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Chem."},{"key":"D0NP00078G\/cit90\/1","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1021\/np970493u","volume":"61","author":"Franco","year":"1998","journal-title":"J. Nat. Prod."},{"key":"D0NP00078G\/cit91\/1","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ejmech.2015.05.020","volume":"98","author":"Yadav","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"D0NP00078G\/cit92\/1","doi-asserted-by":"crossref","first-page":"5290","DOI":"10.1021\/ol102351z","volume":"12","author":"Avil\u00e9s","year":"2010","journal-title":"Org. Lett."},{"key":"D0NP00078G\/cit93\/1","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1021\/jm0110892","volume":"45","author":"Wright","year":"2002","journal-title":"J. Med. 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Prod."},{"key":"D0NP00078G\/cit104\/1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1021\/jm900672t","volume":"53","author":"Peng","year":"2010","journal-title":"J. Med. Chem."},{"key":"D0NP00078G\/cit105\/1","doi-asserted-by":"crossref","first-page":"6425","DOI":"10.1021\/ja981303k","volume":"120","author":"Winkler","year":"1998","journal-title":"J. Am. Chem. Soc."},{"key":"D0NP00078G\/cit106\/1","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1021\/ja9829259","volume":"121","author":"Martin","year":"1999","journal-title":"J. Am. Chem. Soc."},{"key":"D0NP00078G\/cit107\/1","doi-asserted-by":"crossref","first-page":"8584","DOI":"10.1021\/ja0202964","volume":"124","author":"Humphrey","year":"2002","journal-title":"J. Am. Chem. Soc."},{"key":"D0NP00078G\/cit108\/1","doi-asserted-by":"crossref","first-page":"10233","DOI":"10.1021\/ja103721s","volume":"132","author":"Toma","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"D0NP00078G\/cit109\/1","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.7164\/antibiotics.39.1066","volume":"39","author":"Nakanishi","year":"1986","journal-title":"J. Antibiot."},{"key":"D0NP00078G\/cit110\/1","doi-asserted-by":"crossref","first-page":"9652","DOI":"10.1021\/ja971304x","volume":"119","author":"Wood","year":"1997","journal-title":"J. Am. Chem. Soc."},{"key":"D0NP00078G\/cit111\/1","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1021\/ol015894m","volume":"3","author":"Tamaki","year":"2001","journal-title":"Org. Lett."},{"key":"D0NP00078G\/cit112\/1","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1021\/ja00106a072","volume":"117","author":"Link","year":"1995","journal-title":"J. Am. Chem. Soc."},{"key":"D0NP00078G\/cit113\/1","doi-asserted-by":"crossref","first-page":"2706","DOI":"10.1039\/C5SC04399A","volume":"7","author":"Fox","year":"2016","journal-title":"Chem. 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