{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T17:28:53Z","timestamp":1789147733402,"version":"build-2803163510"},"reference-count":48,"publisher":"Royal Society of Chemistry (RSC)","issue":"58","license":[{"start":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T00:00:00Z","timestamp":1600992000000},"content-version":"vor","delay-in-days":268,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["ECR\/2015\/000448"],"award-info":[{"award-number":["ECR\/2015\/000448"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012190","name":"Ministry of Science and Higher Education of the Russian Federation","doi-asserted-by":"publisher","award":["FENU-2020-0019"],"award-info":[{"award-number":["FENU-2020-0019"]}],"id":[{"id":"10.13039\/501100012190","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["BT\/PR21569\/NNT\/28\/1234\/2017"],"award-info":[{"award-number":["BT\/PR21569\/NNT\/28\/1234\/2017"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007656","name":"Loyola University Chicago","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007656","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<jats:p>\n                    Malaria, a global threat to the human population, remains a challenge partly due to the fast-growing drug-resistant strains of\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    species.\n                  <\/jats:p>","DOI":"10.1039\/d0ra03997g","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T05:53:46Z","timestamp":1601013226000},"page":"35516-35530","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Multistage antiplasmodial activity of hydroxyethylamine compounds,\n                    <i>in vitro<\/i>\n                    and\n                    <i>in vivo<\/i>\n                    evaluations"],"prefix":"10.1039","volume":"10","author":[{"given":"Neha","family":"Sharma","sequence":"first","affiliation":[{"name":"Laboratory for Translational Chemistry and Drug Discovery, Department of Chemistry, Hansraj College University Enclave, University of Delhi, Delhi 110007, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yash","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Medicine, Stritch School of Medicine, Loyola University Chicago, 2160 South 1st Avenue, Maywood, IL 60153, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4460-2682","authenticated-orcid":false,"given":"Meenakshi","family":"Bansal","sequence":"additional","affiliation":[{"name":"Laboratory for Translational Chemistry and Drug Discovery, Department of Chemistry, Hansraj College University Enclave, University of Delhi, Delhi 110007, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Snigdha","family":"Singh","sequence":"additional","affiliation":[{"name":"Laboratory for Translational Chemistry and Drug Discovery, Department of Chemistry, Hansraj College University Enclave, University of Delhi, Delhi 110007, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6160-9755","authenticated-orcid":false,"given":"Prateek","family":"Pathak","sequence":"additional","affiliation":[{"name":"South Ural State University, Laboratory of Computational Modelling of Drugs, 454080, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd","family":"Shahbaaz","sequence":"additional","affiliation":[{"name":"South Ural State University, Laboratory of Computational Modelling of Drugs, 454080, Russia"},{"name":"South African National Bioinformatics Institute, University of the Western Cape, Private Bag X17, Bellville, Cape Town 7535, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raman","family":"Mathur","sequence":"additional","affiliation":[{"name":"Department of Medicine, Stritch School of Medicine, Loyola University Chicago, 2160 South 1st Avenue, Maywood, IL 60153, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyoti","family":"Singh","sequence":"additional","affiliation":[{"name":"Infectious Diseases Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Kashif","sequence":"additional","affiliation":[{"name":"Infectious Diseases Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Grishina","sequence":"additional","affiliation":[{"name":"South Ural State University, Laboratory of Computational Modelling of Drugs, 454080, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5244-8718","authenticated-orcid":false,"given":"Vladimir","family":"Potemkin","sequence":"additional","affiliation":[{"name":"South Ural State University, Laboratory of Computational Modelling of Drugs, 454080, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinoth","family":"Rajendran","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Life Sciences, Pondicherry University, Puducherry 605014, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3759-1057","authenticated-orcid":false,"family":"Poonam","sequence":"additional","affiliation":[{"name":"South Ural State University, Laboratory of Computational Modelling of Drugs, 454080, Russia"},{"name":"Department of Chemistry, Miranda House, University of Delhi, Delhi 110007, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prakasha","family":"Kempaiah","sequence":"additional","affiliation":[{"name":"Department of Medicine, Stritch School of Medicine, Loyola University Chicago, 2160 South 1st Avenue, Maywood, IL 60153, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4262-2556","authenticated-orcid":false,"given":"Agam Prasad","family":"Singh","sequence":"additional","affiliation":[{"name":"Infectious Diseases Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2133-8847","authenticated-orcid":false,"given":"Brijesh","family":"Rathi","sequence":"additional","affiliation":[{"name":"Laboratory for Translational Chemistry and Drug Discovery, Department of Chemistry, Hansraj College University Enclave, University of Delhi, Delhi 110007, India"},{"name":"South Ural State University, Laboratory of Computational Modelling of Drugs, 454080, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2020]]},"reference":[{"key":"D0RA03997G\/cit1\/1","volume-title":"World malaria report","author":"WHO","year":"2019","unstructured":"WHO ,  World malaria report ,  World Health Organization ,  Geneva ,  2019"},{"key":"D0RA03997G\/cit2\/1","doi-asserted-by":"publisher","first-page":"17050","DOI":"10.1038\/nrdp.2017.50","volume":"3","author":"Phillips","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"D0RA03997G\/cit3\/1","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1016\/j.cell.2016.07.055","volume":"167","author":"Cowman","year":"2016","journal-title":"Cell"},{"key":"D0RA03997G\/cit4\/1","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.pt.2015.11.015","volume":"32","author":"Galatas","year":"2016","journal-title":"Trends Parasitol."},{"key":"D0RA03997G\/cit5\/1","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1038\/nrd4573","volume":"14","author":"Wells","year":"2015","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D0RA03997G\/cit6\/1","doi-asserted-by":"publisher","first-page":"2143","DOI":"10.2174\/1568026617666170130123520","volume":"17","author":"Gorobets","year":"2017","journal-title":"Curr. Top. Med. Chem."},{"key":"D0RA03997G\/cit7\/1","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/nature15535","volume":"526","author":"Bhatt","year":"2015","journal-title":"Nature"},{"key":"D0RA03997G\/cit8\/1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1101\/cshperspect.a025619","volume":"7","author":"Menard","year":"2017","journal-title":"Cold Spring Harbor Perspect. Med."},{"key":"D0RA03997G\/cit9\/1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep17412","volume":"5","author":"Imwong","year":"2015","journal-title":"Sci. Rep."},{"key":"D0RA03997G\/cit10\/1","doi-asserted-by":"publisher","first-page":"1960","DOI":"10.1016\/s0140-6736(12)60484-x","volume":"379","author":"Phyo","year":"2012","journal-title":"Lancet"},{"key":"D0RA03997G\/cit11\/1","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.drudis.2018.08.006","volume":"24","author":"Pazhayam","year":"2019","journal-title":"Drug Discovery Today"},{"key":"D0RA03997G\/cit12\/1","doi-asserted-by":"publisher","first-page":"e15","DOI":"10.1016\/s1473-3099(16)30269-9","volume":"17","author":"White","year":"2017","journal-title":"Lancet Infect. Dis."},{"key":"D0RA03997G\/cit13\/1","doi-asserted-by":"publisher","first-page":"1962","DOI":"10.1056\/nejmc1713777","volume":"379","author":"Das","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"D0RA03997G\/cit14\/1","unstructured":"CDC,  https:\/\/www.cdc.gov\/malaria\/malaria_worldwide\/impact.html , CDC Malaria Impact,  https:\/\/www.cdc.gov\/malaria\/malaria_worldwide\/impact.html , 2018"},{"key":"D0RA03997G\/cit15\/1","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/s0140-6736(15)60721-8","volume":"386","author":"S.C.T.P. RTS","year":"2017","journal-title":"Lancet"},{"key":"D0RA03997G\/cit16\/1","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1002\/med.21486","volume":"38","author":"Poonam","year":"2018","journal-title":"Med. Res. Rev."},{"key":"D0RA03997G\/cit17\/1","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1038\/nature09107","volume":"465","author":"Gamo","year":"2010","journal-title":"Nature"},{"key":"D0RA03997G\/cit18\/1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s12936-019-2724-z","volume":"18","author":"Tse","year":"2019","journal-title":"Malar. J."},{"key":"D0RA03997G\/cit19\/1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cbpa.2019.01.029","volume":"50","author":"Yahiya","year":"2019","journal-title":"Curr. Opin. Chem. Biol."},{"key":"D0RA03997G\/cit20\/1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pmed.1001335","volume":"9","author":"Delves","year":"2012","journal-title":"PLoS Med."},{"key":"D0RA03997G\/cit21\/1","doi-asserted-by":"publisher","first-page":"2013","DOI":"10.1172\/jci82981","volume":"126","author":"Raphemot","year":"2016","journal-title":"J. Clin. Invest."},{"key":"D0RA03997G\/cit22\/1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-018-04928-9","volume":"9","author":"Delves","year":"2018","journal-title":"Nat. Commun."},{"key":"D0RA03997G\/cit23\/1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0139347","volume":"10","author":"Singh","year":"2015","journal-title":"PLoS One"},{"key":"D0RA03997G\/cit24\/1","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1021\/acsinfecdis.8b00197","volume":"5","author":"Singh","year":"2019","journal-title":"ACS Infect. Dis."},{"key":"D0RA03997G\/cit25\/1","doi-asserted-by":"publisher","first-page":"3837","DOI":"10.1016\/j.bmc.2018.06.037","volume":"26","author":"Singh","year":"2018","journal-title":"Bioorg. Med. Chem."},{"key":"D0RA03997G\/cit26\/1","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1016\/s1473-3099(13)70252-4","volume":"13","author":"Witkowski","year":"2013","journal-title":"Lancet Infect. Dis."},{"key":"D0RA03997G\/cit27\/1","doi-asserted-by":"publisher","first-page":"2554","DOI":"10.3389\/fimmu.2019.02554","volume":"10","author":"Sato","year":"2019","journal-title":"Front. Immunol."},{"key":"D0RA03997G\/cit28\/1","first-page":"14","volume":"6","author":"Sharma","year":"2019","journal-title":"Chem. Biol. Lett."},{"key":"D0RA03997G\/cit29\/1","doi-asserted-by":"publisher","first-page":"2008","DOI":"10.2174\/1568026619666181129143623","volume":"18","author":"Singh","year":"2018","journal-title":"Curr. Top. Med. Chem."},{"key":"D0RA03997G\/cit30\/1","doi-asserted-by":"publisher","first-page":"e1002456","DOI":"10.1371\/journal.pmed.1002456","volume":"14","author":"Rabinovich","year":"2017","journal-title":"PLoS Med."},{"key":"D0RA03997G\/cit31\/1","doi-asserted-by":"publisher","first-page":"e1006336","DOI":"10.1371\/journal.ppat.1006336","volume":"13","author":"Sinden","year":"2017","journal-title":"PLoS Pathog."},{"key":"D0RA03997G\/cit32\/1","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1016\/j.drudis.2008.07.006","volume":"13","author":"Potemkin","year":"2008","journal-title":"Drug Discovery Today"},{"key":"D0RA03997G\/cit33\/1","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1107\/S0907444902014695","volume":"58","author":"Asojo","year":"2002","journal-title":"Acta Crystallogr., Sect. D: Biol. Crystallogr."},{"key":"D0RA03997G\/cit34\/1","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1080\/00034983.1975.11686997","volume":"69","author":"Peter","year":"1995","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"D0RA03997G\/cit35\/1","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1186\/1475-2875-9-348","volume":"9","author":"Ma","year":"2010","journal-title":"Malar. J."},{"key":"D0RA03997G\/cit36\/1","volume-title":"Cell viability assays, Assay Guidance Manual","author":"Riss","year":"2016","unstructured":"T. L.Riss ,  et al. ,  Cell viability assays, Assay Guidance Manual ,  Eli Lilly & Company and the National Centre for Advancing Translational Sciences ,  2016 ,  https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK144065"},{"key":"D0RA03997G\/cit37\/1","first-page":"14","volume":"35","author":"Potemkin","year":"2010","journal-title":"Drugs Future"},{"key":"D0RA03997G\/cit38\/1","doi-asserted-by":"publisher","first-page":"181","DOI":"10.2174\/1570163814666170207144018","volume":"14","author":"Potemkin","year":"2017","journal-title":"Curr. Drug Discovery Technol."},{"key":"D0RA03997G\/cit40\/1","doi-asserted-by":"publisher","first-page":"42717","DOI":"10.1038\/srep42717","volume":"7","author":"Daina","year":"2017","journal-title":"Sci. Rep."},{"key":"D0RA03997G\/cit41\/1","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1021\/ci050357s","volume":"46","author":"Cheeseright","year":"2006","journal-title":"J. Chem. Inf. Model."},{"key":"D0RA03997G\/cit42\/1","doi-asserted-by":"publisher","first-page":"D901","DOI":"10.1093\/nar\/gkm958","volume":"36","author":"Wishart","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"D0RA03997G\/cit43\/1","doi-asserted-by":"publisher","first-page":"2785","DOI":"10.1002\/jcc.21256","volume":"30","author":"Morris","year":"2009","journal-title":"J. Comput. Chem."},{"key":"D0RA03997G\/cit44\/1","doi-asserted-by":"publisher","first-page":"2731","DOI":"10.1021\/ci200274q","volume":"51","author":"Neudert","year":"2011","journal-title":"J. Chem. Inf. Model."},{"key":"D0RA03997G\/cit45\/1","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1093\/bioinformatics\/btt055","volume":"29","author":"Pronk","year":"2013","journal-title":"Bioinformatics"},{"key":"D0RA03997G\/cit46\/1","doi-asserted-by":"publisher","first-page":"1656","DOI":"10.1002\/jcc.20090","volume":"25","author":"Oostenbrink","year":"2004","journal-title":"J. Comput. Chem."},{"key":"D0RA03997G\/cit47\/1","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1107\/s0907444904011679","volume":"60","author":"Schuttelkopf","year":"2004","journal-title":"Acta Crystallogr., Sect. D: Biol. Crystallogr."},{"key":"D0RA03997G\/cit49\/1","doi-asserted-by":"publisher","first-page":"104501","DOI":"10.1063\/1.2018637","volume":"123","author":"Zielkiewicz","year":"2005","journal-title":"J. Chem. Phys."},{"key":"D0RA03997G\/cit50\/1","doi-asserted-by":"publisher","first-page":"1951","DOI":"10.1021\/ci500020m","volume":"54","author":"Kumari","year":"2014","journal-title":"J. Chem. Inf. Model."}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2020\/RA\/D0RA03997G","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:54:07Z","timestamp":1782928447000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ra\/article\/10\/58\/35516-35530\/701984"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":48,"journal-issue":{"issue":"58","published-print":{"date-parts":[[2020,9,21]]}},"URL":"https:\/\/doi.org\/10.1039\/d0ra03997g","relation":{},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}