{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T07:05:20Z","timestamp":1782889520709,"version":"3.54.5"},"reference-count":58,"publisher":"Royal Society of Chemistry (RSC)","issue":"6","license":[{"start":{"date-parts":[[2021,5,29]],"date-time":"2021-05-29T00:00:00Z","timestamp":1622246400000},"content-version":"am","delay-in-days":514,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81601983"],"award-info":[{"award-number":["81601983"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007194","name":"Wenzhou Municipal Science and Technology Bureau","doi-asserted-by":"crossref","award":["Y20180322"],"award-info":[{"award-number":["Y20180322"]}],"id":[{"id":"10.13039\/501100007194","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<p>Obesity is related to osteoarthritis (OA).<\/p>","DOI":"10.1039\/d0fo00571a","type":"journal-article","created":{"date-parts":[[2020,5,29]],"date-time":"2020-05-29T07:43:41Z","timestamp":1590738221000},"page":"5513-5524","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Asiatic acid ameliorates obesity-related osteoarthritis by inhibiting myeloid differentiation protein-2"],"prefix":"10.1039","volume":"11","author":[{"given":"Xingfang","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery"},{"name":"The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University"},{"name":"325027 Wenzhou"},{"name":"China"},{"name":"The Second School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery"},{"name":"The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University"},{"name":"325027 Wenzhou"},{"name":"China"},{"name":"The Second School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhichao","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery"},{"name":"The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University"},{"name":"325027 Wenzhou"},{"name":"China"},{"name":"The Second School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangkun","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery"},{"name":"The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University"},{"name":"325027 Wenzhou"},{"name":"China"},{"name":"The Second School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7077-5333","authenticated-orcid":false,"given":"Jianchen","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery"},{"name":"The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University"},{"name":"325027 Wenzhou"},{"name":"China"},{"name":"The Second School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation"},{"name":"The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University"},{"name":"325027 Wenzhou"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery"},{"name":"Shanghai Jiao Tong University Affiliated Sixth People's Hospital"},{"name":"Shanghai 200233"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0994-2005","authenticated-orcid":false,"given":"Haixiao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery"},{"name":"The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University"},{"name":"325027 Wenzhou"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2020]]},"reference":[{"key":"D0FO00571A-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1016\/S0140-6736(18)31064-X","volume":"391","author":"Barnett","year":"2018","journal-title":"Lancet"},{"key":"D0FO00571A-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1016\/j.joca.2011.08.004","volume":"19","author":"Guillemin","year":"2011","journal-title":"Osteoarthritis Cartilage"},{"key":"D0FO00571A-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.joca.2017.09.009","volume":"26","author":"Peffers","year":"2018","journal-title":"Osteoarthritis Cartilage"},{"key":"D0FO00571A-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.joca.2005.04.014","volume":"13","author":"Srikanth","year":"2005","journal-title":"Osteoarthritis Cartilage"},{"key":"D0FO00571A-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/nrrheum.2011.107","volume":"7","author":"Gomez","year":"2011","journal-title":"Nat. Rev. Rheumatol."},{"key":"D0FO00571A-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.maturitas.2016.04.006","volume":"89","author":"Kulkarni","year":"2016","journal-title":"Maturitas"},{"key":"D0FO00571A-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1093\/rheumatology\/keu464","volume":"54","author":"Thijssen","year":"2015","journal-title":"Rheumatology"},{"key":"D0FO00571A-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"S143","DOI":"10.1016\/j.joca.2014.02.266","volume":"22","author":"Alvarez-Garcia","year":"2014","journal-title":"Osteoarthritis Cartilage"},{"key":"D0FO00571A-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.joca.2015.11.020","volume":"24","author":"Haywood","year":"2016","journal-title":"Osteoarthritis Cartilage"},{"key":"D0FO00571A-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1016\/j.joca.2017.05.011","volume":"25","author":"Nazli","year":"2017","journal-title":"Osteoarthritis Cartilage"},{"key":"D0FO00571A-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8909","DOI":"10.1021\/ac301853q","volume":"84","author":"Cillero-Pastor","year":"2012","journal-title":"Anal. Chem."},{"key":"D0FO00571A-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"20793","DOI":"10.3390\/ijms141020793","volume":"14","author":"Villalvilla","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"D0FO00571A-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"S145","DOI":"10.1016\/j.pmrj.2012.02.022","volume":"4","author":"Lopez","year":"2012","journal-title":"PM R"},{"key":"D0FO00571A-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/35100529","volume":"1","author":"Medzhitov","year":"2001","journal-title":"Nat. Rev. Immunol."},{"key":"D0FO00571A-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nrrheum.2014.209","volume":"11","author":"Gomez","year":"2015","journal-title":"Nat. Rev. Rheumatol."},{"key":"D0FO00571A-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1159\/000447798","volume":"39","author":"Sindhu","year":"2016","journal-title":"Cell. Physiol. Biochem."},{"key":"D0FO00571A-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e0176793","DOI":"10.1371\/journal.pone.0176793","volume":"12","author":"Nicholas","year":"2017","journal-title":"PLoS One"},{"key":"D0FO00571A-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1007\/s00109-004-0555-y","volume":"82","author":"Kumar","year":"2004","journal-title":"J. Mol. Med."},{"key":"D0FO00571A-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.3390\/molecules16021310","volume":"16","author":"Hashim","year":"2011","journal-title":"Molecules"},{"key":"D0FO00571A-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1039\/C4FO00862F","volume":"6","author":"Chao","year":"2015","journal-title":"Food Funct."},{"key":"D0FO00571A-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1039\/C6FO00041J","volume":"7","author":"Chao","year":"2016","journal-title":"Food Funct."},{"key":"D0FO00571A-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.cbi.2017.10.024","volume":"278","author":"Siddique","year":"2017","journal-title":"Chem.-Biol. Interact."},{"key":"D0FO00571A-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1046\/j.1529-8019.2003.01618.x","volume":"16","author":"Dattner","year":"2003","journal-title":"Dermatol. Ther."},{"key":"D0FO00571A-(cit24)\/*[position()=1]","first-page":"179","volume":"10","author":"Chen","year":"2017","journal-title":"Int. J. Ophthalmol."},{"key":"D0FO00571A-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1186\/s12974-017-1009-0","volume":"14","author":"Park","year":"2017","journal-title":"J. Neuroinflammation"},{"key":"D0FO00571A-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"785","DOI":"10.3389\/fimmu.2017.00785","volume":"8","author":"Lv","year":"2017","journal-title":"Front. Immunol."},{"key":"D0FO00571A-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1007\/s10753-016-0398-z","volume":"39","author":"Li","year":"2016","journal-title":"Inflammation"},{"key":"D0FO00571A-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jep.2015.04.050","volume":"171","author":"Chen","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"D0FO00571A-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1001\/jama.2013.281053","volume":"310","author":"World Medical","year":"2013","journal-title":"J. Am. Med. Assoc."},{"key":"D0FO00571A-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.joca.2007.07.009","volume":"15","author":"Au","year":"2007","journal-title":"Osteoarthritis Cartilage"},{"issue":"Suppl 3","key":"D0FO00571A-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1016\/j.joca.2010.05.025","volume":"18","author":"Glasson","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"key":"D0FO00571A-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.mcna.2008.09.006","volume":"93","author":"Goldring","year":"2009","journal-title":"Med. Clin. North Am."},{"key":"D0FO00571A-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1186\/s12917-015-0458-x","volume":"11","author":"Permuy","year":"2015","journal-title":"BMC Vet. Res."},{"key":"D0FO00571A-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.joca.2011.04.011","volume":"19","author":"Lewis","year":"2011","journal-title":"Osteoarthritis Cartilage"},{"key":"D0FO00571A-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/art.33332","volume":"64","author":"Griffin","year":"2012","journal-title":"Arthritis Rheum."},{"key":"D0FO00571A-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/00001648-199903000-00013","volume":"10","author":"Oliveria","year":"1999","journal-title":"Epidemiology"},{"key":"D0FO00571A-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S0950-3579(97)80003-9","volume":"11","author":"Felson","year":"1997","journal-title":"Baillieres Clin. Rheumatol."},{"key":"D0FO00571A-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/1471-2474-9-132","volume":"9","author":"Grotle","year":"2008","journal-title":"BMC Musculoskelet. Disord."},{"key":"D0FO00571A-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s00296-009-0920-9","volume":"30","author":"Kalichman","year":"2009","journal-title":"Rheumatol. Int."},{"key":"D0FO00571A-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s10266-005-0056-7","volume":"93","author":"Milam","year":"2005","journal-title":"Odontology"},{"key":"D0FO00571A-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1186\/ar4422","volume":"15","author":"Ioan-Facsinay","year":"2013","journal-title":"Arthritis Res. Ther."},{"issue":"Suppl 42","key":"D0FO00571A-(cit42)\/*[position()=1]","first-page":"46","volume":"95","author":"de Graaf","year":"2002","journal-title":"J. Royal Soc. Med."},{"key":"D0FO00571A-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1136\/annrheumdis-2013-203755","volume":"74","author":"Frommer","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"D0FO00571A-(cit44)\/*[position()=1]","first-page":"7659023","volume":"2017","author":"Jiang","year":"2017","journal-title":"Mediators Inflamm."},{"key":"D0FO00571A-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.coph.2007.03.002","volume":"7","author":"Khanna","year":"2007","journal-title":"Curr. Opin. Pharmacol."},{"key":"D0FO00571A-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/art.33332","volume":"64","author":"Griffin","year":"2012","journal-title":"Arthritis Rheum."},{"key":"D0FO00571A-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.joca.2018.03.002","volume":"26","author":"Zhang","year":"2018","journal-title":"Osteoarthritis Cartilage"},{"key":"D0FO00571A-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1080\/03008207.2019.1601187","volume":"60","author":"Xu","year":"2019","journal-title":"Connect. Tissue Res."},{"key":"D0FO00571A-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1002\/art.38399","volume":"66","author":"Alvarez-Garcia","year":"2014","journal-title":"Arthritis Rheum."},{"key":"D0FO00571A-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e00204","DOI":"10.1042\/BSR20150071","volume":"35","author":"Xie","year":"2015","journal-title":"Biosci. Rep."},{"key":"D0FO00571A-(cit51)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1016\/j.biocel.2013.08.018","volume":"45","author":"Rigoglou","year":"2013","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"D0FO00571A-(cit52)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e000061","DOI":"10.1136\/rmdopen-2015-000061","volume":"1","author":"Eleonora Olivotto","year":"2015","journal-title":"RMD Open"},{"key":"D0FO00571A-(cit53)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1093\/oxfordjournals.jbchem.a021955","volume":"123","author":"Sasaki","year":"1998","journal-title":"J. Biochem."},{"key":"D0FO00571A-(cit54)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1002\/art.10356","volume":"46","author":"Hardy","year":"2002","journal-title":"Arthritis Rheum."},{"key":"D0FO00571A-(cit55)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1038\/nature07830","volume":"458","author":"Park","year":"2009","journal-title":"Nature"},{"key":"D0FO00571A-(cit56)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.joca.2018.03.002","volume":"26","author":"Zhang","year":"2018","journal-title":"Osteoarthritis Cartilage"},{"key":"D0FO00571A-(cit57)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","volume":"22","author":"Reagan-Shaw","year":"2008","journal-title":"FASEB J."},{"key":"D0FO00571A-(cit58)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1080\/00498254.2016.1273562","volume":"48","author":"Hengjumrut","year":"2018","journal-title":"Xenobiotica"}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2020\/FO\/D0FO00571A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:29:35Z","timestamp":1782883775000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/11\/6\/5513-5524\/686723"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":58,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6,24]]}},"URL":"https:\/\/doi.org\/10.1039\/d0fo00571a","relation":{},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/D0FO00571A","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Jianchen Xu (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-7077-5333","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Haixiao Liu (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-0994-2005","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 4 March 2020; Accepted 22 May 2020;  Accepted Manuscript published 29 May 2020;  Advance Article published 9 June 2020;  Version of Record published 24 June 2020","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}