{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T01:10:31Z","timestamp":1790298631838,"version":"4.1.0"},"reference-count":45,"publisher":"Royal Society of Chemistry (RSC)","issue":"7","license":[{"start":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T00:00:00Z","timestamp":1641340800000},"content-version":"am","delay-in-days":369,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"crossref","award":["MOST 108-2113-M-006-012-MY3"],"award-info":[{"award-number":["MOST 108-2113-M-006-012-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"crossref","award":["MOST 108-2622-M-006-001-CC1"],"award-info":[{"award-number":["MOST 108-2622-M-006-001-CC1"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"crossref","award":["MOST 109-2327-B-009-001-"],"award-info":[{"award-number":["MOST 109-2327-B-009-001-"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100015835","name":"Department of Health, Taipei City Government","doi-asserted-by":"crossref","award":["10901-62-001"],"award-info":[{"award-number":["10901-62-001"]}],"id":[{"id":"10.13039\/501100015835","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ministry of Education","award":["Featured Areas Research Center Program"],"award-info":[{"award-number":["Featured Areas Research Center Program"]}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Nanoscale"],"abstract":"<p>Post chemical engineering of crude Au nanoparticles on a soft substrate using a gentle reductant for radioactive growth to promote SERS amplification.<\/p>","DOI":"10.1039\/d0nr06537d","type":"journal-article","created":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T21:47:53Z","timestamp":1609796873000},"page":"3991-3999","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["A facile wet-chemistry approach to engineer an Au-based SERS substrate and enhance sensitivity down to ppb-level detection"],"prefix":"10.1039","volume":"13","author":[{"given":"Chien-Wei","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Photonics"},{"name":"Center of Applied Nanomedicine"},{"name":"Center for Micro\/Nano Science and Technology"},{"name":"National Cheng Kung University"},{"name":"Tainan70101"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi Chun","family":"Chia","sequence":"additional","affiliation":[{"name":"Department of Photonics"},{"name":"Center of Applied Nanomedicine"},{"name":"Center for Micro\/Nano Science and Technology"},{"name":"National Cheng Kung University"},{"name":"Tainan70101"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6462-9009","authenticated-orcid":false,"given":"Yi-Ting","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Chemistry"},{"name":"Soochow University"},{"name":"Taipei 11102"},{"name":"Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiao-Chieh","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Chemistry"},{"name":"Soochow University"},{"name":"Taipei 11102"},{"name":"Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yenpo","family":"Tai","sequence":"additional","affiliation":[{"name":"Department of Resources Engineering"},{"name":"National Cheng Kung University"},{"name":"Tainan 70101"},{"name":"Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teng-To","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Resources Engineering"},{"name":"National Cheng Kung University"},{"name":"Tainan 70101"},{"name":"Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9486-8665","authenticated-orcid":false,"given":"Chih-Chia","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Photonics"},{"name":"Center of Applied Nanomedicine"},{"name":"Center for Micro\/Nano Science and Technology"},{"name":"National Cheng Kung University"},{"name":"Tainan70101"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2021]]},"reference":[{"key":"D0NR06537D-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1910335","DOI":"10.1002\/adfm.201910335","volume":"30","author":"Plou","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"D0NR06537D-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"13041","DOI":"10.1039\/C8TA03878C","volume":"6","author":"Huang","year":"2018","journal-title":"J. Mater. Chem. A"},{"key":"D0NR06537D-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5318","DOI":"10.1039\/C8GC02123F","volume":"20","author":"Lee","year":"2018","journal-title":"Green Chem."},{"key":"D0NR06537D-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1021\/acsnano.0c00515","volume":"14","author":"Kao","year":"2020","journal-title":"ACS Nano"},{"key":"D0NR06537D-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8213","DOI":"10.1021\/acs.analchem.9b00775","volume":"91","author":"Yang","year":"2019","journal-title":"Anal. Chem."},{"key":"D0NR06537D-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3866","DOI":"10.1039\/C7CS00158D","volume":"46","author":"Reguera","year":"2017","journal-title":"Chem. Soc. Rev."},{"key":"D0NR06537D-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"21721","DOI":"10.1039\/C8NR06028B","volume":"10","author":"Tran","year":"2018","journal-title":"Nanoscale"},{"key":"D0NR06537D-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11152","DOI":"10.1021\/acsami.7b19081","volume":"10","author":"Kuttner","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D0NR06537D-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6484","DOI":"10.1021\/acs.jpclett.9b02380","volume":"10","author":"Ding","year":"2019","journal-title":"J. Phys. Chem. Lett."},{"key":"D0NR06537D-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7888","DOI":"10.1021\/acsanm.0c01371","volume":"3","author":"Chuang","year":"2020","journal-title":"ACS Appl. Nano Mater."},{"key":"D0NR06537D-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.bios.2016.09.072","volume":"92","author":"Ouyang","year":"2017","journal-title":"Biosens. Bioelectron."},{"key":"D0NR06537D-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5689","DOI":"10.1039\/C8TB00599K","volume":"6","author":"Hong","year":"2018","journal-title":"J. Mater. Chem. B"},{"key":"D0NR06537D-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9792","DOI":"10.1021\/acsami.7b17461","volume":"10","author":"Zhang","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D0NR06537D-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4892","DOI":"10.1021\/nn300352b","volume":"6","author":"Kho","year":"2012","journal-title":"ACS Nano"},{"key":"D0NR06537D-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1021\/jp9083508","volume":"114","author":"Mohl","year":"2010","journal-title":"J. Phys. Chem. C"},{"key":"D0NR06537D-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6831","DOI":"10.1021\/acsami.7b15085","volume":"10","author":"Ko","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D0NR06537D-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1800628","DOI":"10.1002\/admt.201800628","volume":"4","author":"Xu","year":"2019","journal-title":"Adv. Mater. Technol."},{"key":"D0NR06537D-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3956","DOI":"10.1039\/D0TC00002G","volume":"8","author":"Li","year":"2020","journal-title":"J. Mater. Chem. C"},{"key":"D0NR06537D-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4572","DOI":"10.1039\/C4CC09466B","volume":"51","author":"Zheng","year":"2015","journal-title":"Chem. Commun."},{"key":"D0NR06537D-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5795","DOI":"10.1039\/D0CC00648C","volume":"56","author":"Saravanan","year":"2020","journal-title":"Chem. Commun."},{"key":"D0NR06537D-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7100","DOI":"10.1021\/acsnano.8b02917","volume":"12","author":"Kim","year":"2018","journal-title":"ACS Nano"},{"key":"D0NR06537D-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6448","DOI":"10.1021\/acs.analchem.7b00300","volume":"89","author":"Kim","year":"2017","journal-title":"Anal. Chem."},{"key":"D0NR06537D-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5164","DOI":"10.1039\/C4AN01037J","volume":"139","author":"Yang","year":"2014","journal-title":"Analyst"},{"key":"D0NR06537D-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1007\/s10570-019-02297-0","volume":"26","author":"Wu","year":"2019","journal-title":"Cellulose"},{"key":"D0NR06537D-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"42156","DOI":"10.1021\/acsami.7b16618","volume":"9","author":"Chen","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D0NR06537D-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"32535","DOI":"10.1039\/C9RA05399A","volume":"9","author":"Lartey","year":"2019","journal-title":"RSC Adv."},{"key":"D0NR06537D-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1021\/cm020732l","volume":"15","author":"Nikoobakht","year":"2003","journal-title":"Chem. Mater."},{"key":"D0NR06537D-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"12634","DOI":"10.1021\/ja806043p","volume":"38","author":"Khanal","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"D0NR06537D-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1002\/adma.201305106","volume":"26","author":"Liu","year":"2014","journal-title":"Adv. Mater."},{"key":"D0NR06537D-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1002\/adfm.201302405","volume":"24","author":"Zhou","year":"2014","journal-title":"Adv. Funct. Mater."},{"key":"D0NR06537D-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"21149","DOI":"10.1039\/C4CP04904G","volume":"17","author":"Lu","year":"2015","journal-title":"Phys. Chem. Chem. Phys."},{"key":"D0NR06537D-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3322","DOI":"10.1039\/C8TC05942J","volume":"7","author":"Zhu","year":"2019","journal-title":"J. Mater. Chem. C"},{"key":"D0NR06537D-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1901506","DOI":"10.1002\/smll.201901506","volume":"15","author":"Li","year":"2019","journal-title":"Small"},{"key":"D0NR06537D-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.aca.2020.03.060","volume":"1114","author":"Sen","year":"2020","journal-title":"Anal. Chim. Acta"},{"key":"D0NR06537D-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"18236","DOI":"10.1039\/c1jm13790e","volume":"21","author":"Huang","year":"2011","journal-title":"J. Mater. Chem."},{"key":"D0NR06537D-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5567","DOI":"10.1021\/acsnano.5b01800","volume":"9","author":"Costas","year":"2015","journal-title":"ACS Nano"},{"key":"D0NR06537D-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"18013","DOI":"10.1038\/s41598-019-54534-y","volume":"9","author":"Ali","year":"2019","journal-title":"Sci. Rep."},{"key":"D0NR06537D-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7806","DOI":"10.1039\/C7TC01384A","volume":"5","author":"Chen","year":"2017","journal-title":"J. Mater. Chem. C"},{"key":"D0NR06537D-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/jrs.4874","volume":"47","author":"Yamamoto","year":"2016","journal-title":"J. Raman Spectrosc."},{"key":"D0NR06537D-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7523","DOI":"10.1021\/acsami.7b19865","volume":"10","author":"Ryu","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D0NR06537D-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7610","DOI":"10.1021\/cr400544s","volume":"15","author":"Thanh","year":"2014","journal-title":"Chem. Rev."},{"key":"D0NR06537D-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1039\/C4NR06323F","volume":"7","author":"Chateau","year":"2015","journal-title":"Nanoscale"},{"key":"D0NR06537D-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"19291","DOI":"10.1021\/jp063711d","volume":"110","author":"Wu","year":"2006","journal-title":"J. Phys. Chem. B"},{"key":"D0NR06537D-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"28086","DOI":"10.1021\/acsami.5b07006","volume":"7","author":"Sun","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D0NR06537D-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1007\/s00604-020-04262-2","volume":"187","author":"Yang","year":"2020","journal-title":"Microchim. Acta"}],"container-title":["Nanoscale"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2021\/NR\/D0NR06537D","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T21:58:11Z","timestamp":1782943091000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/nr\/article\/13\/7\/3991-3999\/695597"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":45,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,2,25]]}},"URL":"https:\/\/doi.org\/10.1039\/d0nr06537d","relation":{},"ISSN":["2040-3364","2040-3372"],"issn-type":[{"value":"2040-3364","type":"print"},{"value":"2040-3372","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/D0NR06537D","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Yi-Ting Hsieh (ORCID)","URL":"http:\/\/orcid.org\/0000-0001-6462-9009","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Chih-Chia Huang (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-9486-8665","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 10 September 2020; Accepted 4 January 2021;  Accepted Manuscript published 5 January 2021;  Advance Article published 27 January 2021;  Version of Record published 25 February 2021","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}