{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T08:49:51Z","timestamp":1791967791694,"version":"4.3.4"},"reference-count":35,"publisher":"Royal Society of Chemistry (RSC)","issue":"19","license":[{"start":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T00:00:00Z","timestamp":1618963200000},"content-version":"am","delay-in-days":476,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81788101"],"award-info":[{"award-number":["81788101"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["21805311"],"award-info":[{"award-number":["21805311"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81630044"],"award-info":[{"award-number":["81630044"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81601432"],"award-info":[{"award-number":["81601432"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81550023"],"award-info":[{"award-number":["81550023"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81325019"],"award-info":[{"award-number":["81325019"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81771763"],"award-info":[{"award-number":["81771763"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81273312"],"award-info":[{"award-number":["81273312"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["91542000"],"award-info":[{"award-number":["91542000"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81801635"],"award-info":[{"award-number":["81801635"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"crossref","award":["CIFMS 2017-12M-1-008"],"award-info":[{"award-number":["CIFMS 2017-12M-1-008"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"crossref","award":["2016-12M-1-003"],"award-info":[{"award-number":["2016-12M-1-003"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"crossref","award":["2017-I2M-3-011"],"award-info":[{"award-number":["2017-I2M-3-011"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"crossref","award":["2016-12M-1-008"],"award-info":[{"award-number":["2016-12M-1-008"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"crossref","award":["2017PT31035"],"award-info":[{"award-number":["2017PT31035"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Nanoscale"],"abstract":"<p>A polyhydroxyalkanoate terpolymer based drug delivery platform loaded with immunosuppressant for systemic lupus erythematosus therapy with less systemic toxicity.<\/p>","DOI":"10.1039\/d0nr01308k","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T22:22:26Z","timestamp":1587421346000},"page":"10799-10808","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["A novel long-acting azathioprine polyhydroxyalkanoate nanoparticle enhances treatment efficacy for systemic lupus erythematosus with reduced side effects"],"prefix":"10.1039","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7597-0875","authenticated-orcid":false,"given":"Jin","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Medical Research Center"},{"name":"Peking Union Medical College Hospital"},{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College"},{"name":"Beijing 100730"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0707-6027","authenticated-orcid":false,"given":"Min","family":"Wang","sequence":"additional","affiliation":[{"name":"Clinical Immunology Center& Epigenetics Center"},{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College"},{"name":"Beijing 100730"},{"name":"China"},{"name":"Department of Rheumatology and Clinical Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Xiao","sequence":"additional","affiliation":[{"name":"Clinical Immunology Center& Epigenetics Center"},{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College"},{"name":"Beijing 100730"},{"name":"China"},{"name":"Department of Rheumatology and Clinical Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medical Research Center"},{"name":"Peking Union Medical College Hospital"},{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College"},{"name":"Beijing 100730"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Medical Research Center"},{"name":"Peking Union Medical College Hospital"},{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College"},{"name":"Beijing 100730"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjie","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Medical Research Center"},{"name":"Peking Union Medical College Hospital"},{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College"},{"name":"Beijing 100730"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengjie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Research Center"},{"name":"Peking Union Medical College Hospital"},{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College"},{"name":"Beijing 100730"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhifa","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Medical Research Center"},{"name":"Peking Union Medical College Hospital"},{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College"},{"name":"Beijing 100730"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4893-1579","authenticated-orcid":false,"given":"Daixu","family":"Wei","sequence":"additional","affiliation":[{"name":"Key Laboratory of Resource Biology and Biotechnology in Western China"},{"name":"Ministry of Education"},{"name":"School of Medicine"},{"name":"Department of Life Sciences and Medicine"},{"name":"Northwest University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8775-1699","authenticated-orcid":false,"given":"Xuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Clinical Immunology Center& Epigenetics Center"},{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College"},{"name":"Beijing 100730"},{"name":"China"},{"name":"Department of Rheumatology and Clinical Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2020]]},"reference":[{"key":"D0NR01308K-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1002\/art.34473","volume":"64","author":"Petri","year":"2012","journal-title":"Arthritis Rheum."},{"key":"D0NR01308K-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"73ra20","DOI":"10.1126\/scitranslmed.3001201","volume":"3","author":"Garcia-Romo","year":"2011","journal-title":"Sci. Transl. Med."},{"key":"D0NR01308K-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.2174\/138161208799316401","volume":"14","author":"Sanna","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"D0NR01308K-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1136\/ard.2005.049924","volume":"65","author":"Suarez","year":"2006","journal-title":"Ann. Rheum. Dis."},{"key":"D0NR01308K-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/nrclinonc.2010.139","volume":"7","author":"Jain","year":"2010","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"D0NR01308K-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/nrc.2016.108","volume":"17","author":"Shi","year":"2017","journal-title":"Nat. Rev. Cancer"},{"key":"D0NR01308K-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6207","DOI":"10.1021\/acs.nanolett.8b02229","volume":"18","author":"Tang","year":"2018","journal-title":"Nano Lett."},{"key":"D0NR01308K-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"18782","DOI":"10.1039\/C6NR05498F","volume":"8","author":"Lin","year":"2016","journal-title":"Nanoscale"},{"key":"D0NR01308K-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/j.biopha.2016.08.020","volume":"83","author":"Rostamzadeh","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"D0NR01308K-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/nnano.2007.387","volume":"2","author":"Peer","year":"2007","journal-title":"Nat. Nanotechnol."},{"key":"D0NR01308K-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.addr.2013.11.009","volume":"66","author":"Bertrand","year":"2014","journal-title":"Adv. Drug Delivery Rev."},{"key":"D0NR01308K-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1002\/anie.200802585","volume":"48","author":"Riehemann","year":"2009","journal-title":"Angew. Chem., Int. Ed."},{"key":"D0NR01308K-(cit13)\/*[position()=1]","first-page":"2434","volume":"363","author":"Kim","year":"2010","journal-title":"Nanomedicine"},{"key":"D0NR01308K-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1163\/1568562041959991","volume":"15","author":"Grayson","year":"2004","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"D0NR01308K-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e1802273","DOI":"10.1002\/adma.201802273","volume":"30","author":"Wei","year":"2018","journal-title":"Adv. Mater."},{"key":"D0NR01308K-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S1369-703X(03)00040-8","volume":"16","author":"Martin","year":"2003","journal-title":"Biochem. Eng. J."},{"key":"D0NR01308K-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1089\/ten.2006.12.301","volume":"12","author":"Ceonzo","year":"2006","journal-title":"Tissue Eng."},{"key":"D0NR01308K-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1111\/j.1365-2672.2007.03335.x","volume":"102","author":"Verlinden","year":"2007","journal-title":"J. Appl. Microbiol."},{"key":"D0NR01308K-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1111\/j.1462-2920.2011.02684.x","volume":"14","author":"Escapa","year":"2012","journal-title":"Environ. Microbiol."},{"key":"D0NR01308K-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.ijbiomac.2017.12.007","volume":"108","author":"Castro-Mayorga","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"D0NR01308K-(cit21)\/*[position()=1]","first-page":"1","volume":"16","author":"Tortajada","year":"2013","journal-title":"Int. Microbiol."},{"key":"D0NR01308K-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5187","DOI":"10.1016\/j.biomaterials.2005.01.037","volume":"26","author":"Kose","year":"2005","journal-title":"Biomaterials"},{"key":"D0NR01308K-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1089\/ten.2004.10.1234","volume":"10","author":"Kose","year":"2004","journal-title":"Tissue Eng."},{"key":"D0NR01308K-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7104","DOI":"10.1039\/b912871a","author":"Kim","year":"2009","journal-title":"Chem. Commun."},{"key":"D0NR01308K-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1016\/j.bmcl.2011.03.058","volume":"21","author":"Lee","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D0NR01308K-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0142-9612(00)00170-8","volume":"22","author":"Gursel","year":"2001","journal-title":"Biomaterials"},{"key":"D0NR01308K-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0168-3659(98)00195-3","volume":"59","author":"Sendil","year":"1999","journal-title":"J. Controlled Release"},{"key":"D0NR01308K-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e1429","DOI":"10.1002\/wnan.1429","volume":"9","author":"Li","year":"2017","journal-title":"Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol."},{"key":"D0NR01308K-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1163\/156856201750180924","volume":"12","author":"Turesin","year":"2001","journal-title":"J. Biomater. Sci., Polym. Ed."},{"key":"D0NR01308K-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"581684","DOI":"10.1155\/2013\/581684","volume":"2013","author":"Shrivastav","year":"2013","journal-title":"BioMed. Res. Int."},{"key":"D0NR01308K-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7552","DOI":"10.1016\/j.biomaterials.2013.06.043","volume":"34","author":"Zhang","year":"2013","journal-title":"Biomaterials"},{"key":"D0NR01308K-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1021\/bm049465y","volume":"6","author":"Cheng","year":"2005","journal-title":"Biomacromolecules"},{"key":"D0NR01308K-(cit33)\/*[position()=1]","first-page":"374","volume":"45","author":"Su","year":"2014","journal-title":"Tissue Eng., C"},{"key":"D0NR01308K-(cit34)\/*[position()=1]","first-page":"w20022","volume":"149","author":"von Kempis","year":"2019","journal-title":"Swiss Med. Wkly."},{"key":"D0NR01308K-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0960-8524(02)00212-2","volume":"87","author":"Reddy","year":"2003","journal-title":"Bioresour. Technol."}],"container-title":["Nanoscale"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2020\/NR\/D0NR01308K","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T20:25:28Z","timestamp":1782851128000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/nr\/article\/12\/19\/10799-10808\/694385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":35,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2020,5,21]]}},"URL":"https:\/\/doi.org\/10.1039\/d0nr01308k","relation":{},"ISSN":["2040-3364","2040-3372"],"issn-type":[{"value":"2040-3364","type":"print"},{"value":"2040-3372","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/D0NR01308K","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Jin Hu (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-7597-0875","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Min Wang (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-0707-6027","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Daixu Wei (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-4893-1579","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Xuan Zhang (ORCID)","URL":"http:\/\/orcid.org\/0000-0001-8775-1699","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 15 February 2020; Accepted 18 April 2020;  Accepted Manuscript published 21 April 2020;  Advance Article published 11 May 2020;  Version of Record published 21 May 2020","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}