{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:24:24Z","timestamp":1790245464445,"version":"4.1.0"},"reference-count":55,"publisher":"Royal Society of Chemistry (RSC)","issue":"6","license":[{"start":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T00:00:00Z","timestamp":1610668800000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100006144","name":"Kerala State Council for Science, Technology and Environment","doi-asserted-by":"crossref","award":["341\/2013\/KSCSTE dated 15.03.2013"],"award-info":[{"award-number":["341\/2013\/KSCSTE dated 15.03.2013"]}],"id":[{"id":"10.13039\/501100006144","id-type":"DOI","asserted-by":"crossref"}]},{"name":"University Grants Commission"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<p>Heterocycles are abundant in several pharmaceutical and naturally occurring compounds. Copper-catalyzed multicomponent reactions are a convenient method for easy access to heterocycles. In this review, we focus on the advancement in this field for the past two years.<\/p>","DOI":"10.1039\/d0ra10472h","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T04:34:18Z","timestamp":1610685258000},"page":"3452-3469","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Recent developments and perspectives in the copper-catalyzed multicomponent synthesis of heterocycles"],"prefix":"10.1039","volume":"11","author":[{"given":"Jaleel","family":"Fairoosa","sequence":"first","affiliation":[{"name":"School of Chemical Sciences"},{"name":"Mahatma Gandhi University"},{"name":"Kottayam"},{"name":"India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohan","family":"Neetha","sequence":"additional","affiliation":[{"name":"School of Chemical Sciences"},{"name":"Mahatma Gandhi University"},{"name":"Kottayam"},{"name":"India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7907-5616","authenticated-orcid":false,"given":"Gopinathan","family":"Anilkumar","sequence":"additional","affiliation":[{"name":"School of Chemical Sciences"},{"name":"Mahatma Gandhi University"},{"name":"Kottayam"},{"name":"India"},{"name":"Advanced Molecular Materials Research Centre (AMMRC)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2021]]},"reference":[{"key":"D0RA10472H-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2942","DOI":"10.1021\/cr300122t","volume":"114","author":"Majumdar","year":"2014","journal-title":"Chem. Rev."},{"key":"D0RA10472H-(cit2)\/*[position()=1]","first-page":"2241","volume":"24","author":"Hu","year":"2017","journal-title":"Curr. Med. Chem."},{"key":"D0RA10472H-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/tcr.201500228","volume":"16","author":"Zhou","year":"2016","journal-title":"Chem. Rec."},{"key":"D0RA10472H-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/nrd2445","volume":"6","author":"Leeson","year":"2007","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D0RA10472H-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1021\/cc049879v","volume":"7","author":"Ziegert","year":"2005","journal-title":"J. Comb. Chem."},{"key":"D0RA10472H-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1039\/b611177g","volume":"36","author":"Fairlamb","year":"2007","journal-title":"Chem. Soc. Rev."},{"key":"D0RA10472H-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4816","DOI":"10.1039\/C5OB00200A","volume":"13","author":"Thapa","year":"2015","journal-title":"Org. Biomol. Chem."},{"key":"D0RA10472H-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1351\/pac200173010187","volume":"73","author":"Ugi","year":"2001","journal-title":"Pure Appl. Chem."},{"key":"D0RA10472H-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5180","DOI":"10.1002\/slct.202000683","volume":"5","author":"Fairoosa","year":"2020","journal-title":"ChemistrySelect"},{"key":"D0RA10472H-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/ajoc.201800619","volume":"8","author":"Cherian","year":"2019","journal-title":"Asian J. Org. Chem."},{"key":"D0RA10472H-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6859","DOI":"10.1002\/ejoc.202000688","volume":"2020","author":"Pal","year":"2020","journal-title":"Eur. J. Org. Chem."},{"key":"D0RA10472H-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e5600","DOI":"10.1002\/aoc.5600","volume":"34","author":"Shiri","year":"2020","journal-title":"Appl. Organomet. Chem."},{"key":"D0RA10472H-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1002\/jhet.3614","volume":"56","author":"Samzadeh-Kermani","year":"2019","journal-title":"J. Heterocycl. Chem."},{"key":"D0RA10472H-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1021\/acs.orglett.7b00171","volume":"19","author":"Yuan","year":"2017","journal-title":"Org. Lett."},{"key":"D0RA10472H-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8603","DOI":"10.1021\/acs.orglett.9b03189","volume":"21","author":"Ba","year":"2019","journal-title":"Org. Lett."},{"key":"D0RA10472H-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4501","DOI":"10.1002\/aoc.4501","volume":"32","author":"Hamrahian","year":"2018","journal-title":"Appl. Organomet. Chem."},{"key":"D0RA10472H-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/adsc.201801478","volume":"361","author":"Xu","year":"2019","journal-title":"Adv. Synth. Catal."},{"key":"D0RA10472H-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8533","DOI":"10.1021\/acs.orglett.9b02934","volume":"21","author":"Xiao","year":"2019","journal-title":"Org. Lett."},{"key":"D0RA10472H-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"16214","DOI":"10.1021\/acs.joc.9b02760","volume":"84","author":"Wang","year":"2019","journal-title":"J. Org. Chem."},{"key":"D0RA10472H-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"14109","DOI":"10.1021\/acs.joc.0c02172","volume":"85","author":"Huang","year":"2020","journal-title":"J. Org. Chem."},{"key":"D0RA10472H-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10118","DOI":"10.1021\/acs.joc.0c01381","volume":"85","author":"Wang","year":"2020","journal-title":"J. Org. Chem."},{"key":"D0RA10472H-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5046","DOI":"10.1021\/acs.joc.8b03244","volume":"84","author":"Zhang","year":"2019","journal-title":"J. Org. Chem."},{"key":"D0RA10472H-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1007\/s00706-019-2363-7","volume":"150","author":"Khalaj","year":"2019","journal-title":"Monatsh. Chem."},{"key":"D0RA10472H-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1007\/s11164-017-3247-2","volume":"44","author":"Keivanloo","year":"2018","journal-title":"Res. Chem. Intermed."},{"key":"D0RA10472H-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7218","DOI":"10.1021\/acs.orglett.9b02295","volume":"21","author":"Bao","year":"2019","journal-title":"Org. Lett."},{"key":"D0RA10472H-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3576","DOI":"10.1021\/acs.joc.9b03285","volume":"85","author":"Wang","year":"2020","journal-title":"J. Org. Chem."},{"key":"D0RA10472H-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2963","DOI":"10.1007\/s11164-019-03773-9","volume":"45","author":"Esmaeili-Shahri","year":"2019","journal-title":"Res. Chem. Intermed."},{"key":"D0RA10472H-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jorganchem.2019.01.016","volume":"884","author":"Velpuri","year":"2019","journal-title":"J. Organomet. Chem."},{"key":"D0RA10472H-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5074","DOI":"10.1002\/aoc.5074","volume":"33","author":"Shaabani","year":"2019","journal-title":"Appl. Organomet. Chem."},{"key":"D0RA10472H-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"152273","DOI":"10.1016\/j.tetlet.2020.152273","volume":"61","author":"Saikia","year":"2020","journal-title":"Tetrahedron Lett."},{"key":"D0RA10472H-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3229","DOI":"10.1016\/j.tetlet.2010.04.060","volume":"51","author":"Mudd","year":"2010","journal-title":"Tetrahedron Lett."},{"key":"D0RA10472H-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1080\/00397911.2019.1611857","volume":"49","author":"Mayooufi","year":"2019","journal-title":"Synth. Commun."},{"key":"D0RA10472H-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1007\/s10562-018-2318-3","volume":"148","author":"Yahyazadeh","year":"2018","journal-title":"Catal. Lett."},{"key":"D0RA10472H-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"100233","DOI":"10.1016\/j.cdc.2019.100233","volume":"21","author":"Patil","year":"2019","journal-title":"Chem. Data Collect."},{"key":"D0RA10472H-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"13953","DOI":"10.1039\/C8CC06868B","volume":"54","author":"Sun","year":"2018","journal-title":"Chem. Commun."},{"key":"D0RA10472H-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9487","DOI":"10.1039\/C8OB02694G","volume":"16","author":"Shi","year":"2018","journal-title":"Org. Biomol. Chem."},{"key":"D0RA10472H-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5202","DOI":"10.1021\/acs.orglett.0c01645","volume":"22","author":"Lou","year":"2020","journal-title":"Org. Lett."},{"key":"D0RA10472H-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7143","DOI":"10.1039\/C8OB01532E","volume":"16","author":"Li","year":"2018","journal-title":"Org. Biomol. Chem."},{"key":"D0RA10472H-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4481","DOI":"10.1021\/acsomega.8b03581","volume":"4","author":"Bhutia","year":"2019","journal-title":"ACS Omega"},{"key":"D0RA10472H-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4558","DOI":"10.1002\/adsc.201900643","volume":"361","author":"Gan","year":"2019","journal-title":"Adv. Synth. Catal."},{"key":"D0RA10472H-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"15100","DOI":"10.1021\/acsomega.8b02061","volume":"3","author":"Sharma","year":"2018","journal-title":"ACS Omega"},{"key":"D0RA10472H-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3576","DOI":"10.1002\/adsc.202000598","volume":"362","author":"Kim","year":"2020","journal-title":"Adv. Synth. Catal."},{"key":"D0RA10472H-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jorganchem.2019.04.023","volume":"893","author":"Saeidiroshan","year":"2019","journal-title":"J. Organomet. Chem."},{"key":"D0RA10472H-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1166\/jnn.2020.16923","volume":"20","author":"Alghamdi","year":"2020","journal-title":"J. Nanosci. Nanotechnol."},{"key":"D0RA10472H-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4454","DOI":"10.1002\/adsc.201900658","volume":"361","author":"Rodrigues","year":"2019","journal-title":"Adv. Synth. Catal."},{"key":"D0RA10472H-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4774","DOI":"10.1039\/C9OB00392D","volume":"17","author":"Satish","year":"2019","journal-title":"Org. Biomol. Chem."},{"key":"D0RA10472H-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4725","DOI":"10.1021\/acs.orglett.9b01608","volume":"21","author":"Liang","year":"2019","journal-title":"Org. Lett."},{"key":"D0RA10472H-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1002\/adsc.201701532","volume":"360","author":"Wang","year":"2018","journal-title":"Adv. Synth. Catal."},{"key":"D0RA10472H-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1055\/s-0040-1707236","volume":"52","author":"Jin","year":"2020","journal-title":"Synthesis"},{"key":"D0RA10472H-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4981","DOI":"10.1021\/acs.orglett.9b01507","volume":"21","author":"Gopal Das","year":"2019","journal-title":"Org. Lett."},{"key":"D0RA10472H-(cit51)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7386","DOI":"10.1021\/acs.orglett.9b02698","volume":"21","author":"Wang","year":"2019","journal-title":"Org. Lett."},{"key":"D0RA10472H-(cit52)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8630","DOI":"10.1021\/acs.orglett.9b03241","volume":"21","author":"Xu","year":"2019","journal-title":"Org. Lett."},{"key":"D0RA10472H-(cit53)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1002\/slct.201803412","volume":"4","author":"Taherinia","year":"2019","journal-title":"ChemistrySelect"},{"key":"D0RA10472H-(cit54)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"12266","DOI":"10.1039\/D0NJ02100H","volume":"44","author":"He","year":"2020","journal-title":"New J. Chem."},{"key":"D0RA10472H-(cit55)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1021\/acs.joc.9b02865","volume":"85","author":"Wang","year":"2020","journal-title":"J. Org. Chem."}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2021\/RA\/D0RA10472H","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T04:31:51Z","timestamp":1782880311000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ra\/article\/11\/6\/3452-3469\/704653"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":55,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,1,15]]}},"URL":"https:\/\/doi.org\/10.1039\/d0ra10472h","relation":{},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Gopinathan Anilkumar (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-7907-5616","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 13 December 2020; Accepted 8 January 2021; Version of Record published 15 January 2021","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}