{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:55:46Z","timestamp":1787961346982,"version":"build-2784847793"},"reference-count":115,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T00:00:00Z","timestamp":1619049600000},"content-version":"am","delay-in-days":356,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["16-33-60004 mol_a_dk"],"award-info":[{"award-number":["16-33-60004 mol_a_dk"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009104","name":"Universit\u00e0 Degli Studi di Modena e Reggio Emila","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009104","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Russian Foundation for Basic Research","award":["16-33-60004 mol_a_dk"],"award-info":[{"award-number":["16-33-60004 mol_a_dk"]}]},{"DOI":"10.13039\/100009104","name":"Universit\u00e0 Degli Studi di Modena e Reggio Emila","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100009104","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Amyotrophic lateral sclerosis is a progressive neurodegenerative disease characterized by a loss of function of motor neurons. The etiology of this disorder is still largely unknown. Gene-environment interaction arises as a possible key factor in the development of amyotrophic lateral sclerosis. We assessed the levels of trace metals, copper (Cu), iron (Fe), and manganese (Mn), of 9 amyotrophic lateral sclerosis cases and 40 controls by measuring their content in cerebrospinal fluid. The following trace element species were quantified using ion chromatography-inductively coupled plasma mass spectrometry: univalent copper (Cu-I), divalent Cu (Cu-II), divalent Fe (Fe-II), trivalent Fe (Fe-III), divalent Mn (Mn-II), trivalent Mn (Mn-III), and also unidentified Mn species (Mn-unknown) were present in some samples. When computing the relative risks for amyotrophic lateral sclerosis through an unconditional logistic regression model, we observed a weak and imprecise positive association for iron (Fe III, adjusted odds ratio 1.48, 95% CI 0.46\u20134.76) and manganese (total-Mn and Mn-II; adjusted odds ratio 1.11, 95% CI 0.74\u20131.67, and 1.13, 95% CI 0.79\u20131.61, respectively). Increased risk for copper was found both in the crude analysis (odds ratio 1.14, 95% CI 0.99\u20131.31) and in multivariable analysis after adjusting for sex, age, and year of storage (1.09, 95% CI 0.90\u20131.32). Our results suggest a possible positive association between Cu and genetic amyotrophic lateral sclerosis, while they give little indication of involvement of Fe and Mn in disease, though some correlations found also for these elements deserve further investigation.<\/jats:p>","DOI":"10.1039\/d0mt00051e","type":"journal-article","created":{"date-parts":[[2020,4,22]],"date-time":"2020-04-22T13:06:53Z","timestamp":1587560813000},"page":"668-681","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["The study of levels from redox-active elements in cerebrospinal fluid of amyotrophic lateral sclerosis patients carrying disease-related gene mutations shows potential copper dyshomeostasis"],"prefix":"10.1093","volume":"12","author":[{"given":"Federica","family":"Violi","sequence":"first","affiliation":[{"name":"CREAGEN Research Center of Environmental, Genetic and Nutritional Epidemiology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy"},{"name":"Clinical and Experimental Medicine PhD Program, University of Modena and Reggio Emilia, Modena, Italy"},{"name":"Azienda USL-IRCCS di Reggio Emilia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6217-6963","authenticated-orcid":false,"given":"Nikolay","family":"Solovyev","sequence":"additional","affiliation":[{"name":"St. Petersburg State University, Institute of Chemistry, Universitetskaya nab. 7\/9, 199034 St. Petersburg, Russia"},{"name":"Analytical BioGeoChemistry Research Unit, Helmholtz Center Munich \u2013 German Research Center for Environmental Health GmbH, Ingolst\u00e4dter Landstr. 1, 85764 Neuherberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0551-2473","authenticated-orcid":false,"given":"Marco","family":"Vinceti","sequence":"additional","affiliation":[{"name":"CREAGEN Research Center of Environmental, Genetic and Nutritional Epidemiology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy"},{"name":"Department of Epidemiology, Boston University School of Public Health, 715 Albany Street, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Mandrioli","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, St. Agostino Estense Hospital, Azienda Ospedaliero Universitaria di Modena, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Lucio","sequence":"additional","affiliation":[{"name":"Analytical BioGeoChemistry Research Unit, Helmholtz Center Munich \u2013 German Research Center for Environmental Health GmbH, Ingolst\u00e4dter Landstr. 1, 85764 Neuherberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6376-2588","authenticated-orcid":false,"given":"Bernhard","family":"Michalke","sequence":"additional","affiliation":[{"name":"Analytical BioGeoChemistry Research Unit, Helmholtz Center Munich \u2013 German Research Center for Environmental Health GmbH, Ingolst\u00e4dter Landstr. 1, 85764 Neuherberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,5,6]]},"reference":[{"key":"2021121004371491900_cit1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1056\/NEJMra1603471","article-title":"Amyotrophic Lateral Sclerosis","volume":"377","author":"Brown","year":"2017","journal-title":"N. 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