volume":"340","author":"Paik","year":"1999","journal-title":"Biochem. J."},{"issue":"4","key":"D0DT01138J-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jchemneu.2010.12.001","volume":"42","author":"Cheng","year":"2011","journal-title":"J. Chem. Neuroanant."},{"key":"D0DT01138J-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1038\/s41593-018-0235-9","volume":"21","author":"Soto","year":"2018","journal-title":"Nat. Neurosci."},{"key":"D0DT01138J-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/42166","volume":"388","author":"Spillantini","year":"1997","journal-title":"Nature"},{"key":"D0DT01138J-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4194","DOI":"10.1073\/pnas.1100976108","volume":"108","author":"Winner","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D0DT01138J-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1039\/C4MT00345D","volume":"7","author":"Dell'Acqua","year":"2015","journal-title":"Metallomics"},{"key":"D0DT01138J-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4885","DOI":"10.1021\/cr9000176","volume":"109","author":"Scott","year":"2009","journal-title":"Chem. Rev."},{"key":"D0DT01138J-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1089\/ars.2015.6343","volume":"24","author":"Deas","year":"2016","journal-title":"Antioxid. Redox Signal."},{"key":"D0DT01138J-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/S0896-6273(01)00317-8","volume":"30","author":"Cherny","year":"2001","journal-title":"Neuron"},{"key":"D0DT01138J-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1755-5949.2010.00231.x","volume":"18","author":"Bareggi","year":"2012","journal-title":"CNS Neurosci. Ther."},{"key":"D0DT01138J-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1021\/ar300074t","volume":"45","author":"Crouch","year":"2012","journal-title":"Acc. Chem. Res."},{"key":"D0DT01138J-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s40478-017-0456-2","volume":"5","author":"Finkelstein","year":"2017","journal-title":"Acta Neuropathol. Commun."},{"issue":"P5","key":"D0DT01138J-(cit25)\/*[position()=1]","first-page":"8","volume":"92","author":"Finkelstein","year":"2019","journal-title":"Neurology"},{"key":"D0DT01138J-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S1474-4422(08)70167-4","volume":"7","author":"Lannfelt","year":"2008","journal-title":"Lancet Neurol."},{"key":"D0DT01138J-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.trci.2017.10.001","volume":"3","author":"Villemagne","year":"2017","journal-title":"Alzheimers Dement"},{"key":"D0DT01138J-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.2147\/DDDT.S49763","volume":"7","author":"Prachayasittikul","year":"2013","journal-title":"Drug Des., Dev. Ther."},{"key":"D0DT01138J-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jinorgbio.2014.04.011","volume":"139","author":"Gomes","year":"2014","journal-title":"J. Inorg. Biochem."},{"key":"D0DT01138J-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1007\/s00775-018-1606-0","volume":"23","author":"Cukierman","year":"2018","journal-title":"J. Biol. Inorg. Chem."},{"key":"D0DT01138J-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.saa.2013.06.105","volume":"116","author":"de Freitas","year":"2013","journal-title":"Spectrochim. Acta, Part A"},{"key":"D0DT01138J-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1039\/C5MT00003C","volume":"7","author":"Hauser-Davis","year":"2015","journal-title":"Metallomics"},{"key":"D0DT01138J-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jinorgbio.2017.02.020","volume":"170","author":"Cukierman","year":"2017","journal-title":"J. Inorg. Biochem."},{"key":"D0DT01138J-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1007\/s00775-019-01700-2","volume":"24","author":"Cukierman","year":"2019","journal-title":"J. Biol. Inorg. Chem."},{"key":"D0DT01138J-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1107\/S1600576715001132","volume":"48","author":"Burla","year":"2015","journal-title":"J. Appl. Crystallogr."},{"key":"D0DT01138J-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1107\/S2053229614024218","volume":"71","author":"Sheldrick","year":"2015","journal-title":"Acta Crystallogr., Sect. C: Struct. Chem."},{"key":"D0DT01138J-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1107\/S0021889897006638","volume":"30","author":"Barnes","year":"1997","journal-title":"J. Appl. Crystallogr."},{"key":"D0DT01138J-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1107\/S0021889807067908","volume":"41","author":"Macrae","year":"2008","journal-title":"J. Appl. Crystallogr."},{"key":"D0DT01138J-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/978-1-62703-305-3_15","volume":"981","author":"Johnson","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"D0DT01138J-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"16233","DOI":"10.1021\/bi048453u","volume":"43","author":"Hoyer","year":"2004","journal-title":"Biochemistry"},{"key":"D0DT01138J-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1021\/ja107842f","volume":"133","author":"Binolfi","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"D0DT01138J-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e1004741","DOI":"10.1371\/journal.pgen.1004741","volume":"10","author":"L\u00e1zaro","year":"2014","journal-title":"PLoS Genet."},{"key":"D0DT01138J-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/1521-3773(20020104)41:1<48::AID-ANIE48>3.0.CO;2-U","volume":"41","author":"Steiner","year":"2002","journal-title":"Angew. Chem., Int. Ed."},{"key":"D0DT01138J-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(00)00129-0","volume":"46","author":"Lipinski","year":"2001","journal-title":"Adv. Drug Delivery Rev."},{"key":"D0DT01138J-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1602\/neurorx.2.4.541","volume":"2","author":"Pajouhesh","year":"2005","journal-title":"NeuroRx"},{"key":"D0DT01138J-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10668","DOI":"10.1021\/ic1016752","volume":"49","author":"Binolfi","year":"2010","journal-title":"Inorg. Chem."},{"key":"D0DT01138J-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6444","DOI":"10.1021\/jacs.5b01911","volume":"137","author":"Miotto","year":"2015","journal-title":"J. Am. Chem. Soc."},{"key":"D0DT01138J-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0166-2236(99)01543-X","volume":"23","author":"Rice","year":"2000","journal-title":"Trends Neurosci."},{"key":"D0DT01138J-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1016\/j.freeradbiomed.2011.02.003","volume":"50","author":"Meloni","year":"2011","journal-title":"Free Radicals Biol. Med."},{"key":"D0DT01138J-(cit51)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"21558","DOI":"10.1074\/jbc.M117.817452","volume":"292","author":"Morgan","year":"2017","journal-title":"J. Biol. Chem."},{"key":"D0DT01138J-(cit52)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1517\/14728222.2012.674111","volume":"16","author":"Vekrellis","year":"2012","journal-title":"Expert Opin. Ther. Targets"},{"key":"D0DT01138J-(cit53)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/nrneurol.2013.275","volume":"10","author":"Lee","year":"2014","journal-title":"Nat. Rev. Neurol."},{"key":"D0DT01138J-(cit54)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1515\/hsz-2016-0201","volume":"398","author":"Ottolini","year":"2017","journal-title":"Biol. Chem."},{"key":"D0DT01138J-(cit55)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s12035-018-1082-0","volume":"56","author":"Wilkaniec","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"D0DT01138J-(cit56)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1039\/C8MT00223A","volume":"11","author":"Lothian","year":"2019","journal-title":"Metallomics"},{"key":"D0DT01138J-(cit57)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"140298","DOI":"10.1016\/j.bbapap.2019.140298","volume":"1868","author":"Masaracchia","year":"2020","journal-title":"Biochim. Biophys. Acta, Proteins Proteomics"},{"key":"D0DT01138J-(cit58)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1006\/nbdi.2000.0286","volume":"7","author":"Campbell","year":"2000","journal-title":"Neurobiol. Dis."},{"key":"D0DT01138J-(cit59)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1016\/S0002-9440(10)63072-6","volume":"159","author":"Kahle","year":"2001","journal-title":"Am. J. Pathol."}],"container-title":["Dalton Transactions"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2020\/DT\/D0DT01138J","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T03:56:29Z","timestamp":1782878189000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/dt\/article\/49\/45\/16252-16267\/683666"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":58,"journal-issue":{"issue":"45","published-print":{"date-parts":[[2020,11,25]]}},"URL":"https:\/\/doi.org\/10.1039\/d0dt01138j","relation":{},"ISSN":["1477-9226","1477-9234"],"issn-type":[{"value":"1477-9226","type":"print"},{"value":"1477-9234","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/D0DT01138J","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Crystal Structure Data","URL":"http:\/\/xlink.rsc.org?ccdc=true&msid=D0DT01138J","name":"related_data"},{"value":"Daphne S. Cukierman (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-8606-2194","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Renata Diniz (ORCID)","URL":"http:\/\/orcid.org\/0000-0001-9042-9094","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Renata Diniz (ResearcherID)","URL":"http:\/\/www.researcherid.com\/rid\/B-3546-2015","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Claudio O. Fern\u00e1ndez (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-0454-7735","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Nicol\u00e1s A. Rey (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-0624-7560","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Nicol\u00e1s A. Rey (ResearcherID)","URL":"http:\/\/www.researcherid.com\/rid\/Q-2593-2019","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 25 March 2020; Accepted 5 May 2020;  Advance Article published 11 May 2020;  Version of Record published 25 November 2020","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}