{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T18:32:50Z","timestamp":1783017170940,"version":"3.54.6"},"reference-count":36,"publisher":"Royal Society of Chemistry (RSC)","issue":"13","license":[{"start":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T00:00:00Z","timestamp":1590624000000},"content-version":"vor","delay-in-days":148,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["JP18K18390"],"award-info":[{"award-number":["JP18K18390"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Lab Chip"],"abstract":"<p>We have developed a high-throughput method for obtaining hydrophilic, rigid, low-absorption\/adsorption, and sterilized multi-layer 3D integrated PDMS microfluidic chips simply by applying electron beam or \u03b3-ray irradiation to stacked PDMS layers.<\/p>","DOI":"10.1039\/d0lc00316f","type":"journal-article","created":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T05:23:49Z","timestamp":1590643429000},"page":"2354-2363","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["A simple method for production of hydrophilic, rigid, and sterilized multi-layer 3D integrated polydimethylsiloxane microfluidic chips"],"prefix":"10.1039","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5722-2726","authenticated-orcid":false,"given":"Tomoko Gowa","family":"Oyama","sequence":"first","affiliation":[{"name":"Quantum Beam Science Research Directorate"},{"name":"National Institutes for Quantum and Radiological Science and Technology (QST)"},{"name":"Takasaki-shi"},{"name":"Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4090-025X","authenticated-orcid":false,"given":"Kotaro","family":"Oyama","sequence":"additional","affiliation":[{"name":"Quantum Beam Science Research Directorate"},{"name":"National Institutes for Quantum and Radiological Science and Technology (QST)"},{"name":"Takasaki-shi"},{"name":"Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5545-4689","authenticated-orcid":false,"given":"Mitsumasa","family":"Taguchi","sequence":"additional","affiliation":[{"name":"Quantum Beam Science Research Directorate"},{"name":"National Institutes for Quantum and Radiological Science and Technology (QST)"},{"name":"Takasaki-shi"},{"name":"Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2020]]},"reference":[{"key":"D0LC00316F-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/(SICI)1522-2683(20000101)21:1<27::AID-ELPS27>3.0.CO;2-C","volume":"21","author":"McDonald","year":"2000","journal-title":"Electrophoresis"},{"key":"D0LC00316F-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1039\/b612140c","volume":"6","author":"Toepke","year":"2006","journal-title":"Lab Chip"},{"key":"D0LC00316F-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1039\/B813061B","volume":"9","author":"Hardy","year":"2009","journal-title":"Lab Chip"},{"key":"D0LC00316F-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3102","DOI":"10.1039\/C3RA46708B","volume":"4","author":"Kang","year":"2014","journal-title":"RSC Adv."},{"key":"D0LC00316F-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.mee.2014.10.013","volume":"132","author":"Temiz","year":"2015","journal-title":"Microelectron. Eng."},{"key":"D0LC00316F-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4974","DOI":"10.1021\/ac980656z","volume":"70","author":"Duffy","year":"1998","journal-title":"Anal. Chem."},{"key":"D0LC00316F-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1126\/science.288.5463.113","volume":"288","author":"Unger","year":"2000","journal-title":"Science"},{"key":"D0LC00316F-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"067001","DOI":"10.1088\/0960-1317\/18\/6\/067001","volume":"18","author":"Eddings","year":"2008","journal-title":"J. Micromech. Microeng."},{"key":"D0LC00316F-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1039\/b923101c","volume":"10","author":"Zhang","year":"2010","journal-title":"Lab Chip"},{"key":"D0LC00316F-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1039\/C6LC01338D","volume":"17","author":"Chu","year":"2017","journal-title":"Lab Chip"},{"key":"D0LC00316F-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3372","DOI":"10.1021\/la903154y","volume":"26","author":"B\u00e9fahy","year":"2010","journal-title":"Langmuir"},{"key":"D0LC00316F-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/elps.200900475","volume":"31","author":"Zhou","year":"2010","journal-title":"Electrophoresis"},{"key":"D0LC00316F-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1039\/c0lc00522c","volume":"11","author":"Li","year":"2011","journal-title":"Lab Chip"},{"key":"D0LC00316F-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"213704","DOI":"10.1063\/1.5025076","volume":"112","author":"Oyama","year":"2018","journal-title":"Appl. Phys. Lett."},{"key":"D0LC00316F-(cit15)\/*[position()=1]","volume-title":"Comprehensive Biomaterials, Volume 4: Biocompatibility, Surface engineering, and Delivery of Drugs, Genes and Other Molecules","author":"Qiu","year":"2011","unstructured":"Q. Q. Qiu  ,  W. Q.Sun  and  J.Connor ,  Comprehensive Biomaterials, Volume 4: Biocompatibility, Surface engineering, and Delivery of Drugs, Genes and Other Molecules , ed.  P. Duchevne ,  Elsevier ,  Amsterdam , 1st edn,  2011 ,  pp. 127\u2013144"},{"key":"D0LC00316F-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1039\/C9LC00039A","volume":"19","author":"Iyer","year":"2019","journal-title":"Lab Chip"},{"key":"D0LC00316F-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.sna.2015.04.011","volume":"230","author":"Seghir","year":"2015","journal-title":"Sens. Actuators, A"},{"key":"D0LC00316F-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1557\/JMR.2008.0029","volume":"23","author":"Mills","year":"2008","journal-title":"J. Mater. Res."},{"key":"D0LC00316F-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"855","DOI":"10.3390\/mi6070855","volume":"6","author":"Liu","year":"2015","journal-title":"Micromachines"},{"key":"D0LC00316F-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9132","DOI":"10.1038\/s41598-018-27317-0","volume":"8","author":"Zeranska-Chudek","year":"2018","journal-title":"Sci. Rep."},{"key":"D0LC00316F-(cit22)\/*[position()=1]","first-page":"157","volume":"35","author":"Kang","year":"2011","journal-title":"Polymer"},{"key":"D0LC00316F-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3842","DOI":"10.1021\/la200202u","volume":"27","author":"Huszank","year":"2011","journal-title":"Langmuir"},{"key":"D0LC00316F-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.jpha.2017.05.003","volume":"7","author":"Waters","year":"2017","journal-title":"J. Pharm. Anal."},{"key":"D0LC00316F-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3174","DOI":"10.1002\/elps.200900132","volume":"30","author":"Zhang","year":"2009","journal-title":"Electrophoresis"},{"key":"D0LC00316F-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6627","DOI":"10.1021\/ac900551m","volume":"81","author":"Zhou","year":"2009","journal-title":"Anal. Chem."},{"key":"D0LC00316F-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7377","DOI":"10.1038\/s41598-019-43625-5","volume":"9","author":"G\u00f6kaltun","year":"2019","journal-title":"Sci. Rep."},{"key":"D0LC00316F-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0969-806X(01)00416-9","volume":"62","author":"Hill","year":"2001","journal-title":"Radiat. Phys. Chem."},{"key":"D0LC00316F-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/S0032-3861(01)00711-X","volume":"43","author":"Hill","year":"2002","journal-title":"Polymer"},{"key":"D0LC00316F-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3519","DOI":"10.1021\/ja01499a011","volume":"82","author":"Miller","year":"1960","journal-title":"J. Am. Chem. Soc."},{"key":"D0LC00316F-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.2320\/matertrans.M2011129","volume":"52","author":"Nishi","year":"2011","journal-title":"Mater. Trans."},{"key":"D0LC00316F-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.2320\/matertrans.M2012124","volume":"53","author":"Nishi","year":"2012","journal-title":"Mater. Trans."},{"key":"D0LC00316F-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"503","DOI":"10.2320\/jinstmet.J2016001","volume":"80","author":"Yamaguchi","year":"2016","journal-title":"J. Jpn. Inst. Met. Mater."},{"key":"D0LC00316F-(cit34)\/*[position()=1]","volume-title":"Radiation: Fundamentals, Applications, Risks, and Safety","author":"Obodovskiy","year":"2019","unstructured":"I. Obodovskiy  ,  Radiation: Fundamentals, Applications, Risks, and Safety ,  Elsevier ,  The Netherlands ,  2019"},{"key":"D0LC00316F-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"483","DOI":"10.3769\/radioisotopes.53.483","volume":"53","author":"Tabei","year":"2004","journal-title":"Radioisotopes"},{"key":"D0LC00316F-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3858","DOI":"10.1021\/acs.analchem.7b00136","volume":"89","author":"Macdonald","year":"2017","journal-title":"Anal. Chem."},{"key":"D0LC00316F-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"17019","DOI":"10.1038\/natrevmats.2017.19","volume":"2","author":"Zhang","year":"2017","journal-title":"Nat. Rev. Mater."}],"container-title":["Lab on a Chip"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2020\/LC\/D0LC00316F","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:33:37Z","timestamp":1783013617000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/lc\/article\/20\/13\/2354-2363\/688864"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":36,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2020,6,30]]}},"URL":"https:\/\/doi.org\/10.1039\/d0lc00316f","relation":{},"ISSN":["1473-0197","1473-0189"],"issn-type":[{"value":"1473-0197","type":"print"},{"value":"1473-0189","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/D0LC00316F","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Tomoko Gowa Oyama (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-5722-2726","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Tomoko Gowa Oyama (ResearcherID)","URL":"http:\/\/www.researcherid.com\/rid\/E-7643-2012","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Kotaro Oyama (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-4090-025X","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Mitsumasa Taguchi (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-5545-4689","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 29 March 2020; Accepted 22 May 2020;  Accepted Manuscript published 28 May 2020;  Advance Article published 4 June 2020;  Version of Record published 30 June 2020","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}