{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T20:06:50Z","timestamp":1791662810378,"version":"4.3.4"},"reference-count":49,"publisher":"Royal Society of Chemistry (RSC)","issue":"16","license":[{"start":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T00:00:00Z","timestamp":1654732800000},"content-version":"am","delay-in-days":524,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100013795","name":"Fujian Medical University","doi-asserted-by":"publisher","award":["2018QH2031"],"award-info":[{"award-number":["2018QH2031"]}],"id":[{"id":"10.13039\/501100013795","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<jats:p>Potential mechanisms of LF in alleviating pathological cardiac hypertrophy of aging.<\/jats:p>","DOI":"10.1039\/d0fo03346d","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T09:24:15Z","timestamp":1623230655000},"page":"7514-7526","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Lactoferrin ameliorates pathological cardiac hypertrophy related to mitochondrial quality control in aged mice"],"prefix":"10.1039","volume":"12","author":[{"given":"Lishan","family":"Huang","sequence":"first","affiliation":[{"name":"School of Pharmacy, Fujian Medical University, Fuzhou, China"},{"name":"Department of Endocrinology, Fujian Medical University Union Hospital, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiyu","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Fujian Medical University, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Fujian Medical University Union Hospital, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Fujian Medical University, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9810-7310","authenticated-orcid":false,"given":"Zhou","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Fujian Medical University, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2021]]},"reference":[{"key":"D0FO03346D\/cit2","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.mcna.2011.11.003","volume":"96","author":"Dhingra","year":"2012","journal-title":"Med. Clin. North Am."},{"key":"D0FO03346D\/cit3","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1161\/CIRCRESAHA.116.307474","volume":"118","author":"Shirakabe","year":"2016","journal-title":"Circ. Res."},{"key":"D0FO03346D\/cit4","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1093\/cvr\/cvr015","volume":"90","author":"Abel","year":"2011","journal-title":"Cardiovasc. Res."},{"key":"D0FO03346D\/cit5","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1038\/cr.2014.94","volume":"24","author":"Li","year":"2014","journal-title":"Cell Res."},{"key":"D0FO03346D\/cit6","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1056\/NEJM199005313222203","volume":"322","author":"Levy","year":"1990","journal-title":"N. Engl. J. Med."},{"key":"D0FO03346D\/cit7","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1007\/s00204-015-1477-x","volume":"89","author":"Tham","year":"2015","journal-title":"Arch. Toxicol."},{"key":"D0FO03346D\/cit8","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/s41580-019-0173-8","volume":"21","author":"Bock","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"D0FO03346D\/cit9","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.yjmcc.2015.04.015","volume":"83","author":"Biala","year":"2015","journal-title":"J. Mol. Cell. Cardiol."},{"key":"D0FO03346D\/cit10","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.arr.2018.08.003","volume":"47","author":"Park","year":"2018","journal-title":"Ageing Res. Rev."},{"key":"D0FO03346D\/cit11","doi-asserted-by":"crossref","first-page":"107","DOI":"10.2174\/157340308784245801","volume":"4","author":"Terman","year":"2008","journal-title":"Curr. Cardiol. Rev."},{"key":"D0FO03346D\/cit12","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1080\/10408398.2017.1381583","volume":"59","author":"Wang","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"D0FO03346D\/cit13","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.tem.2013.12.002","volume":"25","author":"Troncoso","year":"2014","journal-title":"Trends Endocrinol. Metab."},{"key":"D0FO03346D\/cit14","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1530\/JME-19-0003","volume":"63","author":"Chen","year":"2019","journal-title":"J. Mol. Endocrinol."},{"key":"D0FO03346D\/cit15","doi-asserted-by":"crossref","first-page":"103736","DOI":"10.1016\/j.jff.2019.103736","volume":"65","author":"Zheng","year":"2020","journal-title":"J. Funct. Foods"},{"key":"D0FO03346D\/cit16","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1113\/jphysiol.2012.244483","volume":"591","author":"Westcott","year":"2013","journal-title":"J. Physiol."},{"key":"D0FO03346D\/cit17","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1128\/JCM.03233-13","volume":"52","author":"Plain","year":"2014","journal-title":"J. Clin. Microbiol."},{"key":"D0FO03346D\/cit18","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.micron.2009.08.010","volume":"41","author":"Balietti","year":"2010","journal-title":"Micron"},{"key":"D0FO03346D\/cit19","doi-asserted-by":"crossref","first-page":"E973","DOI":"10.1152\/ajpendo.00133.2018","volume":"315","author":"Zhou","year":"2018","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"D0FO03346D\/cit20","doi-asserted-by":"crossref","first-page":"e1008638","DOI":"10.1371\/journal.pgen.1008638","volume":"16","author":"Haeussler","year":"2020","journal-title":"PLoS Genet."},{"key":"D0FO03346D\/cit21","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0002-9343(83)90118-3","volume":"75","author":"Messerli","year":"1983","journal-title":"Am. J. Med."},{"key":"D0FO03346D\/cit22","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.mad.2017.07.002","volume":"166","author":"Scridon","year":"2017","journal-title":"Mech. Ageing Dev."},{"key":"D0FO03346D\/cit23","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1124\/pr.56.2.4","volume":"56","author":"McLean","year":"2004","journal-title":"Pharmacol. Rev."},{"key":"D0FO03346D\/cit24","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.exger.2011.02.010","volume":"46","author":"Boyle","year":"2011","journal-title":"Exp. Gerontol."},{"key":"D0FO03346D\/cit25","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1161\/01.RES.68.6.1560","volume":"68","author":"Olivetti","year":"1991","journal-title":"Circ. Res."},{"key":"D0FO03346D\/cit26","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0008-6363(03)00498-X","volume":"59","author":"Gonz\u00e1lez","year":"2003","journal-title":"Cardiovasc. Res."},{"key":"D0FO03346D\/cit27","doi-asserted-by":"crossref","first-page":"520","DOI":"10.3390\/jcm8040520","volume":"8","author":"Li","year":"2019","journal-title":"J. Clin. Med."},{"key":"D0FO03346D\/cit28","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/jnc.14857","volume":"152","author":"Liu","year":"2020","journal-title":"J. Neurochem."},{"key":"D0FO03346D\/cit29","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41569-018-0007-y","volume":"15","author":"Nakamura","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"D0FO03346D\/cit30","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1111\/j.1582-4934.2009.00697.x","volume":"13","author":"Gupta","year":"2009","journal-title":"J. Cell. Mol. Med."},{"key":"D0FO03346D\/cit31","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1161\/CIRCRESAHA.111.246108","volume":"110","author":"Dutta","year":"2012","journal-title":"Circ. Res."},{"key":"D0FO03346D\/cit32","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","volume":"153","author":"L\u00f3pez-Ot\u00edn","year":"2013","journal-title":"Cell"},{"key":"D0FO03346D\/cit33","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1126\/science.1201940","volume":"333","author":"Green","year":"2011","journal-title":"Science"},{"key":"D0FO03346D\/cit34","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.freeradbiomed.2016.03.017","volume":"98","author":"Hepple","year":"2016","journal-title":"Free Radicals Biol. Med."},{"key":"D0FO03346D\/cit35","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1016\/j.bbabio.2008.05.001","volume":"1777","author":"Twig","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"D0FO03346D\/cit36","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1515\/hsz-2012-0247","volume":"394","author":"Calvani","year":"2013","journal-title":"Biol. Chem."},{"key":"D0FO03346D\/cit37","first-page":"9825061","volume":"2019","author":"Wu","year":"2019","journal-title":"Oxid. Med. Cell. Longevity"},{"key":"D0FO03346D\/cit38","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.molcel.2016.01.028","volume":"61","author":"Sun","year":"2016","journal-title":"Mol. Cell"},{"key":"D0FO03346D\/cit39","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1089\/ars.2013.5371","volume":"20","author":"Parzych","year":"2014","journal-title":"Antioxid. Redox Signaling"},{"key":"D0FO03346D\/cit40","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/s41418-019-0286-9","volume":"26","author":"Miyamoto","year":"2019","journal-title":"Cell Death Differ."},{"key":"D0FO03346D\/cit41","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.nbd.2015.03.014","volume":"84","author":"Perluigi","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"D0FO03346D\/cit42","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.tips.2018.10.005","volume":"39","author":"Ren","year":"2018","journal-title":"Trends Pharmacol. Sci."},{"key":"D0FO03346D\/cit43","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.preteyeres.2016.08.001","volume":"55","author":"Boya","year":"2016","journal-title":"Prog. Retinal Eye Res."},{"key":"D0FO03346D\/cit44","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1196\/annals.1297.015","volume":"1019","author":"Terman","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"D0FO03346D\/cit45","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.redox.2017.01.017","volume":"11","author":"K\u00f6nig","year":"2017","journal-title":"Redox Biol."},{"key":"D0FO03346D\/cit46","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S0891-5849(02)00959-0","volume":"33","author":"Brunk","year":"2002","journal-title":"Free Radicals Biol. Med."},{"key":"D0FO03346D\/cit47","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1111\/j.1474-9726.2008.00418.x","volume":"7","author":"Seo","year":"2008","journal-title":"Aging Cell"},{"key":"D0FO03346D\/cit48","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.ijantimicag.2008.07.020","volume":"33","author":"Gonz\u00e1lez-Ch\u00e1vez","year":"2009","journal-title":"Int. J. Antimicrob. Agents"},{"key":"D0FO03346D\/cit49","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1139\/o06-045","volume":"84","author":"Legrand","year":"2006","journal-title":"Biochem. Cell Biol."},{"key":"D0FO03346D\/cit50","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1089\/ars.2015.6458","volume":"24","author":"Mayeur","year":"2016","journal-title":"Antioxid. Redox Signaling"}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2021\/FO\/D0FO03346D","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T18:21:39Z","timestamp":1782930099000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/12\/16\/7514-7526\/687462"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":49,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2021,8,16]]}},"URL":"https:\/\/doi.org\/10.1039\/d0fo03346d","relation":{},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}