{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T12:06:17Z","timestamp":1783771577653,"version":"3.55.0"},"reference-count":61,"publisher":"Royal Society of Chemistry (RSC)","issue":"40","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"vor","delay-in-days":274,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Org. Biomol. Chem."],"abstract":"<p>A convergent synthesis of the actinoallolides with late-stage diversification provides access to a photoaffinity probe to identify the target of these potent anti-trypanosomal natural products.<\/p>","DOI":"10.1039\/d0ob01831g","type":"journal-article","created":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T05:07:36Z","timestamp":1601528856000},"page":"8109-8118","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Total synthesis of the actinoallolides and a designed photoaffinity probe for target identification"],"prefix":"10.1039","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5347-5320","authenticated-orcid":false,"given":"Matthew J.","family":"Anketell","sequence":"first","affiliation":[{"name":"University Chemical Laboratory"},{"name":"University of Cambridge"},{"name":"UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore M.","family":"Sharrock","sequence":"additional","affiliation":[{"name":"University Chemical Laboratory"},{"name":"University of Cambridge"},{"name":"UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8861-9136","authenticated-orcid":false,"given":"Ian","family":"Paterson","sequence":"additional","affiliation":[{"name":"University Chemical Laboratory"},{"name":"University of Cambridge"},{"name":"UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2020]]},"reference":[{"key":"D0OB01831G-(cit1)\/*[position()=1]","author":"Mathers","year":"2016","unstructured":"C. Mathers  ,  G.Stevens ,  W. R.Mahanani ,  J.Ho ,  D. M.Fat  and  D.Hogan ,  Global Health Estimates  2015 : Deaths by Cause, Age, Sex, by Country and by Region , 2000-2015, World health organization technical report,  2016"},{"key":"D0OB01831G-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e412","DOI":"10.1371\/journal.pntd.0000412","volume":"3","author":"Hotez","year":"2009","journal-title":"PLoS Neglected Trop. Dis."},{"key":"D0OB01831G-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1016\/S0140-6736(17)31510-6","volume":"390","author":"B\u00fcscher","year":"2017","journal-title":"Lancet"},{"key":"D0OB01831G-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S0140-6736(09)60829-1","volume":"375","author":"Brun","year":"2010","journal-title":"Lancet"},{"key":"D0OB01831G-(cit5)\/*[position()=1]","volume-title":"Trypanosomes and Trypanosomiasis","year":"2014","unstructured":"Trypanosomes and Trypanosomiasis , ed.  S. Magez  and  M. Radwanska ,  Springer-Verlag ,  Wien ,  2014"},{"key":"D0OB01831G-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actatropica.2015.12.017","volume":"156","author":"Bermudez","year":"2016","journal-title":"Acta Trop."},{"key":"D0OB01831G-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S0140-6736(17)31612-4","volume":"391","author":"P\u00e9rez-Molina","year":"2018","journal-title":"Lancet"},{"key":"D0OB01831G-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1056\/NEJMra1410150","volume":"373","author":"Bern","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"D0OB01831G-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.gheart.2015.06.001","volume":"10","author":"Stanaway","year":"2015","journal-title":"Global Heart"},{"key":"D0OB01831G-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e1498","DOI":"10.1371\/journal.pntd.0001498","volume":"6","author":"Hotez","year":"2012","journal-title":"PLoS Neglected Trop. Dis."},{"key":"D0OB01831G-(cit11)\/*[position()=1]","author":"WHO Disease burden and mortality estimates","unstructured":"WHO Disease burden and mortality estimates  ,  http:\/\/www.who.int\/healthinfo\/global_burden_disease\/estimates\/en\/"},{"key":"D0OB01831G-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-308X(01)49037-3","volume":"49","author":"Barry","year":"2001","journal-title":"Adv. Parasitol."},{"key":"D0OB01831G-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/nrmicro.2016.193","volume":"15","author":"Field","year":"2017","journal-title":"Nat. Rev. Microbiol."},{"key":"D0OB01831G-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1021\/acs.jnatprod.8b00159","volume":"81","author":"Cockram","year":"2018","journal-title":"J. Nat. Prod."},{"key":"D0OB01831G-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","DOI":"10.1201\/9780429258701","volume-title":"Microbiology: A Clinical Approach","author":"Strelkauskas","year":"2015","unstructured":"A. Strelkauskas  ,  A.Edwards ,  B.Fahnert ,  G.Pryor  and  J.Strelkauskas ,  Microbiology: A Clinical Approach ,  Garland Science ,  2015"},{"key":"D0OB01831G-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/nchembio837","volume":"2","author":"Renslo","year":"2006","journal-title":"Nat. Chem. Biol."},{"key":"D0OB01831G-(cit17)\/*[position()=1]","volume-title":"Natural Antimicrobial Agents","author":"Paloque","year":"2018","unstructured":"L. Paloque  ,  A.Triastuti ,  G.Bourdy  and  M.Haddad ,  Natural Antimicrobial Agents ,  Springer International Publishing ,  Cham ,  2018 , pp.  215\u2013245"},{"key":"D0OB01831G-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1021\/ol5037216","volume":"17","author":"Inahashi","year":"2015","journal-title":"Org. Lett."},{"key":"D0OB01831G-(cit19)\/*[position()=1]","volume-title":"The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics","author":"Roth","year":"2008","unstructured":"B. L. Roth  ,  The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics ,  Springer Science and Business Media ,  2008"},{"key":"D0OB01831G-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/s41429-018-0057-8","volume":"71","author":"Inahashi","year":"2018","journal-title":"J. Antibiot."},{"key":"D0OB01831G-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.tetlet.2015.12.022","volume":"57","author":"Oshita","year":"2016","journal-title":"Tetrahedron Lett."},{"key":"D0OB01831G-(cit22)\/*[position()=2]","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1002\/anie.201914042","volume":"59","author":"Anketell","year":"2020","journal-title":"Angew. Chem."},{"key":"D0OB01831G-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1039\/C7NP00048K","volume":"35","author":"Lecourt","year":"2018","journal-title":"Nat. Prod. Rep."},{"key":"D0OB01831G-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"159","DOI":"10.4155\/fmc.14.152","volume":"7","author":"Smith","year":"2015","journal-title":"Future Med. Chem."},{"key":"D0OB01831G-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e0005886","DOI":"10.1371\/journal.pntd.0005886","volume":"11","author":"Tulloch","year":"2017","journal-title":"PLoS Neglected Trop. Dis."},{"key":"D0OB01831G-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9535","DOI":"10.1021\/ja011211m","volume":"123","author":"Paterson","year":"2001","journal-title":"J. Am. Chem. Soc."},{"key":"D0OB01831G-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3118","DOI":"10.1021\/ol401327r","volume":"15","author":"Paterson","year":"2013","journal-title":"Org. Lett."},{"key":"D0OB01831G-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4233","DOI":"10.1016\/S0040-4039(00)74697-1","volume":"33","author":"Paterson","year":"1992","journal-title":"Tetrahedron Lett."},{"key":"D0OB01831G-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6533","DOI":"10.1021\/jo050792l","volume":"70","author":"Solsona","year":"2005","journal-title":"J. Org. Chem."},{"key":"D0OB01831G-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3146","DOI":"10.1002\/ejoc.201000293","author":"Esteve","year":"2010","journal-title":"Eur. J. Org. Chem."},{"key":"D0OB01831G-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5897","DOI":"10.1021\/ja00771a062","volume":"94","author":"Ireland","year":"1972","journal-title":"J. Am. Chem. Soc."},{"key":"D0OB01831G-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3288","DOI":"10.1021\/jo00116a010","volume":"60","author":"Paterson","year":"1995","journal-title":"J. Org. Chem."},{"key":"D0OB01831G-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9087","DOI":"10.1016\/0040-4039(94)88435-8","volume":"35","author":"Paterson","year":"1994","journal-title":"Tetrahedron Lett."},{"key":"D0OB01831G-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1055\/s-1998-5929","author":"Paterson","year":"1998","journal-title":"Synthesis"},{"key":"D0OB01831G-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"131351","DOI":"10.1016\/j.tet.2020.131351","volume":"76","author":"Lee","year":"2020","journal-title":"Tetrahedron"},{"key":"D0OB01831G-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8654","DOI":"10.1021\/ja0015287","volume":"122","author":"Smith","year":"2000","journal-title":"J. Am. Chem. Soc."},{"key":"D0OB01831G-(cit37)\/*[position()=1]","first-page":"3915","author":"Nagase","year":"2006","journal-title":"Synthesis"},{"key":"D0OB01831G-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/S0040-4020(01)82417-0","volume":"40","author":"Seebach","year":"1984","journal-title":"Tetrahedron"},{"key":"D0OB01831G-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"13813","DOI":"10.1021\/ja055137+","volume":"127","author":"Kingsbury","year":"2005","journal-title":"J. Am. Chem. Soc."},{"key":"D0OB01831G-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"14038","DOI":"10.1021\/ja0659572","volume":"128","author":"Ehrlich","year":"2006","journal-title":"J. Am. Chem. Soc."},{"key":"D0OB01831G-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1039\/p19840002371","author":"Johansson","year":"1984","journal-title":"J. Chem. Soc., Perkin Trans. 1"},{"key":"D0OB01831G-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6447","DOI":"10.1021\/ja00173a071","volume":"112","author":"Evans","year":"1990","journal-title":"J. Am. Chem. Soc."},{"key":"D0OB01831G-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3560","DOI":"10.1021\/ja00219a035","volume":"110","author":"Evans","year":"1988","journal-title":"J. Am. Chem. Soc."},{"key":"D0OB01831G-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5125","DOI":"10.1016\/S0040-4039(00)95608-9","volume":"28","author":"Kozikowski","year":"1987","journal-title":"Tetrahedron Lett."},{"key":"D0OB01831G-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5393","DOI":"10.1016\/S0040-4039(01)91293-6","volume":"25","author":"Oikawa","year":"1984","journal-title":"Tetrahedron Lett."},{"key":"D0OB01831G-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7540","DOI":"10.1021\/ja990860j","volume":"121","author":"Evans","year":"1999","journal-title":"J. Am. Chem. Soc."},{"key":"D0OB01831G-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1139\/v01-133","volume":"79","author":"Anderson","year":"2001","journal-title":"Can. J. Chem."},{"key":"D0OB01831G-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1246\/bcsj.52.1989","volume":"52","author":"Inanaga","year":"1979","journal-title":"Bull. Chem. Soc. Jpn."},{"key":"D0OB01831G-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1021\/ol991023p","volume":"1","author":"Chatterjee","year":"1999","journal-title":"Org. Lett."},{"key":"D0OB01831G-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4510","DOI":"10.1039\/C8CS00027A","volume":"47","author":"Ogba","year":"2018","journal-title":"Chem. Soc. Rev."},{"key":"D0OB01831G-(cit51)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8168","DOI":"10.1021\/ja001179g","volume":"122","author":"Garber","year":"2000","journal-title":"J. Am. Chem. Soc."},{"key":"D0OB01831G-(cit52)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9973","DOI":"10.1016\/S0040-4039(00)01808-6","volume":"41","author":"Gessler","year":"2000","journal-title":"Tetrahedron Lett."},{"key":"D0OB01831G-(cit53)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6974","DOI":"10.1021\/jo971046m","volume":"62","author":"De Mico","year":"1997","journal-title":"J. Org. Chem."},{"key":"D0OB01831G-(cit54)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1055\/s-1996-4369","author":"Nooy","year":"1996","journal-title":"Synthesis"},{"key":"D0OB01831G-(cit55)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4155","DOI":"10.1021\/jo00170a070","volume":"48","author":"Dess","year":"1983","journal-title":"J. Org. Chem."},{"key":"D0OB01831G-(cit56)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"14047","DOI":"10.1021\/jacs.5b09869","volume":"137","author":"Ho","year":"2015","journal-title":"J. Am. Chem. Soc."},{"key":"D0OB01831G-(cit57)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1016\/j.chembiol.2018.09.010","volume":"25","author":"Mortison","year":"2018","journal-title":"Cell Chem. Biol."},{"key":"D0OB01831G-(cit58a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8286","DOI":"10.1039\/C8OB01621F","volume":"16","author":"Phillips","year":"2018","journal-title":"Org. Biomol. Chem."},{"key":"D0OB01831G-(cit58b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/anie.201610636","volume":"56","author":"Williams","year":"2017","journal-title":"Angew. Chem., Int. Ed."},{"key":"D0OB01831G-(cit58c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1039\/C7OB03204H","volume":"16","author":"An\u017ei\u010dek","year":"2018","journal-title":"Org. Biomol. Chem."},{"key":"D0OB01831G-(cit58d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9717","DOI":"10.1039\/C9CC05067A","volume":"55","author":"Lam","year":"2019","journal-title":"Chem. Commun."}],"container-title":["Organic &amp; Biomolecular Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2020\/OB\/D0OB01831G","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T17:43:58Z","timestamp":1783532638000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ob\/article\/18\/40\/8109-8118\/697189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":61,"journal-issue":{"issue":"40","published-print":{"date-parts":[[2020,10,21]]}},"URL":"https:\/\/doi.org\/10.1039\/d0ob01831g","relation":{},"ISSN":["1477-0520","1477-0539"],"issn-type":[{"value":"1477-0520","type":"print"},{"value":"1477-0539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/D0OB01831G","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Matthew J. Anketell (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-5347-5320","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Ian Paterson (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-8861-9136","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 4 September 2020; Accepted 25 September 2020;  Accepted Manuscript published 1 October 2020;  Advance Article published 5 October 2020;  Version of Record published 21 October 2020","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}