{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T03:23:40Z","timestamp":1785813820427,"version":"3.56.0"},"reference-count":57,"publisher":"Royal Society of Chemistry (RSC)","issue":"33","license":[{"start":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T00:00:00Z","timestamp":1626393600000},"content-version":"am","delay-in-days":562,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100007112","name":"University of Cape Town","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007112","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"crossref","award":["111707"],"award-info":[{"award-number":["111707"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Dalton Trans."],"abstract":"<p>\n                    Iridium(\n                    <sc>iii<\/sc>\n                    ) half-sandwich complexes containing 7-chloroquinoline-1,2,3-triazole hybrid ligands were synthesised and their inhibitory activities evaluated against the\n                    <italic>Plasmodium falciparum<\/italic>\n                    malaria parasite.\n                  <\/p>","DOI":"10.1039\/d0dt01935f","type":"journal-article","created":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T08:43:38Z","timestamp":1594889018000},"page":"11543-11555","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Quinoline-triazole half-sandwich iridium(\n                    <scp>iii<\/scp>\n                    ) complexes: synthesis, antiplasmodial activity and preliminary transfer hydrogenation studies"],"prefix":"10.1039","volume":"49","author":[{"given":"Diana R.","family":"Melis","sequence":"first","affiliation":[{"name":"Department of Chemistry"},{"name":"University of Cape Town"},{"name":"Cape Town"},{"name":"South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1467-5741","authenticated-orcid":false,"given":"Christopher B.","family":"Barnett","sequence":"additional","affiliation":[{"name":"Department of Chemistry"},{"name":"University of Cape Town"},{"name":"Cape Town"},{"name":"South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lubbe","family":"Wiesner","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology"},{"name":"Department of Medicine"},{"name":"University of Cape Town"},{"name":"Cape Town"},{"name":"South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9575-4929","authenticated-orcid":false,"given":"Ebbe","family":"Nordlander","sequence":"additional","affiliation":[{"name":"Chemical Physics"},{"name":"Department of Chemistry"},{"name":"Lund University"},{"name":"SE-221 00 Lund"},{"name":"Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2892-5481","authenticated-orcid":false,"given":"Gregory S.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Chemistry"},{"name":"University of Cape Town"},{"name":"Cape Town"},{"name":"South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2020]]},"reference":[{"key":"D0DT01935F-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5715","DOI":"10.1021\/om300296n","volume":"31","author":"Navarro","year":"2012","journal-title":"Organometallics"},{"key":"D0DT01935F-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","DOI":"10.30875\/f309483f-en","volume-title":"World Malaria Report 2018","author":"World Health Organization","year":"2018","unstructured":"World Health Organization  ,  World Malaria Report 2018 ,  Geneva ,  2018"},{"key":"D0DT01935F-(cit3)\/*[position()=1]","first-page":"55","volume":"79","author":"Foley","year":"1998","journal-title":"Clin. Pharmacol. Ther."},{"key":"D0DT01935F-(cit4)\/*[position()=1]","volume-title":"Antimalarial Chemotherapy: Mechanisms of Action, Resistance, and New Directions in Drug Discovery","author":"Banerjee","year":"2001","unstructured":"R. Banerjee   and  D. E.Goldberg , in  Antimalarial Chemotherapy: Mechanisms of Action, Resistance, and New Directions in Drug Discovery ,  Humana Press Inc ,  Totowa, NJ , 1st edn.,  2001"},{"key":"D0DT01935F-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3450","DOI":"10.1021\/cr3001252","volume":"113","author":"Salas","year":"2013","journal-title":"Chem. Rev."},{"key":"D0DT01935F-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1475-2875-13-471","volume":"13","author":"Navarro","year":"2014","journal-title":"Malar. J."},{"key":"D0DT01935F-(cit7)\/*[position()=1]","volume-title":"Guidelines for the Treatment of Malaria","author":"World Health Organisation","year":"2006","unstructured":"World Health Organisation  ,  Guidelines for the Treatment of Malaria ,  Geneva ,  2006"},{"key":"D0DT01935F-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/415686a","volume":"415","author":"Ridley","year":"2002","journal-title":"Nature"},{"key":"D0DT01935F-(cit9)\/*[position()=1]","volume-title":"Advances in Bioorganometallic Chemistry","author":"Baartzes","year":"2019","unstructured":"N. Baartzes  ,  T.Stringer  and  G. S.Smith , in  Advances in Bioorganometallic Chemistry , ed.  T. Hirao  and  T. Moriuchi ,  Elsevier ,  2019 , pp.  193\u2013213"},{"key":"D0DT01935F-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8243","DOI":"10.1016\/j.bmc.2010.10.009","volume":"18","author":"Guantai","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"D0DT01935F-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/cbdd.12335","volume":"84","author":"Fisher","year":"2014","journal-title":"Chem. Biol. Drug Des."},{"key":"D0DT01935F-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/cbdd.12321","volume":"84","author":"Boechat","year":"2014","journal-title":"Chem. Biol. Drug Des."},{"key":"D0DT01935F-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.ejmech.2019.01.047","volume":"166","author":"Chu","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"D0DT01935F-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5098","DOI":"10.1016\/j.bmc.2014.12.018","volume":"23","author":"Vandekerckhove","year":"2015","journal-title":"Bioorg. Med. Chem."},{"key":"D0DT01935F-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","DOI":"10.15760\/etd.2503","volume-title":"Antimalarial Drug Discovery using Triazoles to Overcome Chloroquine Resistance","author":"Tesfaselassie","year":"2000","unstructured":"E. Tesfaselassie  ,  Antimalarial Drug Discovery using Triazoles to Overcome Chloroquine Resistance ,  Portland, OR ,  2000"},{"key":"D0DT01935F-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.1016\/j.ejmech.2010.04.002","volume":"45","author":"Kategaonkar","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"D0DT01935F-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/j.1747-0285.2011.01115.x","volume":"78","author":"Manohar","year":"2011","journal-title":"Chem. Biol. Drug Des."},{"key":"D0DT01935F-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1039\/C9MD00458K","volume":"11","author":"Malik","year":"2020","journal-title":"RSC Med. Chem."},{"key":"D0DT01935F-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5654","DOI":"10.1021\/nn403220e","volume":"7","author":"Barry","year":"2013","journal-title":"ACS Nano"},{"key":"D0DT01935F-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/j.drudis.2010.10.005","volume":"15","author":"Navarro","year":"2010","journal-title":"Drug Discovery Today"},{"key":"D0DT01935F-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.cbpa.2012.01.013","volume":"16","author":"Gasser","year":"2012","journal-title":"Curr. Opin. Chem. Biol."},{"key":"D0DT01935F-(cit22)\/*[position()=1]","volume-title":"Bioorganometallic Chemistry. Topics in Organometallic Chemistry","volume":"17","author":"Allardyce","year":"2006","unstructured":"C. S. Allardyce   and  P. J.Dyson , in  Bioorganometallic Chemistry. Topics in Organometallic Chemistry ,  Springer ,  Berlin, Heidelberg , Vol.  17 ,  2006 , pp.  177\u2013210"},{"key":"D0DT01935F-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1002\/1097-0142(19850515)55:10<2303::AID-CNCR2820551002>3.0.CO;2-L","volume":"55","author":"Rosenberg","year":"1985","journal-title":"Cancer"},{"key":"D0DT01935F-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3715","DOI":"10.1021\/jm970401y","volume":"40","author":"Biot","year":"1997","journal-title":"J. Med. Chem."},{"key":"D0DT01935F-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1051\/parasite\/2011183207","volume":"18","author":"Biot","year":"2011","journal-title":"Parasite"},{"key":"D0DT01935F-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-16154-2","volume":"7","author":"Kondratskyi","year":"2017","journal-title":"Sci. Rep."},{"key":"D0DT01935F-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4400","DOI":"10.1073\/pnas.1015762108","volume":"108","author":"Charman","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D0DT01935F-(cit28)\/*[position()=1]","unstructured":"To Evaluate the Efficacy of a Single Dose Regimen of Ferroquine and Artefenomel in Adults and Children With Uncomplicated Plasmodium Falciparum Malaria (FALCI),  https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02497612"},{"key":"D0DT01935F-(cit29)\/*[position()=1]","doi-asserted-by":"publisher","author":"Ong","journal-title":"Drug Discovery Today: Technol.","DOI":"10.1016\/j.ddtec.2019.06.001"},{"key":"D0DT01935F-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.jinorgbio.2018.11.018","volume":"191","author":"Stringer","year":"2019","journal-title":"J. Inorg. Biochem."},{"key":"D0DT01935F-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ejmech.2018.10.019","volume":"161","author":"Rylands","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"D0DT01935F-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3905","DOI":"10.1039\/C5DT03739E","volume":"45","author":"Ekengard","year":"2016","journal-title":"Dalton Trans."},{"key":"D0DT01935F-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1021\/acs.chemrev.8b00493","volume":"119","author":"Soldevila-Barreda","year":"2019","journal-title":"Chem. Rev."},{"key":"D0DT01935F-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1039\/C2CC37832A","volume":"49","author":"Sasmal","year":"2013","journal-title":"Chem. Commun."},{"key":"D0DT01935F-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4540","DOI":"10.1021\/cr400460s","volume":"114","author":"Mjos","year":"2014","journal-title":"Chem. Rev."},{"key":"D0DT01935F-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"14113","DOI":"10.1002\/chem.201701714","volume":"23","author":"Yu","year":"2017","journal-title":"Chem. \u2013 Eur. J."},{"key":"D0DT01935F-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3897","DOI":"10.1002\/anie.201108175","volume":"51","author":"Betanzos-Lara","year":"2012","journal-title":"Angew. Chem., Int. Ed."},{"key":"D0DT01935F-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5958","DOI":"10.1021\/om3006307","volume":"31","author":"Soldevila-Barreda","year":"2012","journal-title":"Organometallics"},{"key":"D0DT01935F-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6582","DOI":"10.1038\/ncomms7582","volume":"6","author":"Soldevila-Barreda","year":"2015","journal-title":"Nat. Commun."},{"key":"D0DT01935F-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"13143","DOI":"10.1039\/C9DT02030F","volume":"48","author":"Stringer","year":"2019","journal-title":"Dalton Trans."},{"key":"D0DT01935F-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1021\/ja0471525","volume":"127","author":"Himo","year":"2005","journal-title":"J. Am. Chem. Soc."},{"key":"D0DT01935F-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1002\/1521-3773(20020715)41:14<2596::AID-ANIE2596>3.0.CO;2-4","volume":"41","author":"Rostovtsev","year":"2002","journal-title":"Angew. Chem., Int. Ed."},{"key":"D0DT01935F-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4132","DOI":"10.1039\/B303737A","volume":"2","author":"Davies","year":"2003","journal-title":"Dalton Trans."},{"key":"D0DT01935F-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1021\/jm2000932","volume":"54","author":"Liu","year":"2011","journal-title":"J. Med. Chem."},{"key":"D0DT01935F-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2880","DOI":"10.1021\/acs.organomet.8b00402","volume":"37","author":"Du","year":"2018","journal-title":"Organometallics"},{"key":"D0DT01935F-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1002\/(SICI)1099-0682(199903)1999:3<471::AID-EJIC471>3.0.CO;2-H","volume":"1999","author":"Hubel","year":"1999","journal-title":"Eur. J. Inorg. Chem."},{"key":"D0DT01935F-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.4155\/fmc.11.91","volume":"3","author":"Burrows","year":"2011","journal-title":"Future Med. Chem."},{"key":"D0DT01935F-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1186\/1475-2875-12-187","volume":"12","author":"Burrows","year":"2013","journal-title":"Malar. J."},{"key":"D0DT01935F-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1186\/1475-2875-12-424","volume":"12","author":"Le Manach","year":"2013","journal-title":"Malar. J."},{"key":"D0DT01935F-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.1128\/AAC.00121-11","volume":"55","author":"Sandlin","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"D0DT01935F-(cit51)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.ab.2004.11.022","volume":"338","author":"Ncokazi","year":"2005","journal-title":"Anal. Biochem."},{"key":"D0DT01935F-(cit52)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s00775-006-0098-5","volume":"11","author":"Yan","year":"2006","journal-title":"J. Biol. Inorg. Chem."},{"key":"D0DT01935F-(cit53)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5970","DOI":"10.1021\/ja01050a008","volume":"91","author":"Kang","year":"1969","journal-title":"J. Am. Chem. Soc."},{"key":"D0DT01935F-(cit56)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S1472-7862(02)00030-8","volume":"1","author":"Barbour","year":"2001","journal-title":"J. Supramol. Chem."},{"key":"D0DT01935F-(cit57)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1021\/cg020063o","volume":"3","author":"Atwood","year":"2003","journal-title":"Cryst. Growth Des."},{"key":"D0DT01935F-(cit58)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1126\/science.781840","volume":"193","author":"Trager","year":"1976","journal-title":"Science"},{"key":"D0DT01935F-(cit59)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"205","DOI":"10.4269\/ajtmh.1993.48.205","volume":"48","author":"Makler","year":"1993","journal-title":"Am. J. Trop. Med. Hyg."}],"container-title":["Dalton Transactions"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2020\/DT\/D0DT01935F","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:43:11Z","timestamp":1783014191000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/dt\/article\/49\/33\/11543-11555\/684000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":57,"journal-issue":{"issue":"33","published-print":{"date-parts":[[2020,8,25]]}},"URL":"https:\/\/doi.org\/10.1039\/d0dt01935f","relation":{},"ISSN":["1477-9226","1477-9234"],"issn-type":[{"value":"1477-9226","type":"print"},{"value":"1477-9234","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/D0DT01935F","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Crystal Structure Data","URL":"http:\/\/xlink.rsc.org?ccdc=true&msid=D0DT01935F","name":"related_data"},{"value":"Christopher B. Barnett (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-1467-5741","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Ebbe Nordlander (ORCID)","URL":"http:\/\/orcid.org\/0000-0001-9575-4929","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Gregory S. Smith (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-2892-5481","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 29 May 2020; Accepted 15 July 2020;  Accepted Manuscript published 16 July 2020;  Advance Article published 22 July 2020;  Version of Record published 25 August 2020","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}