{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T19:37:40Z","timestamp":1782934660572,"version":"3.54.5"},"reference-count":44,"publisher":"Royal Society of Chemistry (RSC)","issue":"5","license":[{"start":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T00:00:00Z","timestamp":1610409600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Ministarstvo Prosvete, Nauke i Tehnolo\u0161kog Razvoja","award":["451-03-68\/2020-14\/200122"],"award-info":[{"award-number":["451-03-68\/2020-14\/200122"]}]},{"name":"Ministarstvo Prosvete, Nauke i Tehnolo\u0161kog Razvoja","award":["451-03-68\/2020-14\/200378"],"award-info":[{"award-number":["451-03-68\/2020-14\/200378"]}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<p>Identification of potential inhibitory effect of acid\u2013base species of quercetin and its metabolite as well as chloroquine, hydroxychloroquine, and cinanserin, at physiological pH, on proteins essential for SARS-CoV-2 virus survival.<\/p>","DOI":"10.1039\/d0ra09632f","type":"journal-article","created":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T03:10:41Z","timestamp":1610507441000},"page":"2838-2847","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Inhibitory activity of quercetin, its metabolite, and standard antiviral drugs towards enzymes essential for SARS-CoV-2: the role of acid\u2013base equilibria"],"prefix":"10.1039","volume":"11","author":[{"given":"\u017diko B.","family":"Milanovi\u0107","sequence":"first","affiliation":[{"name":"University of Kragujevac"},{"name":"Faculty of Science"},{"name":"Department of Chemistry"},{"name":"34000 Kragujevac"},{"name":"Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3810-1694","authenticated-orcid":false,"given":"Marko R.","family":"Antonijevi\u0107","sequence":"additional","affiliation":[{"name":"University of Kragujevac"},{"name":"Institute for Information Technologies"},{"name":"Department of Science"},{"name":"34000 Kragujevac"},{"name":"Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana D.","family":"Ami\u0107","sequence":"additional","affiliation":[{"name":"Juraj Strossmayer University of Osijek"},{"name":"Department of Chemistry"},{"name":"Osijek"},{"name":"Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edina H.","family":"Avdovi\u0107","sequence":"additional","affiliation":[{"name":"University of Kragujevac"},{"name":"Institute for Information Technologies"},{"name":"Department of Science"},{"name":"34000 Kragujevac"},{"name":"Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8127-5396","authenticated-orcid":false,"given":"Du\u0161an S.","family":"Dimi\u0107","sequence":"additional","affiliation":[{"name":"University of Belgrade"},{"name":"Faculty of Physical Chemistry"},{"name":"11000 Belgrade"},{"name":"Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7083-2257","authenticated-orcid":false,"given":"Dejan A.","family":"Milenkovi\u0107","sequence":"additional","affiliation":[{"name":"University of Kragujevac"},{"name":"Institute for Information Technologies"},{"name":"Department of Science"},{"name":"34000 Kragujevac"},{"name":"Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2287-6049","authenticated-orcid":false,"given":"Zoran S.","family":"Markovi\u0107","sequence":"additional","affiliation":[{"name":"University of Kragujevac"},{"name":"Institute for Information Technologies"},{"name":"Department of Science"},{"name":"34000 Kragujevac"},{"name":"Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2021]]},"reference":[{"key":"D0RA09632F-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","volume":"395","author":"Huang","year":"2020","journal-title":"Lancet"},{"key":"D0RA09632F-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3730","DOI":"10.1021\/acs.est.0c01102","volume":"54","author":"Qu","year":"2020","journal-title":"Environ. Sci. Technol."},{"key":"D0RA09632F-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1002\/jmv.24736","volume":"89","author":"Elfiky","year":"2017","journal-title":"J. Med. Virol."},{"key":"D0RA09632F-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1128\/CMR.00102-14","volume":"28","author":"Chan","year":"2015","journal-title":"Clin. Microbiol. Rev."},{"key":"D0RA09632F-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"12256","DOI":"10.1021\/acs.jmedchem.0c00502","volume":"63","author":"Xiu","year":"2020","journal-title":"J. Med. Chem."},{"key":"D0RA09632F-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.jinf.2020.02.026","volume":"80","author":"Ibrahim","year":"2020","journal-title":"J. Infec."},{"key":"D0RA09632F-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"101646","DOI":"10.1016\/j.tmaid.2020.101646","author":"Hall Jr","year":"2020","journal-title":"Travel Med. Infect. Di."},{"key":"D0RA09632F-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s11427-020-1637-5","volume":"63","author":"Xu","year":"2020","journal-title":"Sci. China Life Sci."},{"key":"D0RA09632F-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.1128\/JVI.06882-11","volume":"86","author":"Li","year":"2012","journal-title":"J. Virol."},{"key":"D0RA09632F-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"15214","DOI":"10.1073\/pnas.1407087111","volume":"111","author":"Millet","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D0RA09632F-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"15214","DOI":"10.1073\/pnas.1407087111","volume":"111","author":"Millet","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D0RA09632F-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11196","DOI":"10.1073\/pnas.1613630113","volume":"113","author":"Dahms","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D0RA09632F-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"104742","DOI":"10.1016\/j.antiviral.2020.104742","volume":"176","author":"Coutard","year":"2020","journal-title":"Antiviral Res."},{"key":"D0RA09632F-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"108254","DOI":"10.1016\/j.celrep.2020.108254","volume":"33","author":"Cheng","year":"2020","journal-title":"Cell Rep."},{"key":"D0RA09632F-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/jmv.1890150110","volume":"15","author":"Kaul","year":"1985","journal-title":"J. Med. Virol."},{"key":"D0RA09632F-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11002","DOI":"10.1021\/acs.jafc.7b05214","volume":"65","author":"Fuentes","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"D0RA09632F-(cit17)\/*[position()=1]","first-page":"840","volume":"20","author":"Zhu","year":"2013","journal-title":"Curr. Med. Chem."},{"key":"D0RA09632F-(cit18)\/*[position()=1]","first-page":"113","volume":"13","author":"Pusztai","year":"1996","journal-title":"Acta Microbiol. Acad. Sci. Hungar."},{"key":"D0RA09632F-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13020-019-0281-6","volume":"15","author":"Luo","year":"2020","journal-title":"Chin. Med."},{"key":"D0RA09632F-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41422-020-0282-0","volume":"30","author":"Wang","year":"2020","journal-title":"Cell Res."},{"key":"D0RA09632F-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"105932","DOI":"10.1016\/j.ijantimicag.2020.105932","volume":"55","author":"Colson","year":"2020","journal-title":"Int. J. Antimicrob. Agents"},{"key":"D0RA09632F-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"58","DOI":"10.5582\/ddt.2020.01012","volume":"14","author":"Dong","year":"2020","journal-title":"Drug Discoveries Ther."},{"key":"D0RA09632F-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41421-019-0132-8","volume":"6","author":"Liu","year":"2020","journal-title":"Cell Discovery"},{"key":"D0RA09632F-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7095","DOI":"10.1128\/JVI.79.11.7095-7103.2005","volume":"79","author":"Chen","year":"2005","journal-title":"J. Virol."},{"key":"D0RA09632F-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1177\/106002807801200906","volume":"12","author":"Newton","year":"1978","journal-title":"Drug Intell. Clin. Pharm."},{"key":"D0RA09632F-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"13101","DOI":"10.1021\/jp208315k","volume":"115","author":"Galano","year":"2011","journal-title":"J. Phys. Chem. B"},{"key":"D0RA09632F-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"12347","DOI":"10.1021\/jp4049617","volume":"117","author":"Alvarez-Diduk","year":"2013","journal-title":"J. Phys. Chem. B"},{"key":"D0RA09632F-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1093\/jac\/dkv018","volume":"70","author":"Al-Bari","year":"2015","journal-title":"J. Antimicrob. Chemother."},{"key":"D0RA09632F-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.1002\/jcc.23409","volume":"34","author":"Galano","year":"2013","journal-title":"J. Comput. Chem."},{"key":"D0RA09632F-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1021\/ar700111a","volume":"41","author":"Zhao","year":"2008","journal-title":"Acc. Chem. Res."},{"key":"D0RA09632F-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1002\/jcc.10189","volume":"24","author":"Cossi","year":"2003","journal-title":"J. Comput. Chem."},{"key":"D0RA09632F-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","volume":"30","author":"Morris","year":"2009","journal-title":"J. Comput. Chem."},{"key":"D0RA09632F-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11196","DOI":"10.1073\/pnas.1613630113","volume":"113","author":"Dahms","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D0RA09632F-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1126\/science.abb2507","volume":"367","author":"Wrapp","year":"2020","journal-title":"Science"},{"key":"D0RA09632F-(cit37)\/*[position()=1]","volume-title":"Discovery Studio Modeling Environment, Release 2017","author":"BIOVIA, Dassault Syst\u00e8mes","year":"2017","unstructured":"BIOVIA, Dassault Syst\u00e8mes .  Discovery Studio Modeling Environment, Release 2017 ,  Dassault Syst\u00e8mes ,  San Diego ,  2017"},{"key":"D0RA09632F-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1002\/jcc.20634","volume":"28","author":"Huey","year":"2007","journal-title":"J. Comp. Chem."},{"key":"D0RA09632F-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1002\/(SICI)1096-987X(19981115)19:14<1639::AID-JCC10>3.0.CO;2-B","volume":"19","author":"Morris","year":"1998","journal-title":"J. Comp. Chem."},{"key":"D0RA09632F-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.2174\/138945008786949450","volume":"9","author":"Dias","year":"2008","journal-title":"Curr. Drug Targets"},{"key":"D0RA09632F-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"119465","DOI":"10.1016\/j.ica.2020.119465","volume":"504","author":"Avdovi\u0107","year":"2005","journal-title":"Inorg. Chim. Acta"},{"key":"D0RA09632F-(cit42)\/*[position()=1]","first-page":"840","volume":"20","author":"Zhu","year":"2013","journal-title":"Curr. Med. Chem."},{"key":"D0RA09632F-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3641","DOI":"10.2174\/092986712801323162","volume":"19","author":"Zhu","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"D0RA09632F-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1080\/10715769800300381","volume":"29","author":"J\u00f8rgensen","year":"1998","journal-title":"Free Radical Res."},{"key":"D0RA09632F-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/prot.21253","volume":"67","author":"Panigrahi","year":"2007","journal-title":"Proteins"},{"key":"D0RA09632F-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1021\/acschembio.6b01110","volume":"12","author":"Dahms","year":"2017","journal-title":"ACS Chem. Bio."}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2021\/RA\/D0RA09632F","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:48:48Z","timestamp":1782928128000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ra\/article\/11\/5\/2838-2847\/704299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":44,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,1,12]]}},"URL":"https:\/\/doi.org\/10.1039\/d0ra09632f","relation":{},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/D0RA09632F","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Marko R. Antonijevi\u0107 (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-3810-1694","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Du\u0161an S. Dimi\u0107 (ORCID)","URL":"http:\/\/orcid.org\/0000-0001-8127-5396","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Dejan A. Milenkovi\u0107 (ORCID)","URL":"http:\/\/orcid.org\/0000-0001-7083-2257","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Zoran S. Markovi\u0107 (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-2287-6049","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 12 November 2020; Accepted 31 December 2020;  Version of Record published 12 January 2021","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}