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Chem."],"abstract":"<p>\n                    A RuCl\n                    <sub>3<\/sub>\n                    -catalyzed tandem N\u2013H insertion\/cyclization sequence from simple \u03b1-amino ketones and diazo pyruvates is realized, resulting a series of substituted 1,4-oxazines that show promising anticancer activities toward HCT116.\n                  <\/p>","DOI":"10.1039\/d0ob01913e","type":"journal-article","created":{"date-parts":[[2020,12,8]],"date-time":"2020-12-08T00:55:49Z","timestamp":1607388949000},"page":"1769-1772","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Facile synthesis of 1,4-oxazines by ruthenium-catalyzed tandem N\u2013H insertion\/cyclization of \u03b1-arylamino ketones and diazo pyruvates"],"prefix":"10.1039","volume":"19","author":[{"given":"Farrukh","family":"Sajjad","sequence":"first","affiliation":[{"name":"Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development"},{"name":"School of Chemistry and Molecular Engineering"},{"name":"East China Normal University"},{"name":"Shanghai"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmei","family":"Chen","sequence":"additional","affiliation":[{"name":"Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development"},{"name":"School of Chemistry and Molecular Engineering"},{"name":"East China Normal University"},{"name":"Shanghai"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Tian","sequence":"additional","affiliation":[{"name":"A School of Pharmaceutical Sciences"},{"name":"Sun Yat-sen University"},{"name":"Guangzhou"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6716-6115","authenticated-orcid":false,"given":"Suzhen","family":"Dong","sequence":"additional","affiliation":[{"name":"Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development"},{"name":"School of Chemistry and Molecular Engineering"},{"name":"East China Normal University"},{"name":"Shanghai"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alavala","family":"Gopi Krishna Reddy","sequence":"additional","affiliation":[{"name":"A School of Pharmaceutical Sciences"},{"name":"Sun Yat-sen University"},{"name":"Guangzhou"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1511-2614","authenticated-orcid":false,"given":"Wenhao","family":"Hu","sequence":"additional","affiliation":[{"name":"Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development"},{"name":"School of Chemistry and Molecular Engineering"},{"name":"East China Normal University"},{"name":"Shanghai"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3718-4539","authenticated-orcid":false,"given":"Dong","family":"Xing","sequence":"additional","affiliation":[{"name":"Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development"},{"name":"School of Chemistry and Molecular Engineering"},{"name":"East China Normal University"},{"name":"Shanghai"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2021]]},"reference":[{"key":"D0OB01913E-(cit1a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5845","DOI":"10.1021\/jm4017625","volume":"57","author":"Taylor","year":"2014","journal-title":"J. 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