{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:02:03Z","timestamp":1791201723490,"version":"4.2.0"},"reference-count":29,"publisher":"Royal Society of Chemistry (RSC)","issue":"11","license":[{"start":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T00:00:00Z","timestamp":1632268800000},"content-version":"am","delay-in-days":630,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/100009666","name":"Salt Science Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100009666","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<p>\n                    Orally administered KFWGK exhibits potent and long-lasting antihypertensive effects in SHR with advanced hypertension, at which known hypotensive drugs are sometimes less effective. The minimum effective dose of KFWGK was 5\u00a0\u03bcg kg\n                    <sup>\u22121<\/sup>\n                    .\n                  <\/p>","DOI":"10.1039\/d0fo01122c","type":"journal-article","created":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T07:00:56Z","timestamp":1600758056000},"page":"9489-9494","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["A milk-derived pentapeptide reduces blood pressure in advanced hypertension in a CCK system-dependent manner"],"prefix":"10.1039","volume":"11","author":[{"given":"Daiki","family":"Koyama","sequence":"first","affiliation":[{"name":"Division of Food Science and Biotechnology"},{"name":"Graduate School of Agriculture"},{"name":"Kyoto University"},{"name":"Kyoto 611-0011"},{"name":"Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Sasai","sequence":"additional","affiliation":[{"name":"Division of Food Science and Biotechnology"},{"name":"Graduate School of Agriculture"},{"name":"Kyoto University"},{"name":"Kyoto 611-0011"},{"name":"Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigenobu","family":"Matsumura","sequence":"additional","affiliation":[{"name":"Division of Food Science and Biotechnology"},{"name":"Graduate School of Agriculture"},{"name":"Kyoto University"},{"name":"Kyoto 611-0011"},{"name":"Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Inoue","sequence":"additional","affiliation":[{"name":"Division of Food Science and Biotechnology"},{"name":"Graduate School of Agriculture"},{"name":"Kyoto University"},{"name":"Kyoto 611-0011"},{"name":"Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9944-8635","authenticated-orcid":false,"given":"Kousaku","family":"Ohinata","sequence":"additional","affiliation":[{"name":"Division of Food Science and Biotechnology"},{"name":"Graduate School of Agriculture"},{"name":"Kyoto University"},{"name":"Kyoto 611-0011"},{"name":"Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2020]]},"reference":[{"issue":"16","key":"D0FO01122C-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1002\/1873-3468.12306","volume":"590","author":"Nakato","year":"2016","journal-title":"FEBS Lett."},{"issue":"14","key":"D0FO01122C-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1002\/1873-3468.12731","volume":"591","author":"Aoki","year":"2017","journal-title":"FEBS Lett."},{"issue":"4","key":"D0FO01122C-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/j.bbrc.2018.09.195","volume":"505","author":"Kimura","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"2","key":"D0FO01122C-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1096\/fj.201700333RR","volume":"32","author":"Mori","year":"2018","journal-title":"FASEB J."},{"issue":"1","key":"D0FO01122C-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1161\/HYPERTENSIONAHA.115.05236","volume":"66","author":"Hashimoto","year":"2015","journal-title":"Hypertension"},{"issue":"6","key":"D0FO01122C-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1161\/CIRCRESAHA.116.303697","volume":"116","author":"McMaster","year":"2015","journal-title":"Circ. Res."},{"issue":"4","key":"D0FO01122C-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1161\/HYPERTENSIONAHA.115.05463","volume":"66","author":"Corrao","year":"2015","journal-title":"Hypertension"},{"issue":"2","key":"D0FO01122C-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1161\/HYPERTENSIONAHA.114.03617","volume":"65","author":"Sun","year":"2015","journal-title":"Hypertension"},{"issue":"9","key":"D0FO01122C-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1002\/mnfr.201200168","volume":"56","author":"Kagebayashi","year":"2012","journal-title":"Mol. Nutr. Food Res."},{"issue":"2","key":"D0FO01122C-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1002\/mnfr.201300334","volume":"58","author":"Kontani","year":"2014","journal-title":"Mol. Nutr. Food Res."},{"issue":"2","key":"D0FO01122C-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/j.bbrc.2018.06.118","volume":"503","author":"Sasai","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"5","key":"D0FO01122C-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1021\/acs.jafc.8b06341","volume":"67","author":"Shobako","year":"2019","journal-title":"J. Agric. Food Chem."},{"issue":"6","key":"D0FO01122C-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1007\/s00253-019-09633-1","volume":"103","author":"Morales-Camacho","year":"2019","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"D0FO01122C-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.peptides.2015.07.013","volume":"72","author":"Yoshikawa","year":"2015","journal-title":"Peptides"},{"issue":"5","key":"D0FO01122C-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.peptides.2010.02.013","volume":"31","author":"Yamada","year":"2010","journal-title":"Peptides"},{"issue":"21","key":"D0FO01122C-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9492","DOI":"10.18632\/aging.102400","volume":"11","author":"Koyama","year":"2019","journal-title":"Aging"},{"issue":"5424","key":"D0FO01122C-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/245323a0","volume":"245","author":"Gibbs","year":"1973","journal-title":"Nature"},{"issue":"3","key":"D0FO01122C-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.regpep.2006.06.006","volume":"137","author":"Ruiz-Gayo","year":"2006","journal-title":"Regul. Pept."},{"issue":"1","key":"D0FO01122C-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.brainresrev.2008.07.002","volume":"59","author":"Sartor","year":"2008","journal-title":"Brain Res. Rev."},{"issue":"2 Pt 1","key":"D0FO01122C-(cit20)\/*[position()=1]","first-page":"G250","volume":"249","author":"Premen","year":"1985","journal-title":"Am. J. Physiol."},{"issue":"2","key":"D0FO01122C-(cit21)\/*[position()=1]","first-page":"H103","volume":"232","author":"Chou","year":"1977","journal-title":"Am. J. Physiol."},{"issue":"5","key":"D0FO01122C-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1152\/ajplegacy.1975.229.5.1365","volume":"229","author":"Fara","year":"1975","journal-title":"Am. J. Physiol."},{"issue":"5","key":"D0FO01122C-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1152\/ajplegacy.1972.223.5.1058","volume":"223","author":"Fara","year":"1972","journal-title":"Am. J. Physiol."},{"issue":"1","key":"D0FO01122C-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1476-5381.1991.tb12143.x","volume":"102","author":"Janssen","year":"1991","journal-title":"Br. J. Pharmacol."},{"issue":"2","key":"D0FO01122C-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/sj.bjp.0705245","volume":"139","author":"Saita","year":"2003","journal-title":"Br. J. Pharmacol."},{"key":"D0FO01122C-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.foodchem.2016.01.107","volume":"202","author":"Arrutia","year":"2016","journal-title":"Food Chem."},{"key":"D0FO01122C-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1146\/annurev-food-022814-015520","volume":"6","author":"Aluko","year":"2015","journal-title":"Annu. Rev. Food Sci. Technol."},{"issue":"1","key":"D0FO01122C-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0016-5085(76)80117-5","volume":"71","author":"Mathews","year":"1976","journal-title":"Gastroenterology"},{"issue":"2\u20133","key":"D0FO01122C-(cit29)\/*[position()=1]","first-page":"235","volume":"27","author":"Borchardt","year":"1997","journal-title":"Adv. Drug Delivery Rev."}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2020\/FO\/D0FO01122C","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T20:11:35Z","timestamp":1782850295000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/11\/11\/9489-9494\/686856"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":29,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11,18]]}},"URL":"https:\/\/doi.org\/10.1039\/d0fo01122c","relation":{},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/D0FO01122C","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Kousaku Ohinata (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-9944-8635","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 30 April 2020; Accepted 18 September 2020; Accepted Manuscript published 22 September 2020; Advance Article published 16 October 2020; Version of Record published 18 November 2020","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}