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The special physiological condition of piglets is the main cause of iron deficiency. Iron metabolism in the intestine is the basis for understanding the effects of iron on the health of piglets. In order to scientifically evaluate dietary iron supplementation doses, it is necessary to recognize the effects of iron deficiency and iron overload on piglet intestinal health. Besides, iron as a cofactor is essential for the growth of microorganisms, and microorganisms compete with the host to absorb iron. Under the stress of iron deficiency and iron overload, various control schemes (such as precise nutrition, element balance, elimination of oxidation, etc.) are effective measures to eliminate adverse effects. In this review, we comprehensively review recent findings on the effects of iron deficiency and iron overload on intestinal health. This review will provide a rational design strategy to achieve a reasonable iron supplement, which will guide the use of iron in animal husbandry.<\/jats:p>","DOI":"10.1039\/d0mt00149j","type":"journal-article","created":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T11:36:07Z","timestamp":1596627367000},"page":"1494-1507","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Iron homeostasis disorder in piglet intestine"],"prefix":"10.1093","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7251-2855","authenticated-orcid":false,"given":"Haoxuan","family":"Ding","sequence":"first","affiliation":[{"name":"College of Animal Science, Zhejiang University, Key Laboratory of animal feed and nutrition of Zhejiang Province, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaonan","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Animal Science, Zhejiang University, Key Laboratory of animal feed and nutrition of Zhejiang Province, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2690-429X","authenticated-orcid":false,"given":"Jie","family":"Feng","sequence":"additional","affiliation":[{"name":"College of Animal Science, Zhejiang University, Key Laboratory of animal feed and nutrition of Zhejiang Province, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,8,27]]},"reference":[{"key":"2021121004310858200_cit1","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s12011-018-1385-z","volume":"187","author":"Zhuo","year":"2019","journal-title":"Biol. 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