{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T23:01:28Z","timestamp":1782946888433,"version":"3.54.5"},"reference-count":78,"publisher":"Royal Society of Chemistry (RSC)","issue":"18","license":[{"start":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T00:00:00Z","timestamp":1659571200000},"content-version":"am","delay-in-days":580,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/100012465","name":"Nemours Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012465","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016935","name":"Lisa Dean Moseley Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016935","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20GM103446"],"award-info":[{"award-number":["P20GM103446"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20GM103446-16S1"],"award-info":[{"award-number":["P20GM103446-16S1"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P30GM114736"],"award-info":[{"award-number":["P30GM114736"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005968","name":"Leukemia Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Biomater. Sci."],"abstract":"<jats:p>Induced pluripotent stem cells (iPSCs) provide an extraordinary tool for disease modeling owing to their potential to differentiate into the desired cell type.<\/jats:p>","DOI":"10.1039\/d1bm00442e","type":"journal-article","created":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T08:24:43Z","timestamp":1628065483000},"page":"6266-6281","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A 3-D hydrogel based system for hematopoietic differentiation and its use in modeling down syndrome associated transient myeloproliferative disorder"],"prefix":"10.1039","volume":"9","author":[{"given":"Ishnoor","family":"Sidhu","sequence":"first","affiliation":[{"name":"Nemours Centers for Childhood Cancer Research and Cancer & Blood Disorders, A.I. DuPont Hospital for Children, Wilmington, DE 19803, USA"},{"name":"University of Delaware, Newark, DE 19711, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonali P.","family":"Barwe","sequence":"additional","affiliation":[{"name":"Nemours Centers for Childhood Cancer Research and Cancer & Blood Disorders, A.I. DuPont Hospital for Children, Wilmington, DE 19803, USA"},{"name":"University of Delaware, Newark, DE 19711, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristi L.","family":"Kiick","sequence":"additional","affiliation":[{"name":"University of Delaware, Newark, DE 19711, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Anders","family":"Kolb","sequence":"additional","affiliation":[{"name":"Nemours Centers for Childhood Cancer Research and Cancer & Blood Disorders, A.I. DuPont Hospital for Children, Wilmington, DE 19803, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0465-578X","authenticated-orcid":false,"given":"Anilkumar","family":"Gopalakrishnapillai","sequence":"additional","affiliation":[{"name":"Nemours Centers for Childhood Cancer Research and Cancer & Blood Disorders, A.I. DuPont Hospital for Children, Wilmington, DE 19803, USA"},{"name":"University of Delaware, Newark, DE 19711, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2021]]},"reference":[{"key":"D1BM00442E\/cit1","doi-asserted-by":"crossref","first-page":"a028373","DOI":"10.1101\/cshperspect.a028373","volume":"7","author":"Sansregret","year":"2017","journal-title":"Cold Spring Harb. Perspect Med."},{"key":"D1BM00442E\/cit2","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1182\/asheducation-2015.1.507","volume":"2015","author":"Kolb","year":"2015","journal-title":"Hematology"},{"key":"D1BM00442E\/cit3","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/ng955","volume":"32","author":"Wechsler","year":"2002","journal-title":"Nat. Genet."},{"key":"D1BM00442E\/cit4","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1182\/blood-2015-05-567859","volume":"126","author":"Gruber","year":"2015","journal-title":"Blood"},{"key":"D1BM00442E\/cit5","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1007\/s12185-020-03066-7","volume":"113","author":"Yamato","year":"2021","journal-title":"Int. J. Hematol."},{"key":"D1BM00442E\/cit6","doi-asserted-by":"crossref","first-page":"2991","DOI":"10.1182\/blood-2007-10-118810","volume":"111","author":"Klusmann","year":"2008","journal-title":"Blood"},{"key":"D1BM00442E\/cit7","doi-asserted-by":"crossref","first-page":"5171032","DOI":"10.1155\/2019\/5171032","volume":"2019","author":"Wattanapanitch","year":"2019","journal-title":"Stem Cells Int."},{"key":"D1BM00442E\/cit8","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1749-6632.2009.04606.x","volume":"1176","author":"Lengerke","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"D1BM00442E\/cit9","doi-asserted-by":"crossref","first-page":"5473","DOI":"10.1182\/blood-2009-04-217406","volume":"114","author":"Ye","year":"2009","journal-title":"Blood"},{"key":"D1BM00442E\/cit10","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1634\/stemcells.2008-0922","volume":"27","author":"Choi","year":"2009","journal-title":"Stem Cells"},{"key":"D1BM00442E\/cit11","doi-asserted-by":"crossref","first-page":"e17829","DOI":"10.1371\/journal.pone.0017829","volume":"6","author":"Salvagiotto","year":"2011","journal-title":"PLoS One"},{"key":"D1BM00442E\/cit12","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/978-1-60761-962-8_15","volume":"690","author":"Mar\u00ed-Buy\u00e9","year":"2011","journal-title":"Methods Mol. Biol."},{"key":"D1BM00442E\/cit13","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s13045-016-0326-6","volume":"9","author":"Xu","year":"2016","journal-title":"J. Hematol. Oncol."},{"key":"D1BM00442E\/cit14","doi-asserted-by":"crossref","first-page":"9068203","DOI":"10.1155\/2018\/9068203","volume":"2018","author":"Bertucci","year":"2018","journal-title":"Stem Cells Int."},{"key":"D1BM00442E\/cit15","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.bioactmat.2016.05.001","volume":"1","author":"Tsou","year":"2016","journal-title":"Bioact. Mater."},{"key":"D1BM00442E\/cit16","doi-asserted-by":"crossref","first-page":"5580","DOI":"10.1073\/pnas.1319685111","volume":"111","author":"Dixon","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D1BM00442E\/cit17","doi-asserted-by":"crossref","first-page":"7053","DOI":"10.1002\/adfm.201401483","volume":"24","author":"Lam","year":"2014","journal-title":"Adv. Funct. Mater."},{"key":"D1BM00442E\/cit18","doi-asserted-by":"crossref","first-page":"e0187665","DOI":"10.1371\/journal.pone.0187665","volume":"12","author":"Ribeiro","year":"2017","journal-title":"PLoS One"},{"key":"D1BM00442E\/cit19","doi-asserted-by":"crossref","first-page":"499","DOI":"10.3389\/fchem.2018.00499","volume":"6","author":"Li","year":"2018","journal-title":"Front. Chem."},{"key":"D1BM00442E\/cit20","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1002\/pmic.200900758","volume":"10","author":"Hughes","year":"2010","journal-title":"Proteomics"},{"key":"D1BM00442E\/cit21","doi-asserted-by":"crossref","first-page":"e113609","DOI":"10.1371\/journal.pone.0113609","volume":"9","author":"Jitraruch","year":"2014","journal-title":"PLoS One"},{"key":"D1BM00442E\/cit22","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.jbiotec.2009.08.008","volume":"144","author":"Wang","year":"2009","journal-title":"J. Biotechnol."},{"key":"D1BM00442E\/cit23","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.actbio.2016.11.016","volume":"49","author":"Hunt","year":"2017","journal-title":"Acta Biomater."},{"key":"D1BM00442E\/cit24","doi-asserted-by":"crossref","first-page":"109904","DOI":"10.1016\/j.msec.2019.109904","volume":"104","author":"Moxon","year":"2019","journal-title":"Mater. Sci. Eng., C"},{"key":"D1BM00442E\/cit25","doi-asserted-by":"crossref","first-page":"42700","DOI":"10.18632\/oncotarget.17446","volume":"8","author":"Zhu","year":"2017","journal-title":"Oncotarget"},{"key":"D1BM00442E\/cit26","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.eurpolymj.2012.12.009","volume":"49","author":"Croisier","year":"2013","journal-title":"Eur. Polym. J."},{"key":"D1BM00442E\/cit27","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.progpolymsci.2011.06.003","volume":"37","author":"Lee","year":"2012","journal-title":"Prog. Polym. Sci."},{"key":"D1BM00442E\/cit29","first-page":"10671","volume":"1","author":"Li","year":"2016","journal-title":"Nat. Rev. Mater."},{"key":"D1BM00442E\/cit30","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1177\/1535370216647129","volume":"241","author":"David","year":"2016","journal-title":"Exp. Biol. Med."},{"key":"D1BM00442E\/cit31","doi-asserted-by":"crossref","first-page":"45146","DOI":"10.1038\/srep45146","volume":"7","author":"Chen","year":"2017","journal-title":"Sci. Rep."},{"key":"D1BM00442E\/cit32","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/978-1-4939-7021-6_5","volume":"1612","author":"Caiazzo","year":"2017","journal-title":"Methods Mol. Biol."},{"key":"D1BM00442E\/cit33","doi-asserted-by":"crossref","first-page":"E5039","DOI":"10.1073\/pnas.1309408110","volume":"110","author":"Lei","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D1BM00442E\/cit34","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1039\/C8BM00099A","volume":"6","author":"Ovadia","year":"2018","journal-title":"Biomater. Sci."},{"key":"D1BM00442E\/cit35","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1126\/science.2821619","volume":"238","author":"Ruoslahti","year":"1987","journal-title":"Science"},{"key":"D1BM00442E\/cit36","doi-asserted-by":"crossref","first-page":"19302","DOI":"10.1073\/pnas.1008291107","volume":"107","author":"Fong","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D1BM00442E\/cit37","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1039\/C3BM60319A","volume":"2","author":"Smithmyer","year":"2014","journal-title":"Biomater. Sci."},{"key":"D1BM00442E\/cit38","doi-asserted-by":"crossref","first-page":"5991","DOI":"10.1016\/j.biomaterials.2005.03.018","volume":"26","author":"Yang","year":"2005","journal-title":"Biomaterials"},{"key":"D1BM00442E\/cit39","doi-asserted-by":"crossref","first-page":"015013","DOI":"10.1088\/1758-5090\/aaf657","volume":"11","author":"Christoffersson","year":"2018","journal-title":"Biofabrication"},{"key":"D1BM00442E\/cit40","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1021\/cm402180t","volume":"26","author":"Nair","year":"2014","journal-title":"Chem. Mater."},{"key":"D1BM00442E\/cit41","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.ymeth.2015.08.001","volume":"94","author":"Chevalier","year":"2016","journal-title":"Methods"},{"key":"D1BM00442E\/cit42","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3390\/gels3010006","volume":"3","author":"Chai","year":"2017","journal-title":"Gels"},{"key":"D1BM00442E\/cit43","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1242\/dev.026211","volume":"136","author":"Zhou","year":"2009","journal-title":"Development"},{"key":"D1BM00442E\/cit44","doi-asserted-by":"crossref","first-page":"e117","DOI":"10.1002\/cpsc.117","volume":"54","author":"Rivera","year":"2020","journal-title":"Curr. Protoc. Stem Cell Biol."},{"key":"D1BM00442E\/cit45","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/nmeth.1593","volume":"8","author":"Chen","year":"2011","journal-title":"Nat. Methods"},{"key":"D1BM00442E\/cit46","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1038\/ncomms2231","volume":"3","author":"Miyazaki","year":"2012","journal-title":"Nat. Commun."},{"key":"D1BM00442E\/cit47","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1039\/C3BM60183H","volume":"2","author":"Tabata","year":"2014","journal-title":"Biomater. Sci."},{"key":"D1BM00442E\/cit48","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1089\/scd.2013.0314","volume":"23","author":"Lou","year":"2014","journal-title":"Stem Cells Dev."},{"key":"D1BM00442E\/cit49","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.scr.2017.07.014","volume":"23","author":"Plotnikov","year":"2017","journal-title":"Stem Cell Res."},{"key":"D1BM00442E\/cit50","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1002\/btpr.1891","volume":"30","author":"Horiguchi","year":"2014","journal-title":"Biotechnol. Prog."},{"key":"D1BM00442E\/cit51","doi-asserted-by":"crossref","first-page":"e74","DOI":"10.1002\/term.389","volume":"5","author":"Allen","year":"2011","journal-title":"J. Tissue Eng. Regener. Med."},{"key":"D1BM00442E\/cit52","doi-asserted-by":"crossref","first-page":"15578","DOI":"10.1038\/s41598-019-51911-5","volume":"9","author":"Goetzke","year":"2019","journal-title":"Sci. Rep."},{"key":"D1BM00442E\/cit53","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1039\/c2ib20083j","volume":"4","author":"Keung","year":"2012","journal-title":"Integr. Biol."},{"key":"D1BM00442E\/cit54","first-page":"190","volume":"84","author":"Rybtsov","year":"2019","journal-title":"Biochemistry"},{"key":"D1BM00442E\/cit55","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1242\/dev.134866","volume":"144","author":"Ivanovs","year":"2017","journal-title":"Development"},{"key":"D1BM00442E\/cit56","author":"Marrese","unstructured":"M.Marrese ,  N.Antonovait\u00e9 ,  B. K.Nelemans ,  A.Ahmadzada ,  D.Iannuzzi  and  T. H.Smit"},{"key":"D1BM00442E\/cit57","doi-asserted-by":"crossref","first-page":"6367","DOI":"10.3390\/ijms21176367","volume":"21","author":"Garcia-Abrego","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"D1BM00442E\/cit58","doi-asserted-by":"publisher","first-page":"100787","DOI":"10.1016\/j.blre.2020.100787","author":"Sidhu","year":"2020","journal-title":"Blood Rev."},{"key":"D1BM00442E\/cit59","doi-asserted-by":"crossref","first-page":"e103418","DOI":"10.1371\/journal.pone.0103418","volume":"9","author":"Pr\u00e8","year":"2014","journal-title":"PLoS One"},{"key":"D1BM00442E\/cit60","doi-asserted-by":"crossref","first-page":"e0135170","DOI":"10.1371\/journal.pone.0135170","volume":"10","author":"Haque","year":"2015","journal-title":"PLoS One"},{"key":"D1BM00442E\/cit61","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1074\/jbc.AC119.011795","volume":"295","author":"Srivastava","year":"2020","journal-title":"J. Biol. Chem."},{"key":"D1BM00442E\/cit62","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.scr.2013.09.009","volume":"12","author":"Gran\u00e9li","year":"2014","journal-title":"Stem Cell Res."},{"key":"D1BM00442E\/cit63","doi-asserted-by":"crossref","first-page":"S42","DOI":"10.1016\/j.exphem.2017.06.045","volume":"53","author":"Anjos-Afonso","year":"2017","journal-title":"Exp. Hematol."},{"key":"D1BM00442E\/cit64","doi-asserted-by":"crossref","first-page":"5300","DOI":"10.1038\/s41598-019-41803-z","volume":"9","author":"Hua","year":"2019","journal-title":"Sci. Rep."},{"key":"D1BM00442E\/cit65","doi-asserted-by":"crossref","first-page":"4730","DOI":"10.1038\/s41467-019-12726-0","volume":"10","author":"Wagenblast","year":"2019","journal-title":"Nat. Commun."},{"key":"D1BM00442E\/cit66","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.omtm.2020.09.007","volume":"19","author":"Barwe","year":"2020","journal-title":"Mol. Ther.\u2013Methods Clin. Dev."},{"key":"D1BM00442E\/cit67","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1172\/JCI75714","volume":"125","author":"Byrska-Bishop","year":"2015","journal-title":"J. Clin. Invest."},{"key":"D1BM00442E\/cit68","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1016\/j.celrep.2016.04.031","volume":"15","author":"Banno","year":"2016","journal-title":"Cell Rep."},{"key":"D1BM00442E\/cit69","doi-asserted-by":"crossref","first-page":"17567","DOI":"10.1073\/pnas.1215468109","volume":"109","author":"Maclean","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D1BM00442E\/cit70","doi-asserted-by":"crossref","first-page":"249","DOI":"10.15252\/embr.201541465","volume":"17","author":"Tanimura","year":"2016","journal-title":"EMBO Rep."},{"key":"D1BM00442E\/cit71","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/cyto.b.21530","volume":"92","author":"Lambert","year":"2017","journal-title":"Cytometry, Part B"},{"key":"D1BM00442E\/cit72","first-page":"1667","volume":"7","author":"Kwong","year":"1993","journal-title":"Leukemia"},{"key":"D1BM00442E\/cit73","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1046\/j.1365-2141.2003.04463.x","volume":"122","author":"Kwong","year":"2003","journal-title":"Br. J. Haematol."},{"key":"D1BM00442E\/cit74","first-page":"99","volume":"23","author":"Weiss","year":"1995","journal-title":"Exp. Hematol."},{"key":"D1BM00442E\/cit75","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1620\/tjem.242.83","volume":"242","author":"Fujiwara","year":"2017","journal-title":"Tohoku J. Exp. Med."},{"key":"D1BM00442E\/cit76","doi-asserted-by":"crossref","first-page":"438","DOI":"10.2174\/1389202920666191017163837","volume":"20","author":"Alsayegh","year":"2019","journal-title":"Curr. Genomics"},{"key":"D1BM00442E\/cit77","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1111\/jpc.13628","volume":"53","author":"Carruthers","year":"2017","journal-title":"J. Paediatr. Child Health"},{"key":"D1BM00442E\/cit78","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1038\/ng.2759","volume":"45","author":"Yoshida","year":"2013","journal-title":"Nat. Genet."},{"key":"D1BM00442E\/cit79","first-page":"33","volume":"1348","author":"Hansen","year":"2015","journal-title":"Methods Protoc."}],"container-title":["Biomaterials Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2021\/BM\/D1BM00442E","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T21:54:32Z","timestamp":1782942872000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/bm\/article\/9\/18\/6266-6281\/715892"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":78,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2021,9,14]]}},"URL":"https:\/\/doi.org\/10.1039\/d1bm00442e","relation":{},"ISSN":["2047-4830","2047-4849"],"issn-type":[{"value":"2047-4830","type":"print"},{"value":"2047-4849","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}