{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:08:28Z","timestamp":1791284908376,"version":"4.1.0"},"reference-count":66,"publisher":"Royal Society of Chemistry (RSC)","issue":"8","license":[{"start":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T00:00:00Z","timestamp":1646697600000},"content-version":"am","delay-in-days":431,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","award":["2662019PY059"],"award-info":[{"award-number":["2662019PY059"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Key Research and Development Program of China","award":["2017YFD0500503"],"award-info":[{"award-number":["2017YFD0500503"]}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<p>Dietary GlyGln supplementation improved gut microbiota dysbiosis and contributes towards the amelioration of ileum disorder in LPS-challenged weaned piglets.<\/p>","DOI":"10.1039\/d0fo03080e","type":"journal-article","created":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T01:13:42Z","timestamp":1615166022000},"page":"3539-3551","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Dietary glycyl-glutamine supplementation ameliorates intestinal integrity, inflammatory response, and oxidative status in association with the gut microbiota in LPS-challenged piglets"],"prefix":"10.1039","volume":"12","author":[{"given":"Baoyang","family":"Xu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology"},{"name":"College of Animal Sciences and Technology"},{"name":"Huazhong Agricultural University"},{"name":"Wuhan"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqin","family":"Yan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology"},{"name":"College of Animal Sciences and Technology"},{"name":"Huazhong Agricultural University"},{"name":"Wuhan"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boqi","family":"Yin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology"},{"name":"College of Animal Sciences and Technology"},{"name":"Huazhong Agricultural University"},{"name":"Wuhan"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology"},{"name":"College of Animal Sciences and Technology"},{"name":"Huazhong Agricultural University"},{"name":"Wuhan"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxia","family":"Qin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology"},{"name":"College of Animal Sciences and Technology"},{"name":"Huazhong Agricultural University"},{"name":"Wuhan"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaorong","family":"Niu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology"},{"name":"College of Animal Sciences and Technology"},{"name":"Huazhong Agricultural University"},{"name":"Wuhan"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yimei","family":"Tang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology"},{"name":"College of Animal Sciences and Technology"},{"name":"Huazhong Agricultural University"},{"name":"Wuhan"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyi","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology"},{"name":"College of Animal Sciences and Technology"},{"name":"Huazhong Agricultural University"},{"name":"Wuhan"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianghua","family":"Yan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology"},{"name":"College of Animal Sciences and Technology"},{"name":"Huazhong Agricultural University"},{"name":"Wuhan"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6806-6899","authenticated-orcid":false,"given":"Libao","family":"Ma","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology"},{"name":"College of Animal Sciences and Technology"},{"name":"Huazhong Agricultural University"},{"name":"Wuhan"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2021]]},"reference":[{"key":"D0FO03080E-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0168-1591(86)90105-X","volume":"16","author":"Jensen","year":"1986","journal-title":"Appl. Anim. Behav. Sci."},{"key":"D0FO03080E-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/2049-1891-4-19","volume":"4","author":"Campbell","year":"2013","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"D0FO03080E-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.tim.2017.05.004","volume":"25","author":"Gresse","year":"2017","journal-title":"Trends Microbiol."},{"key":"D0FO03080E-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/nri3535","volume":"13","author":"Buffie","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"D0FO03080E-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nri3430","volume":"13","author":"Kamada","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"D0FO03080E-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1126\/science.1232467","volume":"339","author":"Winter","year":"2013","journal-title":"Science"},{"key":"D0FO03080E-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.freeradbiomed.2016.09.022","volume":"105","author":"Rivera-Ch\u00e1vez","year":"2017","journal-title":"Free Radicals Biol. Med."},{"key":"D0FO03080E-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.nut.2013.10.018","volume":"30","author":"Xu","year":"2014","journal-title":"Nutrition"},{"key":"D0FO03080E-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4050","DOI":"10.2527\/jas.2008-1120","volume":"87","author":"Jiang","year":"2009","journal-title":"J. Anim. Sci."},{"key":"D0FO03080E-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/S0899-9007(97)83035-3","volume":"13","author":"F\u00fcrst","year":"1997","journal-title":"Nutrition"},{"key":"D0FO03080E-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1017\/S0029665107005484","volume":"66","author":"Lall\u00e8s","year":"2007","journal-title":"Proc. Nutr. Soc."},{"key":"D0FO03080E-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1007\/s11427-018-9301-y","volume":"61","author":"Lv","year":"2018","journal-title":"Sci. China: Life Sci."},{"key":"D0FO03080E-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.aninu.2016.04.005","volume":"2","author":"Xiao","year":"2016","journal-title":"Anim. Nutr."},{"key":"D0FO03080E-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.3389\/fmicb.2019.03125","volume":"10","author":"Yan","year":"2019","journal-title":"Front. Microbiol."},{"key":"D0FO03080E-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.nut.2015.01.004","volume":"31","author":"de Souza","year":"2015","journal-title":"Nutrition"},{"key":"D0FO03080E-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jnutbio.2007.02.011","volume":"19","author":"Peterson","year":"2008","journal-title":"J. Nutr. Biochem."},{"key":"D0FO03080E-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s12011-016-0767-3","volume":"175","author":"Zhu","year":"2017","journal-title":"Biol. Trace Elem. Res."},{"key":"D0FO03080E-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.2527\/jas.2013-6619","volume":"92","author":"Yang","year":"2014","journal-title":"J. Anim. Sci."},{"key":"D0FO03080E-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1093\/jn\/138.6.1025","volume":"138","author":"Wang","year":"2008","journal-title":"J. Nutr."},{"key":"D0FO03080E-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1111\/j.1432-2277.2003.tb00256.x","volume":"16","author":"Li","year":"2003","journal-title":"Transplant Int."},{"key":"D0FO03080E-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4050","DOI":"10.2527\/jas.2008-1120","volume":"87","author":"Jiang","year":"2009","journal-title":"J. Anim. Sci."},{"key":"D0FO03080E-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.jnutbio.2013.12.006","volume":"25","author":"Pi","year":"2014","journal-title":"J. Nutr. Biochem."},{"key":"D0FO03080E-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.3945\/jn.112.164947","volume":"142","author":"Liu","year":"2012","journal-title":"J. Nutr."},{"key":"D0FO03080E-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3694","DOI":"10.2527\/1990.68113694x","volume":"68","author":"Li","year":"1990","journal-title":"J. Anim. Sci."},{"key":"D0FO03080E-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/nbt.3960","volume":"35","author":"Costea","year":"2017","journal-title":"Nat. Biotechnol."},{"key":"D0FO03080E-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2049-2618-2-6","volume":"2","author":"Fadrosh","year":"2014","journal-title":"Microbiome"},{"key":"D0FO03080E-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1093\/bioinformatics\/btr507","volume":"27","author":"Mago\u010d","year":"2011","journal-title":"Bioinformatics"},{"key":"D0FO03080E-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1038\/nmeth.2604","volume":"10","author":"Edgar","year":"2013","journal-title":"Nat. Methods"},{"key":"D0FO03080E-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5069","DOI":"10.1128\/AEM.03006-05","volume":"72","author":"DeSantis","year":"2006","journal-title":"Appl. Environ. Microbiol."},{"key":"D0FO03080E-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7537","DOI":"10.1128\/AEM.01541-09","volume":"75","author":"Schloss","year":"2009","journal-title":"Appl. Environ. Microbiol."},{"key":"D0FO03080E-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/s41587-019-0209-9","volume":"37","author":"Bolyen","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"D0FO03080E-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"R60","DOI":"10.1186\/gb-2011-12-6-r60","volume":"12","author":"Segata","year":"2011","journal-title":"Genome Biol."},{"key":"D0FO03080E-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/s41587-020-0548-6","volume":"38","author":"Douglas","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"D0FO03080E-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nature18849","volume":"535","author":"Baumler","year":"2016","journal-title":"Nature"},{"key":"D0FO03080E-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s40168-018-0473-9","volume":"6","author":"Zhang","year":"2018","journal-title":"Microbiome"},{"key":"D0FO03080E-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e00324","DOI":"10.1128\/mSystems.00324-18","volume":"4","author":"McCormack","year":"2019","journal-title":"mSystems"},{"key":"D0FO03080E-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3123","DOI":"10.1093\/bioinformatics\/btu494","volume":"30","author":"Parks","year":"2014","journal-title":"Bioinformatics"},{"key":"D0FO03080E-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1194\/jlr.R036012","volume":"54","author":"den Besten","year":"2013","journal-title":"J. Lipid Res."},{"key":"D0FO03080E-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.3945\/jn.109.104638","volume":"139","author":"Peng","year":"2009","journal-title":"J. Nutr."},{"key":"D0FO03080E-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1038\/nature08530","volume":"461","author":"Maslowski","year":"2009","journal-title":"Nature"},{"key":"D0FO03080E-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3389\/fphar.2016.00253","volume":"7","author":"Tong","year":"2016","journal-title":"Front. Pharmacol."},{"key":"D0FO03080E-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1093\/jn\/131.5.1520","volume":"131","author":"Spreeuwenberg","year":"2001","journal-title":"J. Nutr."},{"key":"D0FO03080E-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1039\/C7FO01820G","volume":"9","author":"Requena","year":"2018","journal-title":"Food Funct."},{"key":"D0FO03080E-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1039\/C9FO00123A","volume":"10","author":"Chen","year":"2019","journal-title":"Food Funct."},{"key":"D0FO03080E-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1097\/MIB.0000000000000204","volume":"20","author":"S\u00e1nchez de Medina","year":"2014","journal-title":"Inflammatory Bowel Dis."},{"key":"D0FO03080E-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1006\/anae.1997.0121","volume":"3","author":"Smith","year":"1997","journal-title":"Anaerobe"},{"key":"D0FO03080E-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"15124","DOI":"10.1038\/s41598-018-33345-7","volume":"8","author":"Qin","year":"2018","journal-title":"Sci. Rep."},{"key":"D0FO03080E-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1089\/ars.2012.5149","volume":"20","author":"Mittal","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"D0FO03080E-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"eaaw3159","DOI":"10.1126\/scisignal.aaw3159","volume":"12","author":"Yardeni","year":"2019","journal-title":"Sci. Signaling"},{"key":"D0FO03080E-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.theriogenology.2019.06.028","volume":"136","author":"Wang","year":"2019","journal-title":"Theriogenology"},{"key":"D0FO03080E-(cit51)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1136\/vr.103.4.68","volume":"103","author":"Chia","year":"1978","journal-title":"Vet. Rec."},{"key":"D0FO03080E-(cit52)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1053\/j.gastro.2014.07.020","volume":"147","author":"Albenberg","year":"2014","journal-title":"Gastroenterology"},{"key":"D0FO03080E-(cit53)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s40168-015-0091-8","volume":"3","author":"Frese","year":"2015","journal-title":"Microbiome"},{"key":"D0FO03080E-(cit54)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1126\/science.1232467","volume":"339","author":"Winter","year":"2013","journal-title":"Science"},{"key":"D0FO03080E-(cit55)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1093\/jn\/134.6.1467","volume":"134","author":"Niinikoski","year":"2004","journal-title":"J. Nutr."},{"key":"D0FO03080E-(cit56)\/*[position()=1]","first-page":"G225","volume":"270","author":"Alican","year":"1996","journal-title":"Am. J. Physiol."},{"key":"D0FO03080E-(cit57)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1053\/jpsu.2001.22940","volume":"36","author":"Di Lorenzo","year":"2001","journal-title":"J. Pediatr. Surg."},{"key":"D0FO03080E-(cit58)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e00430","DOI":"10.1128\/mBio.00430-13","volume":"4","author":"Spees","year":"2013","journal-title":"mBio"},{"key":"D0FO03080E-(cit59)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"473","DOI":"10.3920\/BM2016.0142","volume":"8","author":"Moens","year":"2017","journal-title":"Benefic. Microbes"},{"key":"D0FO03080E-(cit60)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1099\/00207713-44-1-87","volume":"44","author":"Cornick","year":"1994","journal-title":"Int. J. Syst. Bacteriol."},{"key":"D0FO03080E-(cit61)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3122","DOI":"10.3892\/etm.2017.4878","volume":"14","author":"Wu","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"D0FO03080E-(cit62)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1099\/00207713-52-5-1615","volume":"52","author":"Duncan","year":"2002","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"D0FO03080E-(cit63)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e0169851","DOI":"10.1371\/journal.pone.0169851","volume":"12","author":"Dou","year":"2017","journal-title":"PLoS One"},{"key":"D0FO03080E-(cit64)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1111\/j.1462-2920.2009.01949.x","volume":"11","author":"Hugenholtz","year":"2009","journal-title":"Environ. Microbiol."},{"key":"D0FO03080E-(cit65)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s40168-016-0181-2","volume":"4","author":"Ormerod","year":"2016","journal-title":"Microbiome"},{"key":"D0FO03080E-(cit66)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"246","DOI":"10.3389\/fcimb.2018.00246","volume":"8","author":"Chen","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2021\/FO\/D0FO03080E","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:11:55Z","timestamp":1783447915000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/12\/8\/3539-3551\/687388"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":66,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,4,26]]}},"URL":"https:\/\/doi.org\/10.1039\/d0fo03080e","relation":{},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/D0FO03080E","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Libao Ma (ORCID)","URL":"http:\/\/orcid.org\/0000-0001-6806-6899","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 23 November 2020; Accepted 5 March 2021; Accepted Manuscript published 8 March 2021; Advance Article published 29 March 2021; Version of Record published 26 April 2021","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}