{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T14:59:12Z","timestamp":1793026752690,"version":"4.5.0"},"reference-count":160,"publisher":"Royal Society of Chemistry (RSC)","issue":"5","license":[{"start":{"date-parts":[[2022,2,26]],"date-time":"2022-02-26T00:00:00Z","timestamp":1645833600000},"content-version":"am","delay-in-days":421,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["DEO29661"],"award-info":[{"award-number":["DEO29661"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Med. Chem."],"abstract":"<p>\n                    Local and\/or systemic antibacterial therapy has been extensively studied and suggested to control periodontopathogens like\n                    <italic>P. gingivalis<\/italic>\n                    . However, more effective and specific antibacterial agents against oral pathobionts remain to be developed.\n                  <\/p>","DOI":"10.1039\/d0md00424c","type":"journal-article","created":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T06:14:50Z","timestamp":1614320090000},"page":"666-704","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["<i>Porphyromonas gingivalis<\/i>\n                    : where do we stand in our battle against this oral pathogen?"],"prefix":"10.1039","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8844-062X","authenticated-orcid":false,"given":"Kaitlind C.","family":"Howard","sequence":"first","affiliation":[{"name":"College of Pharmacy"},{"name":"Department of Pharmaceutical Sciences"},{"name":"University of Kentucky"},{"name":"Lexington"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8885-8604","authenticated-orcid":false,"given":"Octavio A.","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"College of Dentistry"},{"name":"Center for Oral Health Research and Division of Periodontics"},{"name":"University of Kentucky"},{"name":"Lexington"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7961-5555","authenticated-orcid":false,"given":"Sylvie","family":"Garneau-Tsodikova","sequence":"additional","affiliation":[{"name":"College of Pharmacy"},{"name":"Department of Pharmaceutical Sciences"},{"name":"University of Kentucky"},{"name":"Lexington"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2021]]},"reference":[{"key":"D0MD00424C-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.cden.2016.11.005","volume":"61","author":"Harvey","year":"2017","journal-title":"Dent. Clin. North Am."},{"key":"D0MD00424C-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1902\/jop.1965.36.3.177","volume":"36","author":"Loe","year":"1965","journal-title":"J. Periodontol."},{"key":"D0MD00424C-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4944","DOI":"10.1038\/s41598-019-41467-9","volume":"9","author":"Zhu","year":"2019","journal-title":"Sci. Rep."},{"key":"D0MD00424C-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1177\/0022034512457373","volume":"91","author":"Eke","year":"2012","journal-title":"J. Dent. Res."},{"key":"D0MD00424C-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4689","DOI":"10.1128\/IAI.72.8.4689-4698.2004","volume":"72","author":"Andrian","year":"2004","journal-title":"Infect. Immun."},{"key":"D0MD00424C-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3965","DOI":"10.2741\/2363","volume":"12","author":"Amano","year":"2007","journal-title":"Front. Biosci."},{"key":"D0MD00424C-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3754","DOI":"10.5504\/BBEQ.2013.0027","volume":"27","author":"Popova","year":"2013","journal-title":"Biotechnol. Biotechnol. Equip."},{"key":"D0MD00424C-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3389\/fcimb.2017.00057","volume":"7","author":"Geng","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"D0MD00424C-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"408","DOI":"10.3389\/fnagi.2017.00408","volume":"9","author":"Carter","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"D0MD00424C-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e108074","DOI":"10.1371\/journal.pone.0108074","volume":"9","author":"Akcali","year":"2014","journal-title":"PLoS One"},{"key":"D0MD00424C-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"CR646","DOI":"10.12659\/MSM.882050","volume":"17","author":"Straka","year":"2011","journal-title":"Med. Sci. Monit."},{"key":"D0MD00424C-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"eaau3333","DOI":"10.1126\/sciadv.aau3333","volume":"5","author":"Dominy","year":"2019","journal-title":"Sci. Adv."},{"key":"D0MD00424C-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"ftv009","DOI":"10.1093\/femspd\/ftv009","volume":"73","author":"Chukkapalli","year":"2015","journal-title":"Pathog. Dis."},{"key":"D0MD00424C-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"R109","DOI":"10.1186\/ar4289","volume":"15","author":"Arvikar","year":"2013","journal-title":"Arthritis Res. Ther."},{"key":"D0MD00424C-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/nrrheum.2017.132","volume":"13","author":"Potempa","year":"2017","journal-title":"Nat. Rev. Rheumatol."},{"issue":"Suppl 20","key":"D0MD00424C-(cit16)\/*[position()=1]","first-page":"S1","volume":"45","author":"Caton","year":"2018","journal-title":"J. Clin. Periodontol."},{"key":"D0MD00424C-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"435","DOI":"10.4161\/viru.2.5.16140","volume":"2","author":"Huang","year":"2011","journal-title":"Virulence"},{"key":"D0MD00424C-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0718-5391(09)70033-3","volume":"2","author":"D\u00edaz","year":"2009","journal-title":"Revista Cl\u00ednica De Periodoncia, Implantolog\u00eda Y Rehabilitaci\u00f3n Oral"},{"key":"D0MD00424C-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"915","DOI":"10.2217\/fmb-2018-0043","volume":"13","author":"Zhu","year":"2018","journal-title":"Future Microbiol."},{"issue":"Suppl 1","key":"D0MD00424C-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/eos.12425","volume":"126","author":"Valen","year":"2018","journal-title":"Eur. J. Oral Sci."},{"key":"D0MD00424C-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"71","DOI":"10.4103\/0976-9668.82317","volume":"2","author":"Saini","year":"2011","journal-title":"J. Nat. Sci., Biol. Med."},{"key":"D0MD00424C-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e65520","DOI":"10.1371\/journal.pone.0065520","volume":"8","author":"Ge","year":"2013","journal-title":"PLoS One"},{"key":"D0MD00424C-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1007\/s40496-014-0033-8","volume":"1","author":"K\u00f6n\u00f6nen","year":"2014","journal-title":"Curr Oral Health Rep"},{"key":"D0MD00424C-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e71727","DOI":"10.1371\/journal.pone.0071727","volume":"8","author":"Zhu","year":"2013","journal-title":"PLoS One"},{"key":"D0MD00424C-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1111\/apm.12688","volume":"125","author":"Larsen","year":"2017","journal-title":"APMIS"},{"key":"D0MD00424C-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1600-051X.1998.tb02419.x","volume":"25","author":"Socransky","year":"1998","journal-title":"J. Clin. Periodontol."},{"key":"D0MD00424C-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1099\/00221287-148-2-467","volume":"148","author":"Diaz","year":"2002","journal-title":"Microbiology"},{"key":"D0MD00424C-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1574-6968.1999.tb13630.x","volume":"175","author":"Nakamura","year":"1999","journal-title":"FEMS Microbiol. Lett."},{"key":"D0MD00424C-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1600-0757.2006.00187.x","volume":"42","author":"Kolenbrander","year":"2006","journal-title":"Periodontol 2000"},{"key":"D0MD00424C-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"E791","DOI":"10.1073\/pnas.1522149113","volume":"113","author":"Mark Welch","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D0MD00424C-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"432","DOI":"10.3389\/fcimb.2019.00432","volume":"9","author":"Ng","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"D0MD00424C-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.chom.2011.10.006","volume":"10","author":"Hajishengallis","year":"2011","journal-title":"Cell Host Microbe"},{"key":"D0MD00424C-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/nrmicro2873","volume":"10","author":"Hajishengallis","year":"2012","journal-title":"Nat. Rev. Microbiol."},{"key":"D0MD00424C-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1902\/jop.2003.74.1.90","volume":"74","author":"Amano","year":"2003","journal-title":"J. Periodontol."},{"key":"D0MD00424C-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"609","DOI":"10.2319\/082310-352.1","volume":"81","author":"Liu","year":"2011","journal-title":"Angle Orthod."},{"key":"D0MD00424C-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.micpath.2015.03.016","volume":"82","author":"Sanchez","year":"2015","journal-title":"Microb. Pathog."},{"key":"D0MD00424C-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.micinf.2004.10.007","volume":"7","author":"Nakagawa","year":"2005","journal-title":"Microbes Infect."},{"key":"D0MD00424C-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.ijmm.2015.08.018","volume":"305","author":"Vielkind","year":"2015","journal-title":"Int. J. Med. Microbiol."},{"key":"D0MD00424C-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1902\/jop.2014.130291","volume":"85","author":"Rams","year":"2014","journal-title":"J. Periodontol."},{"key":"D0MD00424C-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3389\/fcimb.2018.00243","volume":"8","author":"Liu","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"D0MD00424C-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1902\/jop.2005.76.2.194","volume":"76","author":"Ciantar","year":"2005","journal-title":"J. Periodontol."},{"key":"D0MD00424C-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1902\/jop.1998.69.1.92","volume":"69","author":"Hagiwara","year":"1998","journal-title":"J. Periodontol."},{"key":"D0MD00424C-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1365-2672.2006.03211.x","volume":"103","author":"Apolonio","year":"2007","journal-title":"J. Appl. Microbiol."},{"key":"D0MD00424C-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.3389\/fmicb.2020.01219","volume":"11","author":"Han","year":"2020","journal-title":"Front. Microbiol."},{"key":"D0MD00424C-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e0157516","DOI":"10.1371\/journal.pone.0157516","volume":"11","author":"Mashima","year":"2016","journal-title":"PLoS One"},{"key":"D0MD00424C-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1128\/JB.02512-14","volume":"197","author":"Mashima","year":"2015","journal-title":"J. Bacteriol."},{"key":"D0MD00424C-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1177\/0022034514538283","volume":"93","author":"Aruni","year":"2014","journal-title":"J. Dent. Res."},{"key":"D0MD00424C-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s40496-014-0044-5","volume":"2","author":"Aruni","year":"2015","journal-title":"Curr. Oral Health Rep."},{"key":"D0MD00424C-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3872","DOI":"10.1128\/IAI.05631-11","volume":"79","author":"Aruni","year":"2011","journal-title":"Infect. Immun."},{"key":"D0MD00424C-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/prd.12121","volume":"71","author":"Jepsen","year":"2016","journal-title":"Periodontol 2000"},{"key":"D0MD00424C-(cit51)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1902\/annals.1996.1.1.443","volume":"1","author":"Cobb","year":"1996","journal-title":"Ann. Periodontol."},{"issue":"Suppl 2","key":"D0MD00424C-(cit52)\/*[position()=1]","first-page":"6","volume":"29","author":"Cobb","year":"2002","journal-title":"J. Clin. Periodontol."},{"key":"D0MD00424C-(cit53)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1111\/jcpe.12441","volume":"42","author":"Harks","year":"2015","journal-title":"J. Clin. Periodontol."},{"key":"D0MD00424C-(cit54)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1600-0757.2010.00382.x","volume":"55","author":"Jepsen","year":"2011","journal-title":"Periodontol 2000"},{"key":"D0MD00424C-(cit55)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1902\/jop.2010.100308","volume":"82","author":"Tomasi","year":"2011","journal-title":"J. Periodontol."},{"key":"D0MD00424C-(cit56)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/j.1600-051X.2012.01864.x","volume":"39","author":"Tonetti","year":"2012","journal-title":"J. Clin. Periodontol."},{"key":"D0MD00424C-(cit57)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1902\/jop.2012.120040","volume":"84","author":"Zandbergen","year":"2013","journal-title":"J. Periodontol."},{"key":"D0MD00424C-(cit58)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1111\/jcpe.12004","volume":"39","author":"Feres","year":"2012","journal-title":"J. Clin. Periodontol."},{"key":"D0MD00424C-(cit59)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1111\/j.1600-051X.2005.00814.x","volume":"32","author":"Guerrero","year":"2005","journal-title":"J. Clin. Periodontol."},{"key":"D0MD00424C-(cit60)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/prd.12075","volume":"67","author":"Feres","year":"2015","journal-title":"Periodontol 2000"},{"key":"D0MD00424C-(cit61)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/adj.12641","volume":"63","author":"Sum","year":"2018","journal-title":"Aust. Dent. J."},{"key":"D0MD00424C-(cit62)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1039\/C9MD00074G","volume":"10","author":"Thamban Chandrika","year":"2019","journal-title":"MedChemComm"},{"key":"D0MD00424C-(cit63)\/*[position()=1]","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-662-46623-0","volume-title":"Non-surgical control of periodontal diseases: A comprehensive handbook","author":"Levi Jr.","year":"2016","unstructured":"P. A. Levi Jr. , R. J.Rudy , Y. N.Jeong and D.Coleman , Non-surgical control of periodontal diseases: A comprehensive handbook , Srpinger , 1st edn, 2016 , pp. 163\u2013173"},{"key":"D0MD00424C-(cit64)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"505","DOI":"10.4103\/1735-3327.104866","volume":"9","author":"Kapoor","year":"2012","journal-title":"Dent. Res. J."},{"key":"D0MD00424C-(cit65)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"12","DOI":"10.4103\/ejd.ejd_141_16","volume":"11","author":"Dubey","year":"2017","journal-title":"Eur. J. Dent."},{"key":"D0MD00424C-(cit66)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"162","DOI":"10.4103\/0972-124X.113063","volume":"17","author":"Patil","year":"2013","journal-title":"J. Indian Soc. Periodontol."},{"key":"D0MD00424C-(cit67)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3390\/dj5010012","volume":"5","author":"Khurshid","year":"2017","journal-title":"Dent. J."},{"key":"D0MD00424C-(cit68)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.archoralbio.2011.03.021","volume":"56","author":"Pradeep","year":"2011","journal-title":"Arch. Oral Biol."},{"key":"D0MD00424C-(cit69)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/AOG.0000000000003568","volume":"135","author":"Duffy","year":"2020","journal-title":"Obstet. Gynecol."},{"key":"D0MD00424C-(cit70)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"S252","DOI":"10.4103\/0975-7406.100226","volume":"4","author":"Prakasam","year":"2012","journal-title":"J. Pharm. BioAllied Sci."},{"key":"D0MD00424C-(cit71)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jphotobiol.2018.09.010","volume":"188","author":"Tavares","year":"2018","journal-title":"J. Photochem. Photobiol., B"},{"key":"D0MD00424C-(cit72)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/j.1600-0765.1997.tb00560.x","volume":"32","author":"Wright","year":"1997","journal-title":"J. Periodontal Res."},{"key":"D0MD00424C-(cit73)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.3389\/fmicb.2018.01369","volume":"9","author":"Griffith","year":"2018","journal-title":"Front. Microbiol."},{"key":"D0MD00424C-(cit74)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"482","DOI":"10.3934\/microbiol.2018.3.482","volume":"4","author":"Reygaert","year":"2018","journal-title":"AIMS Microbiol."},{"key":"D0MD00424C-(cit75)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.3389\/fmicb.2018.01058","volume":"9","author":"Markley","year":"2018","journal-title":"Front. Microbiol."},{"key":"D0MD00424C-(cit76)\/*[position()=1]","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.VMBF-0016-2015","volume":"2","author":"Munita","year":"2016","journal-title":"Microbiol. Spectrum"},{"key":"D0MD00424C-(cit77)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"300","DOI":"10.4103\/joacp.JOACP_349_15","volume":"33","author":"Kapoor","year":"2017","journal-title":"J. Anaesthesiol., Clin. Pharmacol."},{"key":"D0MD00424C-(cit78)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e0152020","DOI":"10.1371\/journal.pone.0152020","volume":"11","author":"Holloway","year":"2016","journal-title":"PLoS One"},{"key":"D0MD00424C-(cit79)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1136\/bmj.2.4534.863","volume":"2","author":"Barber","year":"1947","journal-title":"Br. Med. J."},{"key":"D0MD00424C-(cit80)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1128\/CMR.00086-12","volume":"26","author":"Brook","year":"2013","journal-title":"Clin. Microbiol. Rev."},{"key":"D0MD00424C-(cit81)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1054\/drup.2000.0146","volume":"3","author":"Skold","year":"2000","journal-title":"Drug Resist. Updates"},{"key":"D0MD00424C-(cit82)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1093\/emboj\/cdg093","volume":"22","author":"Connell","year":"2003","journal-title":"EMBO J."},{"key":"D0MD00424C-(cit83)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1128\/AAC.42.11.3022","volume":"42","author":"Andres","year":"1998","journal-title":"Antimicrob. Agents Chemother."},{"key":"D0MD00424C-(cit84)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1574-6968.2002.tb11025.x","volume":"207","author":"Lee","year":"2002","journal-title":"FEMS Microbiol. Lett."},{"key":"D0MD00424C-(cit85)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1111\/odi.13043","volume":"25","author":"Arredondo","year":"2019","journal-title":"Oral Dis."},{"key":"D0MD00424C-(cit86)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1128\/AAC.01095-09","volume":"54","author":"Stamm","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"D0MD00424C-(cit87)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1093\/cid\/ciu395","volume":"59","author":"Schuetz","year":"2014","journal-title":"Clin. Infect. Dis."},{"key":"D0MD00424C-(cit88)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1590\/S1678-77572012000300002","volume":"20","author":"Soares","year":"2012","journal-title":"J. Appl. Oral Sci."},{"key":"D0MD00424C-(cit89)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1093\/jac\/46.4.583","volume":"46","author":"Eick","year":"2000","journal-title":"J. Antimicrob. Chemother."},{"key":"D0MD00424C-(cit90)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5410","DOI":"10.1016\/j.bmc.2016.08.059","volume":"24","author":"Patil","year":"2016","journal-title":"Bioorg. Med. Chem."},{"key":"D0MD00424C-(cit91)\/*[position()=1]","first-page":"e00400","volume":"62","author":"Tan","year":"2018","journal-title":"Antimicrob. Agents Chemother."},{"key":"D0MD00424C-(cit92)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.anaerobe.2017.01.005","volume":"44","author":"Olczak","year":"2017","journal-title":"Anaerobe"},{"key":"D0MD00424C-(cit93)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/j.1574-6968.2008.01069.x","volume":"280","author":"Kang","year":"2008","journal-title":"FEMS Microbiol. Lett."},{"key":"D0MD00424C-(cit94)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1007\/s00044-017-2129-x","volume":"27","author":"Laurentiz","year":"2018","journal-title":"Med. Chem. Res."},{"key":"D0MD00424C-(cit95)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1515\/hc-2014-0107","volume":"20","author":"S\u0105czewski","year":"2014","journal-title":"Heterocycl. Commun."},{"key":"D0MD00424C-(cit96)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.1021\/ja973881r","volume":"120","author":"Li","year":"1998","journal-title":"J. Am. Chem. Soc."},{"key":"D0MD00424C-(cit97)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1021\/ja982938m","volume":"121","author":"Li","year":"1999","journal-title":"J. Am. Chem. Soc."},{"key":"D0MD00424C-(cit98)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/j.1399-302X.2008.00464.x","volume":"24","author":"Isogai","year":"2009","journal-title":"Oral Microbiol. Immunol."},{"key":"D0MD00424C-(cit99)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5133","DOI":"10.1016\/j.bmc.2014.08.015","volume":"22","author":"Alafeefy","year":"2014","journal-title":"Bioorg. Med. Chem."},{"key":"D0MD00424C-(cit100)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"592","DOI":"10.3109\/14756366.2014.957202","volume":"30","author":"Alafeefy","year":"2015","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"D0MD00424C-(cit101)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e0141126","DOI":"10.1371\/journal.pone.0141126","volume":"10","author":"Stone","year":"2015","journal-title":"PLoS One"},{"key":"D0MD00424C-(cit102)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"Fnx005","DOI":"10.1093\/femsle\/fnx005","volume":"364","author":"Gerits","year":"2017","journal-title":"FEMS Microbiol. Lett."},{"key":"D0MD00424C-(cit103)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1021\/acsmedchemlett.9b00614","volume":"11","author":"Howard","year":"2020","journal-title":"ACS Med. Chem. Lett."},{"key":"D0MD00424C-(cit104)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e01846","DOI":"10.1128\/AAC.01846-16","volume":"61","author":"Gerits","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"D0MD00424C-(cit105)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.ejmech.2017.08.024","volume":"139","author":"Rea","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"D0MD00424C-(cit106)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/omi.12015","volume":"28","author":"Frohlich","year":"2013","journal-title":"Mol. Oral Microbiol."},{"key":"D0MD00424C-(cit107)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"725","DOI":"10.18388\/abp.2003_3663","volume":"50","author":"Eick","year":"2003","journal-title":"Acta Biochim. Pol."},{"key":"D0MD00424C-(cit108)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.3892\/mmr.2015.3584","volume":"12","author":"Li","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"D0MD00424C-(cit109)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jep.2008.06.005","volume":"119","author":"Rivero-Cruz","year":"2008","journal-title":"J. Ethnopharmacol."},{"key":"D0MD00424C-(cit110)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1002\/ptr.2473","volume":"22","author":"Park","year":"2008","journal-title":"Phytother. Res."},{"key":"D0MD00424C-(cit111)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"839019","DOI":"10.1155\/2014\/839019","volume":"2014","author":"Karygianni","year":"2014","journal-title":"BioMed Res. Int."},{"key":"D0MD00424C-(cit112)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s12906-019-2461-4","volume":"19","author":"Karygianni","year":"2019","journal-title":"BMC Complementary Altern. Med."},{"key":"D0MD00424C-(cit113)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1080\/14786419.2010.534996","volume":"25","author":"Rivero-Cruz","year":"2011","journal-title":"Nat. Prod. Res."},{"key":"D0MD00424C-(cit114)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.1021\/np2004775","volume":"74","author":"Gafner","year":"2011","journal-title":"J. Nat. Prod."},{"key":"D0MD00424C-(cit115)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"016006","DOI":"10.1088\/1752-7155\/6\/1\/016006","volume":"6","author":"Tanabe","year":"2012","journal-title":"J. Breath Res."},{"key":"D0MD00424C-(cit116)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1186\/1756-0500-4-406","volume":"4","author":"Raja","year":"2011","journal-title":"BMC Res. Notes"},{"key":"D0MD00424C-(cit117)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3706","DOI":"10.1016\/j.bmcl.2007.04.034","volume":"17","author":"Singh","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D0MD00424C-(cit118)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/jre.12372","volume":"52","author":"Kariu","year":"2017","journal-title":"J. Periodontal Res."},{"key":"D0MD00424C-(cit119)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.fitote.2012.06.003","volume":"83","author":"Bonifait","year":"2012","journal-title":"Fitoterapia"},{"key":"D0MD00424C-(cit120)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"178","DOI":"10.3389\/fcimb.2018.00178","volume":"8","author":"Li","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"D0MD00424C-(cit121)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1111\/j.1365-2672.2012.05329.x","volume":"113","author":"Feldman","year":"2012","journal-title":"J. Appl. Microbiol."},{"key":"D0MD00424C-(cit122)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/1472-6882-12-80","volume":"12","author":"Marquis","year":"2012","journal-title":"BMC Complementary Altern. Med."},{"key":"D0MD00424C-(cit123)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5419","DOI":"10.1016\/j.bmcl.2009.07.110","volume":"19","author":"Genovese","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D0MD00424C-(cit124)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.phytol.2008.07.007","volume":"1","author":"Rivero-Cruz","year":"2008","journal-title":"Phytochem. Lett."},{"key":"D0MD00424C-(cit125)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.1016\/S0960-894X(01)00647-3","volume":"11","author":"Zhu","year":"2001","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D0MD00424C-(cit126)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S1631-0748(03)00066-3","volume":"6","author":"Hichri","year":"2003","journal-title":"C. R. Chim."},{"key":"D0MD00424C-(cit127)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1021\/np990633v","volume":"63","author":"Kashiwada","year":"2000","journal-title":"J. Nat. Prod."},{"key":"D0MD00424C-(cit128)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1021\/jm950922q","volume":"39","author":"Kashiwada","year":"1996","journal-title":"J. Med. Chem."},{"key":"D0MD00424C-(cit129)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"543","DOI":"10.3390\/molecules160100543","volume":"16","author":"Carvalho","year":"2011","journal-title":"Molecules"},{"key":"D0MD00424C-(cit130)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0305-1978(03)00139-X","volume":"32","author":"Ambrosio","year":"2004","journal-title":"Biochem. Syst. Ecol."},{"key":"D0MD00424C-(cit131)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1055\/s-2006-957971","volume":"62","author":"da Costa","year":"1996","journal-title":"Planta Med."},{"key":"D0MD00424C-(cit132)\/*[position()=1]","first-page":"349","volume":"48","author":"Dalo","year":"2007","journal-title":"Invest. Clin."},{"key":"D0MD00424C-(cit133)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1590\/S1517-83822012000200045","volume":"43","author":"Dos Santos","year":"2012","journal-title":"Braz. J. Microbiol."},{"key":"D0MD00424C-(cit134)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1007\/s10295-010-0935-y","volume":"38","author":"Capel","year":"2011","journal-title":"J. Ind. Microbiol. Biotechnol."},{"key":"D0MD00424C-(cit135)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1016\/j.ejmech.2010.03.049","volume":"45","author":"Reddy","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"D0MD00424C-(cit136)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"40426","DOI":"10.1039\/C8RA08435A","volume":"8","author":"Singh","year":"2018","journal-title":"RSC Adv."},{"key":"D0MD00424C-(cit137)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5236","DOI":"10.1039\/b912093a","author":"Newman","year":"2009","journal-title":"Chem. Commun."},{"key":"D0MD00424C-(cit138)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ejmech.2017.05.037","volume":"137","author":"Park","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"D0MD00424C-(cit139)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S1074-5521(03)00002-4","volume":"10","author":"Smith","year":"2003","journal-title":"Chem. Biol."},{"key":"D0MD00424C-(cit140)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1111\/j.1365-2672.2011.05194.x","volume":"112","author":"Asahi","year":"2012","journal-title":"J. Appl. Microbiol."},{"key":"D0MD00424C-(cit141)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/omi.12060","volume":"29","author":"Wright","year":"2014","journal-title":"Mol. Oral Microbiol."},{"key":"D0MD00424C-(cit142)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.micpath.2018.01.009","volume":"116","author":"Wang","year":"2018","journal-title":"Microb. Pathog."},{"key":"D0MD00424C-(cit143)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9611","DOI":"10.3390\/molecules16119611","volume":"16","author":"Souza","year":"2011","journal-title":"Molecules"},{"key":"D0MD00424C-(cit144)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2576548","DOI":"10.1155\/2017\/2576548","volume":"2017","author":"Albabtain","year":"2017","journal-title":"J. Evidence-Based Complementary Altern. Med."},{"key":"D0MD00424C-(cit145)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"273","DOI":"10.3109\/13880209.2013.833948","volume":"52","author":"Wongsariya","year":"2014","journal-title":"Pharm. Biol."},{"key":"D0MD00424C-(cit146)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.archoralbio.2011.02.005","volume":"56","author":"Moon","year":"2011","journal-title":"Arch. Oral Biol."},{"key":"D0MD00424C-(cit147)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.3390\/molecules22122135","volume":"22","author":"Azizan","year":"2017","journal-title":"Molecules"},{"key":"D0MD00424C-(cit148)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s13197-011-0330-3","volume":"48","author":"Miyake","year":"2011","journal-title":"J. Food Sci. Technol."},{"key":"D0MD00424C-(cit149)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/omi.12260","volume":"34","author":"Ben Lagha","year":"2019","journal-title":"Mol. Oral Microbiol."},{"key":"D0MD00424C-(cit150)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1186\/1472-6882-14-343","volume":"14","author":"Patra","year":"2014","journal-title":"BMC Complementary Altern. Med."},{"key":"D0MD00424C-(cit151)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1111\/jam.12458","volume":"116","author":"Asahi","year":"2014","journal-title":"J. Appl. Microbiol."},{"key":"D0MD00424C-(cit152)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.archoralbio.2016.01.014","volume":"65","author":"Fournier-Larente","year":"2016","journal-title":"Arch. Oral Biol."},{"key":"D0MD00424C-(cit153)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1016\/j.ejmech.2007.11.001","volume":"43","author":"Bodet","year":"2008","journal-title":"Eur. J. Med. Chem."},{"key":"D0MD00424C-(cit154)\/*[position()=1]","first-page":"543","volume":"5","author":"Wolska","year":"2010","journal-title":"Cent. Eur. J. Biol."},{"key":"D0MD00424C-(cit155)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e0143158","DOI":"10.1371\/journal.pone.0143158","volume":"10","author":"Lombardo Bedran","year":"2015","journal-title":"PLoS One"},{"key":"D0MD00424C-(cit156)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.archoralbio.2014.08.019","volume":"60","author":"Kong","year":"2015","journal-title":"Arch. Oral Biol."},{"key":"D0MD00424C-(cit157)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/j.archoralbio.2014.07.008","volume":"59","author":"Jang","year":"2014","journal-title":"Arch. Oral Biol."},{"key":"D0MD00424C-(cit158)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e105286","DOI":"10.1371\/journal.pone.0105286","volume":"9","author":"Lien","year":"2014","journal-title":"PLoS One"},{"key":"D0MD00424C-(cit159)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e0131758","DOI":"10.1371\/journal.pone.0131758","volume":"10","author":"Grenier","year":"2015","journal-title":"PLoS One"},{"key":"D0MD00424C-(cit160)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1600-0757.2005.00148.x","volume":"40","author":"Feng","year":"2006","journal-title":"Periodontol 2000"}],"container-title":["RSC Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2021\/MD\/D0MD00424C","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T18:19:12Z","timestamp":1783275552000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/md\/article\/12\/5\/666-704\/690003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":160,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5,26]]}},"URL":"https:\/\/doi.org\/10.1039\/d0md00424c","relation":{},"ISSN":["2632-8682"],"issn-type":[{"value":"2632-8682","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Kaitlind C. Howard (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-8844-062X","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Octavio A. Gonzalez (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-8885-8604","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Sylvie Garneau-Tsodikova (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-7961-5555","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 16 December 2020; Accepted 16 February 2021; Advance Article published 26 February 2021; Version of Record published 26 May 2021","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}