{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:15:39Z","timestamp":1792671339119,"version":"4.5.0"},"reference-count":45,"publisher":"Royal Society of Chemistry (RSC)","issue":"9","license":[{"start":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T00:00:00Z","timestamp":1647907200000},"content-version":"am","delay-in-days":445,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["22078212"],"award-info":[{"award-number":["22078212"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<p>\n                    The current work is novel as the first to report the detailed mechanisms illustrating how the consistent gastric emptying for a difficult emptying material-solid cheese was achieved in an advanced novel dynamic\n                    <italic>in vitro<\/italic>\n                    human gastric system.\n                  <\/p>","DOI":"10.1039\/d0fo03364b","type":"journal-article","created":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T05:14:00Z","timestamp":1616390040000},"page":"3965-3977","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Achieving realistic gastric emptying curve in an advanced dynamic\n                    <i>in vitro<\/i>\n                    human digestion system: experiences with cheese\u2014a difficult to empty material"],"prefix":"10.1039","volume":"12","author":[{"given":"Zhen","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering and Biochemical Engineering"},{"name":"College of Chemistry and Chemical Engineering"},{"name":"Xiamen University"},{"name":"Xiamen 361005"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3339-4179","authenticated-orcid":false,"given":"Peng","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Chemical and Environmental Engineering"},{"name":"College of Chemistry"},{"name":"Chemical Engineering and Material Science"},{"name":"Soochow University"},{"name":"Suzhou 215123"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Wang","sequence":"additional","affiliation":[{"name":"Xiao Dong Pro-health (Suzhou) Instrumentation Co Ltd"},{"name":"Suzhou"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Dupont","sequence":"additional","affiliation":[{"name":"STLO"},{"name":"UMR 1253"},{"name":"INRA"},{"name":"Agrocampus Ouest"},{"name":"35000 Rennes"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliva","family":"Menard","sequence":"additional","affiliation":[{"name":"STLO"},{"name":"UMR 1253"},{"name":"INRA"},{"name":"Agrocampus Ouest"},{"name":"35000 Rennes"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Jeantet","sequence":"additional","affiliation":[{"name":"STLO"},{"name":"UMR 1253"},{"name":"INRA"},{"name":"Agrocampus Ouest"},{"name":"35000 Rennes"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao Dong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Biochemical Engineering"},{"name":"College of Chemistry and Chemical Engineering"},{"name":"Xiamen University"},{"name":"Xiamen 361005"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2021]]},"reference":[{"key":"D0FO03364B-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9397","DOI":"10.1039\/D0FO01981J","volume":"11","author":"Mackie","year":"2020","journal-title":"Food Funct."},{"key":"D0FO03364B-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.tibtech.2012.08.001","volume":"30","author":"Guerra","year":"2012","journal-title":"Trends Biotechnol."},{"key":"D0FO03364B-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"R67","DOI":"10.1111\/j.1750-3841.2008.00766.x","volume":"73","author":"Kong","year":"2008","journal-title":"J. Food Sci."},{"key":"D0FO03364B-(cit4)\/*[position()=1]","first-page":"G1038","volume":"304","author":"Mackie","year":"2013","journal-title":"Am. J. Physiol.: Gastrointest. Liver Physiol."},{"key":"D0FO03364B-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.ces.2017.05.048","volume":"171","author":"Moxon","year":"2017","journal-title":"Chem. Eng. Sci."},{"key":"D0FO03364B-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e67482","DOI":"10.1371\/journal.pone.0067482","volume":"8","author":"Zhu","year":"2013","journal-title":"PLoS One"},{"key":"D0FO03364B-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1093\/gerona\/60.12.1581","volume":"60","author":"Di Francesco","year":"2005","journal-title":"J. Gerontol., Ser. A"},{"key":"D0FO03364B-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/bdd.1937","volume":"36","author":"Bonner","year":"2015","journal-title":"Biopharm. Drug Dispos."},{"key":"D0FO03364B-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ejpb.2020.02.002","volume":"149","author":"Vrbanac","year":"2020","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"D0FO03364B-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7596","DOI":"10.1039\/D0FO01104E","volume":"11","author":"Shang","year":"2020","journal-title":"Food Funct."},{"key":"D0FO03364B-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/ejcn.2013.78","volume":"67","author":"Marciani","year":"2013","journal-title":"Eur. J. Clin. Nutr."},{"key":"D0FO03364B-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3202","DOI":"10.1039\/C7FO01226H","volume":"9","author":"Harrison","year":"2018","journal-title":"Food Funct."},{"key":"D0FO03364B-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1365-2982.2006.00759.x","volume":"18","author":"Schulze","year":"2006","journal-title":"Neurogastroenterol. Motil."},{"key":"D0FO03364B-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"101S","DOI":"10.1007\/BF02300384","volume":"39","author":"Schwizer","year":"1994","journal-title":"Dig. Dis. Sci."},{"key":"D0FO03364B-(cit15)\/*[position()=1]","first-page":"1155","volume":"45","author":"Simonian","year":"2004","journal-title":"J. Nucl. Med."},{"key":"D0FO03364B-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2914","DOI":"10.1039\/C8FO02586J","volume":"10","author":"Wang","year":"2019","journal-title":"Food Funct."},{"key":"D0FO03364B-(cit17)\/*[position()=1]","first-page":"R1712","volume":"275","author":"Doran","year":"1998","journal-title":"Am. J. Physiol.: Regul., Integr. Comp. Physiol."},{"key":"D0FO03364B-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1007\/BF01324951","volume":"28","author":"Moore","year":"1983","journal-title":"Dig. Dis. Sci."},{"key":"D0FO03364B-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"20190266","DOI":"10.1098\/rsif.2019.0266","volume":"16","author":"Ishida","year":"2019","journal-title":"J. R. Soc., Interface"},{"key":"D0FO03364B-(cit20)\/*[position()=1]","first-page":"G1227","volume":"280","author":"Marciani","year":"2001","journal-title":"Am. J. Physiol.: Gastrointest. Liver Physiol."},{"key":"D0FO03364B-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1159\/000065500","volume":"48","author":"Shimamoto","year":"2002","journal-title":"Gerontology"},{"key":"D0FO03364B-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.tifs.2019.12.015","volume":"96","author":"Li","year":"2019","journal-title":"Trends Food Sci. Technol."},{"key":"D0FO03364B-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1177\/026119299502300205","volume":"23","author":"Minekus","year":"1995","journal-title":"Altern. Lab. Anim."},{"key":"D0FO03364B-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"E627","DOI":"10.1111\/j.1750-3841.2010.01856.x","volume":"75","author":"Kong","year":"2010","journal-title":"J. Food Sci."},{"key":"D0FO03364B-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3136\/fstr.20.225","volume":"20","author":"Kozu","year":"2014","journal-title":"Food Sci. Technol. Res."},{"key":"D0FO03364B-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.fm.2015.03.002","volume":"53","author":"Adouard","year":"2016","journal-title":"Food Microbiol."},{"key":"D0FO03364B-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.foodres.2019.04.015","volume":"122","author":"Liu","year":"2019","journal-title":"Food Res. Int."},{"key":"D0FO03364B-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"108598","DOI":"10.1016\/j.foodres.2019.108598","volume":"125","author":"Li","year":"2019","journal-title":"Food Res. Int."},{"key":"D0FO03364B-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.cofs.2019.12.004","volume":"35","author":"Wu","year":"2020","journal-title":"Curr. Opin. Food Sci."},{"key":"D0FO03364B-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jfoodeng.2016.02.025","volume":"183","author":"Chen","year":"2016","journal-title":"J. Food Eng."},{"key":"D0FO03364B-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0278-6915(00)00136-8","volume":"39","author":"DeSesso","year":"2001","journal-title":"Food Chem. Toxicol."},{"key":"D0FO03364B-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1098\/rspb.2004.2886","volume":"271","author":"Pal","year":"2004","journal-title":"Proc. R. Soc. London, Ser. B"},{"key":"D0FO03364B-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1111\/1750-3841.13683","volume":"82","author":"Wu","year":"2017","journal-title":"J. Food Sci."},{"key":"D0FO03364B-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jfoodeng.2017.01.011","volume":"202","author":"Wu","year":"2017","journal-title":"J. Food Eng."},{"key":"D0FO03364B-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.foodres.2017.12.082","volume":"106","author":"Zhang","year":"2018","journal-title":"Food Res. Int."},{"key":"D0FO03364B-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.talanta.2012.04.013","volume":"97","author":"Lvova","year":"2012","journal-title":"Talanta"},{"key":"D0FO03364B-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1039\/c2fo10256k","volume":"3","author":"Lamothe","year":"2012","journal-title":"Food Funct."},{"key":"D0FO03364B-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.lwt.2018.03.028","volume":"93","author":"Tran Do","year":"2018","journal-title":"Lebensm.-Wiss. Technol."},{"key":"D0FO03364B-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1016\/S0016-5085(82)80145-5","volume":"83","author":"Elashoff","year":"1982","journal-title":"Gastroenterology"},{"key":"D0FO03364B-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.foodqual.2007.01.010","volume":"18","author":"Jalabert-Malbos","year":"2007","journal-title":"Food Qual. Prefer."},{"key":"D0FO03364B-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.jtbi.2013.09.005","volume":"340","author":"Doyennette","year":"2014","journal-title":"J. Theor. Biol."},{"key":"D0FO03364B-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/BF01324736","volume":"24","author":"Malagelada","year":"1979","journal-title":"Dig. Dis. Sci."},{"key":"D0FO03364B-(cit43)\/*[position()=1]","first-page":"G71","volume":"239","author":"Kelly","year":"1980","journal-title":"Am. J. Physiol.: Gastrointest. Liver Physiol."},{"key":"D0FO03364B-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/0016-5085(85)90576-1","volume":"89","author":"Meyer","year":"1985","journal-title":"Gastroenterology"},{"key":"D0FO03364B-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.jfoodeng.2014.06.010","volume":"142","author":"Wu","year":"2014","journal-title":"J. Food Eng."}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2021\/FO\/D0FO03364B","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T21:50:11Z","timestamp":1782942611000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/12\/9\/3965-3977\/687466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":45,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,5,11]]}},"URL":"https:\/\/doi.org\/10.1039\/d0fo03364b","relation":{},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/D0FO03364B","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Peng Wu (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-3339-4179","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 22 December 2020; Accepted 16 March 2021;  Accepted Manuscript published 22 March 2021;  Advance Article published 6 April 2021;  Version of Record published 11 May 2021","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}