{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T21:04:11Z","timestamp":1782853451467,"version":"3.54.5"},"reference-count":22,"publisher":"Royal Society of Chemistry (RSC)","issue":"37","license":[{"start":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T00:00:00Z","timestamp":1660953600000},"content-version":"am","delay-in-days":596,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11904007"],"award-info":[{"award-number":["11904007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21874034"],"award-info":[{"award-number":["21874034"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21922403"],"award-info":[{"award-number":["21922403"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017668","name":"Anhui Provincial Key Research and Development Plan","doi-asserted-by":"publisher","award":["202104a07020013"],"award-info":[{"award-number":["202104a07020013"]}],"id":[{"id":"10.13039\/501100017668","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["KJ2016A341"],"award-info":[{"award-number":["KJ2016A341"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["2019jyxm0994"],"award-info":[{"award-number":["2019jyxm0994"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Anal. Methods"],"abstract":"<jats:p>A double-aptamer sandwich strategy for dual-reporter SERS assay with reduced false-positive as practical protein testing tool in clinical diagnostics and prognosis.<\/jats:p>","DOI":"10.1039\/d1ay01002f","type":"journal-article","created":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T04:40:59Z","timestamp":1629434459000},"page":"4328-4333","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Highly stable surface-enhanced Raman spectroscopy assay on abnormal thrombin levels in the blood plasma of cancer patients"],"prefix":"10.1039","volume":"13","author":[{"given":"Lingling","family":"Liao","sequence":"first","affiliation":[{"name":"First Affiliated Hospital of Anhui Medical University, Hefei 230022, China"},{"name":"Institute of Physical Science and Information Technology, Anhui University, Hefei, Anhui, 230039, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Du","sequence":"additional","affiliation":[{"name":"Institute of Physical Science and Information Technology, Anhui University, Hefei, Anhui, 230039, China"},{"name":"School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Ding","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Anhui Medical University, Hefei 230022, China"},{"name":"School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengke","family":"Su","sequence":"additional","affiliation":[{"name":"School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingmei","family":"Duan","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Anhui Medical University, Hefei 230022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghe","family":"Li","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Anhui Medical University, Hefei 230022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengnan","family":"He","sequence":"additional","affiliation":[{"name":"Institute of Physical Science and Information Technology, Anhui University, Hefei, Anhui, 230039, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Wang","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Anhui Medical University, Hefei 230022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0910-2444","authenticated-orcid":false,"given":"Honglin","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2021]]},"reference":[{"key":"D1AY01002F\/cit1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aca.2014.04.055","volume":"837","author":"Deng","year":"2014","journal-title":"Anal. Chim. Acta"},{"key":"D1AY01002F\/cit2","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1200\/JCO.2010.32.8294","volume":"29","author":"Ay","year":"2011","journal-title":"J. Clin. Oncol."},{"key":"D1AY01002F\/cit3","doi-asserted-by":"crossref","first-page":"E566","DOI":"10.1016\/S1470-2045(19)30336-5","volume":"20","author":"Farge","year":"2019","journal-title":"Lancet Oncol."},{"key":"D1AY01002F\/cit4","doi-asserted-by":"crossref","first-page":"4042","DOI":"10.1039\/C7CS00238F","volume":"46","author":"Ding","year":"2017","journal-title":"Chem. Soc. Rev."},{"key":"D1AY01002F\/cit5","doi-asserted-by":"crossref","first-page":"4946","DOI":"10.1021\/acs.chemrev.7b00668","volume":"118","author":"Zong","year":"2018","journal-title":"Chem. Rev."},{"key":"D1AY01002F\/cit6","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nrd.2016.199","volume":"16","author":"Zhou","year":"2017","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D1AY01002F\/cit7","doi-asserted-by":"crossref","first-page":"9056","DOI":"10.1073\/pnas.1700317114","volume":"114","author":"Chuong","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D1AY01002F\/cit8","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.bios.2013.03.003","volume":"47","author":"Yoon","year":"2013","journal-title":"Biosens. Bioelectron."},{"key":"D1AY01002F\/cit9","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.bios.2019.01.039","volume":"130","author":"Pang","year":"2019","journal-title":"Biosens. Bioelectron."},{"key":"D1AY01002F\/cit10","first-page":"20","volume":"241","author":"Frens","year":"1973","journal-title":"Nature"},{"key":"D1AY01002F\/cit11","doi-asserted-by":"crossref","first-page":"4215","DOI":"10.1021\/ac0702084","volume":"79","author":"Haiss","year":"2007","journal-title":"Anal. Chem."},{"key":"D1AY01002F\/cit12","doi-asserted-by":"crossref","first-page":"8313","DOI":"10.1021\/ac0613582","volume":"78","author":"Hurst","year":"2006","journal-title":"Anal. Chem."},{"key":"D1AY01002F\/cit13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aca.2014.04.055","volume":"837","author":"Deng","year":"2014","journal-title":"Anal. Chim. Acta"},{"key":"D1AY01002F\/cit14","doi-asserted-by":"crossref","first-page":"3016","DOI":"10.1021\/ac070096g","volume":"79","author":"Bini","year":"2007","journal-title":"Anal. Chem."},{"key":"D1AY01002F\/cit15","doi-asserted-by":"crossref","first-page":"5599","DOI":"10.1021\/acs.jpcc.8b00701","volume":"122","author":"Zhang","year":"2018","journal-title":"J. Phys. Chem. C"},{"key":"D1AY01002F\/cit16","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.bios.2013.07.065","volume":"51","author":"Lin","year":"2014","journal-title":"Biosens. Bioelectron."},{"key":"D1AY01002F\/cit17","doi-asserted-by":"crossref","first-page":"9910","DOI":"10.1021\/ja303787e","volume":"134","author":"Zhang","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"D1AY01002F\/cit18","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.aca.2013.05.043","volume":"787","author":"Bai","year":"2013","journal-title":"Anal. Chim. Acta"},{"key":"D1AY01002F\/cit19","doi-asserted-by":"crossref","first-page":"8867","DOI":"10.1021\/ac202823m","volume":"83","author":"Olmsted","year":"2011","journal-title":"Anal. Chem."},{"key":"D1AY01002F\/cit20","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.snb.2015.08.009","volume":"222","author":"Xu","year":"2016","journal-title":"Sens. Actuators, B"},{"key":"D1AY01002F\/cit21","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.bios.2017.02.024","volume":"92","author":"Hou","year":"2017","journal-title":"Biosens. Bioelectron."},{"key":"D1AY01002F\/cit22","first-page":"11","author":"Reddel","year":"2019","journal-title":"Cancers"}],"container-title":["Analytical Methods"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2021\/AY\/D1AY01002F","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T20:10:04Z","timestamp":1782850204000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ay\/article\/13\/37\/4328-4333\/715318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":22,"journal-issue":{"issue":"37","published-print":{"date-parts":[[2021,9,30]]}},"URL":"https:\/\/doi.org\/10.1039\/d1ay01002f","relation":{},"ISSN":["1759-9660","1759-9679"],"issn-type":[{"value":"1759-9660","type":"print"},{"value":"1759-9679","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}