{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:37:59Z","timestamp":1791563879203,"version":"4.3.4"},"reference-count":137,"publisher":"Royal Society of Chemistry (RSC)","issue":"13","license":[{"start":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T00:00:00Z","timestamp":1651968000000},"content-version":"am","delay-in-days":492,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<p>The \u201cbrain\u2013gut\u2013bone\u201d axis is related to osteoporosis and can be a potential target for the prevention and treatment of it. The \u201cbrain\u2013bone\u201d, \u201cgut\u2013bone\u201d and \u201cbrain\u2013gut\u201d connections are all closely relevant between the gut microbiota and osteoporosis.<\/p>","DOI":"10.1039\/d0fo03468a","type":"journal-article","created":{"date-parts":[[2021,5,7]],"date-time":"2021-05-07T20:26:50Z","timestamp":1620419210000},"page":"5703-5718","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":87,"title":["The modulatory effect and implication of gut microbiota on osteoporosis: from the perspective of \u201cbrain\u2013gut\u2013bone\u201d axis"],"prefix":"10.1039","volume":"12","author":[{"given":"Yuan-Wei","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Orthopaedics"},{"name":"Zhongda Hospital"},{"name":"School of Medicine"},{"name":"Southeast University"},{"name":"Nanjing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Juan","family":"Li","sequence":"additional","affiliation":[{"name":"Multidisciplinary Team (MDT) for Geriatric Hip Fracture Management"},{"name":"Zhongda Hospital"},{"name":"School of Medicine"},{"name":"Southeast University"},{"name":"Nanjing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan-Pan","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics"},{"name":"Zhongda Hospital"},{"name":"School of Medicine"},{"name":"Southeast University"},{"name":"Nanjing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-Chun","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics"},{"name":"Zhongda Hospital"},{"name":"School of Medicine"},{"name":"Southeast University"},{"name":"Nanjing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Xu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics"},{"name":"Zhongda Hospital"},{"name":"School of Medicine"},{"name":"Southeast University"},{"name":"Nanjing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9019-5531","authenticated-orcid":false,"given":"Yun-Feng","family":"Rui","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics"},{"name":"Zhongda Hospital"},{"name":"School of Medicine"},{"name":"Southeast University"},{"name":"Nanjing"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2021]]},"reference":[{"key":"D0FO03468A-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1056\/NEJMoa1916525","volume":"383","author":"Black","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"D0FO03468A-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/S2213-8587(19)30346-8","volume":"7","author":"McClung","year":"2019","journal-title":"Lancet Diabetes Endocrinol."},{"key":"D0FO03468A-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.cmet.2020.08.012","volume":"32","author":"Chevalier","year":"2020","journal-title":"Cell Metab."},{"key":"D0FO03468A-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S2213-8587(19)30255-4","volume":"7","author":"Tsai","year":"2019","journal-title":"Lancet Diabetes Endocrinol."},{"key":"D0FO03468A-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1001\/jama.2019.11889","volume":"322","author":"Burt","year":"2019","journal-title":"J. Am. Med. Assoc."},{"key":"D0FO03468A-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1016\/j.jacc.2019.08.1025","volume":"74","author":"Binding","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"D0FO03468A-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"177","DOI":"10.2147\/CIA.S291071","volume":"16","author":"Zhang","year":"2021","journal-title":"Clin. Interventions Aging"},{"key":"D0FO03468A-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1001\/jamainternmed.2020.2975","volume":"180","author":"Swayambunathan","year":"2020","journal-title":"JAMA Intern. Med."},{"key":"D0FO03468A-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1001\/jamainternmed.2020.2986","volume":"180","author":"Crandall","year":"2020","journal-title":"JAMA Intern. Med."},{"key":"D0FO03468A-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1021\/acs.jafc.0c06671","volume":"69","author":"Mei","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"D0FO03468A-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s00198-020-05728-y","volume":"32","author":"Ozaki","year":"2021","journal-title":"Osteoporosis Int."},{"key":"D0FO03468A-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"109811","DOI":"10.1016\/j.foodres.2020.109811","volume":"138","author":"Liu","year":"2020","journal-title":"Food Res. Int."},{"key":"D0FO03468A-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1177\/0022034518797275","volume":"98","author":"Jia","year":"2019","journal-title":"J. Dent. Res."},{"key":"D0FO03468A-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1099\/jmm.0.000936","volume":"68","author":"Zhao","year":"2019","journal-title":"J. Med. Microbiol."},{"key":"D0FO03468A-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1002\/jbmr.3947","volume":"35","author":"Schepper","year":"2020","journal-title":"J. Bone Miner. Res."},{"key":"D0FO03468A-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.21037\/atm-20-5307","volume":"8","author":"Lin","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"D0FO03468A-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1172\/JCI86062","volume":"126","author":"Li","year":"2016","journal-title":"J. Clin. Invest."},{"key":"D0FO03468A-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/s12264-010-9142-0","volume":"26","author":"Gong","year":"2010","journal-title":"Neurosci. Bull."},{"key":"D0FO03468A-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0092-8674(02)01049-8","volume":"111","author":"Takeda","year":"2002","journal-title":"Cell"},{"key":"D0FO03468A-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/nature03398","volume":"434","author":"Elefteriou","year":"2005","journal-title":"Nature"},{"key":"D0FO03468A-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bone.2017.08.004","volume":"105","author":"Pawlak","year":"2017","journal-title":"Bone"},{"key":"D0FO03468A-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/s41467-019-14076-3","volume":"11","author":"Fu","year":"2020","journal-title":"Nat. Commun."},{"key":"D0FO03468A-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"30085","DOI":"10.1038\/srep30085","volume":"6","author":"Jiao","year":"2016","journal-title":"Sci. Rep."},{"key":"D0FO03468A-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1097\/GME.0000000000000680","volume":"23","author":"Zang","year":"2016","journal-title":"Menopause"},{"key":"D0FO03468A-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1001\/jama.292.11.1326","volume":"292","author":"Schlienger","year":"2004","journal-title":"J. Am. Med. Assoc."},{"key":"D0FO03468A-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s00223-006-0213-1","volume":"80","author":"de Vries","year":"2007","journal-title":"Calcif. Tissue Int."},{"key":"D0FO03468A-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1249\/MSS.0b013e31828d39bc","volume":"45","author":"Swift","year":"2013","journal-title":"Med. Sci. Sports Exercise"},{"key":"D0FO03468A-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"509","DOI":"10.2147\/CIA.S60669","volume":"9","author":"A\u011fa\u00e7ayak","year":"2014","journal-title":"Clin. Interventions Aging"},{"key":"D0FO03468A-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5212","DOI":"10.1210\/jc.2005-0573","volume":"90","author":"Reid","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"9","key":"D0FO03468A-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3390\/biomedicines8090369","volume":"8","author":"Iimura","year":"2020","journal-title":"Biomedicines"},{"key":"D0FO03468A-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"101995","DOI":"10.1016\/j.npep.2019.101995","volume":"81","author":"Xie","year":"2020","journal-title":"Neuropeptides"},{"key":"D0FO03468A-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.biopha.2018.04.044","volume":"104","author":"Liu","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"D0FO03468A-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1002\/prot.25595","volume":"86","author":"Wells","year":"2018","journal-title":"Proteins"},{"key":"D0FO03468A-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.lfs.2017.01.011","volume":"173","author":"Wu","year":"2017","journal-title":"Life Sci."},{"issue":"12","key":"D0FO03468A-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1177\/0333102420929026","volume":"40","author":"Edvinsson","year":"2020","journal-title":"Cephalalgia"},{"key":"D0FO03468A-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"114","DOI":"10.3109\/10799893.2013.770528","volume":"33","author":"Tuo","year":"2013","journal-title":"J. Recept. Signal Transduction Res."},{"issue":"4","key":"D0FO03468A-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.3390\/ijms21041343","volume":"21","author":"Zhu","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"D0FO03468A-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/s41467-020-14285-1","volume":"11","author":"Brunner","year":"2020","journal-title":"Nat. Commun."},{"key":"D0FO03468A-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4811","DOI":"10.1172\/JCI134214","volume":"130","author":"Andreev","year":"2020","journal-title":"J. Clin. Invest."},{"key":"D0FO03468A-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/aps.2015.85","volume":"37","author":"Zeng","year":"2016","journal-title":"Acta Pharmacol. Sin."},{"key":"D0FO03468A-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"16052","DOI":"10.1002\/jcb.28886","volume":"120","author":"Ma","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"D0FO03468A-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"112115","DOI":"10.1016\/j.yexcr.2020.112115","volume":"394","author":"Chen","year":"2020","journal-title":"Exp. Cell Res."},{"key":"D0FO03468A-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/s41586-020-2039-9","volume":"579","author":"Talbot","year":"2020","journal-title":"Nature"},{"key":"D0FO03468A-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"108799","DOI":"10.1016\/j.biopha.2019.108799","volume":"114","author":"Yang","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"D0FO03468A-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s12031-014-0389-1","volume":"54","author":"Juh\u00e1sz","year":"2014","journal-title":"J. Mol. Neurosci."},{"key":"D0FO03468A-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s40478-018-0533-1","volume":"6","author":"Dufresne","year":"2018","journal-title":"Acta Neuropathol. Commun."},{"key":"D0FO03468A-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.bone.2018.01.032","volume":"110","author":"Macari","year":"2018","journal-title":"Bone"},{"key":"D0FO03468A-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/j.joen.2016.05.009","volume":"42","author":"De Rossi","year":"2016","journal-title":"J. Endod."},{"key":"D0FO03468A-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3214","DOI":"10.1172\/JCI125915","volume":"129","author":"Bonnet","year":"2019","journal-title":"J. Clin. Invest."},{"key":"D0FO03468A-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S2213-8587(17)30138-9","volume":"5","author":"Bone","year":"2017","journal-title":"Lancet Diabetes Endocrinol."},{"key":"D0FO03468A-(cit51)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S2213-8587(20)30063-2","volume":"8","author":"Leere","year":"2020","journal-title":"Lancet Diabetes Endocrinol."},{"key":"D0FO03468A-(cit52)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3233\/JAD-2010-101467","volume":"24","author":"Zhou","year":"2011","journal-title":"J. Alzheimer's Dis."},{"key":"D0FO03468A-(cit53)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e763","DOI":"10.1210\/clinem\/dgaa864","volume":"106","author":"Feng","year":"2021","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"D0FO03468A-(cit54)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1007\/s00198-018-4409-9","volume":"29","author":"Lee","year":"2018","journal-title":"Osteoporosis Int."},{"key":"D0FO03468A-(cit55)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.jocn.2008.08.027","volume":"16","author":"Song","year":"2009","journal-title":"J. Clin. Neurosci."},{"key":"D0FO03468A-(cit56)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1093\/clinchem\/47.6.1102","volume":"47","author":"Blandini","year":"2001","journal-title":"Clin. Chem."},{"key":"D0FO03468A-(cit57)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1097\/gme.0b013e31823dbec7","volume":"19","author":"Lee","year":"2012","journal-title":"Menopause"},{"key":"D0FO03468A-(cit58)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.3945\/jn.113.180794","volume":"143","author":"Ooi","year":"2013","journal-title":"J. Nutr."},{"key":"D0FO03468A-(cit59)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.cmet.2014.10.016","volume":"20","author":"Sharon","year":"2014","journal-title":"Cell Metab."},{"key":"D0FO03468A-(cit60)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/ni.3400","volume":"17","author":"Mathewson","year":"2016","journal-title":"Nat. Immunol."},{"key":"D0FO03468A-(cit61)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nm.3444","volume":"20","author":"Trompette","year":"2014","journal-title":"Nat. Med."},{"key":"D0FO03468A-(cit62)\/*[position()=1]","first-page":"G855","volume":"264","author":"R\u00e9m\u00e9sy","year":"1993","journal-title":"Am. J. Physiol."},{"key":"D0FO03468A-(cit63)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/s41586-020-2396-4","volume":"582","author":"Funabashi","year":"2020","journal-title":"Nature"},{"key":"D0FO03468A-(cit64)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1172\/JCI133473","volume":"130","author":"Li","year":"2020","journal-title":"J. Clin. Invest."},{"key":"D0FO03468A-(cit65)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5997","DOI":"10.1038\/s41467-020-19793-8","volume":"11","author":"Thomas","year":"2020","journal-title":"Nat. Commun."},{"key":"D0FO03468A-(cit66)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.ejphar.2015.05.048","volume":"762","author":"Tanaka","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"D0FO03468A-(cit67)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1002\/jbmr.3838","volume":"35","author":"Plum","year":"2020","journal-title":"J. Bone Miner. Res."},{"key":"D0FO03468A-(cit68)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1002\/jbmr.3921","volume":"35","author":"Sun","year":"2020","journal-title":"J. Bone Miner. Res."},{"key":"D0FO03468A-(cit69)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.1210\/jc.2012-4262","volume":"98","author":"Jones","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"D0FO03468A-(cit70)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1007\/s10068-019-00561-4","volume":"28","author":"Yamada","year":"2019","journal-title":"Food Sci. Biotechnol."},{"key":"D0FO03468A-(cit71)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/jbmr.3600","volume":"34","author":"Li","year":"2019","journal-title":"J. Bone Miner. Res."},{"key":"D0FO03468A-(cit72)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.molimm.2017.09.003","volume":"91","author":"Ganesan","year":"2017","journal-title":"Mol. Immunol."},{"key":"D0FO03468A-(cit73)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e44552","DOI":"10.1371\/journal.pone.0044552","volume":"7","author":"Tyagi","year":"2012","journal-title":"PLoS One"},{"key":"D0FO03468A-(cit74)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1136\/gutjnl-2014-306947","volume":"64","author":"Ciucci","year":"2015","journal-title":"Gut"},{"key":"D0FO03468A-(cit75)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3522","DOI":"10.1182\/bloodadvances.2019000411","volume":"3","author":"B\u00e9zie","year":"2019","journal-title":"Blood Adv."},{"issue":"3","key":"D0FO03468A-(cit76)\/*[position()=1]","first-page":"e124427","volume":"4","author":"Lucca","year":"2019","journal-title":"J. Clin. Invest. Insight"},{"key":"D0FO03468A-(cit77)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1126\/science.1198469","volume":"331","author":"Atarashi","year":"2011","journal-title":"Science"},{"issue":"12","key":"D0FO03468A-(cit78)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.3390\/cells9122571","volume":"9","author":"Gancarcikova","year":"2020","journal-title":"Cells"},{"key":"D0FO03468A-(cit79)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1038\/s41467-019-14148-4","volume":"11","author":"Yu","year":"2020","journal-title":"Nat. Commun."},{"issue":"4","key":"D0FO03468A-(cit80)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e143137","DOI":"10.1172\/JCI143137","volume":"131","author":"Yu","year":"2021","journal-title":"J. Clin. Invest."},{"key":"D0FO03468A-(cit81)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"489","DOI":"10.3389\/fcimb.2017.00489","volume":"7","author":"Huo","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"D0FO03468A-(cit82)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.jhep.2016.11.008","volume":"66","author":"Ferrere","year":"2017","journal-title":"J. Hepatol."},{"issue":"22","key":"D0FO03468A-(cit83)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4952","DOI":"10.1111\/febs.15286","volume":"287","author":"Nardella","year":"2020","journal-title":"FEBS J."},{"key":"D0FO03468A-(cit84)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/nm.2098","volume":"16","author":"Yadav","year":"2010","journal-title":"Nat. Med."},{"key":"D0FO03468A-(cit85)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.psyneuen.2015.06.002","volume":"60","author":"Golubeva","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"D0FO03468A-(cit86)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1056\/NEJMoa1700089","volume":"377","author":"Taylor","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"D0FO03468A-(cit87)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"E7554","DOI":"10.1073\/pnas.1607235113","volume":"113","author":"Yan","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D0FO03468A-(cit88)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1002\/jcp.26788","volume":"234","author":"Guo","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"D0FO03468A-(cit89)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s00223-020-00687-2","volume":"107","author":"Fu","year":"2020","journal-title":"Calcif. Tissue Int."},{"key":"D0FO03468A-(cit90)\/*[position()=1]","first-page":"664","volume":"158","author":"Sato","year":"2017","journal-title":"Endocrinology"},{"key":"D0FO03468A-(cit91)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1186\/s13075-019-1962-3","volume":"21","author":"Fenton","year":"2019","journal-title":"Arthritis Res. Ther."},{"key":"D0FO03468A-(cit92)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"754","DOI":"10.3389\/fimmu.2017.00754","volume":"8","author":"Fransen","year":"2017","journal-title":"Front. Immunol."},{"key":"D0FO03468A-(cit93)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1002\/jcp.24636","volume":"229","author":"Britton","year":"2014","journal-title":"J. Cell. Physiol."},{"key":"D0FO03468A-(cit94)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/s41586-020-2425-3","volume":"585","author":"Teratani","year":"2020","journal-title":"Nature"},{"key":"D0FO03468A-(cit95)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s12974-020-01760-1","volume":"17","author":"Shi","year":"2020","journal-title":"J. Neuroinflammation"},{"issue":"12","key":"D0FO03468A-(cit96)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3701","DOI":"10.3390\/nu12123701","volume":"12","author":"Hung","year":"2020","journal-title":"Nutrients"},{"key":"D0FO03468A-(cit97)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1186\/s40168-020-00920-y","volume":"8","author":"Shi","year":"2020","journal-title":"Microbiome"},{"key":"D0FO03468A-(cit98)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/jpi.12013","volume":"54","author":"Sommansson","year":"2013","journal-title":"J. Pineal Res."},{"key":"D0FO03468A-(cit99)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1113\/EP086110","volume":"102","author":"Wan Saudi","year":"2017","journal-title":"Exp. Physiol."},{"key":"D0FO03468A-(cit100)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/s00248-010-9673-y","volume":"61","author":"Dhanasiri","year":"2011","journal-title":"Microb. Ecol."},{"key":"D0FO03468A-(cit101)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"14184","DOI":"10.1038\/s41598-018-32366-6","volume":"8","author":"Hayes","year":"2018","journal-title":"Sci. Rep."},{"key":"D0FO03468A-(cit102)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.3389\/fimmu.2018.02757","volume":"9","author":"Treangen","year":"2018","journal-title":"Front. Immunol."},{"issue":"1","key":"D0FO03468A-(cit103)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e00698-18","DOI":"10.1128\/mSphereDirect.00698-18","volume":"4","author":"Leslie","year":"2019","journal-title":"mSphere"},{"key":"D0FO03468A-(cit104)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1136\/gutjnl-2016-313214","volume":"67","author":"Cabinian","year":"2018","journal-title":"Gut"},{"key":"D0FO03468A-(cit105)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/s41586-019-1579-3","volume":"574","author":"Godinho-Silva","year":"2019","journal-title":"Nature"},{"key":"D0FO03468A-(cit106)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.cell.2015.12.023","volume":"164","author":"Gabanyi","year":"2016","journal-title":"Cell"},{"key":"D0FO03468A-(cit107)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/289317a0","volume":"289","author":"Livett","year":"1981","journal-title":"Nature"},{"key":"D0FO03468A-(cit108)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.cell.2015.02.047","volume":"161","author":"Yano","year":"2015","journal-title":"Cell"},{"key":"D0FO03468A-(cit109)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1136\/gutjnl-2013-306236","volume":"64","author":"Vicario","year":"2015","journal-title":"Gut"},{"key":"D0FO03468A-(cit110)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.molmet.2018.03.016","volume":"12","author":"Egerod","year":"2018","journal-title":"Mol. Metab."},{"key":"D0FO03468A-(cit111)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1111\/j.1365-2982.2009.01317.x","volume":"21","author":"Bucinskaite","year":"2009","journal-title":"Neurogastroenterol. Motil."},{"key":"D0FO03468A-(cit112)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.cell.2016.05.011","volume":"166","author":"Williams","year":"2016","journal-title":"Cell"},{"key":"D0FO03468A-(cit113)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"eaba0466","DOI":"10.1126\/sciadv.aba0466","volume":"6","author":"Chen","year":"2020","journal-title":"Sci. Adv."},{"key":"D0FO03468A-(cit114)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4457","DOI":"10.1038\/s41467-020-18262-6","volume":"11","author":"Yang","year":"2020","journal-title":"Nat. Commun."},{"issue":"6408","key":"D0FO03468A-(cit115)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"eaat5236","DOI":"10.1126\/science.aat5236","volume":"361","author":"Kaelberer","year":"2018","journal-title":"Science"},{"key":"D0FO03468A-(cit116)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1038\/s41467-020-16491-3","volume":"11","author":"Green","year":"2020","journal-title":"Nat. Commun."},{"key":"D0FO03468A-(cit117)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1053\/j.gastro.2018.07.023","volume":"155","author":"Gracz","year":"2018","journal-title":"Gastroenterology"},{"key":"D0FO03468A-(cit118)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"12515","DOI":"10.1038\/s41598-019-48775-0","volume":"9","author":"M\u00fcller","year":"2019","journal-title":"Sci. Rep."},{"key":"D0FO03468A-(cit119)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1038\/s41467-018-04697-5","volume":"9","author":"Byun","year":"2018","journal-title":"Nat. Commun."},{"key":"D0FO03468A-(cit120)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/exd.12890","volume":"25","author":"Skobowiat","year":"2016","journal-title":"Exp. Dermatol."},{"key":"D0FO03468A-(cit121)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"E3028","DOI":"10.1073\/pnas.1208208109","volume":"109","author":"Spurny","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D0FO03468A-(cit122)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/s41398-017-0078-2","volume":"8","author":"Li","year":"2018","journal-title":"Transl. Psychiatry"},{"key":"D0FO03468A-(cit123)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/nn.4030","volume":"18","author":"Erny","year":"2015","journal-title":"Nat. Neurosci."},{"key":"D0FO03468A-(cit124)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s00401-017-1747-1","volume":"134","author":"Hagemeyer","year":"2017","journal-title":"Acta Neuropathol."},{"key":"D0FO03468A-(cit125)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/s41586-018-0119-x","volume":"557","author":"Rothhammer","year":"2018","journal-title":"Nature"},{"key":"D0FO03468A-(cit126)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/s41398-020-00878-3","volume":"10","author":"Zhang","year":"2020","journal-title":"Transl. Psychiatry"},{"key":"D0FO03468A-(cit127)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8311","DOI":"10.1038\/s41598-020-65444-9","volume":"10","author":"Mach","year":"2020","journal-title":"Sci. Rep."},{"key":"D0FO03468A-(cit128)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e3450","DOI":"10.7717\/peerj.3450","volume":"5","author":"Wang","year":"2017","journal-title":"PeerJ"},{"key":"D0FO03468A-(cit129)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8583","DOI":"10.18632\/aging.103168","volume":"12","author":"He","year":"2020","journal-title":"Aging"},{"key":"D0FO03468A-(cit130)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1089\/ten.tea.2017.0462","volume":"24","author":"Liu","year":"2018","journal-title":"Tissue Eng., Part A"},{"issue":"11","key":"D0FO03468A-(cit131)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3531","DOI":"10.3390\/ijms19113531","volume":"19","author":"Kauschke","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"D0FO03468A-(cit132)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.ajpath.2018.10.017","volume":"189","author":"Hathaway-Schrader","year":"2019","journal-title":"Am. J. Pathol."},{"key":"D0FO03468A-(cit133)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1002\/jbmr.1588","volume":"27","author":"Sj\u00f6gren","year":"2012","journal-title":"J. Bone Miner. Res."},{"key":"D0FO03468A-(cit134)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1210\/jc.2017-02799","volume":"103","author":"Insenser","year":"2018","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"D0FO03468A-(cit135)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1002\/jcp.24340","volume":"228","author":"McCabe","year":"2013","journal-title":"J. Cell. Physiol."},{"key":"D0FO03468A-(cit136)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6501","DOI":"10.1021\/jf2009777","volume":"59","author":"Weaver","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"D0FO03468A-(cit137)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1017\/S000711451300055X","volume":"110","author":"Whisner","year":"2013","journal-title":"Br. J. Nutr."}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2021\/FO\/D0FO03468A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:38:56Z","timestamp":1782927536000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/12\/13\/5703-5718\/687487"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":137,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2021,7,5]]}},"URL":"https:\/\/doi.org\/10.1039\/d0fo03468a","relation":{},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Yun-Feng Rui (ORCID)","URL":"http:\/\/orcid.org\/0000-0001-9019-5531","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 30 December 2020; Accepted 7 May 2021;  Accepted Manuscript published 8 May 2021;  Advance Article published 28 May 2021;  Version of Record published 5 July 2021","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}