{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T08:44:02Z","timestamp":1787993042992,"version":"build-2784847793"},"reference-count":46,"publisher":"Royal Society of Chemistry (RSC)","issue":"10","license":[{"start":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T00:00:00Z","timestamp":1649203200000},"content-version":"am","delay-in-days":460,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"crossref","award":["2017ZX09301060"],"award-info":[{"award-number":["2017ZX09301060"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100019075","name":"National Ethnic Affairs Commission of the People's Republic of China","doi-asserted-by":"crossref","award":["MZR20001"],"award-info":[{"award-number":["MZR20001"]}],"id":[{"id":"10.13039\/501100019075","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100019981","name":"South-Central University for Nationalities","doi-asserted-by":"crossref","award":["CZJ19001"],"award-info":[{"award-number":["CZJ19001"]}],"id":[{"id":"10.13039\/501100019981","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<p>Genistein, a flavonoid, is one of the main components of soybeans. It was shown to alleviate contact dermatitis through the inhibition of the allergen-induced activation of MAP2K2 in keratinocytes.<\/p>","DOI":"10.1039\/d0fo03238g","type":"journal-article","created":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T12:04:10Z","timestamp":1617710650000},"page":"4556-4569","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Genistein suppresses allergic contact dermatitis through regulating the MAP2K2\/ERK pathway"],"prefix":"10.1039","volume":"12","author":[{"given":"Jinhong","family":"Xu","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences"},{"name":"South-Central University for Nationalities"},{"name":"Wuhan 430074"},{"name":"China"},{"name":"Institute of Ethnomedicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Xiong","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences"},{"name":"South-Central University for Nationalities"},{"name":"Wuhan 430074"},{"name":"China"},{"name":"Institute of Ethnomedicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongqiu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Center for the Study of Itch"},{"name":"Department of Anesthesiology"},{"name":"Washington University School of Medicine"},{"name":"St Louis"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Luo","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences"},{"name":"South-Central University for Nationalities"},{"name":"Wuhan 430074"},{"name":"China"},{"name":"Institute of Ethnomedicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yankun","family":"Ju","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences"},{"name":"South-Central University for Nationalities"},{"name":"Wuhan 430074"},{"name":"China"},{"name":"Institute of Ethnomedicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9853-5078","authenticated-orcid":false,"given":"Guangzhong","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences"},{"name":"South-Central University for Nationalities"},{"name":"Wuhan 430074"},{"name":"China"},{"name":"Institute of Ethnomedicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0455-0902","authenticated-orcid":false,"given":"Zhinan","family":"Mei","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences"},{"name":"South-Central University for Nationalities"},{"name":"Wuhan 430074"},{"name":"China"},{"name":"Institute of Ethnomedicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2021]]},"reference":[{"key":"D0FO03238G-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"106061","DOI":"10.1016\/j.intimp.2019.106061","volume":"78","author":"Aye","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"D0FO03238G-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1111\/exd.13911","volume":"28","author":"Moyle","year":"2019","journal-title":"Exp. Dermatol."},{"key":"D0FO03238G-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3390\/molecules24020265","volume":"24","author":"Jin","year":"2019","journal-title":"Molecules"},{"key":"D0FO03238G-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jdermsci.2018.04.009","volume":"91","author":"Xu","year":"2018","journal-title":"J. Dermatol. Sci."},{"key":"D0FO03238G-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6257","DOI":"10.1039\/C8FO01718B","volume":"9","author":"Luo","year":"2018","journal-title":"Food Funct."},{"key":"D0FO03238G-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.foodchem.2011.07.063","volume":"130","author":"Kim","year":"2012","journal-title":"Food Chem."},{"key":"D0FO03238G-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1039\/c0fo00103a","volume":"1","author":"Pan","year":"2010","journal-title":"Food Funct."},{"key":"D0FO03238G-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1039\/C2FO30199G","volume":"4","author":"Gilbert","year":"2013","journal-title":"Food Funct."},{"key":"D0FO03238G-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.biopha.2015.10.026","volume":"76","author":"Ganai","year":"2015","journal-title":"Biomed. Pharmacother."},{"key":"D0FO03238G-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.3389\/fphar.2019.01336","volume":"10","author":"Tuli","year":"2019","journal-title":"Front. Pharmacol."},{"key":"D0FO03238G-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1039\/C9FO00861F","volume":"11","author":"Gan","year":"2020","journal-title":"Food Funct."},{"key":"D0FO03238G-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.intimp.2019.01.054","volume":"69","author":"Wang","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"D0FO03238G-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"622","DOI":"10.3390\/nu9060622","volume":"9","author":"Irrera","year":"2017","journal-title":"Nutrients"},{"key":"D0FO03238G-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"105110","DOI":"10.1016\/j.ejps.2019.105110","volume":"141","author":"Zhu","year":"2020","journal-title":"Eur. J. Pharm. Sci."},{"key":"D0FO03238G-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jep.2012.08.049","volume":"144","author":"Sung","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"D0FO03238G-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.fct.2014.03.021","volume":"68","author":"Choi","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"D0FO03238G-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/978-3-662-44605-8_9","volume":"226","author":"Storan","year":"2015","journal-title":"Handb. Exp. Pharmacol."},{"key":"D0FO03238G-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4657","DOI":"10.1093\/emboj\/18.17.4657","volume":"18","author":"Sano","year":"1999","journal-title":"EMBO J."},{"key":"D0FO03238G-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/978-94-017-7537-3_2","volume":"904","author":"LaMotte","year":"2016","journal-title":"Adv. Exp. Med. Biol."},{"key":"D0FO03238G-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.jpain.2015.04.009","volume":"16","author":"Pall","year":"2015","journal-title":"J. Pain"},{"key":"D0FO03238G-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1038\/s41467-017-01056-8","volume":"8","author":"Feng","year":"2017","journal-title":"Nat. Commun."},{"key":"D0FO03238G-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.bbi.2019.05.020","volume":"80","author":"Liu","year":"2019","journal-title":"Brain, Behav., Immun."},{"key":"D0FO03238G-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"115209","DOI":"10.1016\/j.taap.2020.115209","volume":"405","author":"Xiang","year":"2020","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"D0FO03238G-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1038\/s41467-020-15230-y","volume":"11","author":"Barry","year":"2020","journal-title":"Nat. Commun."},{"key":"D0FO03238G-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1007\/s12264-017-0125-2","volume":"34","author":"Barry","year":"2018","journal-title":"Neurosci. Bull."},{"key":"D0FO03238G-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1039\/C4FO00280F","volume":"5","author":"Fern\u00e1ndez-Garc\u00eda","year":"2014","journal-title":"Food Funct."},{"key":"D0FO03238G-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"408","DOI":"10.3945\/an.114.008052","volume":"6","author":"Spagnuolo","year":"2015","journal-title":"Adv. Nutr."},{"key":"D0FO03238G-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"167","DOI":"10.2152\/jmi.55.167","volume":"55","author":"Sakai","year":"2008","journal-title":"J. Med. Invest."},{"key":"D0FO03238G-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/sj.bjc.6602875","volume":"94","author":"Laux","year":"2006","journal-title":"Br. J. Cancer"},{"key":"D0FO03238G-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1093\/jjco\/hyv207","volume":"46","author":"Kozuki","year":"2016","journal-title":"Jpn. J. Clin. Oncol."},{"key":"D0FO03238G-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e781","DOI":"10.1097\/PR9.0000000000000781","volume":"4","author":"Zhang","year":"2019","journal-title":"Pain Rep."},{"key":"D0FO03238G-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1097\/DER.0000000000000391","volume":"29","author":"Smith","year":"2018","journal-title":"Dermatitis"},{"key":"D0FO03238G-(cit33)\/*[position()=1]","first-page":"619","volume":"47","author":"McDermott","year":"2001","journal-title":"Cell. Mol. Biol."},{"key":"D0FO03238G-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s12264-017-0124-3","volume":"34","author":"Miao","year":"2018","journal-title":"Neurosci. Bull."},{"key":"D0FO03238G-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1097\/j.pain.0000000000000208","volume":"156","author":"Qu","year":"2015","journal-title":"Pain"},{"key":"D0FO03238G-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.cell.2013.08.057","volume":"155","author":"Wilson","year":"2013","journal-title":"Cell"},{"key":"D0FO03238G-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1177\/0394632017707611","volume":"30","author":"El Darzi","year":"2017","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"D0FO03238G-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1097\/ACI.0b013e3282a644d2","volume":"7","author":"Cevikbas","year":"2007","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"key":"D0FO03238G-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1016\/j.jid.2020.01.016","volume":"140","author":"Liu","year":"2020","journal-title":"J. Invest. Dermatol."},{"key":"D0FO03238G-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"354","DOI":"10.3389\/fphar.2019.00354","volume":"10","author":"Gong","year":"2019","journal-title":"Front. Pharmacol."},{"key":"D0FO03238G-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/nri3495","volume":"13","author":"Arthur","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"D0FO03238G-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4310","DOI":"10.1111\/bph.14487","volume":"175","author":"An","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"D0FO03238G-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"998","DOI":"10.7150\/thno.40076","volume":"10","author":"Chen","year":"2020","journal-title":"Theranostics"},{"key":"D0FO03238G-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10697","DOI":"10.18632\/aging.102485","volume":"11","author":"Liu","year":"2019","journal-title":"Aging"},{"key":"D0FO03238G-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/ng.1026","volume":"44","author":"Nikolaev","year":"2011","journal-title":"Nat. Genet."},{"key":"D0FO03238G-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1186\/s12967-019-2077-y","volume":"17","author":"He","year":"2019","journal-title":"J. Transl. Med."}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2021\/FO\/D0FO03238G","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:57:02Z","timestamp":1783015022000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/12\/10\/4556-4569\/687428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":46,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,5,25]]}},"URL":"https:\/\/doi.org\/10.1039\/d0fo03238g","relation":{},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/D0FO03238G","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Guangzhong Yang (ORCID)","URL":"http:\/\/orcid.org\/0000-0001-9853-5078","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Zhinan Mei (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-0455-0902","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 10 December 2020; Accepted 4 April 2021;  Accepted Manuscript published 6 April 2021;  Advance Article published 27 April 2021;  Version of Record published 25 May 2021","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}