{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:13:46Z","timestamp":1790896426812,"version":"4.1.0"},"reference-count":44,"publisher":"Royal Society of Chemistry (RSC)","issue":"53","license":[{"start":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T00:00:00Z","timestamp":1598572800000},"content-version":"vor","delay-in-days":240,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<p>SARS-CoV-2 is a novel coronavirus that was first identified during the outbreak in Wuhan, China in 2019.<\/p>","DOI":"10.1039\/d0ra05679k","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T11:25:31Z","timestamp":1598613931000},"page":"32148-32155","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Inhibition of SARS-CoV-2 main protease by phenolic compounds from\n                    <i>Manilkara hexandra<\/i>\n                    (Roxb.) Dubard assisted by metabolite profiling and\n                    <i>in silico<\/i>\n                    virtual screening"],"prefix":"10.1039","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5554-2064","authenticated-orcid":false,"given":"Fatma M.","family":"Abd El-Mordy","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy"},{"name":"Faculty of Pharmacy (Girls)"},{"name":"Al-Azhar University"},{"name":"11754 Cairo"},{"name":"Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed M.","family":"El-Hamouly","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy"},{"name":"Faculty of Pharmacy (Boys)"},{"name":"Al-Azhar University"},{"name":"11371 Cairo"},{"name":"Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magda T.","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy"},{"name":"Faculty of Pharmacy"},{"name":"Sinai University"},{"name":"Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gehad Abd","family":"El-Rheem","sequence":"additional","affiliation":[{"name":"Department of Pharmacology"},{"name":"National Research Centre"},{"name":"12622 Giza"},{"name":"Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar M.","family":"Aly","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry"},{"name":"Faculty of Pharmacy"},{"name":"Minia University"},{"name":"61519 Minia"},{"name":"Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adel M.","family":"Abd El-kader","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy"},{"name":"Faculty of Pharmacy"},{"name":"Deraya University"},{"name":"61111 Minia"},{"name":"Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khayrya A.","family":"Youssif","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy"},{"name":"Faculty of Pharmacy"},{"name":"Modern University for Technology and Information"},{"name":"Cairo"},{"name":"Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1014-6922","authenticated-orcid":false,"given":"Usama Ramadan","family":"Abdelmohsen","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy"},{"name":"Faculty of Pharmacy"},{"name":"Deraya University"},{"name":"61111 Minia"},{"name":"Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2020]]},"reference":[{"issue":"8","key":"D0RA05679K-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1056\/NEJMoa2001017","volume":"382","author":"Zhu","year":"2020","journal-title":"N. Engl. J. Med."},{"issue":"13","key":"D0RA05679K-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1056\/NEJMoa2001316","volume":"382","author":"Li","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"D0RA05679K-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-020-2012-7","volume":"579","author":"Zhou","year":"2020","journal-title":"Nature"},{"key":"D0RA05679K-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/s41586-020-2008-3","volume":"579","author":"Wu","year":"2020","journal-title":"Nature"},{"key":"D0RA05679K-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"13190","DOI":"10.1073\/pnas.1835675100","volume":"100","author":"Yang","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D0RA05679K-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.1093\/emboj\/cdf327","volume":"21","author":"Anand","year":"2002","journal-title":"EMBO J."},{"key":"D0RA05679K-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/s41586-020-2223-y","volume":"582","author":"Jin","year":"2020","journal-title":"Nature"},{"key":"D0RA05679K-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1099\/0022-1317-83-3-595","volume":"83","author":"Hegyi","year":"2002","journal-title":"J. Gen. Virol."},{"key":"D0RA05679K-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6595","DOI":"10.1021\/acs.jmedchem.5b01461","volume":"59","author":"Pillaiyar","year":"2016","journal-title":"J. Med. Chem."},{"key":"D0RA05679K-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/jmv.1890150110","volume":"15","author":"Kaul","year":"1985","journal-title":"J. Med. Virol."},{"key":"D0RA05679K-(cit11)\/*[position()=1]","first-page":"1037","volume":"18","author":"Thomas","year":"2019","journal-title":"Journal of Experimental and Clinical Science"},{"key":"D0RA05679K-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/S0076-6879(99)99017-1","volume":"299","author":"Singletone","year":"1999","journal-title":"Methods Enzymol."},{"key":"D0RA05679K-(cit13)\/*[position()=1]","first-page":"178","volume":"10","author":"Chang","year":"2002","journal-title":"J. Food Drug Anal."},{"key":"D0RA05679K-(cit14)\/*[position()=1]","volume-title":"Plant Functional Genomics","author":"Rambla","year":"2015","unstructured":"L.Rambla ,  P.Lopez ,  M.Belles  and  A.Granell ,  Metabolomic Profiling of Plant Tissues , in  Plant Functional Genomics ,  Springer ,  New York, NY, USA ,  2015 ,  pp. 221\u2013235"},{"key":"D0RA05679K-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1177\/0192623307310947","volume":"36","author":"Clarke","year":"2008","journal-title":"Toxicol. Pathol."},{"key":"D0RA05679K-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/pca.1187","volume":"21","author":"Allwood","year":"2010","journal-title":"Phytochem. Anal."},{"key":"D0RA05679K-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"85","DOI":"10.4103\/0974-8490.94723","volume":"4","author":"Fayek","year":"2012","journal-title":"Pharmacogn. Res."},{"key":"D0RA05679K-(cit18)\/*[position()=1]","first-page":"201","volume":"1","author":"Asante","year":"2009","journal-title":"Pharmacogn. J."},{"key":"D0RA05679K-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0031-9422(00)00346-0","volume":"55","author":"Seidel","year":"2000","journal-title":"Phytochemistry"},{"key":"D0RA05679K-(cit20)\/*[position()=1]","first-page":"223","volume":"5","author":"Gao","year":"2010","journal-title":"Nat. Prod. Commun."},{"key":"D0RA05679K-(cit21)\/*[position()=1]","first-page":"1","author":"Fernandes","year":"2013","journal-title":"BioMed Res. Int."},{"key":"D0RA05679K-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"13","DOI":"10.20510\/ukjpb\/2\/i3\/91163","volume":"2","author":"Ram","year":"2014","journal-title":"J. Pharm. BioSci."},{"key":"D0RA05679K-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1515\/znb-2009-0416","volume":"64","author":"El-Desouky","year":"2009","journal-title":"Z. Naturforsch."},{"key":"D0RA05679K-(cit24)\/*[position()=1]","first-page":"64","volume":"1","author":"Kadam","year":"2012","journal-title":"J. Pharmacogn. Phytochem."},{"key":"D0RA05679K-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1021\/np020576x","volume":"66","author":"Ma","year":"2003","journal-title":"J. Nat. Prod."},{"key":"D0RA05679K-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3158","DOI":"10.1007\/s13197-013-1156-y","volume":"52","author":"Banerjee","year":"2015","journal-title":"J. Food Sci. Technol."},{"key":"D0RA05679K-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"12313","DOI":"10.3390\/molecules181012313","volume":"18","author":"Simelane","year":"2013","journal-title":"Molecules"},{"key":"D0RA05679K-(cit28)\/*[position()=1]","first-page":"20","volume":"2","author":"Roqaiya","year":"2015","journal-title":"Int. J. Tradit. Herb. Med."},{"key":"D0RA05679K-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/0031-9422(93)85370-7","volume":"34","author":"Chang","year":"1993","journal-title":"Phytochemistry"},{"key":"D0RA05679K-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/S0031-9422(01)00365-X","volume":"58","author":"Mahmoud","year":"2001","journal-title":"Phytochemistry"},{"key":"D0RA05679K-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/s41586-020-2223-y","volume":"582","author":"Jin","year":"2020","journal-title":"Nature"},{"issue":"10","key":"D0RA05679K-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1371\/journal.pbio.0030324","volume":"3","author":"Yang","year":"2005","journal-title":"PLoS Biol."},{"key":"D0RA05679K-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"19790","DOI":"10.1039\/D0RA04199H","author":"Sayed","year":"2020","journal-title":"RSC Adv."},{"issue":"970","key":"D0RA05679K-(cit34)\/*[position()=1]","first-page":"1","volume":"8","author":"Sayed","year":"2020","journal-title":"Microorganisms"},{"key":"D0RA05679K-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"19570","DOI":"10.1039\/D0RA03582C","volume":"10","author":"Owis","year":"2020","journal-title":"RSC Adv."},{"issue":"1","key":"D0RA05679K-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1080\/14756366.2019.1690480","volume":"35","author":"Jo","year":"2020","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"D0RA05679K-(cit37)\/*[position()=1]","doi-asserted-by":"publisher","DOI":"10.26434\/chemrxiv.12362333.v2","volume":"2","author":"Rehman","year":"2020","journal-title":"Chemrxiv"},{"key":"D0RA05679K-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.3390\/md12031220","volume":"12","author":"Abdelmohsen","year":"2014","journal-title":"Mar. Drugs"},{"key":"D0RA05679K-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6217","DOI":"10.2147\/IJN.S214171","volume":"14","author":"Haggag","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"D0RA05679K-(cit40)\/*[position()=1]","first-page":"1","author":"Youssif","year":"2019","journal-title":"PLoS One"},{"key":"D0RA05679K-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13321-017-0216-0","volume":"9","author":"G\u00fcrsoy","year":"2017","journal-title":"J. Cheminf."},{"key":"D0RA05679K-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/1568026617666170130110827","volume":"17","author":"Lohning","year":"2017","journal-title":"Curr. Top. Med. Chem."},{"key":"D0RA05679K-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/jns.2016.41","volume":"5","author":"Panche","year":"2016","journal-title":"J. Nutr. Sci."},{"key":"D0RA05679K-(cit44)\/*[position()=1]","volume-title":"Bioactive Food as Dietary Interventions for Arthritis and\nRelated Inflammatory Diseases","author":"Patel","year":"2019","unstructured":"K.Patel  and  D. K.Patel ,  The Beneficial Role of Rutin, A Naturally Occurring Flavonoid in Health Promotion and Disease Prevention: A Systematic Review and Update ,  Bioactive Food as Dietary Interventions for Arthritis and\nRelated Inflammatory Diseases , 2nd edn,  2019 ,  pp. 457\u2013479"}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2020\/RA\/D0RA05679K","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:00:37Z","timestamp":1782882037000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ra\/article\/10\/53\/32148-32155\/702656"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":44,"journal-issue":{"issue":"53","published-print":{"date-parts":[[2020,8,28]]}},"URL":"https:\/\/doi.org\/10.1039\/d0ra05679k","relation":{},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/D0RA05679K","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Fatma M. Abd El-Mordy (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-5554-2064","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Usama Ramadan Abdelmohsen (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-1014-6922","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 29 June 2020; Accepted 17 August 2020;  Version of Record published 28 August 2020","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}