{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:03:16Z","timestamp":1787004196568,"version":"build-2736575974"},"reference-count":33,"publisher":"Royal Society of Chemistry (RSC)","issue":"20","license":[{"start":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T00:00:00Z","timestamp":1616544000000},"content-version":"vor","delay-in-days":82,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["KAKENHI\/19K05697"],"award-info":[{"award-number":["KAKENHI\/19K05697"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["KAKENHI\/19H02527"],"award-info":[{"award-number":["KAKENHI\/19H02527"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005365","name":"Ehime University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005365","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003006","name":"Eidgen\u00f6ssische Technische Hochschule Z\u00fcrich","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003006","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<p>We demonstrated molecular detection using aptamer-modified gold nanoparticles with DNA-brush for the prevention of non-specific aggregation and smartphone darkfield microscopy.<\/p>","DOI":"10.1039\/d0ra05149g","type":"journal-article","created":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T11:13:39Z","timestamp":1616584419000},"page":"11984-11991","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Molecular detection using aptamer-modified gold nanoparticles with an immobilized DNA brush for the prevention of non-specific aggregation"],"prefix":"10.1039","volume":"11","author":[{"given":"Yuki","family":"Yano-Ozawa","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biology"},{"name":"Graduate School of Science and Engineering"},{"name":"Ehime University"},{"name":"Matsuyama"},{"name":"Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Lobsiger","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biology"},{"name":"Graduate School of Science and Engineering"},{"name":"Ehime University"},{"name":"Matsuyama"},{"name":"Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Muto","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biology"},{"name":"Graduate School of Science and Engineering"},{"name":"Ehime University"},{"name":"Matsuyama"},{"name":"Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biology"},{"name":"Graduate School of Science and Engineering"},{"name":"Ehime University"},{"name":"Matsuyama"},{"name":"Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Yoshimura","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biology"},{"name":"Graduate School of Science and Engineering"},{"name":"Ehime University"},{"name":"Matsuyama"},{"name":"Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Yano","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biology"},{"name":"Graduate School of Science and Engineering"},{"name":"Ehime University"},{"name":"Matsuyama"},{"name":"Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3078-0354","authenticated-orcid":false,"given":"Wendelin Jan","family":"Stark","sequence":"additional","affiliation":[{"name":"Institute for Chemical and Bioengineering"},{"name":"ETH Z\u00fcrich"},{"name":"CH-8093 Z\u00fcrich"},{"name":"Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mizuo","family":"Maeda","sequence":"additional","affiliation":[{"name":"Bioengineering Laboratory"},{"name":"RIKEN Cluster for Pioneering Research"},{"name":"Wako"},{"name":"Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Asahi","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biology"},{"name":"Graduate School of Science and Engineering"},{"name":"Ehime University"},{"name":"Matsuyama"},{"name":"Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5240-3395","authenticated-orcid":false,"given":"Atsushi","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Proteo-Science Center"},{"name":"Ehime University"},{"name":"Matsuyama"},{"name":"Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7106-5766","authenticated-orcid":false,"given":"Tamotsu","family":"Zako","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biology"},{"name":"Graduate School of Science and Engineering"},{"name":"Ehime University"},{"name":"Matsuyama"},{"name":"Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2021]]},"reference":[{"key":"D0RA05149G-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1039\/b712170a","volume":"37","author":"Sperling","year":"2008","journal-title":"Chem. Soc. Rev."},{"key":"D0RA05149G-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1039\/b806051g","volume":"38","author":"Boisselier","year":"2009","journal-title":"Chem. Soc. Rev."},{"key":"D0RA05149G-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1021\/cr030698+","volume":"104","author":"Daniel","year":"2004","journal-title":"Chem. Rev."},{"key":"D0RA05149G-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1039\/C8BM01026A","volume":"7","author":"Djohan","year":"2019","journal-title":"Biomater. Sci."},{"key":"D0RA05149G-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1039\/C4BM00026A","volume":"2","author":"Zako","year":"2014","journal-title":"Biomater. Sci."},{"key":"D0RA05149G-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1021\/cr2001178","volume":"112","author":"Saha","year":"2012","journal-title":"Chem. Rev."},{"key":"D0RA05149G-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1039\/C5AN02651B","volume":"141","author":"Yuan","year":"2016","journal-title":"Analyst"},{"key":"D0RA05149G-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7531","DOI":"10.1039\/c3cc44182b","volume":"49","author":"Bu","year":"2013","journal-title":"Chem. Commun."},{"key":"D0RA05149G-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1039\/c0cc05171c","volume":"47","author":"Kanayama","year":"2011","journal-title":"Chem. Commun."},{"key":"D0RA05149G-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4666","DOI":"10.1039\/b910288d","author":"Ogawa","year":"2009","journal-title":"Chem. Commun."},{"key":"D0RA05149G-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8102","DOI":"10.1021\/ja034876s","volume":"125","author":"Sato","year":"2003","journal-title":"J. Am. Chem. Soc."},{"key":"D0RA05149G-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1038\/346818a0","volume":"346","author":"Ellington","year":"1990","journal-title":"Nature"},{"key":"D0RA05149G-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S1367-5931(97)80105-6","volume":"1","author":"Breaker","year":"1997","journal-title":"Curr. Opin. Chem. Biol."},{"key":"D0RA05149G-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1002\/smll.200800057","volume":"4","author":"Zhang","year":"2008","journal-title":"Small"},{"key":"D0RA05149G-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/nprot.2006.38","volume":"1","author":"Liu","year":"2006","journal-title":"Nat. Protoc."},{"key":"D0RA05149G-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1002\/cbic.200700014","volume":"8","author":"Zhao","year":"2007","journal-title":"ChemBioChem"},{"key":"D0RA05149G-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4171","DOI":"10.1039\/c2an35711a","volume":"137","author":"Wu","year":"2012","journal-title":"Analyst"},{"key":"D0RA05149G-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7661","DOI":"10.1021\/la400582v","volume":"29","author":"Zakaria","year":"2013","journal-title":"Langmuir"},{"key":"D0RA05149G-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"35492","DOI":"10.1021\/acsami.7b12796","volume":"9","author":"Wang","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D0RA05149G-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8313","DOI":"10.1021\/ac0613582","volume":"78","author":"Hurst","year":"2006","journal-title":"Anal. Chem."},{"key":"D0RA05149G-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.bmcl.2010.11.048","volume":"21","author":"Ogawa","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D0RA05149G-(cit22)\/*[position()=1]","first-page":"56","volume":"180","author":"Nikoleris","year":"2016","journal-title":"Comp. Biochem. Physiol., Part C: Toxicol. Pharmacol."},{"key":"D0RA05149G-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.envint.2016.12.010","volume":"99","author":"Adeel","year":"2017","journal-title":"Environ. Int."},{"key":"D0RA05149G-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7571","DOI":"10.1038\/srep07571","volume":"4","author":"Liu","year":"2014","journal-title":"Sci. Rep."},{"key":"D0RA05149G-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7644","DOI":"10.1021\/acs.analchem.5b00875","volume":"87","author":"Soh","year":"2015","journal-title":"Anal. Chem."},{"key":"D0RA05149G-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4201","DOI":"10.1021\/acs.analchem.5b00335","volume":"87","author":"Alsager","year":"2015","journal-title":"Anal. Chem."},{"key":"D0RA05149G-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"685","DOI":"10.2116\/analsci.18P571","volume":"35","author":"Yano","year":"2019","journal-title":"Anal. Sci."},{"key":"D0RA05149G-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.bios.2017.08.025","volume":"99","author":"Sun","year":"2018","journal-title":"Biosens. Bioelectron."},{"key":"D0RA05149G-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1021\/ja2084256","volume":"134","author":"Yang","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"D0RA05149G-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"307","DOI":"10.2116\/analsci.32.307","volume":"32","author":"Bu","year":"2016","journal-title":"Anal. Sci."},{"key":"D0RA05149G-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8121","DOI":"10.1039\/c1cc11503k","volume":"47","author":"Liu","year":"2011","journal-title":"Chem. Commun."},{"key":"D0RA05149G-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.matt.2019.08.008","volume":"1","author":"Liu","year":"2019","journal-title":"Matter"},{"key":"D0RA05149G-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.jcis.2011.11.021","volume":"368","author":"Fujita","year":"2012","journal-title":"J. Colloid Interface Sci."}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2021\/RA\/D0RA05149G","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:28:42Z","timestamp":1783013322000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ra\/article\/11\/20\/11984-11991\/702435"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":33,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2021,3,24]]}},"URL":"https:\/\/doi.org\/10.1039\/d0ra05149g","relation":{},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/D0RA05149G","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Wendelin Jan Stark (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-3078-0354","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Atsushi Ogawa (ORCID)","URL":"http:\/\/orcid.org\/0000-0001-5240-3395","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Tamotsu Zako (ORCID)","URL":"http:\/\/orcid.org\/0000-0001-7106-5766","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 11 June 2020; Accepted 15 March 2021;  Version of Record published 24 March 2021","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}