{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:09:19Z","timestamp":1791461359304,"version":"4.3.4"},"reference-count":51,"publisher":"Royal Society of Chemistry (RSC)","issue":"5","license":[{"start":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T00:00:00Z","timestamp":1642464000000},"content-version":"am","delay-in-days":382,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81771624"],"award-info":[{"award-number":["81771624"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100011930","name":"Beijing Medical and Health Foundation","doi-asserted-by":"crossref","award":["B17137"],"award-info":[{"award-number":["B17137"]}],"id":[{"id":"10.13039\/501100011930","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007194","name":"Wenzhou Municipal Science and Technology Bureau","doi-asserted-by":"crossref","award":["Y20190001"],"award-info":[{"award-number":["Y20190001"]}],"id":[{"id":"10.13039\/501100007194","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<p>Neonatal hypoxic-ischemic (HI) brain injury can lead to mortality and severe long-term disabilities including cerebral palsy and brain injury.<\/p>","DOI":"10.1039\/d0fo02555k","type":"journal-article","created":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T10:57:09Z","timestamp":1610967429000},"page":"2270-2281","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Neuroprotective effect of apigenin against hypoxic-ischemic brain injury in neonatal rats\n                    <i>via<\/i>\n                    activation of the PI3K\/Akt\/Nrf2 signaling pathway"],"prefix":"10.1039","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4766-8879","authenticated-orcid":false,"given":"Changchang","family":"Fu","sequence":"first","affiliation":[{"name":"Department of Neonatology"},{"name":"The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University"},{"name":"Wenzhou"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihui","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Neonatology"},{"name":"The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University"},{"name":"Wenzhou"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Lin","sequence":"additional","affiliation":[{"name":"The University of Illinois at Chicago"},{"name":"College of Pharmacy"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongzeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neonatology"},{"name":"The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University"},{"name":"Wenzhou"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neonatology"},{"name":"The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University"},{"name":"Wenzhou"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neonatology"},{"name":"The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University"},{"name":"Wenzhou"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neonatology"},{"name":"The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University"},{"name":"Wenzhou"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Lin","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University"},{"name":"Wenzhou"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianghu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Neonatology"},{"name":"The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University"},{"name":"Wenzhou"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peijun","family":"Li","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University"},{"name":"Wenzhou"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqin","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Neonatology"},{"name":"The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University"},{"name":"Wenzhou"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenlang","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neonatology"},{"name":"The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University"},{"name":"Wenzhou"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2021]]},"reference":[{"key":"D0FO02555K-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.jpeds.2014.01.028","volume":"164","author":"Hochwald","year":"2014","journal-title":"J. Pediatr."},{"key":"D0FO02555K-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1001\/jamapediatrics.2014.3269","volume":"169","author":"Martha","year":"2015","journal-title":"JAMA Pediatr."},{"key":"D0FO02555K-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.2174\/1381612820999141029162457","volume":"21","author":"Zalewska","year":"2015","journal-title":"Curr. Pharm. Des."},{"key":"D0FO02555K-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/sj.jp.7211412","volume":"26","author":"Lin","year":"2006","journal-title":"J. Perinatol."},{"key":"D0FO02555K-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1001\/jamapediatrics.2019.4011","volume":"174","author":"Finder","year":"2019","journal-title":"JAMA Pediatr."},{"key":"D0FO02555K-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1001\/archpediatrics.2011.1772","volume":"166","author":"Tagin","year":"2012","journal-title":"Arch. Pediatr. Adolesc. Med."},{"key":"D0FO02555K-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/j.clinthera.2006.09.005","volume":"28","author":"Perlman","year":"2006","journal-title":"Clin. Ther."},{"key":"D0FO02555K-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1523\/JNEUROSCI.4043-13.2014","volume":"34","author":"Zhang","year":"2014","journal-title":"J. Neurosci."},{"key":"D0FO02555K-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1007\/s11064-014-1384-1","volume":"39","author":"Guo","year":"2014","journal-title":"Neurochem. Res."},{"key":"D0FO02555K-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.brainres.2010.04.036","volume":"1343","author":"Ping","year":"2010","journal-title":"Brain Res."},{"key":"D0FO02555K-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.freeradbiomed.2019.04.028","volume":"142","author":"Solev\u00e5g","year":"2019","journal-title":"Free Radicals Biol. Med."},{"key":"D0FO02555K-(cit12)\/*[position()=1]","first-page":"10","volume":"30","author":"Ginwala","year":"2020","journal-title":"J. Neuroimmune Pharmacol."},{"key":"D0FO02555K-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"514","DOI":"10.3389\/fphar.2020.00514","volume":"11","author":"Zhao","year":"2020","journal-title":"Front. Pharmacol."},{"key":"D0FO02555K-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"104585","DOI":"10.1016\/j.pestbp.2020.104585","volume":"167","author":"Jahedsani","year":"2020","journal-title":"Pestic. Biochem. Physiol."},{"key":"D0FO02555K-(cit15)\/*[position()=1]","first-page":"9420704","volume":"2020","author":"Zhang","year":"2020","journal-title":"Oxid. Med. Cell. Longevity"},{"key":"D0FO02555K-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"116623","DOI":"10.1016\/j.lfs.2019.116623","volume":"232","author":"Zare","year":"2019","journal-title":"Life Sci."},{"key":"D0FO02555K-(cit17)\/*[position()=1]","first-page":"955","volume":"2","author":"Taniguchi","year":"2008","journal-title":"J. Visualized Exp."},{"key":"D0FO02555K-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"15988","DOI":"10.1074\/jbc.M112.428789","volume":"288","author":"Tian","year":"2013","journal-title":"J. Biol. Chem."},{"key":"D0FO02555K-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1016\/j.jstrokecerebrovasdis.2017.06.018","volume":"26","author":"Liang","year":"2017","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"D0FO02555K-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.neuropharm.2015.07.007","volume":"99","author":"Min","year":"2015","journal-title":"Neuropharmacology"},{"key":"D0FO02555K-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1177\/0271678X18785480","volume":"39","author":"Zhang","year":"2019","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"D0FO02555K-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.expneurol.2019.02.013","volume":"317","author":"Ye","year":"2019","journal-title":"Exp. Neurol."},{"key":"D0FO02555K-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.2174\/1381612820999141029162457","volume":"21","author":"Zalewska","year":"2015","journal-title":"Curr. Pharm. Des."},{"key":"D0FO02555K-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1056\/NEJMoa0900854","volume":"361","author":"Azzopardi","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"D0FO02555K-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"S78","DOI":"10.1016\/j.jped.2015.07.004","volume":"91","author":"Silveira","year":"2015","journal-title":"J. Pediatr."},{"key":"D0FO02555K-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/S1474-4422(11)70016-3","volume":"10","author":"Johnston","year":"2011","journal-title":"Lancet Neurol."},{"key":"D0FO02555K-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1002\/ana.22419","volume":"69","author":"Northington","year":"2011","journal-title":"Ann. Neurol."},{"key":"D0FO02555K-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3402","DOI":"10.1111\/j.1460-9568.2007.05948.x","volume":"26","author":"Zhu","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"D0FO02555K-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1007\/s10571-019-00691-7","volume":"37","author":"Tu","year":"2019","journal-title":"Cell. Mol. Neurobiol."},{"key":"D0FO02555K-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/s41419-020-2280-z","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis."},{"key":"D0FO02555K-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.neuint.2013.03.004","volume":"62","author":"Liu","year":"2013","journal-title":"Neurochem. Int."},{"key":"D0FO02555K-(cit32)\/*[position()=1]","first-page":"4901014","author":"Eridan","year":"2016","journal-title":"Neural Plast."},{"key":"D0FO02555K-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1242\/jeb.01022","volume":"207","author":"Warner","year":"2004","journal-title":"J. Exp. Biol."},{"key":"D0FO02555K-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1159\/000046143","volume":"23","author":"Ferriero","year":"2001","journal-title":"Dev. Neurosci."},{"key":"D0FO02555K-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/bpa.12272","volume":"26","author":"Revuelta","year":"2016","journal-title":"Brain Pathol."},{"key":"D0FO02555K-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.2310\/JIM.0b013e3182a07921","volume":"61","author":"Burchell","year":"2013","journal-title":"J. Invest. Med."},{"key":"D0FO02555K-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.taap.2011.08.027","volume":"257","author":"Chang","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"D0FO02555K-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"S2291","DOI":"10.3109\/14767058.2013.796170","volume":"28","author":"Perrone","year":"2015","journal-title":"J. Matern.-Fetal Neonat. Med."},{"key":"D0FO02555K-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/s41390-019-0639-6","volume":"87","author":"Martini","year":"2020","journal-title":"Pediatr. Res."},{"key":"D0FO02555K-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11196","DOI":"10.3390\/molecules190811196","volume":"19","author":"Huang","year":"2014","journal-title":"Molecules"},{"key":"D0FO02555K-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.bbrc.2006.10.102","volume":"351","author":"Thimmulappa","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"D0FO02555K-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1007\/s11064-018-2538-3","volume":"43","author":"Tu","year":"2018","journal-title":"Neurochem. Res."},{"key":"D0FO02555K-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e22548","DOI":"10.1002\/jbt.22548","author":"Liu","year":"2020","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"D0FO02555K-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"16502","DOI":"10.1074\/jbc.M611336200","volume":"282","author":"Jain","year":"2007","journal-title":"J. Biol. Chem."},{"key":"D0FO02555K-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/s12974-019-1559-4","volume":"16","author":"Doycheva","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"D0FO02555K-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"454","DOI":"10.3109\/10715762.2015.1136411","volume":"50","author":"Zhai","year":"2016","journal-title":"Free Radical Res."},{"key":"D0FO02555K-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"108942","DOI":"10.1016\/j.cbi.2020.108942","volume":"317","author":"He","year":"2020","journal-title":"Chem.-Biol. Interact."},{"key":"D0FO02555K-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.pestbp.2019.06.010","volume":"159","author":"Ahmad","year":"2019","journal-title":"Pestic. Biochem. Physiol."},{"key":"D0FO02555K-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"105697","DOI":"10.1016\/j.intimp.2019.105697","volume":"75","author":"Zhao","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"D0FO02555K-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s12192-020-01071-7","volume":"25","author":"Zhang","year":"2020","journal-title":"Cell Stress Chaperones"},{"key":"D0FO02555K-(cit51)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5280","DOI":"10.12659\/MSM.915038","volume":"25","author":"Zhang","year":"2019","journal-title":"Med. Sci. Monit."}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2021\/FO\/D0FO02555K","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:02:13Z","timestamp":1782882133000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/12\/5\/2270-2281\/687236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":51,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,3,15]]}},"URL":"https:\/\/doi.org\/10.1039\/d0fo02555k","relation":{},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Changchang Fu (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-4766-8879","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 27 September 2020; Accepted 8 January 2021; Accepted Manuscript published 18 January 2021; Advance Article published 18 February 2021; Version of Record published 15 March 2021","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}