{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:49:39Z","timestamp":1790113779224,"version":"4.0.1"},"reference-count":51,"publisher":"Royal Society of Chemistry (RSC)","issue":"12","license":[{"start":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T00:00:00Z","timestamp":1653091200000},"content-version":"am","delay-in-days":505,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100012249","name":"Jiangxi University of Traditional Chinese Medicine","doi-asserted-by":"crossref","award":["202010412226"],"award-info":[{"award-number":["202010412226"]}],"id":[{"id":"10.13039\/501100012249","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<p>\n                    Study of the effects and protective mechanism of\n                    <italic>Eucommia ulmoides<\/italic>\n                    extract on renal injury caused by long-term high purine diets in rats.\n                  <\/p>","DOI":"10.1039\/d0fo02802a","type":"journal-article","created":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T05:33:41Z","timestamp":1621575221000},"page":"5607-5620","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Effects of\n                    <i>Eucommia ulmoides<\/i>\n                    extract against renal injury caused by long-term high purine diets in rats"],"prefix":"10.1039","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2834-3748","authenticated-orcid":false,"given":"An","family":"Li","sequence":"first","affiliation":[{"name":"National Pharmaceutical Engineering Center for Solid Preparation of Chinese Herbal Medicine"},{"name":"Jiangxi University of Traditional Chinese Medicine"},{"name":"Nanchang"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Feng","family":"Yuan","sequence":"additional","affiliation":[{"name":"National Pharmaceutical Engineering Center for Solid Preparation of Chinese Herbal Medicine"},{"name":"Jiangxi University of Traditional Chinese Medicine"},{"name":"Nanchang"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Gong","sequence":"additional","affiliation":[{"name":"National Pharmaceutical Engineering Center for Solid Preparation of Chinese Herbal Medicine"},{"name":"Jiangxi University of Traditional Chinese Medicine"},{"name":"Nanchang"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ni","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy"},{"name":"Jiangxi University of Traditional Chinese Medicine"},{"name":"Nanchang"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan-Ying","family":"Chen","sequence":"additional","affiliation":[{"name":"National Pharmaceutical Engineering Center for Solid Preparation of Chinese Herbal Medicine"},{"name":"Jiangxi University of Traditional Chinese Medicine"},{"name":"Nanchang"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Ying","family":"Luo","sequence":"additional","affiliation":[{"name":"National Pharmaceutical Engineering Center for Solid Preparation of Chinese Herbal Medicine"},{"name":"Jiangxi University of Traditional Chinese Medicine"},{"name":"Nanchang"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Ru","family":"Cui","sequence":"additional","affiliation":[{"name":"National Pharmaceutical Engineering Center for Solid Preparation of Chinese Herbal Medicine"},{"name":"Jiangxi University of Traditional Chinese Medicine"},{"name":"Nanchang"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Ling","family":"Wang","sequence":"additional","affiliation":[{"name":"National Pharmaceutical Engineering Center for Solid Preparation of Chinese Herbal Medicine"},{"name":"Jiangxi University of Traditional Chinese Medicine"},{"name":"Nanchang"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong-Hua","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmacy"},{"name":"Jiangxi University of Traditional Chinese Medicine"},{"name":"Nanchang"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2021]]},"reference":[{"key":"D0FO02802A-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.3390\/nu11081911","volume":"11","author":"Roumeliotis","year":"2019","journal-title":"Nutrients"},{"key":"D0FO02802A-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.3390\/nu11081736","volume":"11","author":"Jakse","year":"2019","journal-title":"Nutrients"},{"key":"D0FO02802A-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.2147\/CIA.S223048","volume":"14","author":"Han","year":"2019","journal-title":"Clin. Interventions Aging"},{"key":"D0FO02802A-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11529","DOI":"10.1038\/s41598-018-29955-w","volume":"8","author":"Cicero","year":"2018","journal-title":"Sci. Rep."},{"key":"D0FO02802A-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1111\/1756-185X.12156","volume":"17","author":"Lu","year":"2014","journal-title":"Int. J. Rheum. Dis."},{"key":"D0FO02802A-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.biopha.2017.06.022","volume":"93","author":"Zhu","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"D0FO02802A-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1093\/ndt\/gft029","volume":"28","author":"Johnson","year":"2013","journal-title":"Nephrol., Dial., Transplant."},{"issue":"1","key":"D0FO02802A-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/nep.13180","volume":"23","author":"Diwan","year":"2017","journal-title":"Nephrology"},{"key":"D0FO02802A-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jff.2017.03.012","volume":"33","author":"Diwan","year":"2017","journal-title":"J. Funct. Foods"},{"key":"D0FO02802A-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/nrneph.2011.149","volume":"7","author":"Liu","year":"2011","journal-title":"Nat. Rev. Nephrol."},{"key":"D0FO02802A-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1159\/000071739","volume":"139","author":"Cochrane","year":"2003","journal-title":"Contrib. Nephrol."},{"key":"D0FO02802A-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1080\/13880209.2019.1568510","volume":"57","author":"Fang","year":"2019","journal-title":"Pharm. Biol."},{"key":"D0FO02802A-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e18318","DOI":"10.1097\/MD.0000000000018318","volume":"98","author":"Ahn","year":"2019","journal-title":"Medicine"},{"key":"D0FO02802A-(cit14)\/*[position()=1]","first-page":"338","volume":"16","author":"Greenway","year":"2011","journal-title":"Altern. Med. Rev."},{"key":"D0FO02802A-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1142\/S0192415X19500137","volume":"47","author":"Wang","year":"2019","journal-title":"Am. J. Chin. Med."},{"key":"D0FO02802A-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5202908","DOI":"10.1155\/2016\/5202908","volume":"2016","author":"Hussain","year":"2016","journal-title":"J. Evidence-Based Complementary Altern. Med."},{"key":"D0FO02802A-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1002\/cbdv.201200401","volume":"10","author":"Nam","year":"2013","journal-title":"Chem. Biodiversity"},{"issue":"3","key":"D0FO02802A-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1089\/jmf.2011.1756","volume":"15","author":"Zhang","year":"2012","journal-title":"J. Med. Food"},{"key":"D0FO02802A-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.vascn.2013.05.006","volume":"68","author":"Diwan","year":"2013","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"D0FO02802A-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2916","DOI":"10.1097\/01.ASN.0000034909.10994.8A","volume":"13","author":"Lin","year":"2002","journal-title":"J. Am. Soc. Nephrol."},{"key":"D0FO02802A-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.1681\/ASN.2005040435","volume":"16","author":"Lin","year":"2005","journal-title":"J. Am. Soc. Nephrol."},{"key":"D0FO02802A-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1159\/000183992","volume":"44","author":"Yokozawa","year":"1986","journal-title":"Nephron"},{"key":"D0FO02802A-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jphs.2020.09.004","volume":"144","author":"Li","year":"2020","journal-title":"J. Pharmacol. Sci."},{"key":"D0FO02802A-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.etp.2010.02.002","volume":"63","author":"Shuvy","year":"2011","journal-title":"Exp. Toxicol. Pathol."},{"key":"D0FO02802A-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s00418-009-0557-5","volume":"131","author":"Tamura","year":"2009","journal-title":"Histochem. Cell Biol."},{"key":"D0FO02802A-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.1007\/s00018-012-0951-3","volume":"69","author":"Li","year":"2012","journal-title":"Cell. Mol. Life Sci."},{"key":"D0FO02802A-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1755-1536-7-15","volume":"7","author":"Li","year":"2014","journal-title":"Fibrogenesis Tissue Repair"},{"key":"D0FO02802A-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1097\/MNH.0b013e3283046507","volume":"17","author":"Ishibe","year":"2008","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"D0FO02802A-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e0162186","DOI":"10.1371\/journal.pone.0162186","volume":"11","author":"Cho","year":"2016","journal-title":"PLoS One"},{"key":"D0FO02802A-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.3892\/mmr.2017.6208","volume":"15","author":"Zheng","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"D0FO02802A-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1038\/ki.2010.88","volume":"77","author":"Garcia-Sanchez","year":"2010","journal-title":"Kidney Int."},{"key":"D0FO02802A-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4615","DOI":"10.1039\/D0FO00711K","volume":"11","author":"Ma","year":"2020","journal-title":"Food Funct."},{"key":"D0FO02802A-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5891","DOI":"10.1039\/C8RA00018B","volume":"8","author":"Feng","year":"2018","journal-title":"RSC Adv."},{"key":"D0FO02802A-(cit34)\/*[position()=1]","first-page":"1","volume":"2017","author":"Chen","year":"2017","journal-title":"Evidence-Based Complementary Altern. Med."},{"key":"D0FO02802A-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.cyto.2017.10.015","volume":"106","author":"Sun","year":"2018","journal-title":"Cytokine"},{"key":"D0FO02802A-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/emmm.200900043","volume":"1","author":"L\u00f3pez-Novoa","year":"2009","journal-title":"EMBO Mol. Med."},{"key":"D0FO02802A-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/nrneph.2009.74","volume":"5","author":"Grande","year":"2009","journal-title":"Nat. Rev. Nephrol."},{"key":"D0FO02802A-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.ASN.0000106015.29070.E7","volume":"15","author":"Liu","year":"2004","journal-title":"J. Am. Soc. Nephrol."},{"key":"D0FO02802A-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.biopha.2017.08.115","volume":"95","author":"Zhang","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"D0FO02802A-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1007\/s00345-009-0399-8","volume":"27","author":"Grande","year":"2009","journal-title":"World J. Urol."},{"key":"D0FO02802A-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/emmm.200900043","volume":"1","author":"Lopez-Novoa","year":"2009","journal-title":"EMBO Mol. Med."},{"key":"D0FO02802A-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"431","DOI":"10.3390\/biomedicines8100431","volume":"8","author":"Cha","year":"2020","journal-title":"Biomedicines"},{"key":"D0FO02802A-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.biopha.2017.06.022","volume":"93","author":"Zhu","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"D0FO02802A-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0002-9440(10)65155-3","volume":"155","author":"Mooney","year":"1999","journal-title":"Am. J. Pathol."},{"key":"D0FO02802A-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.etap.2017.02.012","volume":"50","author":"Lv","year":"2017","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"D0FO02802A-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"110202","DOI":"10.1016\/j.ecoenv.2020.110202","volume":"191","author":"Chen","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"D0FO02802A-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3782","DOI":"10.1039\/C9FO00373H","volume":"10","author":"Liu","year":"2019","journal-title":"Food Funct."},{"key":"D0FO02802A-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s12013-013-9539-2","volume":"67","author":"Wang","year":"2013","journal-title":"Cell Biochem. Biophys."},{"key":"D0FO02802A-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.matbio.2007.11.003","volume":"27","author":"Cortes-Reynosa","year":"2008","journal-title":"Matrix Biol."},{"key":"D0FO02802A-(cit50)\/*[position()=1]","first-page":"e02451","volume":"23","author":"Huang","year":"2020","journal-title":"Clin. Transl. Oncol."},{"key":"D0FO02802A-(cit51)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"154013","DOI":"10.1016\/j.metabol.2019.154013","volume":"103","author":"Xu","year":"2020","journal-title":"Metabolism"}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2021\/FO\/D0FO02802A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:48:11Z","timestamp":1783450091000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/12\/12\/5607-5620\/687312"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":51,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,6,21]]}},"URL":"https:\/\/doi.org\/10.1039\/d0fo02802a","relation":{},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"An Li (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-2834-3748","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 27 October 2020; Accepted 8 April 2021; Advance Article published 21 May 2021; Version of Record published 21 June 2021","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}