{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:38:37Z","timestamp":1787679517705,"version":"build-2784847793"},"reference-count":56,"publisher":"Royal Society of Chemistry (RSC)","issue":"14","license":[{"start":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T00:00:00Z","timestamp":1583798400000},"content-version":"vor","delay-in-days":69,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"crossref","award":["200021_162767"],"award-info":[{"award-number":["200021_162767"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008931","name":"Sidney Sussex College, University of Cambridge","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008931","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Chem. Sci."],"abstract":"<p>A comprehensive analysis on the impact of sedimentation, microgravity hydrodynamic mixing and air\u2013water interface on \u03b1-synuclein aggregation kinetics.<\/p>","DOI":"10.1039\/d0sc00281j","type":"journal-article","created":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T06:23:19Z","timestamp":1583821399000},"page":"3687-3693","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Effects of sedimentation, microgravity, hydrodynamic mixing and air\u2013water interface on \u03b1-synuclein amyloid formation"],"prefix":"10.1039","volume":"11","author":[{"given":"Jiangtao","family":"Zhou","sequence":"first","affiliation":[{"name":"Laboratory of Physics of Living Matter"},{"name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL)"},{"name":"CH-1015 Lausanne"},{"name":"Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco S.","family":"Ruggeri","sequence":"additional","affiliation":[{"name":"Department of Chemistry"},{"name":"University of Cambridge"},{"name":"Cambridge CB2 1EW"},{"name":"UK"},{"name":"Centre for Misfolding Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela R.","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"Department of Chemistry"},{"name":"University of Cambridge"},{"name":"Cambridge CB2 1EW"},{"name":"UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6562-7715","authenticated-orcid":false,"given":"Georg","family":"Meisl","sequence":"additional","affiliation":[{"name":"Department of Chemistry"},{"name":"University of Cambridge"},{"name":"Cambridge CB2 1EW"},{"name":"UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Longo","sequence":"additional","affiliation":[{"name":"Istituto di Struttura della Materia"},{"name":"CNR"},{"name":"Roma"},{"name":"Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey K.","family":"Sekatskii","sequence":"additional","affiliation":[{"name":"Laboratory of Physics of Living Matter"},{"name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL)"},{"name":"CH-1015 Lausanne"},{"name":"Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0016-3008","authenticated-orcid":false,"given":"Tuomas P. J.","family":"Knowles","sequence":"additional","affiliation":[{"name":"Department of Chemistry"},{"name":"University of Cambridge"},{"name":"Cambridge CB2 1EW"},{"name":"UK"},{"name":"Centre for Misfolding Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7807-0880","authenticated-orcid":false,"given":"Giovanni","family":"Dietler","sequence":"additional","affiliation":[{"name":"Laboratory of Physics of Living Matter"},{"name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL)"},{"name":"CH-1015 Lausanne"},{"name":"Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2020]]},"reference":[{"key":"D0SC00281J-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1146\/annurev.biochem.75.101304.123901","volume":"75","author":"Chiti","year":"2006","journal-title":"Annu. Rev. Biochem."},{"key":"D0SC00281J-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1038\/nature02261","volume":"426","author":"Christopher","year":"2003","journal-title":"Nature"},{"key":"D0SC00281J-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nrm3810","volume":"15","author":"Knowles","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"D0SC00281J-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1126\/science.aan6160","volume":"358","author":"Fusco","year":"2017","journal-title":"Science"},{"key":"D0SC00281J-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/nature15368","volume":"525","author":"Rodriguez","year":"2015","journal-title":"Nature"},{"key":"D0SC00281J-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/s41467-018-03111-4","volume":"9","author":"Lautenschl\u00e4ger","year":"2018","journal-title":"Nat. Commun."},{"key":"D0SC00281J-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1002\/ange.201409050","volume":"127","author":"Ruggeri","year":"2015","journal-title":"Angew. Chem."},{"key":"D0SC00281J-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7230","DOI":"10.1073\/pnas.1721220115","volume":"115","author":"Ruggeri","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D0SC00281J-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6036","DOI":"10.1021\/bi002555c","volume":"40","author":"Nielsen","year":"2001","journal-title":"Biochemistry"},{"key":"D0SC00281J-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1002\/bip.21646","volume":"95","author":"Bekard","year":"2011","journal-title":"Biopolymers"},{"key":"D0SC00281J-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5437","DOI":"10.1039\/c1sm05382e","volume":"7","author":"Adamcik","year":"2011","journal-title":"Soft Matter"},{"key":"D0SC00281J-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"E912","DOI":"10.1073\/pnas.1512876113","volume":"113","author":"Fares","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D0SC00281J-(cit13)\/*[position()=1]","first-page":"358234","author":"Deguire","year":"2018","journal-title":"bioRxiv"},{"key":"D0SC00281J-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11358","DOI":"10.1021\/acsnano.7b05895","volume":"11","author":"Grigolato","year":"2017","journal-title":"ACS Nano"},{"key":"D0SC00281J-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/s41557-018-0031-x","volume":"10","author":"Habchi","year":"2018","journal-title":"Nat. Chem."},{"key":"D0SC00281J-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1002\/psc.2513","volume":"19","author":"Tiiman","year":"2013","journal-title":"J. Pept. Sci."},{"key":"D0SC00281J-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"38006","DOI":"10.1074\/jbc.M112.400580","volume":"287","author":"Lee","year":"2012","journal-title":"J. Biol. Chem."},{"key":"D0SC00281J-(cit18)\/*[position()=1]","first-page":"201702724","author":"Dobson","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D0SC00281J-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.msec.2014.09.015","volume":"48","author":"Batzli","year":"2015","journal-title":"Mater. Sci. Eng. Carbon"},{"key":"D0SC00281J-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1021\/la903340v","volume":"26","author":"Manno","year":"2010","journal-title":"Langmuir"},{"key":"D0SC00281J-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2866","DOI":"10.1021\/ja412105t","volume":"136","author":"Campioni","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"D0SC00281J-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"16076","DOI":"10.1021\/jp409777p","volume":"117","author":"Bernhardt","year":"2013","journal-title":"J. Phys. Chem. B"},{"key":"D0SC00281J-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"12775","DOI":"10.1021\/la203053g","volume":"27","author":"Liao","year":"2011","journal-title":"Langmuir"},{"key":"D0SC00281J-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"12934","DOI":"10.1038\/ncomms12934","volume":"7","author":"Song","year":"2016","journal-title":"Nat. Commun."},{"key":"D0SC00281J-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11071","DOI":"10.1021\/nn504249x","volume":"8","author":"Jordens","year":"2014","journal-title":"ACS Nano"},{"key":"D0SC00281J-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41526-018-0042-3","volume":"4","author":"Wuest","year":"2018","journal-title":"npj Microgravity"},{"key":"D0SC00281J-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"105","DOI":"10.4236\/ojbiphy.2014.44012","volume":"4","author":"Sieber","year":"2014","journal-title":"Open J. Biophys."},{"key":"D0SC00281J-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"361","DOI":"10.4236\/jbise.2016.98031","volume":"9","author":"Sieber","year":"2016","journal-title":"J. Biomed. Sci. Eng."},{"key":"D0SC00281J-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-22870-0","volume":"8","author":"Dinarelli","year":"2018","journal-title":"Sci. Rep."},{"key":"D0SC00281J-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/BF02873330","volume":"13","author":"Goldermann","year":"2001","journal-title":"Microgravity Sci. Technol."},{"key":"D0SC00281J-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"16013","DOI":"10.1038\/npjmgrav.2016.13","volume":"2","author":"Takamatsu","year":"2016","journal-title":"npj Microgravity"},{"key":"D0SC00281J-(cit32)\/*[position()=1]","volume-title":"Gravitational and Space Research","volume":"vol. 6","author":"Bell","year":"2018","unstructured":"D. Bell , S.Durrance , D.Kirk , H.Gutierrez , D.Woodard , J.Avendano , J.Sargent , C.Leite , B.Saldana , T.Melles , S.Jackson and S.Xu , Gravitational and Space Research , 2018 , vol. 6 , pp. 10\u201326"},{"key":"D0SC00281J-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3950","DOI":"10.2174\/1381612822666160518141911","volume":"22","author":"Ruggeri","year":"2016","journal-title":"Curr. Pharm. Des."},{"key":"D0SC00281J-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"E1009","DOI":"10.1073\/pnas.1610586114","volume":"114","author":"Perni","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D0SC00281J-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.abb.2019.02.001","volume":"664","author":"Ruggeri","year":"2019","journal-title":"Arch. Biochem. Biophys."},{"key":"D0SC00281J-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"31155","DOI":"10.1038\/srep31155","volume":"6","author":"Ruggeri","year":"2016","journal-title":"Sci. Rep."},{"key":"D0SC00281J-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/nprot.2016.010","volume":"11","author":"Meisl","year":"2016","journal-title":"Nat. Protoc."},{"key":"D0SC00281J-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1126\/science.1178250","volume":"326","author":"Knowles","year":"2009","journal-title":"Science"},{"key":"D0SC00281J-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"971474","DOI":"10.1155\/2015\/971474","volume":"2015","author":"Wuest","year":"2015","journal-title":"BioMed Res. Int."},{"key":"D0SC00281J-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9797","DOI":"10.1021\/ja102896h","volume":"132","author":"Pronchik","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"D0SC00281J-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7606","DOI":"10.1039\/C4CP05563B","volume":"17","author":"Arosio","year":"2015","journal-title":"Phys. Chem. Chem. Phys."},{"key":"D0SC00281J-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e25020","DOI":"10.1371\/journal.pone.0025020","volume":"6","author":"Zhu","year":"2011","journal-title":"PLoS One"},{"key":"D0SC00281J-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/nchembio.1750","volume":"11","author":"Galvagnion","year":"2015","journal-title":"Nat. Chem. Biol."},{"key":"D0SC00281J-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10855","DOI":"10.1021\/acsnano.8b03575","volume":"12","author":"Iljina","year":"2018","journal-title":"ACS Nano"},{"key":"D0SC00281J-(cit45)\/*[position()=1]","volume-title":"Amyloid Proteins","author":"Meisl","year":"2018","unstructured":"G. Meisl , T. C. T.Michaels , S.Linse and T. P. J.Knowles , in Amyloid Proteins , Humana Press , New York, NY , 2018 , pp. 181\u2013196"},{"key":"D0SC00281J-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"36010","DOI":"10.1038\/srep36010","volume":"6","author":"Brown","year":"2016","journal-title":"Sci. Rep."},{"key":"D0SC00281J-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1039\/c2sm07017k","volume":"8","author":"Rudiuk","year":"2012","journal-title":"Soft Matter"},{"key":"D0SC00281J-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1039\/C3SM51994E","volume":"10","author":"Monica Castellanos","year":"2014","journal-title":"Soft Matter"},{"key":"D0SC00281J-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5","DOI":"10.2174\/156720512799015064","volume":"9","author":"Cai","year":"2012","journal-title":"Curr. Alzheimer Res."},{"issue":"8","key":"D0SC00281J-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"a006239","DOI":"10.1101\/cshperspect.a006239","volume":"2","author":"Mayeux","year":"2012","journal-title":"Cold Spring Harbor Perspect. Med."},{"key":"D0SC00281J-(cit51)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9758","DOI":"10.1073\/pnas.1218402110","volume":"110","author":"Cohen","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D0SC00281J-(cit52)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0022-2836(02)00775-1","volume":"322","author":"Hoyer","year":"2002","journal-title":"J. Mol. Biol."},{"key":"D0SC00281J-(cit53)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41526-018-0041-4","volume":"4","author":"Manzano","year":"2018","journal-title":"npj Microgravity"},{"key":"D0SC00281J-(cit54)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/ast.2012.0876","volume":"13","author":"Herranz","year":"2012","journal-title":"Astrobiology"},{"key":"D0SC00281J-(cit55)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1002\/pmic.201000817","volume":"11","author":"Pietsch","year":"2011","journal-title":"Proteomics"},{"key":"D0SC00281J-(cit56)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.asr.2007.02.016","volume":"39","author":"van Loon","year":"2007","journal-title":"Adv. Space Res."}],"container-title":["Chemical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2020\/SC\/D0SC00281J","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:22:19Z","timestamp":1783448539000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/sc\/article\/11\/14\/3687-3693\/705183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":56,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2020,4,8]]}},"URL":"https:\/\/doi.org\/10.1039\/d0sc00281j","relation":{},"ISSN":["2041-6520","2041-6539"],"issn-type":[{"value":"2041-6520","type":"print"},{"value":"2041-6539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/D0SC00281J","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Georg Meisl (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-6562-7715","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Tuomas P. J. Knowles (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-0016-3008","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Giovanni Dietler (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-7807-0880","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 15 January 2020; Accepted 6 March 2020; Accepted Manuscript published 10 March 2020; Advance Article published 17 March 2020; Version of Record published 8 April 2020","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}